List of Publication by tag - National Autism Resource Centre (NARC)

Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z

Factors associated with autism severity among Malaysian children with Autism Spectrum Disorder Journal Article

Research in Developmental Disabilities, 100 , 2020, ISSN: 08914222, (cited By 0).

Abstract | Links | BibTeX | Tags: Article, Autism, Body Weight, Children, Cross-Sectional Study, Demography, Disease Association, Disease Severity, Employment, Female, Human, Lifestyle, Major Clinical Study, Malaysia, Malaysian, Male, Parents, Preschool Child, School Child, Social Status

de Vries, M; Cader, S; Colleer, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E

University Students’ Notion of Autism Spectrum Conditions: A Cross-Cultural Study Journal Article

Journal of Autism and Developmental Disorders, 50 (4), pp. 1281-1294, 2020, ISSN: 01623257, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Attitude to Health, Autism, Female, Health Belief, Human, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Malaysian, Male, Priority Journal, Social Acceptance, Social Interactions, Sociology, Student Attitude, Students, United Kingdom, University Student, Young Adult

Leong, D; Hedley, D; Uljarević, M

Poh-tay-toe, Poh-tah-toe: Autism Diagnosis and Conceptualization Journal Article

Journal of Child Neurology, 35 (3), pp. 247-248, 2020, ISSN: 08830738, (cited By 0).

Links | BibTeX | Tags: Anxiety, Attention Deficit Disorder, Autism, Caregiver, Children, Clinical Article, Clinical Practice, Disruptive Behavior, DSM-5, Follow Up, Human, Learning Disorder, Letter, Mental Health, Mood Disorder, Multidisciplinary Team, Neuropsychiatry, Priority Journal, Unemployment, Workforce

Taresh, S; Ahmad, N A; Roslan, S; Ma’rof, A M; Zaid, S

Pre-school teachers’ knowledge, belief, identification skills, and self-efficacy in identifying autism spectrum disorder (ASD): A conceptual framework to identify children with ASD Journal Article

Brain Sciences, 10 (3), 2020, ISSN: 20763425, (cited By 0).

Abstract | Links | BibTeX | Tags: Attitude to Disability, Autism, Cognition, Conceptual Framework, Education, Health Belief, Health Care, Health Care Personnel, Human, Interpersonal Communication, Mental Health, Physiotherapist, Psychological Aspect, Questionnaires, Review, School Teacher, Self Concept, Social Behaviour, Social Cognitive Theory, Social Interactions, Social Stigma, Teaching, Training

Djatmika, ; Wibowo, A H; Sugini, ; Halim, H; Mohamad, B

Multimodal strategies in teaching children with autism: A discourse analysis Journal Article

Systematic Reviews in Pharmacy, 11 (2), pp. 219-229, 2020, ISSN: 09758453, (cited By 0).

Abstract | Links | BibTeX | Tags: Article, Autism, Body Movement, Children, Discourse Analysis, Gesture, Human, Language, Loudness, Nonverbal Communication, Paralanguage, Priority Journal, Standing, Strategic Planning, Students, Teacher, Teaching, Verbal Behaviour, Verbal Communication

Alnajjar, F; Cappuccio, M; Renawi, A; Mubin, O; Loo, C K

Personalized Robot Interventions for Autistic Children: An Automated Methodology for Attention Assessment Journal Article

International Journal of Social Robotics, 2020, ISSN: 18754791, (cited By 0).

Abstract | Links | BibTeX | Tags: Assessment, Attention, Autism, Children with Autism, Diseases, Emotion, Emotional Response, Interaction Systems, Robotics, Robots, Therapy

Bakar, Wan Norliza Wan

THE EFFECTIVENESS OF MULTI SENSORY INTEGRATION VIA ISLAMIC WAY IN CAPTURING THE INTEREST OF PERVASIVE DEVELOPMENTAL DISORDER AUTISTICS Journal Article

Jurnal Penyelidikan Sains Sosial (JOSSR), 2 (5), pp. 1-6, 2019, ISSN: 2637 - 0956.

Abstract | BibTeX | Tags: Autism, Autistic, Pervasive Developmental Disorder

Pervasive Developmental Disorder is one of the categories of autism. Autistics suffering from this type of autism show a lack of interest in other people. They display difficulty in communication and exhibit repetitive behaviour. Autistics with the pervasive developmental disorder have a cognitive profile with high skills in spatial organization (Girardot, 2012). The purpose of this study is to spark interest in learning in the autistics suffering from pervasive developmental disorder. Three autistic suffering from pervasive developmental disorder namely from The Special Inclusive Class in a school at Kelantan was selected. A multiple baseline design was implemented. The procedure of the research is divided into three stages. Firstly, a set of Quran verses is played through a cassette to the first pervasive developmental disorder. The Quran Verses of Al Fatihah, Al-Qadr and Al Insyirah are played repeatedly through a cassette player to the first pervasive developmental disorder. After he reaches the state of stability then the multi-sensory integration was given by the researcher to the pervasive developmental disorder.it is by giving a toy car to him and made him play to and fro. After a few minutes he reaches the state of stability. Secondly, the set of Quran verses is again applied to the second pervasive developmental disorder. After half an hour he reaches the state of stability. Then the researcher use multi-sensory integration approach by giving him a toy car and made him play to and fro. After a few minutes he reaches the state of stability. Thirdly the set of Quran verses is again applied to the second pervasive developmental disorder. After half an hour he reaches the state of stability. Then the researcher use multi-sensory integration approach by giving him a toy car and made him play to and fro. The results indicated that by using the Quran verses the pervasive developmental disorder autistic became calm and this enabled him to speak and to play cheerfully. Future research should be implemented on the pervasive developmental disorder’s interest that will lead to his career path.

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Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Sami, F M; Badgujar, S; Govindan, S N; Ansari, M T

Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Journal Article

Human Vaccines and Immunotherapeutics, 15 (11), pp. 2544-2551, 2019, ISSN: 21645515, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Attitude, Attitude to Health, Autism, Child Health, Childhood Vaccination, Children, Cross-Sectional Study, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Education, Employment, Ethnicity, Female, Health Knowledge, Human, Immunization Programs, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Mother, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Preschool Child, Preventive Health Service, Psychology, Questionnaires, Seasonal Influenza, Surveys, Vaccination, Young Adult

Ramachandram, S

Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia Journal Article

Medical Journal of Malaysia, 74 (5), pp. 372-376, 2019, ISSN: 03005283, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Article, Asthma, Autism, Birth Weight, Child Development, Children, Chinese, Conception, Demography, Diet Restriction, DSM-5, Eczema, Education, Educational Status, Epilepsy, Female, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Human, Indian, Major Clinical Study, Malay, Male, Medical Record Review, Penang, Prematurity, Speech Disorder, Upper Respiratory Tract Congestion, Wakefulness

Ong, J J

Parental satisfaction and perception of Progress in influencing the Practice of complementary health approaches in children with autism: A cross sectional survey from Negeri Sembilan, Malaysia Journal Article

BMC Complementary and Alternative Medicine, 19 (1), 2019, ISSN: 14726882, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Alternative Medicine, Autism, Autism Spectrum Disorders, Child Behaviour, Child Parent Relation, Children, Complementary Therapies, Cross-Sectional Study, Female, Human, Infant, Malaysia, Male, Middle Aged, Parents, Personal Satisfaction, Preschool, Preschool Child, Psychology, Questionnaires, Satisfaction, Social Competence, Social Skills, Surveys, Treatment Outcome

Sarwar, F; Panatik, S A; Rajab, A; Nordin, N

Social support, optimism, parental self-efficacy and wellbeinin mothers of children with autism spectrum disorder Journal Article

Indian Journal of Public Health Research and Development, 10 (9), pp. 1824-1829, 2019, ISSN: 09760245, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Assessment of Humans, Autism, Children, Correlation Analysis, Cross-Sectional Study, Female, Human, Life Orientation Test, Life Satisfaction, Likert Scale, Male, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Perceived Stress Scale, Positive and Negative Affect Schedule, Questionnaires, Satisfaction with Life Scale, Self Concept, Social Support, Wellbeing

Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care Journal Article

International Journal of Environmental Research and Public Health, 16 (10), 2019, ISSN: 16617827, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia

@article{Adib2019,
title = {Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care},
author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N A Wan Mansor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066861959&doi=10.3390%2fijerph16101684&partnerID=40&md5=7f7b4ccd7484a6dcc6e2f03375b1ffb7},
doi = {10.3390/ijerph16101684},
issn = {16617827},
year = {2019},
date = {2019-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {16},
number = {10},
publisher = {MDPI AG},
abstract = {Background: Caregivers are the initial gatekeepers in the health care management of children with autism spectrum disorder (ASD). Methods: This cross-sectional study aimed to determine the factors associated with caregivers’ satisfaction with different levels of health care services in managing children with ASD in Kelantan. The satisfaction scores of 227 main caregivers of confirmed ASD children were assessed with a modified Parent Satisfaction Scale (PSS) questionnaire. Results: The analysis showed that caregivers who waited longer for a doctor’s consultation in primary care had a reduced PSS score, whereas caregivers who were satisfied with the waiting time in primary care had higher PSS scores. At the secondary care level, caregivers who possessed at least a diploma had reduced PSS scores, whereas caregivers who were satisfied with both doctors’ consultation times and occupational therapy appointments had higher PSS scores. At the tertiary care level, caregivers with an underlying medical problem and who had children undergoing occupational therapy for two months or more had reduced PSS scores. Nevertheless, the analysis showed that caregivers who were concerned with their children’s sleeping problems, who had been informed about parental support, who were satisfied with speech and occupational therapy appointments, who were satisfied with waiting times at tertiary care clinics, and who were satisfied with their doctor’s knowledge and experience had higher PSS scores. Conclusions: This study elucidated the importance of understanding caregivers’ satisfaction in attaining care for their ASD children and highlighted the need to promote factors that would increase caregivers’ satisfaction with current ASD services. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.},
note = {cited By 0},
keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia},
pubstate = {published},
tppubtype = {article}
}

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Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Perceived stress among caregivers of children with autism spectrum disorder: A state-wide study Journal Article

International Journal of Environmental Research and Public Health, 16 (8), 2019, ISSN: 16617827, (cited By 0).

Abstract | Links | BibTeX | Tags: Adaptation, Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Caregiver Burden, Child Care, Children, Coping Behaviour, Cross-Sectional Study, Female, Follow Up, Health Care, Health Care Access, Human, Infant, Learning Disorder, Malaysia, Male, Mental Stress, Middle Aged, Multiple Linear Regression Analysis, Newborn, Normal Human, Patient Transport, Perceived Stress Scale, Prediction, Preschool, Preschool Child, Psychological, Psychology, Psychometrics, Psychometry, Quality of Life, Stress, Tertiary Care Center, University Hospital

@article{Adib2019b,
title = {Perceived stress among caregivers of children with autism spectrum disorder: A state-wide study},
author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N A Wan Mansor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065303613&doi=10.3390%2fijerph16081468&partnerID=40&md5=fc871375f0d307a95820cd87c57ea270},
doi = {10.3390/ijerph16081468},
issn = {16617827},
year = {2019},
date = {2019-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {16},
number = {8},
publisher = {MDPI AG},
abstract = {Background: Caregivers of children with autism spectrum disorder (ASD) experience increased stress and more significant negative caregiving consequences than those with typically developing children. There is a lack of studies specifically focusing on stress among caregivers with ASD children in Asian countries. The current study examines levels of perceived stress and factors associated with it among caregivers in Kelantan, Malaysia. Methods: In a cross-sectional study, the Malay version of the Perceived Stress Scale (PSS) was administered to 227 caregivers of children with ASD. The caregivers were recruited from ASD databases in four tertiary hospitals in Kelantan and a meeting was set up during the child’s follow-up in the clinic. Multiple linear regression analyses were applied to determine the predictors of perceived stress. Results: The mean total perceived stress score was 20.84 (4.72). This was considered higher than average. Higher perceived stress was significantly predicted among caregivers who live far from the health institution, caregivers who do not own transportation to bring the child to the treatment center, and caregivers who have an ASD child with a learning disability. Conclusion: Caregivers of an ASD child perceived significant stress while taking care of their children. Institutions should alleviate the factors that were predicted to increase the caregivers’ perceived stress to improve the quality of the lives of children and ASD families as a whole. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.},
note = {cited By 0},
keywords = {Adaptation, Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Caregiver Burden, Child Care, Children, Coping Behaviour, Cross-Sectional Study, Female, Follow Up, Health Care, Health Care Access, Human, Infant, Learning Disorder, Malaysia, Male, Mental Stress, Middle Aged, Multiple Linear Regression Analysis, Newborn, Normal Human, Patient Transport, Perceived Stress Scale, Prediction, Preschool, Preschool Child, Psychological, Psychology, Psychometrics, Psychometry, Quality of Life, Stress, Tertiary Care Center, University Hospital},
pubstate = {published},
tppubtype = {article}
}

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Liu, Y -W; Liong, M T; Chung, Y -C E; Huang, H -Y; Peng, W -S; Cheng, Y -F; Lin, Y -S; Wu, Y -Y; Tsai, Y -C

Effects of lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial Journal Article

Nutrients, 11 (4), 2019, ISSN: 20726643, (cited By 4).

Abstract | Links | BibTeX | Tags: Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan

@article{Liu2019,
title = {Effects of lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial},
author = {Y -W Liu and M T Liong and Y -C E Chung and H -Y Huang and W -S Peng and Y -F Cheng and Y -S Lin and Y -Y Wu and Y -C Tsai},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817846&doi=10.3390%2fnu11040820&partnerID=40&md5=ca04462e8710198b821b44f8e73061f3},
doi = {10.3390/nu11040820},
issn = {20726643},
year = {2019},
date = {2019-01-01},
journal = {Nutrients},
volume = {11},
number = {4},
publisher = {MDPI AG},
abstract = {This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.},
note = {cited By 4},
keywords = {Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan},
pubstate = {published},
tppubtype = {article}
}

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Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T

Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment Journal Article

PLoS ONE, 14 (3), 2019, ISSN: 19326203, (cited By 4).

Abstract | Links | BibTeX | Tags: Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting

@article{Pichitpunpong2019,
title = {Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment},
author = {C Pichitpunpong and S Thongkorn and S Kanlayaprasit and W Yuwattana and W Plaingam and S Sangsuthum and W M Aizat and S N Baharum and T Tencomnao and V W Hu and T Sarachana},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371%2fjournal.pone.0214198&partnerID=40&md5=0a4c25481edee56984a59de94fedc414},
doi = {10.1371/journal.pone.0214198},
issn = {19326203},
year = {2019},
date = {2019-01-01},
journal = {PLoS ONE},
volume = {14},
number = {3},
publisher = {Public Library of Science},
abstract = {Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the
Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
note = {cited By 4},
keywords = {Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting},
pubstate = {published},
tppubtype = {article}
}

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Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the
Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Mohamad, F H; Has, A T C

The α5-Containing GABA A Receptors—a Brief Summary Journal Article

Journal of Molecular Neuroscience, 67 (2), pp. 343-351, 2019, ISSN: 08958696, (cited By 1).

Abstract | Links | BibTeX | Tags: 4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Animals, Autism, Brain, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetics, Human, Metabolism, Nonhuman, Protein Subunit, Protein Subunits, Receptors, Review, Schizophrenia, Unclassified Drug

@article{Mohamad2019343,
title = {The α5-Containing GABA A Receptors—a Brief Summary},
author = {F H Mohamad and A T C Has},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059596842&doi=10.1007%2fs12031-018-1246-4&partnerID=40&md5=7b2ba0dc86c6c3f890f226cad8195ee5},
doi = {10.1007/s12031-018-1246-4},
issn = {08958696},
year = {2019},
date = {2019-01-01},
journal = {Journal of Molecular Neuroscience},
volume = {67},
number = {2},
pages = {343-351},
publisher = {Springer New York LLC},
abstract = {GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Down syndrome, and autism with a possible alternative benzodiazepine binding site. Therefore, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.},
note = {cited By 1},
keywords = {4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Animals, Autism, Brain, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetics, Human, Metabolism, Nonhuman, Protein Subunit, Protein Subunits, Receptors, Review, Schizophrenia, Unclassified Drug},
pubstate = {published},
tppubtype = {article}
}

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Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, Z

Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Journal Article

Developmental Medicine and Child Neurology, 61 (2), pp. 135-144, 2019, ISSN: 00121622, (cited By 1).

Abstract | Links | BibTeX | Tags: Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability

@article{Jaafar2019135,
title = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review},
author = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&partnerID=40&md5=d02a2bfcd15a25988b9c23855cd87444},
doi = {10.1111/dmcn.13986},
issn = {00121622},
year = {2019},
date = {2019-01-01},
journal = {Developmental Medicine and Child Neurology},
volume = {61},
number = {2},
pages = {135-144},
publisher = {Blackwell Publishing Ltd},
abstract = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Method: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Results: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, and (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press},
note = {cited By 1},
keywords = {Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability},
pubstate = {published},
tppubtype = {article}
}

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Shahbodin, F; Mohd, C K N C K; Azni, A H; Jano, Z

Visual perception games for autistic learners: Research findings Conference

Association for Computing Machinery, 2019, ISBN: 9781450366212, (cited By 0).

Abstract | Links | BibTeX | Tags: ADDIE Model, Autism, Autistic Children, Children with Autism, Conventional Methods, Diagnostic tools, Diseases, Education, Education Computing, Serious Games, Special Education, Students, Vision, Visual Perception

Aziz, N S A; Ahmad, W F W; Hashim, A S

A study on mobile applications developed for children with autism Journal Article

Advances in Intelligent Systems and Computing, 843 , pp. 772-780, 2019, ISSN: 21945357, (cited By 0).

Abstract | Links | BibTeX | Tags: Autism, Children with Autism, Communication Skills, Diseases, Education, Educational Applications, Mobile Applications, Mobile Computing, Mobile Learning, Mobile Technology, Neurological Disorders, Soft Computing

Yap, C Y; Ng, K H; Cheah, Y; Lim, S Y; Price, J; Vries, De M

App4Autism: An integrated assistive technology with heart rate monitoring for children with autism Journal Article

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 11870 LNCS , pp. 498-512, 2019, ISSN: 03029743, (cited By 0).

Abstract | Links | BibTeX | Tags: Assistive Technology, Autism, Diseases, Early Childhoods, Heart, Heart Rate Monitoring, Mobile Applications, Mobile Computing, Patient Monitoring

@article{Yap2019498,
title = {App4Autism: An integrated assistive technology with heart rate monitoring for children with autism},
author = {C Y Yap and K H Ng and Y Cheah and S Y Lim and J Price and M De Vries},
editor = {Ahmad Smeaton Shih Velastin Terutoshi M N A F T K S T Badioze Zaman H. Mohamad Ali N.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077911902&doi=10.1007%2f978-3-030-34032-2_44&partnerID=40&md5=6b173ff9add01d06fd0682db52f48d7b},
doi = {10.1007/978-3-030-34032-2_44},
issn = {03029743},
year = {2019},
date = {2019-01-01},
journal = {Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)},
volume = {11870 LNCS},
pages = {498-512},
publisher = {Springer},
abstract = {Autism Spectrum Disorder (ASD) is a neurological development disorder that affects communication and behavior. Most assistive technologies for children with autistic traits have been designed to support single, targeted activity function such as learning and communication. In this paper, we report the design and development of an assistive mobile application with heart rate monitoring to help children with ASD in their daily life activities. The integrated mobile application, App4Autism was developed using a holistic design approach with the aim of enhancing communication, interaction and learning skills while providing emotion regulation support through music listening and heart rate monitoring. A novel focus of App4Autism is on noise sensitivity; to play music upon automatic detection of loud excessive noise (in decibel) while at the same time, monitoring the user’s heart rate using a pulse sensor. The paper focuses on a study to better understand the potential use and incorporation of music listening and heart rate/anxiety level monitoring in the app. The paper provides results of investigation into which music genre is more suitable to keep users calm. Initial experiment involved a general population sample; with results showing that personal music preference might have calming effects on users in environments with excessive background noise. We further expand on the design guidelines for creating an integrated assistive technology. © Springer Nature Switzerland AG 2019.},
note = {cited By 0},
keywords = {Assistive Technology, Autism, Diseases, Early Childhoods, Heart, Heart Rate Monitoring, Mobile Applications, Mobile Computing, Patient Monitoring},
pubstate = {published},
tppubtype = {article}
}

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Nor, N K; Ghozali, A H; Ismail, J

Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors Journal Article

Frontiers in Pediatrics, 7 (FEB), 2019, ISSN: 22962360, (cited By 5).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight

@article{Nor2019,
title = {Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors},
author = {N K Nor and A H Ghozali and J Ismail},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064414280&doi=10.3389%2ffped.2019.00038&partnerID=40&md5=4bb61b1df043a4adf79618e223d77f26},
doi = {10.3389/fped.2019.00038},
issn = {22962360},
year = {2019},
date = {2019-01-01},
journal = {Frontiers in Pediatrics},
volume = {7},
number = {FEB},
publisher = {Frontiers Media S.A.},
abstract = {Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.},
note = {cited By 5},
keywords = {Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight},
pubstate = {published},
tppubtype = {article}
}

Close

Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.

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Khan, N A; Soopramanien, M; Siddiqui, R

Crocodiles and alligators: Physicians’ answer to cancer? Journal Article

Current Oncology, 26 (3), pp. 186, 2019, ISSN: 11980052, (cited By 1).

Links | BibTeX | Tags: Allergic Disease, Alligators and Crocodiles, Animal Product, Animals, Antineoplastic Activity, Antineoplastic Agent, Article, Atopic Dermatitis, Autism, Cancer Growth, Cancer Therapy, Carcinogen, Contaminated Organism, Crocodilian, End Cretaceous Mass Extinction, Environmental Factor, Environmental Stress, Gastrointestinal Microbiome, Health Behaviour, Heavy Metal, Human, Immune System, Inflammatory Bowel Disease, Intestine Flora, Longevity, Metabolic Disorder, Microbiology, Neoplasm, Neoplasms, Nerve Cell Differentiation, Physician, Schizophrenia, Survival Analysis, Terminal Disease

Hamzaid, Nur Hana Binti; Haron, Hasnah; Ismail, Haziqah

Acceptance of High-Fiber Cookies among Children with Autism Spectrum Disorder Journal Article

ANNALS OF NUTRITION AND METABOLISM, 75 (3), pp. 165, 2019, ISSN: 0250-6807.

BibTeX | Tags: Acceptance, ASD, Autism, High Fiber Cookies

Ghazali, Roslinda; Sakip, Siti Rasidah Md.; Samsuddin, Ismail

Preliminary Study on Sensory Design for Autism Centre Journal Article

ENVIRONMENT-BEHAVIOUR PROCEEDINGS JOURNAL, 3 (8), pp. 46-54, 2018, ISSN: 2398-4287, (8th Asia Pacific International Conference on Environment-Behaviour Studies (AicE-Bs), Univ Sheffield, Sch Architecture, Sheffield, ENGLAND, JUL 14-15, 2018).

Abstract | Links | BibTeX | Tags: Autism, Design Criteria Checklist, physical learning environment, Sensory Design

Ghazali, Roslinda; Sakip, Siti Rasidah Md; Samsuddin, Ismail

A Review of Sensory Design Physical Learning Environment for Autism Centre in Malaysia Journal Article

ENVIRONMENT-BEHAVIOUR PROCEEDINGS JOURNAL, 3 (7), pp. 145-151, 2018, ISSN: 2398-4287, (6th AMER International Conference on Quality of Life in the Built and Natural Environment (AicQoL) / Annual Serial Landmark International Conferences on Quality of Life (ASLI QoL), MALAYSIA, MAR 03-04, 2018).

Abstract | Links | BibTeX | Tags: Autism, physical learning environment, Sensory Design

Al-Hiyali, M I; Ishak, A J; Harun, H; Ahmad, S A; Sulaiman, Wan W A

A review in modification food-intake behavior by brain stimulation: Excess weight cases Journal Article

NeuroQuantology, 16 (12), pp. 86-97, 2018, ISSN: 13035150, (cited By 2).

Abstract | Links | BibTeX | Tags: Amygdala, Anoxia, Article, Autism, Binge Eating Disorder, Body Mass, Body Weight, Brain Depth Stimulation, Depolarization, Dietary Intake, Drug Craving, Eating Disorder, Electric Current, Electroencephalogram, Electroencephalography, Energy Consumption, Energy Expenditure, Feeding Behavior, Food Intake, Functional Magnetic Resonance Imaging, Gender, Health Status, Homeostasis, Human, Hunger, Lifestyle, Nerve Cell Membrane Steady Potential, Nerve Excitability, Neurofeedback, Neuromodulation, Nutritional Assessment, Outcome Assessment, Questionnaires, Repetitive Transcranial Magnetic Stimulation, Signal Processing, Training, Transcranial Direct Current Stimulation, Transcranial Magnetic Stimulation, Underweight

@article{Al-Hiyali201886,
title = {A review in modification food-intake behavior by brain stimulation: Excess weight cases},
author = {M I Al-Hiyali and A J Ishak and H Harun and S A Ahmad and W A Wan Sulaiman},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062843670&doi=10.14704%2fnq.2018.16.12.1894&partnerID=40&md5=235f66cef05a144be23472641f70bd1d},
doi = {10.14704/nq.2018.16.12.1894},
issn = {13035150},
year = {2018},
date = {2018-01-01},
journal = {NeuroQuantology},
volume = {16},
number = {12},
pages = {86-97},
publisher = {Anka Publishers},
abstract = {Obesity and overweight are frequently prescribed for dysfunction in food-intake behavior. Due to the widely prevalence of obesity in last year’s, there is demand for more studies which are aimed to modify the food-intake behavior. For the past decades many researches has applied in modify food-intake by brain training or stimulation. This review for neuroscience studies in modifying food-intake behavior, it’s involved three sections; The first section explained the role of brain activity in food-intake regulation, general ideas about biomedical devices in food-intake behavior are discussed in second section and third section focused on brain-stimulation systems. Finally, this paper concluded with main points that need to be taken into account when designing experimental study for modification food-intake behavior by brain stimulation according to previous studies recommendation and challenges. © 2018, Anka Publishers. All Rights Reserved.},
note = {cited By 2},
keywords = {Amygdala, Anoxia, Article, Autism, Binge Eating Disorder, Body Mass, Body Weight, Brain Depth Stimulation, Depolarization, Dietary Intake, Drug Craving, Eating Disorder, Electric Current, Electroencephalogram, Electroencephalography, Energy Consumption, Energy Expenditure, Feeding Behavior, Food Intake, Functional Magnetic Resonance Imaging, Gender, Health Status, Homeostasis, Human, Hunger, Lifestyle, Nerve Cell Membrane Steady Potential, Nerve Excitability, Neurofeedback, Neuromodulation, Nutritional Assessment, Outcome Assessment, Questionnaires, Repetitive Transcranial Magnetic Stimulation, Signal Processing, Training, Transcranial Direct Current Stimulation, Transcranial Magnetic Stimulation, Underweight},
pubstate = {published},
tppubtype = {article}
}

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Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N

GRIN2D variants in three cases of developmental and epileptic encephalopathy Journal Article

Clinical Genetics, 94 (6), pp. 538-547, 2018, ISSN: 00099163, (cited By 4).

Abstract | Links | BibTeX | Tags: Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing

@article{Tsuchida2018538,
title = {GRIN2D variants in three cases of developmental and epileptic encephalopathy},
author = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&partnerID=40&md5=f0d32670db57261820bc244943cffd62},
doi = {10.1111/cge.13454},
issn = {00099163},
year = {2018},
date = {2018-01-01},
journal = {Clinical Genetics},
volume = {94},
number = {6},
pages = {538-547},
publisher = {Blackwell Publishing Ltd},
abstract = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd},
note = {cited By 4},
keywords = {Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing},
pubstate = {published},
tppubtype = {article}
}

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Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Arifin, W N

Translation and validation of the malay version of the parents’ satisfaction scale (Pss-m) for assessment of caregivers’ satisfaction with health care services for children with autism spectrum disorder Journal Article

International Journal of Environmental Research and Public Health, 15 (11), 2018, ISSN: 16617827, (cited By 2).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia

@article{Adib2018,
title = {Translation and validation of the malay version of the parents’ satisfaction scale (Pss-m) for assessment of caregivers’ satisfaction with health care services for children with autism spectrum disorder},
author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N Arifin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056090545&doi=10.3390%2fijerph15112455&partnerID=40&md5=53650806d46343cc3e95c9b30442f79c},
doi = {10.3390/ijerph15112455},
issn = {16617827},
year = {2018},
date = {2018-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {15},
number = {11},
publisher = {MDPI AG},
abstract = {Background: A Malay version of Parent Satisfaction Scale (PSS-M) is needed to investigate the factors contributing to the Malay caregivers’ satisfaction with health care management for children with autism spectrum disorder (ASD). The aim of the study is to translate and validate the questionnaire to assess the caregivers’ satisfaction on health care services. Methods: A cross-sectional study was conducted among 110 caregivers of children with ASD aged between 2 and 17 years old that received treatment at two tertiary care centres in Kelantan. Permission to use the original version of the PSS questionnaire was obtained. The original English version of the PSS was translated into a Malay version following the 10 steps proposed by an established guideline. Pre-testing of the PSS was carried out with 30 caregivers before confirmatory factor analysis (CFA) was established using 110 caregivers. They were asked to assess their understanding of the questionnaire. The one-dimensional questionnaire consists of 11 items, including staff attitudes, availability of staff, supportiveness, and helpfulness. The 5-point Likert scale provided ratings from 1 (strongly disagree) to 5 (strongly agree). Confirmatory factor analysis was performed using a robust maximum likelihood estimator. Results: The analysis showed model fit data with good reliability. Conclusion: The PSS-M shows overall model fitness based on specific indices, with good construct validity and excellent absolute reliability to determine the satisfaction level of caregivers of children with ASD with respect to health care services. © 2018, MDPI AG. All rights reserved.},
note = {cited By 2},
keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia},
pubstate = {published},
tppubtype = {article}
}

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Paudel, Y N; Shaikh, M F; Shah, S; Kumari, Y; Othman, I

Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy Journal Article

European Journal of Pharmacology, 837 , pp. 145-155, 2018, ISSN: 00142999, (cited By 14).

Abstract | Links | BibTeX | Tags: 3 Dioxygenase, Acetylsalicylic Acid, Adalimumab, Anakinra, Animals, Anti-Inflammatory Agents, Anxiety, Autacoid, Autism, Autism Spectrum Disorders, Behaviour Disorder, Belnacasan, Celecoxib, Cognition, Comorbidity, Complication, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitor, Cytokine, Cytokines, Depression, Dexmedetomidine, Disease Association, Dopaminergic Transmission, Electroencephalogram, Electroencephalography, Epilepsy, Epileptogenesis, Esculetin, High Mobility Group B1 Protein, Human, Ibuprofen, Icariin, IImmunoglobulin Enhancer Binding Protein, Immunology, Indoleamine 2, Inflammation, Inflammation Mediators, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Nerve Cell Plasticity, Nervous System Development, Nervous System Inflammation, Neuroendocrine Regulation, Neurotransmitter Release, Nonhuman, Palmidrol, Paracetamol, Physiology, Priority Journal, Prostaglandin E2, Psychology, Review, SC 51089, Schizophrenia, Toll-Like Receptor 4, Transforming Growth Factor Beta, Tryptophan Hydroxylase, Tumor Necrosis Factor, Unclassified Drug

@article{Paudel2018145,
title = {Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy},
author = {Y N Paudel and M F Shaikh and S Shah and Y Kumari and I Othman},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053082063&doi=10.1016%2fj.ejphar.2018.08.020&partnerID=40&md5=27ff0199bae72f156425637a7ad02228},
doi = {10.1016/j.ejphar.2018.08.020},
issn = {00142999},
year = {2018},
date = {2018-01-01},
journal = {European Journal of Pharmacology},
volume = {837},
pages = {145-155},
publisher = {Elsevier B.V.},
abstract = {Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover, the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities. The neurobehavioral comorbidities discussed herein share a reciprocal and complex relationship with epilepsy, which ultimately complicates the treatment process in PWE. Understanding the mechanistic pathway by which these comorbidities are associated with epilepsy might be instrumental in developing therapeutic interventions. Inflammatory cytokine signaling in the brain regulates important brain functions including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, dopaminergic transmission, the kynurenine pathway, and affects neurogenesis as well as the neural circuitry of moods. In this review, we hypothesize that the complex relationship between epilepsy and its related comorbidities (cognitive impairment, depression, anxiety, autism, and schizophrenia) can be unraveled through the inflammatory mechanism that plays a prominent role in all these individual conditions. An ample amount of evidence is available reporting the role of inflammation in epilepsy and all individual comorbid condition but their complex relationship with epilepsy has not yet been explored through the prospective of inflammatory pathway. Our review suggests that epilepsy and its neurobehavioral comorbidities are associated with elevated levels of several key inflammatory markers. This review also sheds light on the mechanistic association between epilepsy and its neurobehavioral comorbidities. Moreover, we analyzed several anti-inflammatory therapies available for epilepsy and its neurobehavioral comorbidities. We suggest, these anti-inflammatory therapies might be a possible intervention and could be a promising strategy for preventing epileptogenesis and its related neurobehavioral comorbidities. © 2018 Elsevier B.V.},
note = {cited By 14},
keywords = {3 Dioxygenase, Acetylsalicylic Acid, Adalimumab, Anakinra, Animals, Anti-Inflammatory Agents, Anxiety, Autacoid, Autism, Autism Spectrum Disorders, Behaviour Disorder, Belnacasan, Celecoxib, Cognition, Comorbidity, Complication, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitor, Cytokine, Cytokines, Depression, Dexmedetomidine, Disease Association, Dopaminergic Transmission, Electroencephalogram, Electroencephalography, Epilepsy, Epileptogenesis, Esculetin, High Mobility Group B1 Protein, Human, Ibuprofen, Icariin, IImmunoglobulin Enhancer Binding Protein, Immunology, Indoleamine 2, Inflammation, Inflammation Mediators, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Nerve Cell Plasticity, Nervous System Development, Nervous System Inflammation, Neuroendocrine Regulation, Neurotransmitter Release, Nonhuman, Palmidrol, Paracetamol, Physiology, Priority Journal, Prostaglandin E2, Psychology, Review, SC 51089, Schizophrenia, Toll-Like Receptor 4, Transforming Growth Factor Beta, Tryptophan Hydroxylase, Tumor Necrosis Factor, Unclassified Drug},
pubstate = {published},
tppubtype = {article}
}

Close

Kho, Z Y; Lal, S K

The human gut microbiome - A potential controller of wellness and disease Journal Article

Frontiers in Microbiology, 9 (AUG), 2018, ISSN: 1664302X, (cited By 80).

Abstract | Links | BibTeX | Tags: Acetylcholine, Autism, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Human, Hydrocortisone, Immunity, Immunoglobulin A, Inflammatory Bowel Disease, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Intestine Flora, Leptin, Membrane Protein, Metabolism, Metabolite, Nervous System, Nonhuman, Obesity, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Protein Expression, Protein ZO1, Review, RNA 16S, Toll-Like Receptor 4, Transcription Factor FOXP3, Tumor Necrosis Factor, Unclassified Drug, Unindexed Drug, Uvomorulin, Vasculotropin

@article{Kho2018,
title = {The human gut microbiome - A potential controller of wellness and disease},
author = {Z Y Kho and S K Lal},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051459505&doi=10.3389%2ffmicb.2018.01835&partnerID=40&md5=d89097ac9c0963d8ef7666aa99cff46f},
doi = {10.3389/fmicb.2018.01835},
issn = {1664302X},
year = {2018},
date = {2018-01-01},
journal = {Frontiers in Microbiology},
volume = {9},
number = {AUG},
publisher = {Frontiers Media S.A.},
abstract = {Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. In this review, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal.},
note = {cited By 80},
keywords = {Acetylcholine, Autism, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Human, Hydrocortisone, Immunity, Immunoglobulin A, Inflammatory Bowel Disease, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Intestine Flora, Leptin, Membrane Protein, Metabolism, Metabolite, Nervous System, Nonhuman, Obesity, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Protein Expression, Protein ZO1, Review, RNA 16S, Toll-Like Receptor 4, Transcription Factor FOXP3, Tumor Necrosis Factor, Unclassified Drug, Unindexed Drug, Uvomorulin, Vasculotropin},
pubstate = {published},
tppubtype = {article}
}

Close

Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. In this review, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal.

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Low, H M; Zailan, F

Medical students’ perceptions, awareness, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia Journal Article

International Journal of Developmental Disabilities, 64 (2), pp. 86-95, 2018, ISSN: 20473869, (cited By 1).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Awareness, Behaviour, Exploratory Research, Female, Human, Knowledge, Malaysia, Male, Medical Student, Student Attitude, Students, Symptom

@article{Low201886,
title = {Medical students’ perceptions, awareness, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia},
author = {H M Low and F Zailan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002273499&doi=10.1080%2f20473869.2016.1264663&partnerID=40&md5=4b1b16448e16172b2dce10eacf1c3f3d},
doi = {10.1080/20473869.2016.1264663},
issn = {20473869},
year = {2018},
date = {2018-01-01},
journal = {International Journal of Developmental Disabilities},
volume = {64},
number = {2},
pages = {86-95},
publisher = {Taylor and Francis Ltd.},
abstract = {Objectives: This study aimed to investigate the perception, awareness, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Methods: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, awareness, societal attitude, and their recognition of ASD symptoms. Results: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Specifically, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Conclusion: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016.},
note = {cited By 1},
keywords = {Adult, Article, Autism, Awareness, Behaviour, Exploratory Research, Female, Human, Knowledge, Malaysia, Male, Medical Student, Student Attitude, Students, Symptom},
pubstate = {published},
tppubtype = {article}
}

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Ishak, N I; Yusof, H M; Sidek, S N; Jaalan, Z

Interactive robotic platform for education and language skill rehabilitation Conference

2017-November , Institute of Electrical and Electronics Engineers Inc., 2018, ISBN: 9781538639603, (cited By 0).

Abstract | Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Autistic Children, Children with Autism, Communication Skills, Diseases, Eye Movement, Facial Expression, High Level Controllers, Human Robot Interaction, Interactive Robotics, Machine Design, Patient Rehabilitation, Robotics

Masiran, R

Stimming behaviour in a 4-year-old girl with autism spectrum disorder Journal Article

BMJ Case Reports, 2018 , 2018, ISSN: 1757790X, (cited By 0).

Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Biscuit, Biting Hard Object, Case Report, Chew Toy, Child Safety, Children, Clinical Article, Female, Food, Food Texture, Hot Food, Human, Language Disability, Note, Preschool, Preschool Child, Priority Journal, Psychology, Self Stimulation, Spicy Food, Stereotyped Behaviour, Stereotypy, Stimming Behaviour, Teething Biscuit, Vegetable

Hashim, R; Yussof, H

Preparation for adulthood: Benefits of assistive technologies in social skills training of children with autism Conference

2018-January , Institute of Electrical and Electronics Engineers Inc., 2018, ISBN: 9781538613429, (cited By 0).

Abstract | Links | BibTeX | Tags: Assistive Technology, Autism, Children, Diseases, Economic and Social Effects, Economics, Humanoid, Intelligent Control, Robotics, Skill Training, Smart Sensors

@conference{Hashim2018374,
title = {Preparation for adulthood: Benefits of assistive technologies in social skills training of children with autism},
author = {R Hashim and H Yussof},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047431902&doi=10.1109%2fIRIS.2017.8250151&partnerID=40&md5=3089796dde7022fa5a4a56200466013f},
doi = {10.1109/IRIS.2017.8250151},
isbn = {9781538613429},
year = {2018},
date = {2018-01-01},
journal = {Proceedings - 2017 IEEE 5th International Symposium on Robotics and Intelligent Sensors, IRIS 2017},
volume = {2018-January},
pages = {374-378},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {Humanoids as a form of assistive technologies have been shown to have positive effects on the social-cognitive behavior of brain-impaired children, particularly those with autism. However, evidences on the socio-economic benefits in social-skill training on brain-impaired children have been lacking. At the preliminary stage, a case study of a primary school with special classes for gifted children is the case study for pretesting purposes. As it is, interviewers with teachers at the special integration classes form the basis for primary data collection. Findings indicated that the teachers, parents and guardians of these children are not ready for humanoids to train their children but in future such attempts are encouraged. Nonetheless, this paper will highlight the socio-economic benefits of humanoid-assisted social skills training of children with autism. This is important in preparing them for adulthood and independence. In addition, from the literature reviewed, content analyses on humanoid-mediated research articles provide the preliminary empirical support. Evidences and outcomes from similar research projects conducted from social scientists in developing nations further narrows the objectives of the investigation. Theoretical implication from this study is also discussed. © 2017 IEEE.},
note = {cited By 0},
keywords = {Assistive Technology, Autism, Children, Diseases, Economic and Social Effects, Economics, Humanoid, Intelligent Control, Robotics, Skill Training, Smart Sensors},
pubstate = {published},
tppubtype = {conference}
}

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Toh, T -H; Tan, V W -Y; Lau, P S -T; Kiyu, A

Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article

Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9).

Abstract | Links | BibTeX | Tags: Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler

@article{Toh201828,
title = {Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics},
author = {T -H Toh and V W -Y Tan and P S -T Lau and A Kiyu},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028764085&doi=10.1007%2fs10803-017-3287-x&partnerID=40&md5=21bce2407197b8b1e43b4420d274861b},
doi = {10.1007/s10803-017-3287-x},
issn = {01623257},
year = {2018},
date = {2018-01-01},
journal = {Journal of Autism and Developmental Disorders},
volume = {48},
number = {1},
pages = {28-35},
publisher = {Springer New York LLC},
abstract = {This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC.},
note = {cited By 9},
keywords = {Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler},
pubstate = {published},
tppubtype = {article}
}

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Nor, Md Z; Isa, Md Z; Yusof, S N; Ghazi, H F; Jaafar, M H

The development and validation of questionnaire on autism spectrum disorders and its association with plastic-based food contact materials Journal Article

Journal of Nepal Paediatric Society, 38 (3), pp. 182-189, 2018, ISSN: 19907974, (cited By 0).

Abstract | Links | BibTeX | Tags: 4' Isopropylidenediphenol, Article, Autism, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Environmental Factor, Exploratory Factor Analysis, Food Packaging, Human, Internal Consistency, Phthalic Acid, Plastic, Process Development, Questionnaires, Test Retest Reliability, Validation Process

@article{MdNor2018182,
title = {The development and validation of questionnaire on autism spectrum disorders and its association with plastic-based food contact materials},
author = {Z Md Nor and Z Md Isa and S N Yusof and H F Ghazi and M H Jaafar},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083863826&doi=10.3126%2fjnps.v38i3.20671&partnerID=40&md5=13ffb01477ac798ebd7d430305d0a73a},
doi = {10.3126/jnps.v38i3.20671},
issn = {19907974},
year = {2018},
date = {2018-01-01},
journal = {Journal of Nepal Paediatric Society},
volume = {38},
number = {3},
pages = {182-189},
publisher = {Nepal Paediatric Society (NEPAS)},
abstract = {Introduction: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic-based food contact materials (FCM) as a proxy for exposure to this group of EDCs. Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done. Results: The questionnaire achieved kappa value ranged between 0.800 to 0.900 for knowledge, 0.610 to 0.815 for perception and 0.607 to 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 to 0.780. Conclusions: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items. © 2020, Nepal Paediatric Society (NEPAS). All rights reserved.},
note = {cited By 0},
keywords = {4' Isopropylidenediphenol, Article, Autism, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Environmental Factor, Exploratory Factor Analysis, Food Packaging, Human, Internal Consistency, Phthalic Acid, Plastic, Process Development, Questionnaires, Test Retest Reliability, Validation Process},
pubstate = {published},
tppubtype = {article}
}

Close

Masiran, R

Autism and trichotillomania in an adolescent boy Journal Article

BMJ Case Reports, 2018 , 2018, ISSN: 1757790X, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Alopecia, Anxiety, Article, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Autism, Autism Spectrum Disorders, Behaviour Disorder, Body Mass, Case Report, Central Nervous System Stimulants, Child Behaviour Checklist, Clinical Article, Comorbidity, Complication, Diagnosis, Differential, Differential Diagnosis, Drug Dose Titration, Drug Tolerance, DSM-5, Echolalia, Fluvoxamine, Follow Up, Human, Hyperactivity, Intellectual Impairment, Male, Methylphenidate, Obesity, Occupational Therapy, Perceptual Reasoning Index, Priority Journal, Processing Speed Index, Psychiatric Status Rating Scales, Psychological Rating Scale, Rating Scale, Restlessness, Reward, Serotonin Uptake Inhibitor, Serotonin Uptake Inhibitors, Special Education, Speech Delay, Speech Disorder, Speech Therapy, Trichotillomania, Verbal Comprehension Index, Wechsler Intelligence Scale, Working Memory Index

Thu, Ei H; Hussain, Z; Shuid, A N

New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects Journal Article

Current Drug Targets, 19 (8), pp. 865-876, 2018, ISSN: 13894501, (cited By 2).

Abstract | Links | BibTeX | Tags: Amisulpride, Amitriptyline, Animals, Antipsychotic Agents, Anxiety, Aripiprazole, Autism, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Chemistry, Clonazepam, Clozapine, Depression, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Health Care, Human, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Mental Disorders, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Pathophysiology, Permeability, Physical Chemistry, Psychosis, Review, Risperidone, Schizophrenia, Solubility, Sulpiride, Treatment Outcome, Venlafaxine, Ziprasidone

@article{EiThu2018865,
title = {New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects},
author = {H Ei Thu and Z Hussain and A N Shuid},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048981535&doi=10.2174%2f1389450117666161125174625&partnerID=40&md5=d32e5bc9766ff9d68dd79f082b9ca4bc},
doi = {10.2174/1389450117666161125174625},
issn = {13894501},
year = {2018},
date = {2018-01-01},
journal = {Current Drug Targets},
volume = {19},
number = {8},
pages = {865-876},
publisher = {Bentham Science Publishers B.V.},
abstract = {Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. To date, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, anxiety, bipolar disorders and autism spectrum problems. However, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Therefore, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers.},
note = {cited By 2},
keywords = {Amisulpride, Amitriptyline, Animals, Antipsychotic Agents, Anxiety, Aripiprazole, Autism, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Chemistry, Clonazepam, Clozapine, Depression, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Health Care, Human, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Mental Disorders, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Pathophysiology, Permeability, Physical Chemistry, Psychosis, Review, Risperidone, Schizophrenia, Solubility, Sulpiride, Treatment Outcome, Venlafaxine, Ziprasidone},
pubstate = {published},
tppubtype = {article}
}

Close

Noor, Helmi Adly Mohd; Shahbodin, Faaizah; Ananta, Gede Pramudya; Mohd, Cik Ku Nuraini Che Ku; Razali, Syarifah Nadiyah; Khalid, Mohd Sazali; Kassim, Rahimah; Rahman, Fauziah Abdul; Baharum, Zirawani

A prototype development of visual perception diagnosis games for autism children Journal Article

INTERNATIONAL JOURNAL OF ADVANCED AND APPLIED SCIENCES, 4 (3), pp. 68-72, 2017, ISSN: 2313-626X.

Abstract | Links | BibTeX | Tags: Autism, Autistic Children, Children with Autism, Serious Games, Special Education, Visual Perception

Hnoonual, A; Thammachote, W; Tim-Aroon, T; Rojnueangnit, K; Hansakunachai, T; Sombuntham, T; Roongpraiwan, R; Worachotekamjorn, J; Chuthapisith, J; Fucharoen, S; Wattanasirichaigoon, D; Ruangdaraganon, N; Limprasert, P; Jinawath, N

Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder Journal Article

Scientific Reports, 7 (1), 2017, ISSN: 20452322, (cited By 6).

Abstract | Links | BibTeX | Tags: Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism

@article{Hnoonual2017,
title = {Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder},
author = {A Hnoonual and W Thammachote and T Tim-Aroon and K Rojnueangnit and T Hansakunachai and T Sombuntham and R Roongpraiwan and J Worachotekamjorn and J Chuthapisith and S Fucharoen and D Wattanasirichaigoon and N Ruangdaraganon and P Limprasert and N Jinawath},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029864969&doi=10.1038%2fs41598-017-12317-3&partnerID=40&md5=3c1b6a0c064665aab8ace8e8f58c2b01},
doi = {10.1038/s41598-017-12317-3},
issn = {20452322},
year = {2017},
date = {2017-01-01},
journal = {Scientific Reports},
volume = {7},
number = {1},
publisher = {Nature Publishing Group},
abstract = {Chromosomal microarray (CMA) is now recognized as the first-tier genetic test for detection of copy number variations (CNVs) in patients with autism spectrum disorder (ASD). The aims of this study were to identify known and novel ASD associated-CNVs and to evaluate the diagnostic yield of CMA in Thai patients with ASD. The Infinium CytoSNP-850K BeadChip was used to detect CNVs in 114 Thai patients comprised of 68 retrospective ASD patients (group 1) with the use of CMA as a second line test and 46 prospective ASD and developmental delay patients (group 2) with the use of CMA as the first-tier test. We identified 7 (6.1%) pathogenic CNVs and 22 (19.3%) variants of uncertain clinical significance (VOUS). A total of 29 patients with pathogenic CNVs and VOUS were found in 22% (15/68) and 30.4% (14/46) of the patients in groups 1 and 2, respectively. The difference in detected CNV frequencies between the 2 groups was not statistically significant (Chi square = 1.02},
note = {cited By 6},
keywords = {Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism},
pubstate = {published},
tppubtype = {article}
}

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Hameed, S S; Hassan, R; Muhammad, F F

Selection and classification of gene expression in autism disorder: Use of a combination of statistical filters and a GBPSO-SVM algorithm Journal Article

PLoS ONE, 12 (11), 2017, ISSN: 19326203, (cited By 11).

Abstract | Links | BibTeX | Tags: Accuracy, Algorithms, Article, Autism, Autism Spectrum Disorders, CAPS2 Gene, Classification (of information), Classifier, Experimental Study, Gene, Gene Expression, Gene Identification, Genetic Association, Genetic Procedures, Genetic Risk, Genetics, Geometric Binary Particle Swarm Optimization Support Vector Machine Algorithm, Human, RIsk Assessment, Standardization, Statistical Filter, Statistical Parameters, Statistics, Support Vector Machines

@article{Hameed2017,
title = {Selection and classification of gene expression in autism disorder: Use of a combination of statistical filters and a GBPSO-SVM algorithm},
author = {S S Hameed and R Hassan and F F Muhammad},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033361187&doi=10.1371%2fjournal.pone.0187371&partnerID=40&md5=f9260d41165145f229a3cf157699635e},
doi = {10.1371/journal.pone.0187371},
issn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {11},
publisher = {Public Library of Science},
abstract = {In this work, gene expression in autism spectrum disorder (ASD) is analyzed with the goal of selecting the most attributed genes and performing classification. The objective was achieved by utilizing a combination of various statistical filters and a wrapper-based geometric binary particle swarm optimization-support vector machine (GBPSO-SVM) algorithm. The utilization of different filters was accentuated by incorporating a mean and median ratio criterion to remove very similar genes. The results showed that the most discriminative genes that were identified in the first and last selection steps included the presence of a repetitive gene (CAPS2), which was assigned as the gene most highly related to ASD risk. The merged gene subset that was selected by the GBPSO-SVM algorithm was able to enhance the classification accuracy. © 2017 Hameed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
note = {cited By 11},
keywords = {Accuracy, Algorithms, Article, Autism, Autism Spectrum Disorders, CAPS2 Gene, Classification (of information), Classifier, Experimental Study, Gene, Gene Expression, Gene Identification, Genetic Association, Genetic Procedures, Genetic Risk, Genetics, Geometric Binary Particle Swarm Optimization Support Vector Machine Algorithm, Human, RIsk Assessment, Standardization, Statistical Filter, Statistical Parameters, Statistics, Support Vector Machines},
pubstate = {published},
tppubtype = {article}
}

Close

Wo, S W; Ong, L C; Low, W Y; Lai, P S M

The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review Journal Article

Epilepsy Research, 136 , pp. 35-45, 2017, ISSN: 09201211, (cited By 8).

Abstract | Links | BibTeX | Tags: Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement

@article{Wo201735,
title = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review},
author = {S W Wo and L C Ong and W Y Low and P S M Lai},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&partnerID=40&md5=f34a0aada2cc5dc6e4d6beab18ac779c},
doi = {10.1016/j.eplepsyres.2017.07.009},
issn = {09201211},
year = {2017},
date = {2017-01-01},
journal = {Epilepsy Research},
volume = {136},
pages = {35-45},
publisher = {Elsevier B.V.},
abstract = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.},
note = {cited By 8},
keywords = {Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement},
pubstate = {published},
tppubtype = {article}
}

Close

Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.

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Shminan, A S; Adzani, R A; Sharif, S; Lee, N K

AutiPECS: Mobile based learning of picture exchange communication intervention for caregivers of autistic children Conference

2018-January , Institute of Electrical and Electronics Engineers Inc., 2017, ISBN: 9781538607657, (cited By 1).

Abstract | Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Behavioral Disabilities, Diseases, Drones, E-learning, Human Computer Interaction, Intervention, Mobile Based Learning, Mobile Computing, Parents, Surveys, Systems Analysis, Technology Transfer, User Interface Designs, User Interfaces

@conference{Shminan201749,
title = {AutiPECS: Mobile based learning of picture exchange communication intervention for caregivers of autistic children},
author = {A S Shminan and R A Adzani and S Sharif and N K Lee},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050617137&doi=10.1109%2fICONDA.2017.8270398&partnerID=40&md5=67a6c94341aa3b530fede19c93a63d81},
doi = {10.1109/ICONDA.2017.8270398},
isbn = {9781538607657},
year = {2017},
date = {2017-01-01},
journal = {1st International Conference on Computer and Drone Applications: Ethical Integration of Computer and Drone Technology for Humanity Sustainability, IConDA 2017},
volume = {2018-January},
pages = {49-54},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {The aim of this study is to develop and assess a mobile-based learning concerning the Picture Exchange Communication (PECS) for Autism Spectrum Disorder (ASD) children's caregivers. Being an inexpensive intervention, the PECS has been proposed by other parents who have practised it on their children with non-verbal and behavioral disabilities. The underlying motivator for this mobile application is to guarantee that autistic children can have a better alternative intervention through the PECS approach so that they would not rely on the therapist a great deal or go to the autism center which is often costly. This mobile application elaborates on the user requirements which include PECS introduction, the characteristics, initial preparations, strategies and the activities. Instructional System Design (ISD) functions as the methodologies that help create the mobile-based learning. The system design has five stages namely the analysis, design, development, implementation and evaluation. These stages are better known as ADDIE which ensure the user to attain the goals of the instruction for the entire process. To examine the content and the user interface design for this mobile application, a formative evaluation was conducted which was aided by the usability testing by questionnaires and short instructed interviews. With the application of the ADDIE principles and guideline of Human-Computer Interaction (HCI), the best combination of causes of the AutiPECS had been developed properly. In sum, this research has achieved the objectives. The content had been assessed by the expert, and the caregivers know how to adopt D.I.Y concepts as they are working on the learning materials. Future works may also be able to take more advantage of the AutiPECS 2.0 version where they can develop the mobile-based learning of PECS in the extended content and pay more attention to more specific case studies so that the caregivers know how to use PECS with the special children everyday. © 2017 IEEE.},
note = {cited By 1},
keywords = {Autism, Autism Spectrum Disorders, Behavioral Disabilities, Diseases, Drones, E-learning, Human Computer Interaction, Intervention, Mobile Based Learning, Mobile Computing, Parents, Surveys, Systems Analysis, Technology Transfer, User Interface Designs, User Interfaces},
pubstate = {published},
tppubtype = {conference}
}

Close

The aim of this study is to develop and assess a mobile-based learning concerning the Picture Exchange Communication (PECS) for Autism Spectrum Disorder (ASD) children's caregivers. Being an inexpensive intervention, the PECS has been proposed by other parents who have practised it on their children with non-verbal and behavioral disabilities. The underlying motivator for this mobile application is to guarantee that autistic children can have a better alternative intervention through the PECS approach so that they would not rely on the therapist a great deal or go to the autism center which is often costly. This mobile application elaborates on the user requirements which include PECS introduction, the characteristics, initial preparations, strategies and the activities. Instructional System Design (ISD) functions as the methodologies that help create the mobile-based learning. The system design has five stages namely the analysis, design, development, implementation and evaluation. These stages are better known as ADDIE which ensure the user to attain the goals of the instruction for the entire process. To examine the content and the user interface design for this mobile application, a formative evaluation was conducted which was aided by the usability testing by questionnaires and short instructed interviews. With the application of the ADDIE principles and guideline of Human-Computer Interaction (HCI), the best combination of causes of the AutiPECS had been developed properly. In sum, this research has achieved the objectives. The content had been assessed by the expert, and the caregivers know how to adopt D.I.Y concepts as they are working on the learning materials. Future works may also be able to take more advantage of the AutiPECS 2.0 version where they can develop the mobile-based learning of PECS in the extended content and pay more attention to more specific case studies so that the caregivers know how to use PECS with the special children everyday. © 2017 IEEE.

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Hasan, C Z C; Jailani, R; Tahir, Md N; Ilias, S

The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders Journal Article

Research in Developmental Disabilities, 66 , pp. 55-63, 2017, ISSN: 08914222, (cited By 8).

Abstract | Links | BibTeX | Tags: Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking

@article{Hasan201755,
title = {The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders},
author = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi=10.1016%2fj.ridd.2017.02.015&partnerID=40&md5=d6a9839cda7f62bcce9bdcca33d3d33b},
doi = {10.1016/j.ridd.2017.02.015},
issn = {08914222},
year = {2017},
date = {2017-01-01},
journal = {Research in Developmental Disabilities},
volume = {66},
pages = {55-63},
publisher = {Elsevier Inc.},
abstract = {Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd},
note = {cited By 8},
keywords = {Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking},
pubstate = {published},
tppubtype = {article}
}

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Shuib, S; Saaid, N N; Zakaria, Z; Ismail, J; Latiff, Abdul Z

Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay Journal Article

Malaysian Journal of Pathology, 39 (1), pp. 77-81, 2017, ISSN: 01268635, (cited By 0).

Abstract | Links | BibTeX | Tags: Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry

@article{Shuib201777,
title = {Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay},
author = {S Shuib and N N Saaid and Z Zakaria and J Ismail and Z Abdul Latiff},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037028880&partnerID=40&md5=624b87d1e9ebac2d1bf66b4d30c0f6e9},
issn = {01268635},
year = {2017},
date = {2017-01-01},
journal = {Malaysian Journal of Pathology},
volume = {39},
number = {1},
pages = {77-81},
publisher = {Malaysian Society of Pathologists},
abstract = {Potocki-Lupski syndrome (PTLS), also known as duplication 17p11.2 syndrome, trisomy 17p11.2 or dup(17)(p11.2p11.2) syndrome, is a developmental disorder and a rare contiguous gene syndrome affecting 1 in 20,000 live births. Among the key features of such patients are autism spectrum disorder, learning disabilities, developmental delay, attention-deficit disorder, infantile hypotonia and cardiovascular abnormalities. Previous studies using microarray identified variations in the size and extent of the duplicated region of chromosome 17p11.2. However, there are a few genes which are considered as candidates for PTLS which include RAI1, SREBF1, DRG2, LLGL1, SHMT1 and ZFP179. In this report, we investigated a case of a 3-year-old girl who has developmental delay. Her chromosome analysis showed a normal karyotype (46,XX). Analysis using array CGH (4X44 K, Agilent USA) identified an ~4.2 Mb de novo duplication in chromosome 17p11.2. The result was confirmed by fluorescence in situ hybridization (FISH) using probes in the critical PTLS region. This report demonstrates the importance of microarray and FISH in the diagnosis of PTLS. © 2017, Malaysian Society of Pathologists. All rights reserved.},
note = {cited By 0},
keywords = {Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry},
pubstate = {published},
tppubtype = {article}
}

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Hashim, R; Yussof, H

Humanizing Humanoids Towards Social Inclusiveness for Children with Autism Conference

105 , Elsevier B.V., 2017, ISSN: 18770509, (cited By 1).

Abstract | Links | BibTeX | Tags: Assistive Technology, Autism, Children with Autism, Diseases, Human Robot Interaction, Humanoid, Hybrid Methodologies, Intelligent Control, Mental Disabilities, Patient Rehabilitation, Philosophical Aspects, Robotics, Robots, Secondary Data Analysis, Smart Sensors, Social Inclusiveness

@conference{Hashim2017359,
title = {Humanizing Humanoids Towards Social Inclusiveness for Children with Autism},
author = {R Hashim and H Yussof},
editor = {Yussof H.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016094915&doi=10.1016%2fj.procs.2017.01.234&partnerID=40&md5=5b6e1e4faeb0346832c57f23e5ba4a42},
doi = {10.1016/j.procs.2017.01.234},
issn = {18770509},
year = {2017},
date = {2017-01-01},
journal = {Procedia Computer Science},
volume = {105},
pages = {359-364},
publisher = {Elsevier B.V.},
abstract = {Assistive technologies in the form of humanoids have gained mileage in the area of rehabilitation, in particular, for children with various mental disabilities such as autism. The extent of the use of humanoids in augmenting these children are numerous yet, the social inclusiveness in the form of religious values, spirituality and ethics have hardly been explored. In these new and ambiguous dimensions, evidences of inclusiveness through repeated observations and interviews as well as secondary data analyses formed the hybrid methodology for this research project. The findings revealed a positive influence by humanizing humanoids in the social skill augmentation, religious and spiritual enhance of the scope. In attempting such a sensitive project, proper ethical procedures have to be in place because of the focus group. The implications of the findings are important in drafting relevant policies not just in educating the children, but to improve their quality of life, enriching the family well-being and enhance societal awareness for social inclusiveness. © 2017 The Authors.},
note = {cited By 1},
keywords = {Assistive Technology, Autism, Children with Autism, Diseases, Human Robot Interaction, Humanoid, Hybrid Methodologies, Intelligent Control, Mental Disabilities, Patient Rehabilitation, Philosophical Aspects, Robotics, Robots, Secondary Data Analysis, Smart Sensors, Social Inclusiveness},
pubstate = {published},
tppubtype = {conference}
}

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Salleh, M H K; Miskam, M A; Yussof, H; Omar, A R

HRI Assessment of ASKNAO Intervention Framework via Typically Developed Child Conference

105 , Elsevier B.V., 2017, ISSN: 18770509, (cited By 1).

Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, ASKNAO, Autism, Diseases, Humanoid Robot, Humanoid Robot NAO, Intelligent Control, Network Function Virtualization, Rehabilitation Robotics, Robotics, Smart Sensors, Social Interactions

Hashim, R; Yussof, H; Bahrin, N L Z

Religious Perceptions on Use of Humanoid for Spiritual Augmentation of Children with Autism Conference

105 , Elsevier B.V., 2017, ISSN: 18770509, (cited By 2).

Abstract | Links | BibTeX | Tags: Autism, Diseases, Humanoid, Intelligent Control, Islam, Religion, Robotics, Smart Sensors, Spirituality, Teaching

Bhagat, V; Haque, M; Simbak, N B; Husain, R

Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education Journal Article

Journal of Global Pharma Technology, 9 (7), pp. 32-43, 2017, ISSN: 09758542, (cited By 0).

Abstract | Links | BibTeX | Tags: Adaptive Behavior, Amygdala, Autism, Awareness, Cognition, Comorbidity, Conceptual Framework, Cost Benefit Analysis, Education, Emotion, Emotional Disorder, Emotionality, Health Care, Health Promotion, Human, Impulsiveness, Learning, Motivation, Parent Education, Perception, Practice Guideline, Prefrontal Cortex, Prevalence, Problem Behavior, Psychoeducation, Psychological Well Being, Review, Sex Difference, Social Behaviour, Social Cognition, Social Competence, Social Learning

@article{Bhagat201732,
title = {Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education},
author = {V Bhagat and M Haque and N B Simbak and R Husain},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021786235&partnerID=40&md5=ece2d7c28018f0c4526810e08e314461},
issn = {09758542},
year = {2017},
date = {2017-01-01},
journal = {Journal of Global Pharma Technology},
volume = {9},
number = {7},
pages = {32-43},
publisher = {Journal of Global Pharma Technology},
abstract = {Autism spectrum disorders (ASD) may affect all spheres of a child's life. One of the areas of the behavioral spectrum need to be focused is affected. Thus, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Thus, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT.},
note = {cited By 0},
keywords = {Adaptive Behavior, Amygdala, Autism, Awareness, Cognition, Comorbidity, Conceptual Framework, Cost Benefit Analysis, Education, Emotion, Emotional Disorder, Emotionality, Health Care, Health Promotion, Human, Impulsiveness, Learning, Motivation, Parent Education, Perception, Practice Guideline, Prefrontal Cortex, Prevalence, Problem Behavior, Psychoeducation, Psychological Well Being, Review, Sex Difference, Social Behaviour, Social Cognition, Social Competence, Social Learning},
pubstate = {published},
tppubtype = {article}
}

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Ilias, S; Tahir, N M; Jailani, R; Hasan, C Z C

Linear Discriminant Analysis in Classifying Walking Gait of Autistic Children Conference

Institute of Electrical and Electronics Engineers Inc., 2017, ISBN: 9781538614099, (cited By 0).

Abstract | Links | BibTeX | Tags: Autism, Autistic Children, Children with Autism, Discriminant Analysis, Diseases, Extraction, Feature Extraction, Gait Analysis, Gait Classification, Kinematics, Linear Discriminant Analysis, Motion Analysis System, Neural Networks, Principal Component Analysis, Three-Dimensional

@conference{Ilias201767,
title = {Linear Discriminant Analysis in Classifying Walking Gait of Autistic Children},
author = {S Ilias and N M Tahir and R Jailani and C Z C Hasan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048377850&doi=10.1109%2fEMS.2017.22&partnerID=40&md5=06de53be2b4f3976ddcc420067ab6e44},
doi = {10.1109/EMS.2017.22},
isbn = {9781538614099},
year = {2017},
date = {2017-01-01},
journal = {Proceedings - UKSim-AMSS 11th European Modelling Symposium on Computer Modelling and Simulation, EMS 2017},
pages = {67-72},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {The aim of this research is to investigate the effectiveness between Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) along with neural network (NN) in classifying the gait of autistic children as compared to control group. Twelve autistic children and thirty two normal children participated in this study. Firstly the walking gait of these two groups are acquired using VICON Motion Analysis System to extract the three dimensional (3D) gait features that comprised of 21 gait features namely five features from basic temporal spatial, five features represented the kinetic parameters and twelve features from kinematic. Further, PCA and LDA are utilized as feature extraction in determining the significant features among these gait features. With NN as classifier, results showed that LDA as feature extraction outperform PCA for classification of autism versus normal children namely kinematic gait patterns attained 98.44% accuracy followed by basic temporal spatial gait features with accuracy of 87.5%. © 2017 IEEE.},
note = {cited By 0},
keywords = {Autism, Autistic Children, Children with Autism, Discriminant Analysis, Diseases, Extraction, Feature Extraction, Gait Analysis, Gait Classification, Kinematics, Linear Discriminant Analysis, Motion Analysis System, Neural Networks, Principal Component Analysis, Three-Dimensional},
pubstate = {published},
tppubtype = {conference}
}

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