List of Publication by tag - National Autism Resource Centre (NARC)

Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z

Factors associated with autism severity among Malaysian children with Autism Spectrum Disorder Journal Article

Research in Developmental Disabilities, 100 , 2020, ISSN: 08914222, (cited By 0).

Abstract | Links | BibTeX | Tags: Article, Autism, Body Weight, Children, Cross-Sectional Study, Demography, Disease Association, Disease Severity, Employment, Female, Human, Lifestyle, Major Clinical Study, Malaysia, Malaysian, Male, Parents, Preschool Child, School Child, Social Status

Leong, D; Hedley, D; Uljarević, M

Poh-tay-toe, Poh-tah-toe: Autism Diagnosis and Conceptualization Journal Article

Journal of Child Neurology, 35 (3), pp. 247-248, 2020, ISSN: 08830738, (cited By 0).

Links | BibTeX | Tags: Anxiety, Attention Deficit Disorder, Autism, Caregiver, Children, Clinical Article, Clinical Practice, Disruptive Behavior, DSM-5, Follow Up, Human, Learning Disorder, Letter, Mental Health, Mood Disorder, Multidisciplinary Team, Neuropsychiatry, Priority Journal, Unemployment, Workforce

Djatmika, ; Wibowo, A H; Sugini, ; Halim, H; Mohamad, B

Multimodal strategies in teaching children with autism: A discourse analysis Journal Article

Systematic Reviews in Pharmacy, 11 (2), pp. 219-229, 2020, ISSN: 09758453, (cited By 0).

Abstract | Links | BibTeX | Tags: Article, Autism, Body Movement, Children, Discourse Analysis, Gesture, Human, Language, Loudness, Nonverbal Communication, Paralanguage, Priority Journal, Standing, Strategic Planning, Students, Teacher, Teaching, Verbal Behaviour, Verbal Communication

Khowaja, K; Banire, B; Al-Thani, D; Sqalli, M T; Aqle, A; Shah, A; Salim, S S

Augmented reality for learning of children and adolescents with autism spectrum disorder (ASD): A systematic review Journal Article

IEEE Access, 8 , pp. 78779-78807, 2020, ISSN: 21693536, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Augmented Reality, Autism Spectrum Disorders, Bibliographic Database, Children, Classroom Environment, Data Acquisition, Data Collection, Diseases, Evaluation Parameters, Information Services, Maintenance, Parameter Estimation, Research, Social Communications

This paper presents a systematic review of relevant primary studies on the use of augmented reality (AR) to improve various skills of children and adolescents diagnosed with autism spectrum disorder (ASD) from years 2005 to 2018 inclusive in eight bibliographic databases. This systematic review attempts to address eleven specific research questions related to the learing skills, participants, AR technology, research design, data collection methods, settings, evaluation parameters, intervention outcomes, generalization, and maintenance. The social communication skill was the highly targeted skill, and individuals with ASD were part of all the studies. Computer, smartphone, and smartglass are more frequently used technologies. The commonly used research design was pre-test and post-test. Almost all the studies used observation as a data collection method, and classroom environment or controlled research environment were used as a setting of evaluation. Most of the evaluation parameters were human-assisted. The results of the studies show that AR benefited children with ASD in learning skills. The generalization test was conducted in one study only, but the results were not reported. The results of maintenance tests conducted in five studies during a short-term period following the withdrawal of intervention were positive. Although the effect of using AR towards the learning of individuals was positive, given the wide variety of skills targeted in the studies, and the heterogeneity of the participants, a summative conclusion regarding the effectiveness of AR for teaching or learning of skills related to ASD based on the existing literature is not possible. The review also proposes the research taxonomy for ASD. Future research addressing the effectiveness of AR among more participants, different technologies supporting AR for the intervention, generalization, and maintenance of learning skills, and the evaluation in the inslusive classroom environment and other settings is warranted. © 2013 IEEE.

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Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Sami, F M; Badgujar, S; Govindan, S N; Ansari, M T

Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Journal Article

Human Vaccines and Immunotherapeutics, 15 (11), pp. 2544-2551, 2019, ISSN: 21645515, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Attitude, Attitude to Health, Autism, Child Health, Childhood Vaccination, Children, Cross-Sectional Study, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Education, Employment, Ethnicity, Female, Health Knowledge, Human, Immunization Programs, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Mother, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Preschool Child, Preventive Health Service, Psychology, Questionnaires, Seasonal Influenza, Surveys, Vaccination, Young Adult

Ramachandram, S

Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia Journal Article

Medical Journal of Malaysia, 74 (5), pp. 372-376, 2019, ISSN: 03005283, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Article, Asthma, Autism, Birth Weight, Child Development, Children, Chinese, Conception, Demography, Diet Restriction, DSM-5, Eczema, Education, Educational Status, Epilepsy, Female, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Human, Indian, Major Clinical Study, Malay, Male, Medical Record Review, Penang, Prematurity, Speech Disorder, Upper Respiratory Tract Congestion, Wakefulness

Ong, J J

Parental satisfaction and perception of Progress in influencing the Practice of complementary health approaches in children with autism: A cross sectional survey from Negeri Sembilan, Malaysia Journal Article

BMC Complementary and Alternative Medicine, 19 (1), 2019, ISSN: 14726882, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Alternative Medicine, Autism, Autism Spectrum Disorders, Child Behaviour, Child Parent Relation, Children, Complementary Therapies, Cross-Sectional Study, Female, Human, Infant, Malaysia, Male, Middle Aged, Parents, Personal Satisfaction, Preschool, Preschool Child, Psychology, Questionnaires, Satisfaction, Social Competence, Social Skills, Surveys, Treatment Outcome

Sarwar, F; Panatik, S A; Rajab, A; Nordin, N

Social support, optimism, parental self-efficacy and wellbeinin mothers of children with autism spectrum disorder Journal Article

Indian Journal of Public Health Research and Development, 10 (9), pp. 1824-1829, 2019, ISSN: 09760245, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Assessment of Humans, Autism, Children, Correlation Analysis, Cross-Sectional Study, Female, Human, Life Orientation Test, Life Satisfaction, Likert Scale, Male, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Perceived Stress Scale, Positive and Negative Affect Schedule, Questionnaires, Satisfaction with Life Scale, Self Concept, Social Support, Wellbeing

Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care Journal Article

International Journal of Environmental Research and Public Health, 16 (10), 2019, ISSN: 16617827, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia

Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Perceived stress among caregivers of children with autism spectrum disorder: A state-wide study Journal Article

International Journal of Environmental Research and Public Health, 16 (8), 2019, ISSN: 16617827, (cited By 0).

Abstract | Links | BibTeX | Tags: Adaptation, Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Caregiver Burden, Child Care, Children, Coping Behaviour, Cross-Sectional Study, Female, Follow Up, Health Care, Health Care Access, Human, Infant, Learning Disorder, Malaysia, Male, Mental Stress, Middle Aged, Multiple Linear Regression Analysis, Newborn, Normal Human, Patient Transport, Perceived Stress Scale, Prediction, Preschool, Preschool Child, Psychological, Psychology, Psychometrics, Psychometry, Quality of Life, Stress, Tertiary Care Center, University Hospital

Liu, Y -W; Liong, M T; Chung, Y -C E; Huang, H -Y; Peng, W -S; Cheng, Y -F; Lin, Y -S; Wu, Y -Y; Tsai, Y -C

Effects of lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial Journal Article

Nutrients, 11 (4), 2019, ISSN: 20726643, (cited By 4).

Abstract | Links | BibTeX | Tags: Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan

@article{Liu2019,
title = {Effects of lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial},
author = {Y -W Liu and M T Liong and Y -C E Chung and H -Y Huang and W -S Peng and Y -F Cheng and Y -S Lin and Y -Y Wu and Y -C Tsai},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817846&doi=10.3390%2fnu11040820&partnerID=40&md5=ca04462e8710198b821b44f8e73061f3},
doi = {10.3390/nu11040820},
issn = {20726643},
year = {2019},
date = {2019-01-01},
journal = {Nutrients},
volume = {11},
number = {4},
publisher = {MDPI AG},
abstract = {This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.},
note = {cited By 4},
keywords = {Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan},
pubstate = {published},
tppubtype = {article}
}

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Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, Z

Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Journal Article

Developmental Medicine and Child Neurology, 61 (2), pp. 135-144, 2019, ISSN: 00121622, (cited By 1).

Abstract | Links | BibTeX | Tags: Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability

@article{Jaafar2019135,
title = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review},
author = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&partnerID=40&md5=d02a2bfcd15a25988b9c23855cd87444},
doi = {10.1111/dmcn.13986},
issn = {00121622},
year = {2019},
date = {2019-01-01},
journal = {Developmental Medicine and Child Neurology},
volume = {61},
number = {2},
pages = {135-144},
publisher = {Blackwell Publishing Ltd},
abstract = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Method: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Results: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, and (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press},
note = {cited By 1},
keywords = {Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability},
pubstate = {published},
tppubtype = {article}
}

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Nor, N K; Ghozali, A H; Ismail, J

Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors Journal Article

Frontiers in Pediatrics, 7 (FEB), 2019, ISSN: 22962360, (cited By 5).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight

@article{Nor2019,
title = {Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors},
author = {N K Nor and A H Ghozali and J Ismail},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064414280&doi=10.3389%2ffped.2019.00038&partnerID=40&md5=4bb61b1df043a4adf79618e223d77f26},
doi = {10.3389/fped.2019.00038},
issn = {22962360},
year = {2019},
date = {2019-01-01},
journal = {Frontiers in Pediatrics},
volume = {7},
number = {FEB},
publisher = {Frontiers Media S.A.},
abstract = {Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.},
note = {cited By 5},
keywords = {Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight},
pubstate = {published},
tppubtype = {article}
}

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Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.

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Yen, Eow Shiang; Ying, GanWan; Ying, Lim Poh; Hamidin, A

Association between Nutritional Factors and Severity Among Children with Autism Spectrum Disorder in Malaysia Journal Article

ANNALS OF NUTRITION AND METABOLISM, 75 (3), pp. 90, 2019, ISSN: 0250-6807.

BibTeX | Tags: Autism Severity, Autism Spectrum Disorders, Children, Nutritional Factors

Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N

GRIN2D variants in three cases of developmental and epileptic encephalopathy Journal Article

Clinical Genetics, 94 (6), pp. 538-547, 2018, ISSN: 00099163, (cited By 4).

Abstract | Links | BibTeX | Tags: Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing

@article{Tsuchida2018538,
title = {GRIN2D variants in three cases of developmental and epileptic encephalopathy},
author = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&partnerID=40&md5=f0d32670db57261820bc244943cffd62},
doi = {10.1111/cge.13454},
issn = {00099163},
year = {2018},
date = {2018-01-01},
journal = {Clinical Genetics},
volume = {94},
number = {6},
pages = {538-547},
publisher = {Blackwell Publishing Ltd},
abstract = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd},
note = {cited By 4},
keywords = {Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing},
pubstate = {published},
tppubtype = {article}
}

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Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Arifin, W N

Translation and validation of the malay version of the parents’ satisfaction scale (Pss-m) for assessment of caregivers’ satisfaction with health care services for children with autism spectrum disorder Journal Article

International Journal of Environmental Research and Public Health, 15 (11), 2018, ISSN: 16617827, (cited By 2).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia

@article{Adib2018,
title = {Translation and validation of the malay version of the parents’ satisfaction scale (Pss-m) for assessment of caregivers’ satisfaction with health care services for children with autism spectrum disorder},
author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N Arifin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056090545&doi=10.3390%2fijerph15112455&partnerID=40&md5=53650806d46343cc3e95c9b30442f79c},
doi = {10.3390/ijerph15112455},
issn = {16617827},
year = {2018},
date = {2018-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {15},
number = {11},
publisher = {MDPI AG},
abstract = {Background: A Malay version of Parent Satisfaction Scale (PSS-M) is needed to investigate the factors contributing to the Malay caregivers’ satisfaction with health care management for children with autism spectrum disorder (ASD). The aim of the study is to translate and validate the questionnaire to assess the caregivers’ satisfaction on health care services. Methods: A cross-sectional study was conducted among 110 caregivers of children with ASD aged between 2 and 17 years old that received treatment at two tertiary care centres in Kelantan. Permission to use the original version of the PSS questionnaire was obtained. The original English version of the PSS was translated into a Malay version following the 10 steps proposed by an established guideline. Pre-testing of the PSS was carried out with 30 caregivers before confirmatory factor analysis (CFA) was established using 110 caregivers. They were asked to assess their understanding of the questionnaire. The one-dimensional questionnaire consists of 11 items, including staff attitudes, availability of staff, supportiveness, and helpfulness. The 5-point Likert scale provided ratings from 1 (strongly disagree) to 5 (strongly agree). Confirmatory factor analysis was performed using a robust maximum likelihood estimator. Results: The analysis showed model fit data with good reliability. Conclusion: The PSS-M shows overall model fitness based on specific indices, with good construct validity and excellent absolute reliability to determine the satisfaction level of caregivers of children with ASD with respect to health care services. © 2018, MDPI AG. All rights reserved.},
note = {cited By 2},
keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia},
pubstate = {published},
tppubtype = {article}
}

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Masiran, R

Stimming behaviour in a 4-year-old girl with autism spectrum disorder Journal Article

BMJ Case Reports, 2018 , 2018, ISSN: 1757790X, (cited By 0).

Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Biscuit, Biting Hard Object, Case Report, Chew Toy, Child Safety, Children, Clinical Article, Female, Food, Food Texture, Hot Food, Human, Language Disability, Note, Preschool, Preschool Child, Priority Journal, Psychology, Self Stimulation, Spicy Food, Stereotyped Behaviour, Stereotypy, Stimming Behaviour, Teething Biscuit, Vegetable

Toh, T -H; Tan, V W -Y; Lau, P S -T; Kiyu, A

Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article

Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9).

Abstract | Links | BibTeX | Tags: Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler

@article{Toh201828,
title = {Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics},
author = {T -H Toh and V W -Y Tan and P S -T Lau and A Kiyu},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028764085&doi=10.1007%2fs10803-017-3287-x&partnerID=40&md5=21bce2407197b8b1e43b4420d274861b},
doi = {10.1007/s10803-017-3287-x},
issn = {01623257},
year = {2018},
date = {2018-01-01},
journal = {Journal of Autism and Developmental Disorders},
volume = {48},
number = {1},
pages = {28-35},
publisher = {Springer New York LLC},
abstract = {This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC.},
note = {cited By 9},
keywords = {Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler},
pubstate = {published},
tppubtype = {article}
}

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Hashim, R; Yussof, H

Preparation for adulthood: Benefits of assistive technologies in social skills training of children with autism Conference

2018-January , Institute of Electrical and Electronics Engineers Inc., 2018, ISBN: 9781538613429, (cited By 0).

Abstract | Links | BibTeX | Tags: Assistive Technology, Autism, Children, Diseases, Economic and Social Effects, Economics, Humanoid, Intelligent Control, Robotics, Skill Training, Smart Sensors

@conference{Hashim2018374,
title = {Preparation for adulthood: Benefits of assistive technologies in social skills training of children with autism},
author = {R Hashim and H Yussof},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047431902&doi=10.1109%2fIRIS.2017.8250151&partnerID=40&md5=3089796dde7022fa5a4a56200466013f},
doi = {10.1109/IRIS.2017.8250151},
isbn = {9781538613429},
year = {2018},
date = {2018-01-01},
journal = {Proceedings - 2017 IEEE 5th International Symposium on Robotics and Intelligent Sensors, IRIS 2017},
volume = {2018-January},
pages = {374-378},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {Humanoids as a form of assistive technologies have been shown to have positive effects on the social-cognitive behavior of brain-impaired children, particularly those with autism. However, evidences on the socio-economic benefits in social-skill training on brain-impaired children have been lacking. At the preliminary stage, a case study of a primary school with special classes for gifted children is the case study for pretesting purposes. As it is, interviewers with teachers at the special integration classes form the basis for primary data collection. Findings indicated that the teachers, parents and guardians of these children are not ready for humanoids to train their children but in future such attempts are encouraged. Nonetheless, this paper will highlight the socio-economic benefits of humanoid-assisted social skills training of children with autism. This is important in preparing them for adulthood and independence. In addition, from the literature reviewed, content analyses on humanoid-mediated research articles provide the preliminary empirical support. Evidences and outcomes from similar research projects conducted from social scientists in developing nations further narrows the objectives of the investigation. Theoretical implication from this study is also discussed. © 2017 IEEE.},
note = {cited By 0},
keywords = {Assistive Technology, Autism, Children, Diseases, Economic and Social Effects, Economics, Humanoid, Intelligent Control, Robotics, Skill Training, Smart Sensors},
pubstate = {published},
tppubtype = {conference}
}

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Hnoonual, A; Thammachote, W; Tim-Aroon, T; Rojnueangnit, K; Hansakunachai, T; Sombuntham, T; Roongpraiwan, R; Worachotekamjorn, J; Chuthapisith, J; Fucharoen, S; Wattanasirichaigoon, D; Ruangdaraganon, N; Limprasert, P; Jinawath, N

Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder Journal Article

Scientific Reports, 7 (1), 2017, ISSN: 20452322, (cited By 6).

Abstract | Links | BibTeX | Tags: Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism

@article{Hnoonual2017,
title = {Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder},
author = {A Hnoonual and W Thammachote and T Tim-Aroon and K Rojnueangnit and T Hansakunachai and T Sombuntham and R Roongpraiwan and J Worachotekamjorn and J Chuthapisith and S Fucharoen and D Wattanasirichaigoon and N Ruangdaraganon and P Limprasert and N Jinawath},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029864969&doi=10.1038%2fs41598-017-12317-3&partnerID=40&md5=3c1b6a0c064665aab8ace8e8f58c2b01},
doi = {10.1038/s41598-017-12317-3},
issn = {20452322},
year = {2017},
date = {2017-01-01},
journal = {Scientific Reports},
volume = {7},
number = {1},
publisher = {Nature Publishing Group},
abstract = {Chromosomal microarray (CMA) is now recognized as the first-tier genetic test for detection of copy number variations (CNVs) in patients with autism spectrum disorder (ASD). The aims of this study were to identify known and novel ASD associated-CNVs and to evaluate the diagnostic yield of CMA in Thai patients with ASD. The Infinium CytoSNP-850K BeadChip was used to detect CNVs in 114 Thai patients comprised of 68 retrospective ASD patients (group 1) with the use of CMA as a second line test and 46 prospective ASD and developmental delay patients (group 2) with the use of CMA as the first-tier test. We identified 7 (6.1%) pathogenic CNVs and 22 (19.3%) variants of uncertain clinical significance (VOUS). A total of 29 patients with pathogenic CNVs and VOUS were found in 22% (15/68) and 30.4% (14/46) of the patients in groups 1 and 2, respectively. The difference in detected CNV frequencies between the 2 groups was not statistically significant (Chi square = 1.02},
note = {cited By 6},
keywords = {Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism},
pubstate = {published},
tppubtype = {article}
}

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Wo, S W; Ong, L C; Low, W Y; Lai, P S M

The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review Journal Article

Epilepsy Research, 136 , pp. 35-45, 2017, ISSN: 09201211, (cited By 8).

Abstract | Links | BibTeX | Tags: Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement

@article{Wo201735,
title = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review},
author = {S W Wo and L C Ong and W Y Low and P S M Lai},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&partnerID=40&md5=f34a0aada2cc5dc6e4d6beab18ac779c},
doi = {10.1016/j.eplepsyres.2017.07.009},
issn = {09201211},
year = {2017},
date = {2017-01-01},
journal = {Epilepsy Research},
volume = {136},
pages = {35-45},
publisher = {Elsevier B.V.},
abstract = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.},
note = {cited By 8},
keywords = {Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement},
pubstate = {published},
tppubtype = {article}
}

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Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.

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Hasan, C Z C; Jailani, R; Tahir, Md N; Ilias, S

The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders Journal Article

Research in Developmental Disabilities, 66 , pp. 55-63, 2017, ISSN: 08914222, (cited By 8).

Abstract | Links | BibTeX | Tags: Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking

@article{Hasan201755,
title = {The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders},
author = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi=10.1016%2fj.ridd.2017.02.015&partnerID=40&md5=d6a9839cda7f62bcce9bdcca33d3d33b},
doi = {10.1016/j.ridd.2017.02.015},
issn = {08914222},
year = {2017},
date = {2017-01-01},
journal = {Research in Developmental Disabilities},
volume = {66},
pages = {55-63},
publisher = {Elsevier Inc.},
abstract = {Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd},
note = {cited By 8},
keywords = {Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking},
pubstate = {published},
tppubtype = {article}
}

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Singh, Joginder S; Hussein, N H; Kamal, Mustaffa R; Hassan, F H

Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Journal Article

AAC: Augmentative and Alternative Communication, 33 (2), pp. 110-120, 2017, ISSN: 07434618, (cited By 10).

Abstract | Links | BibTeX | Tags: Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research

@article{JoginderSingh2017110,
title = {Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC},
author = {S Joginder Singh and N H Hussein and R Mustaffa Kamal and F H Hassan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131769&doi=10.1080%2f07434618.2017.1309457&partnerID=40&md5=067c39e0c318e76caff96b29bb4dbb21},
doi = {10.1080/07434618.2017.1309457},
issn = {07434618},
year = {2017},
date = {2017-01-01},
journal = {AAC: Augmentative and Alternative Communication},
volume = {33},
number = {2},
pages = {110-120},
publisher = {Taylor and Francis Ltd},
abstract = {Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. To date, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. For this study, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, and (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication.},
note = {cited By 10},
keywords = {Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research},
pubstate = {published},
tppubtype = {article}
}

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Shuib, S; Saaid, N N; Zakaria, Z; Ismail, J; Latiff, Abdul Z

Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay Journal Article

Malaysian Journal of Pathology, 39 (1), pp. 77-81, 2017, ISSN: 01268635, (cited By 0).

Abstract | Links | BibTeX | Tags: Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry

@article{Shuib201777,
title = {Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay},
author = {S Shuib and N N Saaid and Z Zakaria and J Ismail and Z Abdul Latiff},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037028880&partnerID=40&md5=624b87d1e9ebac2d1bf66b4d30c0f6e9},
issn = {01268635},
year = {2017},
date = {2017-01-01},
journal = {Malaysian Journal of Pathology},
volume = {39},
number = {1},
pages = {77-81},
publisher = {Malaysian Society of Pathologists},
abstract = {Potocki-Lupski syndrome (PTLS), also known as duplication 17p11.2 syndrome, trisomy 17p11.2 or dup(17)(p11.2p11.2) syndrome, is a developmental disorder and a rare contiguous gene syndrome affecting 1 in 20,000 live births. Among the key features of such patients are autism spectrum disorder, learning disabilities, developmental delay, attention-deficit disorder, infantile hypotonia and cardiovascular abnormalities. Previous studies using microarray identified variations in the size and extent of the duplicated region of chromosome 17p11.2. However, there are a few genes which are considered as candidates for PTLS which include RAI1, SREBF1, DRG2, LLGL1, SHMT1 and ZFP179. In this report, we investigated a case of a 3-year-old girl who has developmental delay. Her chromosome analysis showed a normal karyotype (46,XX). Analysis using array CGH (4X44 K, Agilent USA) identified an ~4.2 Mb de novo duplication in chromosome 17p11.2. The result was confirmed by fluorescence in situ hybridization (FISH) using probes in the critical PTLS region. This report demonstrates the importance of microarray and FISH in the diagnosis of PTLS. © 2017, Malaysian Society of Pathologists. All rights reserved.},
note = {cited By 0},
keywords = {Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry},
pubstate = {published},
tppubtype = {article}
}

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Hasan, C Z C; Jailani, R; Tahir, Md N

Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder Journal Article

International Journal of Biology and Biomedical Engineering, 11 , pp. 74-79, 2017, ISSN: 19984510, (cited By 1).

Abstract | Links | BibTeX | Tags: Article, Artificial Neural Network, Autism, Body Height, Body Mass, Children, Clinical Article, Controlled Study, Discriminant Analysis, Early Diagnosis, Female, Gait, Gait Analysis, Gait Disorder, Human, Learning, Male, Pediatrics, School Child, Statistical Analysis, Statistics, Time Series Analysis

@article{Hasan201774,
title = {Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder},
author = {C Z C Hasan and R Jailani and N Md Tahir},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043500605&partnerID=40&md5=6f2ffe7c2f5daf9fd02d4456acb94438},
issn = {19984510},
year = {2017},
date = {2017-01-01},
journal = {International Journal of Biology and Biomedical Engineering},
volume = {11},
pages = {74-79},
publisher = {North Atlantic University Union NAUN},
abstract = {Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% accuracy, 93.3% sensitivity, and 90.0% specificity. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. All Rights Reserved.},
note = {cited By 1},
keywords = {Article, Artificial Neural Network, Autism, Body Height, Body Mass, Children, Clinical Article, Controlled Study, Discriminant Analysis, Early Diagnosis, Female, Gait, Gait Analysis, Gait Disorder, Human, Learning, Male, Pediatrics, School Child, Statistical Analysis, Statistics, Time Series Analysis},
pubstate = {published},
tppubtype = {article}
}

Close

Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Vos, T; Daoud, F; Wang, H; Bcheraoui, C E; Khalil, I; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Ali, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Ali, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, I A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Defo, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, O A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, A K; Mitchell, P B; Patton, G; Sagar, R; Satpathy, M; Savuon, K; Seedat, S; Shiue, I; Skogen, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H

The burden of mental disorders in the eastern mediterranean region, 1990-2013 Journal Article

PLoS ONE, 12 (1), 2017, ISSN: 19326203, (cited By 30).

Abstract | Links | BibTeX | Tags: 80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult

@article{Charara2017,
title = {The burden of mental disorders in the eastern mediterranean region, 1990-2013},
author = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371%2fjournal.pone.0169575&partnerID=40&md5=471830ec1239e37c6fc4681bed5698f6},
doi = {10.1371/journal.pone.0169575},
issn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {1},
publisher = {Public Library of Science},
abstract = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
note = {cited By 30},
keywords = {80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult},
pubstate = {published},
tppubtype = {article}
}

Close

The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Hashim, R; Yussof, H

A Review of the Ambit of Politics in Social Robotics Conference

105 , Elsevier B.V., 2017, ISSN: 18770509, (cited By 3).

Abstract | Links | BibTeX | Tags: Acceptance, Autism, Children, Diseases, Economic and Social Effects, Education, Influence, Intelligent Control, Machine Design, Politics, Robotics, Robots, Smart Sensors, Social Robotics, Social Sciences

@conference{Hashim2017316,
title = {A Review of the Ambit of Politics in Social Robotics},
author = {R Hashim and H Yussof},
editor = {Yussof H.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016116583&doi=10.1016%2fj.procs.2017.01.228&partnerID=40&md5=d87a64238e7afb117359db4af16a4b52},
doi = {10.1016/j.procs.2017.01.228},
issn = {18770509},
year = {2017},
date = {2017-01-01},
journal = {Procedia Computer Science},
volume = {105},
pages = {316-321},
publisher = {Elsevier B.V.},
abstract = {This article reviews the range of currently held positions on the politics of social robotics for skill augmentation of children with autism and other brain disabilities. Publications from peer-reviewed journals and conference proceedings were analyzed. From these articles categorizations were accorded into three emerging themes on the politics of social robotics which are, influence, acceptance and adoption. The findings indicated that the social skilling of brain-impaired children are implicated but not present in the development and design process of the robots. Instead, the human social skills were assigned to the capability and general features of the robots. The need for social robots is in tandem with societal changes and the increased demographics as well as demands from the healthcare industry. The conceptualization of brain-impaired children is plagued with stereotypical views that they are both mentally and physically handicapped, helpless, require round-the-clock care and in need of robotic assistance when humans fail. Depending on the nation status, the influence, acceptance and adoption of social robotics are indeed political and the success of science for society needs has to be re-examined and perhaps redefined in order to reap the return on investment of the robot production. © 2017 The Authors.},
note = {cited By 3},
keywords = {Acceptance, Autism, Children, Diseases, Economic and Social Effects, Education, Influence, Intelligent Control, Machine Design, Politics, Robotics, Robots, Smart Sensors, Social Robotics, Social Sciences},
pubstate = {published},
tppubtype = {conference}
}

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Abdullah, M H L; Brereton, M

MyCalendar: Supporting children on the autism spectrum to learn language and appropriate behaviour Conference

Association for Computing Machinery, 2017, ISBN: 9781450353793, (cited By 1).

Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Behaviour, Children, Communication, Diseases, Human Computer Interaction, Interactive Computer Systems, iPad Applications, Language, MyCalendar, Photo and Video, Socialisation, Teaching

@conference{Abdullah2017201,
title = {MyCalendar: Supporting children on the autism spectrum to learn language and appropriate behaviour},
author = {M H L Abdullah and M Brereton},
editor = {Soro Ploderer Waycott Morrison A B J A Brereton M. Vyas D.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044237930&doi=10.1145%2f3152771.3152793&partnerID=40&md5=eebe825991d9c6b91971c67113c9b100},
doi = {10.1145/3152771.3152793},
isbn = {9781450353793},
year = {2017},
date = {2017-01-01},
journal = {ACM International Conference Proceeding Series},
pages = {201-209},
publisher = {Association for Computing Machinery},
abstract = {This paper1 presents a study in which a mobile visual calendar application, 'MyCalendar' was used to try to support communication and interaction of children with Autism Spectrum Disorder. This paper reports findings on how the App was used in school classrooms. MyCalendar was evaluated with 11 children in an Australian Autism Special Education Unit over six months and was found to stimulate excitement with video and photo sharing as well as interaction in specific classroom activities. Our previous work examined interactions between home and school, and interactions at home supported by MyCalendar. This analysis focuses entirely on interactions at school by examining data from classroom activities. Three findings revealed: (1) the MyCalendar application supports learning activities in the classroom and facilitates the inclusion of children with ASD who have limited verbal skills. The sharing of each child's personal experience enabled the teachers and children to form a common basis for communication and adding vocabulary, as well as allowing the teacher to model language so as to identify children's emotions; (2) MyCalendar allowed children with limited verbal skills to better communicate their real interests through photos and videos. This enabled the teacher to better identify each child's interest and thereby scaffold more relevant and meaningful learning; (3) Understanding interests enabled teachers to successfully motivate children to interact more in formal learning activities. While it was initially expected the activities would better support communication between teacher and children, the larger and unanticipated effect has been to create opportunities for structuring and scaffolding communication and social interaction in the classroom. © 2017 Association for Computing Machinery. All rights reserved.},
note = {cited By 1},
keywords = {Autism Spectrum Disorders, Behaviour, Children, Communication, Diseases, Human Computer Interaction, Interactive Computer Systems, iPad Applications, Language, MyCalendar, Photo and Video, Socialisation, Teaching},
pubstate = {published},
tppubtype = {conference}
}

Close

Lee, J X; I, Ong S; Lee, V Y; Nazri, Fairuz A R

Parenting Stress among Malaysian Parents of Children with Autism Spectrum Disorder (ASD) Journal Article

MEDICINE AND HEALTH-KUALA LUMPUR, 12 (1), pp. 42-55, 2017, ISSN: 1823-2140.

Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Children, Parenting Stress

@article{ISI:000424654300006,
title = {Parenting Stress among Malaysian Parents of Children with Autism Spectrum Disorder (ASD)},
author = {J X Lee and S Ong I and V Y Lee and Fairuz A R Nazri},
doi = {10.17576/MH.2017.1201.06},
issn = {1823-2140},
year = {2017},
date = {2017-01-01},
journal = {MEDICINE AND HEALTH-KUALA LUMPUR},
volume = {12},
number = {1},
pages = {42-55},
publisher = {UNIV KEBANGSAAN MALAYSIA, FAC MEDICINE},
address = {DEPT PATHOLOGY, UKM MEDICAL CENTRE, CHERAS, KUALA LUMPUR, 56000, MALAYSIA},
abstract = {Autism Spectrum Disorder (ASD) is a neurodevelopmental childhood
disorder associated with cognitive and language impairments. Previous
research found that children with developmental disorders increase
parenting stress but parents of children with ASD, specifically have
recorded higher parenting stress than any other developmental
disabilities. Hence, this study investigates the difference in parenting
stress levels among parents of children with ASD compared to a typical
development (TD) control group. Parenting Stress Index, 3rd Edition
Short Form was used to assess the parenting stress levels of 30 parents
of children with ASD and 36 parents of TD children. Parents of children
with ASD were sampled at Universiti Kebangsaan Malaysia Medical Centre
(UKMMC), Tangkak Hospital and National Autism Society of Malaysia
(NASOM) in Muar and Segamat. Parents of children with ASD recorded
significantly higher levels of parenting stress compared to the TD group
(p<0.001). Parents of male children of ASD recorded significantly higher
levels of parenting stress compared to the parents of male children of
TD group (p<0.001). Parents of female children of ASD also recorded
significantly higher levels of parenting stress compared to parents of
female children of TD group (p<0.001). Intervention towards ASD children
should not only focus on minimizing the core symptoms but should also
pay attention to the family's mental health as well.},
keywords = {Autism Spectrum Disorders, Children, Parenting Stress},
pubstate = {published},
tppubtype = {article}
}

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Tan, M L; Ho, J J; Teh, K H

Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders Journal Article

Cochrane Database of Systematic Reviews, 2016 (9), 2016, ISSN: 1469493X, (cited By 6).

Abstract | Links | BibTeX | Tags: Attention Deficit Disorder, Autism, Carnosine, Children, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Human, Learning Disorder, Meta Analysis, Outcome Assessment, Placebo, Polyunsaturated Fatty Acid, Priority Journal, Randomized Controlled Trial, Review, Systematic Review

@article{Tan2016,
title = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders},
author = {M L Tan and J J Ho and K H Teh},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988922340&doi=10.1002%2f14651858.CD009398.pub3&partnerID=40&md5=3460f403b8829b4692a0b6f795f4a2a3},
doi = {10.1002/14651858.CD009398.pub3},
issn = {1469493X},
year = {2016},
date = {2016-01-01},
journal = {Cochrane Database of Systematic Reviews},
volume = {2016},
number = {9},
publisher = {John Wiley and Sons Ltd},
abstract = {Background: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objectives: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 children, mainly boys between 10 and 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. In addition, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, writing, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 to 8.15; two studies, 116 children). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.},
note = {cited By 6},
keywords = {Attention Deficit Disorder, Autism, Carnosine, Children, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Human, Learning Disorder, Meta Analysis, Outcome Assessment, Placebo, Polyunsaturated Fatty Acid, Priority Journal, Randomized Controlled Trial, Review, Systematic Review},
pubstate = {published},
tppubtype = {article}
}

Close

Background: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objectives: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 children, mainly boys between 10 and 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. In addition, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, writing, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 to 8.15; two studies, 116 children). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.

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Bhagat, V; Mat, Khairi Che H J; Husain, R; Haque, M

Parent’s negative emotionality impacting parenting and involvement in the intervention of their child with autism spectrum disorder: A review proposed the new model for intervention Journal Article

International Journal of Pharmaceutical Sciences Review and Research, 36 (1), pp. 54-62, 2016, ISSN: 0976044X, (cited By 0).

Abstract | Links | BibTeX | Tags: Autism, Children, Disease Severity, Emotion, Emotionality, Evidence-based Practice, Human, Human Relation, Intervention Study, Negative Emotionality, Parent Counseling, Parental Attitude, Parenting Education, Personality Assessment, Review, Social Status, Stress

@article{Bhagat201654,
title = {Parent’s negative emotionality impacting parenting and involvement in the intervention of their child with autism spectrum disorder: A review proposed the new model for intervention},
author = {V Bhagat and H J Khairi Che Mat and R Husain and M Haque},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957597820&partnerID=40&md5=40212e84a1b6be6ade2617d5c9df29a9},
issn = {0976044X},
year = {2016},
date = {2016-01-01},
journal = {International Journal of Pharmaceutical Sciences Review and Research},
volume = {36},
number = {1},
pages = {54-62},
publisher = {Global Research Online},
abstract = {Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Indeed, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Indeed, their negative emotions disturb their focus on the treatment of their ASD child. Thus, the management of ASD child incapacitates their parents to bring out the best. Therefore, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. However, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. All rights reserved.},
note = {cited By 0},
keywords = {Autism, Children, Disease Severity, Emotion, Emotionality, Evidence-based Practice, Human, Human Relation, Intervention Study, Negative Emotionality, Parent Counseling, Parental Attitude, Parenting Education, Personality Assessment, Review, Social Status, Stress},
pubstate = {published},
tppubtype = {article}
}

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Hussain, A; Abdullah, A; Husni, H; Mkpojiogu, E O C

Interaction design principles for edutainment systems: Enhancing the communication skills of children with autism spectrum disorders Journal Article

Revista Tecnica de la Facultad de Ingenieria Universidad del Zulia, 39 (8), pp. 45-50, 2016, ISSN: 02540770, (cited By 24).

Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Children, Communication Skills, Diseases, Education, Edutainment, Interaction Design, Spectrum Analysis, User Interfaces

Abdullah, M H L; Wilson, C; Brereton, M

MyCalendar: Supporting families to communicate with their child on the autism spectrum Conference

Association for Computing Machinery, Inc, 2016, ISBN: 9781450346184, (cited By 4).

Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Behaviour, Children, Communication, Diseases, Human Computer Interaction, Interactive Computer Systems, iPad Applications, MyCalendar, Photo and Video, Socialisation

Banire, B; Jomhari, N; Ahmad, R

Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism Journal Article

Journal of Autism and Developmental Disorders, 45 (10), pp. 3069-3084, 2015, ISSN: 01623257, (cited By 7).

Abstract | Links | BibTeX | Tags: Article, Attention, Autism, Autism Spectrum Disorders, Children, Computer Interface, Education, Education of Intellectually Disabled, Educational Model, Feedback System, Female, Human, Learning, Male, Models, Occupational Therapist, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Quality of Life, Treatment Duration, User Interfaces, Visual Hybrid Development Learning System, Visual Stimulation

Khowaja, K; Salim, S S

Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD) Journal Article

PLoS ONE, 10 (7), 2015, ISSN: 19326203, (cited By 12).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Bibliographic Database, Children, Computer Interface, Computer Program, Controlled Study, Evaluation Study, Female, Heuristics, Human, Information System, Interactive System, Interrater Reliability, Male, Practice Guideline, Questionnaires, Software, Surveys

@article{Khowaja2015,
title = {Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD)},
author = {K Khowaja and S S Salim},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941313427&doi=10.1371%2fjournal.pone.0132187&partnerID=40&md5=60f3ee4a32fd71be4b842755a58527cf},
doi = {10.1371/journal.pone.0132187},
issn = {19326203},
year = {2015},
date = {2015-01-01},
journal = {PLoS ONE},
volume = {10},
number = {7},
publisher = {Public Library of Science},
abstract = {In this paper, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim.},
note = {cited By 12},
keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Bibliographic Database, Children, Computer Interface, Computer Program, Controlled Study, Evaluation Study, Female, Heuristics, Human, Information System, Interactive System, Interrater Reliability, Male, Practice Guideline, Questionnaires, Software, Surveys},
pubstate = {published},
tppubtype = {article}
}

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Roffeei, Mohd S H; Abdullah, N; Basar, S K R

Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs) Journal Article

International Journal of Medical Informatics, 84 (5), pp. 375-385, 2015, ISSN: 13865056, (cited By 43).

Abstract | Links | BibTeX | Tags: Article, ASD, Autism, Autism Spectrum Disorders, Caregiver, Children, Consumer Health Information, Content Analysis, Diseases, E-mail, Facebook, Family, Friendship, Human, Internet, Parents, Patient Referral, Priority Journal, Psychology, Qualitative Analysis, Self Esteem, Social Media, Social Networking, Social Support, Statistics, Support Group, Telemedicine, Utilization

@article{MohdRoffeei2015375,
title = {Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs)},
author = {S H Mohd Roffeei and N Abdullah and S K R Basar},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924517643&doi=10.1016%2fj.ijmedinf.2015.01.015&partnerID=40&md5=7296825093cbf87388b5b65023e59371},
doi = {10.1016/j.ijmedinf.2015.01.015},
issn = {13865056},
year = {2015},
date = {2015-01-01},
journal = {International Journal of Medical Informatics},
volume = {84},
number = {5},
pages = {375-385},
publisher = {Elsevier Ireland Ltd},
abstract = {Purpose: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (AM) and Autism Children Club (ACA). Method: A total of 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% and 20.2%, respectively. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Conclusion: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd.},
note = {cited By 43},
keywords = {Article, ASD, Autism, Autism Spectrum Disorders, Caregiver, Children, Consumer Health Information, Content Analysis, Diseases, E-mail, Facebook, Family, Friendship, Human, Internet, Parents, Patient Referral, Priority Journal, Psychology, Qualitative Analysis, Self Esteem, Social Media, Social Networking, Social Support, Statistics, Support Group, Telemedicine, Utilization},
pubstate = {published},
tppubtype = {article}
}

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Alwi, N; Harun, D; Jh, L

Multidisciplinary Parent Education for Caregivers of Children With Autism Spectrum Disorders (ASD): Implications for Clinical Practice Journal Article

Archives of Psychiatric Nursing, 29 (1), pp. 5, 2015, ISSN: 08839417, (cited By 0).

Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Caregiver, Child Development Disorders, Children, Human, Parents, Pervasive

Siah, P -C; Tan, S -H

Sense of coherence and WHOQoL among parents of children with ASD in Malaysia Journal Article

International Journal on Disability and Human Development, 14 (1), pp. 59-66, 2015, ISSN: 21911231, (cited By 2).

Abstract | Links | BibTeX | Tags: Adult, Age, Article, Autism, Children, Comprehension, Education, Employment, Environmental Factor, Female, Gender, Han Chinese, Health, Housewife, Human, Income, Indian, Major Clinical Study, Malay, Malaysia, Male, Marriage, Mental Health, Parental Attitude, Pensioner, Psychological Aspect, Quality of Life, Religion, Sampling, Sense of Coherence, Social Interactions

@article{Siah201559,
title = {Sense of coherence and WHOQoL among parents of children with ASD in Malaysia},
author = {P -C Siah and S -H Tan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922567900&doi=10.1515%2fijdhd-2013-0039&partnerID=40&md5=a909c24c26550aebe2c8922063d70001},
doi = {10.1515/ijdhd-2013-0039},
issn = {21911231},
year = {2015},
date = {2015-01-01},
journal = {International Journal on Disability and Human Development},
volume = {14},
number = {1},
pages = {59-66},
publisher = {Walter de Gruyter GmbH},
abstract = {Studies have shown that most parents of children with autism spectrum disorder (ASD) face more stress and have a poorer quality of life (QoL) than other parents. Nonetheless, there are still some parents of children with ASD who are able to maintain or even improve their QoL. This study is aimed to explore the relationship between SoC and WHOQoL among parents of children with ASD. Method: A total of 96 parents of children with ASD were invited to participate using a purposive sampling method. Results: The results suggested that participants in the high SoC group had better QoL in the four domains than those in the low SoC group. More importantly, not all types of SoC were relevant to QoL. Comprehensibility was relevant to all the four QoL domains and manageability was relevant to physical and psychological health, while meaningfulness was not relevant to any of the QoL domains. Conclusions: NGOs may improve the QoL of these parents by providing trainings to improve their SOC, especially in comprehensibility and manageability. © 2015 by De Gruyter.},
note = {cited By 2},
keywords = {Adult, Age, Article, Autism, Children, Comprehension, Education, Employment, Environmental Factor, Female, Gender, Han Chinese, Health, Housewife, Human, Income, Indian, Major Clinical Study, Malay, Malaysia, Male, Marriage, Mental Health, Parental Attitude, Pensioner, Psychological Aspect, Quality of Life, Religion, Sampling, Sense of Coherence, Social Interactions},
pubstate = {published},
tppubtype = {article}
}

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Abdullah, M H L; Brereton, M

MyCalendar: Fostering communication for children with autism spectrum disorder through photos and videos Conference

Association for Computing Machinery, Inc, 2015, ISBN: 9781450336734, (cited By 10).

Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Children, Children with Autism, Communication, Diseases, Education, Human Computer Interaction, iPad Applications, Learning, MyCalendar, Participatory Design, Special Education, Teaching, Visual Languages

@conference{Abdullah20151,
title = {MyCalendar: Fostering communication for children with autism spectrum disorder through photos and videos},
author = {M H L Abdullah and M Brereton},
editor = {Smith Vetere Ploderer W F B Carter M. Gibbs M.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963544904&doi=10.1145%2f2838739.2838785&partnerID=40&md5=1d0388dc4eb2a559796a0c8cf61f0e31},
doi = {10.1145/2838739.2838785},
isbn = {9781450336734},
year = {2015},
date = {2015-01-01},
journal = {OzCHI 2015: Being Human - Conference Proceedings},
pages = {1-9},
publisher = {Association for Computing Machinery, Inc},
abstract = {This paper presents MyCalendar; a visual calendar prototype App that was developed to support children with Autism Spectrum Disorder and language delays to communicate about their own activities and interests across the settings of home and school. MyCalendar was developed following in-depth fieldwork and participatory design sessions with parents, teachers and children from Preparatory year to year 2 of an Australian Primary School Special Education Unit catering largely for children with Autism Spectrum Disorder (ASD). Typically, children with ASD face difficulties in participating at school. MyCalendar was then evaluated over six months with four teachers, ten parents and eleven children. The study resulted in two key findings: (1) MyCalendar supported children who have ASD and limited verbal skills to better communicate their daily personal activities through photos and videos, encouraged by teachers and parents. (2) This deeper understanding of the children's daily lives enabled teachers to successfully model positive behaviours and to scaffold more relevant and meaningful learning opportunities by relating them to the children's lives. While it was initially expected that the activities would better support communication between teachers and parents, the MyCalendar led in fact to novel scaffolding of learning opportunities and modeling of communication in the classroom. Copyright © 2015 ACM.},
note = {cited By 10},
keywords = {Autism Spectrum Disorders, Children, Children with Autism, Communication, Diseases, Education, Human Computer Interaction, iPad Applications, Learning, MyCalendar, Participatory Design, Special Education, Teaching, Visual Languages},
pubstate = {published},
tppubtype = {conference}
}

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Saleh, N M; Hassan, H; Fikry, A; Musa, R; Ahmad, S S; Ismail, Z; Samat, N; Hashim, R

Autism children: Cost and benefit analysis of using humanoid in Malaysia Conference

Institute of Electrical and Electronics Engineers Inc., 2015, ISBN: 9781479957651, (cited By 3).

Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism, Autism Therapies, Autism Treatments, Children, Cost Benefit Analysis, Costs, Curing, Diseases, Humanoid, Humanoid Robot, Manufacture, Quality of Life, Robotics, Robots

@conference{Saleh2015185,
title = {Autism children: Cost and benefit analysis of using humanoid in Malaysia},
author = {N M Saleh and H Hassan and A Fikry and R Musa and S S Ahmad and Z Ismail and N Samat and R Hashim},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959570138&doi=10.1109%2fROMA.2014.7295885&partnerID=40&md5=e3a60d8df8ebd4f38287d5f212c8ab1a},
doi = {10.1109/ROMA.2014.7295885},
isbn = {9781479957651},
year = {2015},
date = {2015-01-01},
journal = {2014 IEEE International Symposium on Robotics and Manufacturing Automation, IEEE-ROMA2014},
pages = {185-187},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {Autism is a permanent disorder that cause quality of life disturbance. As matter of research, there are no single interventions that can cure the heterogeneous syndrome. Since there is no cure for autism children, perhaps using humanoid can help the autism children in order to have appropriate therapy and treatment programs especially to the young children inflicted with it. Robots are normally used for industrial work, but hardly for therapy. Robots have been used to substitute human way back in the 19th century. They are beneficial to society regardless of the fields that they are being utilized. The health sector has been identified as one of the fields that benefit most as a result of using robotics. For decades, people fascinated with the technology's fiction of robots that look and act like a human Therefore, humanoid robots give benefits towards autism therapy for early detection. Many studies have been done in order to determine the ways to conduct autism treatment However, there is no study on cost and benefit analysis conducted using humanoid as a treatment for autism children. Therefore, this study will focus on the cost and benefit analysis of using humanoid for Malaysian autism children. © 2014 IEEE.},
note = {cited By 3},
keywords = {Anthropomorphic Robots, Autism, Autism Therapies, Autism Treatments, Children, Cost Benefit Analysis, Costs, Curing, Diseases, Humanoid, Humanoid Robot, Manufacture, Quality of Life, Robotics, Robots},
pubstate = {published},
tppubtype = {conference}
}

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Brett, M; McPherson, J; Zang, Z J; Lai, A; Tan, E -S; Ng, I; Ong, L -C; Cham, B; Tan, P; Rozen, S; Tan, E -C

Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel Journal Article

PLoS ONE, 9 (4), 2014, ISSN: 19326203, (cited By 20).

Abstract | Links | BibTeX | Tags: Article, ATRX Gene, Autism, Autism Spectrum Disorders, Children, Clinical Article, Congenital Abnormalities, Congenital Malformation, Controlled Study, Diagnostic Test, DNA Mutational Analysis, Female, Gene, Gene Expression Profiling, Gene Mutation, Gene Targeting, Genetic Association, Genetic Association Studies, Genetic Disorder, Genetic Variability, Genetic Variation, Genetics, Genome-Wide Association Study, High Throughput Sequencing, High-Throughput Nucleotide Sequencing, Human, Intellectual Disability, Intellectual Impairment, Karyotype, L1CAM Gene, Male, Mutation, Nonsense Mutation, Nucleotide Sequence, Phenotype, Polymorphism, RNA Splice Sites, RNA Splicing, Single Nucleotide, Single Nucleotide Polymorphism

@article{Brett2014,
title = {Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel},
author = {M Brett and J McPherson and Z J Zang and A Lai and E -S Tan and I Ng and L -C Ong and B Cham and P Tan and S Rozen and E -C Tan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898625023&doi=10.1371%2fjournal.pone.0093409&partnerID=40&md5=f673e204a009bf84de81ea69dcd026db},
doi = {10.1371/journal.pone.0093409},
issn = {19326203},
year = {2014},
date = {2014-01-01},
journal = {PLoS ONE},
volume = {9},
number = {4},
publisher = {Public Library of Science},
abstract = {Developmental delay and/or intellectual disability (DD/ID) affects 1-3% of all children. At least half of these are thought to have a genetic etiology. Recent studies have shown that massively parallel sequencing (MPS) using a targeted gene panel is particularly suited for diagnostic testing for genetically heterogeneous conditions. We report on our experiences with using massively parallel sequencing of a targeted gene panel of 355 genes for investigating the genetic etiology of eight patients with a wide range of phenotypes including DD/ID, congenital anomalies and/or autism spectrum disorder. Targeted sequence enrichment was performed using the Agilent SureSelect Target Enrichment Kit and sequenced on the Illumina HiSeq2000 using paired-end reads. For all eight patients, 81-84% of the targeted regions achieved read depths of at least 20×, with average read depths overlapping targets ranging from 322 × to 798 ×. Causative variants were successfully identified in two of the eight patients: a nonsense mutation in the ATRX gene and a canonical splice site mutation in the L1CAM gene. In a third patient, a canonical splice site variant in the USP9X gene could likely explain all or some of her clinical phenotypes. These results confirm the value of targeted MPS for investigating DD/ID in children for diagnostic purposes. However, targeted gene MPS was less likely to provide a genetic diagnosis for children whose phenotype includes autism. © 2014 Brett et al.},
note = {cited By 20},
keywords = {Article, ATRX Gene, Autism, Autism Spectrum Disorders, Children, Clinical Article, Congenital Abnormalities, Congenital Malformation, Controlled Study, Diagnostic Test, DNA Mutational Analysis, Female, Gene, Gene Expression Profiling, Gene Mutation, Gene Targeting, Genetic Association, Genetic Association Studies, Genetic Disorder, Genetic Variability, Genetic Variation, Genetics, Genome-Wide Association Study, High Throughput Sequencing, High-Throughput Nucleotide Sequencing, Human, Intellectual Disability, Intellectual Impairment, Karyotype, L1CAM Gene, Male, Mutation, Nonsense Mutation, Nucleotide Sequence, Phenotype, Polymorphism, RNA Splice Sites, RNA Splicing, Single Nucleotide, Single Nucleotide Polymorphism},
pubstate = {published},
tppubtype = {article}
}

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Shobana, M; Saravanan, C

Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Journal Article

East Asian Archives of Psychiatry, 24 (1), pp. 16-22, 2014, ISSN: 20789947, (cited By 6).

Abstract | Links | BibTeX | Tags: Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability

@article{Shobana201416,
title = {Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability},
author = {M Shobana and C Saravanan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898619897&partnerID=40&md5=e877e03b868d1a11ed8f859a33057d5d},
issn = {20789947},
year = {2014},
date = {2014-01-01},
journal = {East Asian Archives of Psychiatry},
volume = {24},
number = {1},
pages = {16-22},
publisher = {Hong Kong Academy of Medicine Press},
abstract = {Objective: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Methods: In this study, 112 mothers of children having mild and moderate levels of autism disorder, Down syndrome, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Results: Overall, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, anxiety, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Conclusion: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists.},
note = {cited By 6},
keywords = {Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability},
pubstate = {published},
tppubtype = {article}
}

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Bhat, S; Acharya, U R; Adeli, H; Bairy, G M; Adeli, A

Autism: Cause factors, early diagnosis and therapies Journal Article

Reviews in the Neurosciences, 25 (6), pp. 841-850, 2014, ISSN: 03341763, (cited By 52).

Abstract | Links | BibTeX | Tags: 4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide

@article{Bhat2014841,
title = {Autism: Cause factors, early diagnosis and therapies},
author = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925284617&doi=10.1515%2frevneuro-2014-0056&partnerID=40&md5=caaa32e66af70e70ec325241d01564c9},
doi = {10.1515/revneuro-2014-0056},
issn = {03341763},
year = {2014},
date = {2014-01-01},
journal = {Reviews in the Neurosciences},
volume = {25},
number = {6},
pages = {841-850},
publisher = {Walter de Gruyter GmbH},
abstract = {Autism spectrum disorder (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 in 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH.},
note = {cited By 52},
keywords = {4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide},
pubstate = {published},
tppubtype = {article}
}

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Pillai, D; Sheppard, E; Ropar, D; Marsh, L; Pearson, A; Mitchell, P

Using other minds as a window onto the world: Guessing what happened from clues in behaviour Journal Article

Journal of Autism and Developmental Disorders, 44 (10), pp. 2430-2439, 2014, ISSN: 01623257, (cited By 17).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Child Development Disorders, Children, Clinical Article, Cognition, Controlled Study, Eye Movement, Eye Tracking, Facial Expression, Gaze, Human, Intelligence Quotient, Male, Measurement Accuracy, Mouth, Pathophysiology, Pervasive, Physiology, Psychological Aspect, Psychology, Retrodiction, Task Performance, Theory of Mind, Verbal Communication, Video Recording, Videotape Recording, Young Adult

@article{Pillai20142430,
title = {Using other minds as a window onto the world: Guessing what happened from clues in behaviour},
author = {D Pillai and E Sheppard and D Ropar and L Marsh and A Pearson and P Mitchell},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84912053354&doi=10.1007%2fs10803-014-2106-x&partnerID=40&md5=c3396f6f468e37e253c657f998993859},
doi = {10.1007/s10803-014-2106-x},
issn = {01623257},
year = {2014},
date = {2014-01-01},
journal = {Journal of Autism and Developmental Disorders},
volume = {44},
number = {10},
pages = {2430-2439},
publisher = {Springer New York LLC},
abstract = {It has been proposed that mentalising involves retrodicting as well as predicting behaviour, by inferring previous mental states of a target. This study investigated whether retrodiction is impaired in individuals with autism spectrum disorders (ASD). Participants watched videos of real people reacting to the researcher behaving in one of four possible ways. Their task was to decide which of these four ‘‘scenarios’’ each person responded to. Participants’ eye movements were recorded. Participants with ASD were poorer than comparison participants at identifying the scenario to which people in the videos were responding. There were no group differences in time spent looking at the eyes or mouth. The findings imply those with ASD are impaired in using mentalising skills for retrodiction. © Springer Science+Business Media New York 2014.},
note = {cited By 17},
keywords = {Adolescent, Adult, Article, Autism, Child Development Disorders, Children, Clinical Article, Cognition, Controlled Study, Eye Movement, Eye Tracking, Facial Expression, Gaze, Human, Intelligence Quotient, Male, Measurement Accuracy, Mouth, Pathophysiology, Pervasive, Physiology, Psychological Aspect, Psychology, Retrodiction, Task Performance, Theory of Mind, Verbal Communication, Video Recording, Videotape Recording, Young Adult},
pubstate = {published},
tppubtype = {article}
}

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Chen, B C; Rawi, Mohd R; Meinsma, R; Meijer, J; Hennekam, R C M; Kuilenburg, Van A B P

Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings Journal Article

Molecular Syndromology, 5 (6), pp. 299-303, 2014, ISSN: 16618769, (cited By 4).

Abstract | Links | BibTeX | Tags: Alanine, Article, Asymptomatic Disease, Autism, Autosomal Recessive Disorder, Case Report, Cerebellum Atrophy, Children, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Disease Severity, DPYD Gene, Eye Malformation, Female, Gene, Gene Mutation, Homozygosity, Human, Intellectual Impairment, Malaysian, Male, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Preschool Child, Pyrimidine, Pyrimidine Metabolism, School Child, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil

@article{Chen2014299,
title = {Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings},
author = {B C Chen and R Mohd Rawi and R Meinsma and J Meijer and R C M Hennekam and A B P Van Kuilenburg},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919783242&doi=10.1159%2f000366074&partnerID=40&md5=1ebfb9aedb7cb64e3423811b41b6aa7c},
doi = {10.1159/000366074},
issn = {16618769},
year = {2014},
date = {2014-01-01},
journal = {Molecular Syndromology},
volume = {5},
number = {6},
pages = {299-303},
publisher = {S. Karger AG},
abstract = {Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine metabolism. Deficiency of this enzyme leads to an accumulation of thymine and uracil and a deficiency of metabolites distal to the catabolic enzyme. The disorder presents with a wide clinical spectrum, ranging from asymptomatic to severe neurological manifestations, including intellectual disability, seizures, microcephaly, autistic behavior, and eye abnormalities. Here, we report on an 11-year-old Malaysian girl and her 6-year-old brother with DPD deficiency who presented with intellectual disability, microcephaly, and hypotonia. Brain MRI scans showed generalized cerebral and cerebellar atrophy and callosal body dysgenesis in the boy. Urine analysis showed strongly elevated levels of uracil in the girl and boy (571 and 578 mmol/mol creatinine, respectively) and thymine (425 and 427 mmol/mol creatinine, respectively). Sequence analysis of the DPYD gene showed that both siblings were homozygous for the mutation c.1651G>A (pAla551Thr). © 2014 S. Karger AG, Basel.},
note = {cited By 4},
keywords = {Alanine, Article, Asymptomatic Disease, Autism, Autosomal Recessive Disorder, Case Report, Cerebellum Atrophy, Children, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Disease Severity, DPYD Gene, Eye Malformation, Female, Gene, Gene Mutation, Homozygosity, Human, Intellectual Impairment, Malaysian, Male, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Preschool Child, Pyrimidine, Pyrimidine Metabolism, School Child, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil},
pubstate = {published},
tppubtype = {article}
}

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Ramachandram, Sathyabama; Lope, Raja Juanita Raja; Chandran, Vijayalakshmi; Nor, Norazlin Kamal; Ismail, Juriza

Use of parent administered picture activity cards to teach toileting skills in children with autism Journal Article

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22 (2), pp. S213-S214, 2013, ISSN: 1018-8827.

BibTeX | Tags: Autism, Children, Picture Activity Cards, Toileting

Assaf, M; Hyatt, C J; Wong, C G; Johnson, M R; Schultz, R T; Hendler, T; Pearlson, G D

Mentalizing and motivation neural function during social interactions in autism spectrum disorders Journal Article

NeuroImage: Clinical, 3 , pp. 321-331, 2013, ISSN: 22131582, (cited By 28).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision

@article{Assaf2013321,
title = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders},
author = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&partnerID=40&md5=b63630c997b658167792266e40e855b6},
doi = {10.1016/j.nicl.2013.09.005},
issn = {22131582},
year = {2013},
date = {2013-01-01},
journal = {NeuroImage: Clinical},
volume = {3},
pages = {321-331},
abstract = {Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors.},
note = {cited By 28},
keywords = {Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision},
pubstate = {published},
tppubtype = {article}
}

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Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors.

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Khowaja, K; Salim, S S

A systematic review of strategies and computer-based intervention (CBI) for reading comprehension of children with autism Journal Article

Research in Autism Spectrum Disorders, 7 (9), pp. 1111-1121, 2013, ISSN: 17509467, (cited By 28).

Abstract | Links | BibTeX | Tags: Attention, Autism, Bibliographic Database, Children, Clinical Effectiveness, Clinical Observation, Cognition, Comprehension, Computer Assisted Therapy, Computer Based Intervention, Explicit Memory, Human, Learning, Linguistics, Motivation, Multimedia, Pretest Posttest Design, Priority Journal, Reading, Reading Comprehension, Review, Systematic Review, Treatment Outcome

@article{Khowaja20131111,
title = {A systematic review of strategies and computer-based intervention (CBI) for reading comprehension of children with autism},
author = {K Khowaja and S S Salim},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879609907&doi=10.1016%2fj.rasd.2013.05.009&partnerID=40&md5=6ba3e9315ee8b3cecb6248b97198313d},
doi = {10.1016/j.rasd.2013.05.009},
issn = {17509467},
year = {2013},
date = {2013-01-01},
journal = {Research in Autism Spectrum Disorders},
volume = {7},
number = {9},
pages = {1111-1121},
abstract = {This paper presents a systematic review of relevant published studies on reading comprehension for children with autism, focusing on vocabulary instruction and text comprehension instruction from years 2000 to 2011. This systematic review attempts to address three specific research questions: strategies of vocabulary instruction and text comprehension instruction used, computer-based intervention (CBI) used or developed during study, and the effectiveness of using CBI for teaching children with autism. There are five strategies of vocabulary instruction and seven strategies of text comprehension instruction. Results indicate that two strategies of vocabulary instruction, multimedia methods and explicit instruction were found to be more commonly used than the other three. On the same note, question answering strategy of text comprehension instruction was discovered to be used more often than the other six. Results also indicate that children with autism can benefit from the strategies of reading comprehension and that the use of CBI as a mode of instruction for reading comprehension improved learning of children. This is clearly evident judging from the performance of children between pre-tests and post-tests of studies in which CBI was used. However, due to heterogeneity of participants, this is not always the case; a few studies reported no improvement in the learning of children with autism. © 2013 Elsevier Ltd. Allrights reserved.},
note = {cited By 28},
keywords = {Attention, Autism, Bibliographic Database, Children, Clinical Effectiveness, Clinical Observation, Cognition, Comprehension, Computer Assisted Therapy, Computer Based Intervention, Explicit Memory, Human, Learning, Linguistics, Motivation, Multimedia, Pretest Posttest Design, Priority Journal, Reading, Reading Comprehension, Review, Systematic Review, Treatment Outcome},
pubstate = {published},
tppubtype = {article}
}

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Modugumudi, Y R; Santhosh, J; Anand, S

Efficacy of collaborative virtual environment intervention programs in emotion expression of children with autism Journal Article

Journal of Medical Imaging and Health Informatics, 3 (2), pp. 321-325, 2013, ISSN: 21567018, (cited By 4).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Children, Clinical Article, Collaborative Virtual Environment, Controlled Study, DSM-IV, Electroencephalogram, Electroencephalography, Electrooculogram, Emotion, Environment, Event Related Potential, Facial Expression, Female, Human, Latent Period, Male, Recognition, School Child

Selvaraj, J; Murugappan, M; Wan, K; Yaacob, S

Classification of emotional states from electrocardiogram signals: A non-linear approach based on hurst Journal Article

BioMedical Engineering Online, 12 (1), 2013, ISSN: 1475925X, (cited By 42).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Aged, Article, Audio-Visual Stimulus, Autonomous Nervous Systems, Children, Classification Accuracy, Computer Based Training, Computer-Assisted, Electrocardiogram Signal, Electrocardiography, Emotion, Female, Fuzzy K-nearest Neighbor, Higher-Order Statistic (HOS), Human, Intellectual Disability, Interactive Computer Systems, Methodology, Middle Aged, Nonlinear Dynamics, Nonlinear System, Procedures, Real Time Systems, Signal Processing, Statistics, Young Adult

@article{Selvaraj2013,
title = {Classification of emotional states from electrocardiogram signals: A non-linear approach based on hurst},
author = {J Selvaraj and M Murugappan and K Wan and S Yaacob},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879017985&doi=10.1186%2f1475-925X-12-44&partnerID=40&md5=18c5309ac9f3017f455480f1ff732a30},
doi = {10.1186/1475-925X-12-44},
issn = {1475925X},
year = {2013},
date = {2013-01-01},
journal = {BioMedical Engineering Online},
volume = {12},
number = {1},
publisher = {BioMed Central Ltd.},
abstract = {Background: Identifying the emotional state is helpful in applications involving patients with autism and other intellectual disabilities; computer-based training, human computer interaction etc. Electrocardiogram (ECG) signals, being an activity of the autonomous nervous system (ANS), reflect the underlying true emotional state of a person. However, the performance of various methods developed so far lacks accuracy, and more robust methods need to be developed to identify the emotional pattern associated with ECG signals.Methods: Emotional ECG data was obtained from sixty participants by inducing the six basic emotional states (happiness, sadness, fear, disgust, surprise and neutral) using audio-visual stimuli. The non-linear feature 'Hurst' was computed using Rescaled Range Statistics (RRS) and Finite Variance Scaling (FVS) methods. New Hurst features were proposed by combining the existing RRS and FVS methods with Higher Order Statistics (HOS). The features were then classified using four classifiers - Bayesian Classifier, Regression Tree, K- nearest neighbor and Fuzzy K-nearest neighbor. Seventy percent of the features were used for training and thirty percent for testing the algorithm.Results: Analysis of Variance (ANOVA) conveyed that Hurst and the proposed features were statistically significant (p < 0.001). Hurst computed using RRS and FVS methods showed similar classification accuracy. The features obtained by combining FVS and HOS performed better with a maximum accuracy of 92.87% and 76.45% for classifying the six emotional states using random and subject independent validation respectively.Conclusions: The results indicate that the combination of non-linear analysis and HOS tend to capture the finer emotional changes that can be seen in healthy ECG data. This work can be further fine tuned to develop a real time system. © 2013 Selvaraj et al.; licensee BioMed Central Ltd.},
note = {cited By 42},
keywords = {Adolescent, Adult, Aged, Article, Audio-Visual Stimulus, Autonomous Nervous Systems, Children, Classification Accuracy, Computer Based Training, Computer-Assisted, Electrocardiogram Signal, Electrocardiography, Emotion, Female, Fuzzy K-nearest Neighbor, Higher-Order Statistic (HOS), Human, Intellectual Disability, Interactive Computer Systems, Methodology, Middle Aged, Nonlinear Dynamics, Nonlinear System, Procedures, Real Time Systems, Signal Processing, Statistics, Young Adult},
pubstate = {published},
tppubtype = {article}
}

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