Senarai Penerbitan mengikut label - National Autism Resource Centre (NARC)

Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z

Faktor-faktor yang berkaitan dengan keparahan autisme di kalangan kanak-kanak Malaysia dengan Autism Spectrum Disorder Artikel Jurnal

Penyelidikan Ketidakupayaan Pembangunan, 100 , 2020, ISSN: 08914222, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Berat badan, Anak-anak, Kajian Lintas Bahagian, Demografi, Persatuan Penyakit, Keterukan Penyakit, Pekerjaan, Perempuan, Manusia, Gaya hidup, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Ibu bapa, Kanak-kanak Prasekolah, Budak sekolah, Status sosial

de Vries, M; Cader, S; Rakan sekerja, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E

Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 50 (4), hlm. 1281-1294, 2020, ISSN: 01623257, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda

Prabhakar, S; Cheah, P S; Zhang, X; Zinter, M; Gianatasio, M; Hudry, E; Bronson, R T; Kwiatkowski, D J; Stemmer-Rachamimov, A; Maguire, C A; Sena-Esteves, M; Tannous, B A; Breakefield, X O

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1 Artikel Jurnal

Molecular Therapy - Methods and Clinical Development, 15 , hlm. 18-26, 2019, ISSN: 23290501, (dipetik oleh 2).

Abstrak | Pautan | BibTeX | Tag: Adeno Associated Virus, Adeno Associated Virus Vector, Animal Experiment, Animal Model, Artikel, Beta Actin, Blood Brain Barrier, Berat badan, Body Weight Gain, Brain Nerve Cell, Brain Ventricle, Percambahan Sel, Complementary DNA, Kajian Terkawal, Cre Recombinase, Drug Efficacy, Perempuan, Gen, Gene Replacement Therapy, Hamartin, HEK293 Cell Line, Hydrocephalus, Immunohistochemistry, Inverted Terminal Repeat, Long Term Care, Lelaki, Motor Activity, Motor Performance, Tetikus, Bukan Manusia, Jurnal Keutamaan, Promoter Region, Fungsi Protein, Protein Phosphorylation, Quantitative Analysis, Subventricular Zone, Survival Time, Tuberous Sclerosis, Tuberous Sclerosis Type 1, Vascularization, Viral Gene Delivery System

Ramachandram, S

Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia Artikel Jurnal

Medical Journal of Malaysia, 74 (5), hlm. 372-376, 2019, ISSN: 03005283, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Remaja, Artikel, Asthma, Autisme, Birth Weight, Pembangunan kanak-kanak, Anak-anak, Chinese, Conception, Demografi, Diet Restriction, DSM-5, Eczema, Pendidikan, Educational Status, Epilepsi, Perempuan, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Manusia, Orang India, Kajian Klinikal Utama, Malay, Lelaki, Medical Record Review, Pulau Pinang, Prematurity, Gangguan Pertuturan, Upper Respiratory Tract Congestion, Wakefulness

@article Instagram Feed JS 1,
author = Instagram Feed JS 0,
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073688991&rakan kongsi = 40&md5=3ed147d56181ccd44321c47629a4aa54},
terbitan = {03005283},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Medical Journal of Malaysia},
isi padu = {74},
nombor = {5},
halaman = {372-376},
penerbit = {Malaysian Medical Association},
abstrak = {Objektif: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Keputusan: Daripada 331 children with ASD, 82.5% were males, 17.5% perempuan, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 bulan (SD 31.68 bulan) with age range from 19 months to 18 years and 4 bulan. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% dan 5.7% masing-masing. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 dan 31.6 years respectively. Kesimpulannya: Dalam kajian ini, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. Hak cipta terpelihara.},
nota = {dipetik oleh 0},
kata kunci = {Remaja, Artikel, Asthma, Autisme, Birth Weight, Pembangunan kanak-kanak, Anak-anak, Chinese, Conception, Demografi, Diet Restriction, DSM-5, Eczema, Pendidikan, Educational Status, Epilepsi, Perempuan, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Manusia, Orang India, Kajian Klinikal Utama, Malay, Lelaki, Medical Record Review, Pulau Pinang, Prematurity, Gangguan Pertuturan, Upper Respiratory Tract Congestion, Wakefulness},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Ong, BUKAN PERKATAAN

Kepuasan ibu bapa dan persepsi terhadap Kemajuan dalam mempengaruhi Amalan pendekatan kesihatan pelengkap pada kanak-kanak autisme: Tinjauan keratan rentas dari Negeri Sembilan, Malaysia Artikel Jurnal

Perubatan Komplementari dan Alternatif BMC, 19 (1), 2019, ISSN: 14726882, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Ubatan alternatif, Autisme, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Terapi Pelengkap, Kajian Lintas Bahagian, Perempuan, Manusia, Bayi, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Kepuasan Peribadi, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Soal selidik, Kepuasan hati, Kecekapan Sosial, Kemahiran sosial, Tinjauan, Hasil Rawatan

@artikel{Ong2019,
tajuk = {Kepuasan ibu bapa dan persepsi terhadap Kemajuan dalam mempengaruhi Amalan pendekatan kesihatan pelengkap pada kanak-kanak autisme: Tinjauan keratan rentas dari Negeri Sembilan, Malaysia},
pengarang = {J J Ong},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071968009&doi = 10.1186% 2fs12906-019-2672-8&rakan kongsi = 40&md5=7357d9aa26c64a321790fee9aae89765},
doi = {10.1186/s12906-019-2672-8},
terbitan = {14726882},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Perubatan Komplementari dan Alternatif BMC},
isi padu = {19},
nombor = {1},
penerbit = {BioMed Central Ltd.},
abstrak = {Latar belakang: Penggunaan pendekatan kesihatan pelengkap oleh ibu bapa (TIDAK) untuk kanak-kanak yang mengalami gangguan spektrum autisme (ASD) adalah perkara biasa walaupun terdapat bukti yang tidak pasti tentang manfaatnya. Ibu bapa sering mengamalkan CHA kerana tidak berpuas hati dengan rawatan konvensional. Kajian ini bertujuan untuk mengkaji kepuasan ibu bapa terhadap rawatan ASD dan persepsi mereka terhadap kemajuan dalam perkembangan anak mereka.. Penggunaan CHA oleh ibu bapa dalam kalangan kanak-kanak dengan ASD dan faktor-faktor yang berkaitan juga dinilai. Kaedah: Soal selidik yang ditadbir sendiri telah dilengkapkan oleh 48 ibu bapa yang mempunyai anak ASD di hospital rujukan tertiari tunggal di Malaysia. Analisis korelasi digunakan untuk meneroka perkaitan antara skor kepuasan ibu bapa, persepsi skor kemajuan dan penggunaan CHA. Keputusan: Penggunaan CHA dilaporkan oleh ibu bapa untuk 35.4% kanak-kanak dengan ASD dalam sampel. Ibu bapa yang kurang berpuas hati dengan rawatan konvensional dan ibu bapa yang merasakan kemajuan yang lebih lemah dalam perkembangan anak mereka lebih cenderung menggunakan CHA. Hubungan positif yang kukuh didapati antara kepuasan ibu bapa dengan skor rawatan ASD dan persepsi ibu bapa terhadap skor kemajuan, yang menunjukkan bahawa ibu bapa yang berpuas hati dengan rawatan lebih cenderung untuk melihat kemajuan yang lebih besar dalam perkembangan anak mereka. Peningkatan dalam kemajuan anak amat dihargai oleh ibu bapa dalam tingkah laku anak mereka (85.5%), kemahiran sosial (83.3%) dan kemahiran motor (77.1%). Kesimpulannya: Penggunaan CHA adalah biasa di kalangan kanak-kanak dengan ASD. Ibu bapa lebih cenderung untuk mengamalkan CHA apabila mereka kurang berpuas hati dengan rawatan konvensional dan merasakan kemajuan yang lebih buruk. Kajian berbilang pusat yang lebih besar diperlukan untuk meneroka lebih lanjut amalan CHA dalam kalangan kanak-kanak ASD di seluruh Malaysia. © 2019 Pengarang(s).},
nota = {dipetik oleh 0},
kata kunci = {Remaja, Dewasa, Ubatan alternatif, Autisme, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Terapi Pelengkap, Kajian Lintas Bahagian, Perempuan, Manusia, Bayi, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Kepuasan Peribadi, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Soal selidik, Kepuasan hati, Kecekapan Sosial, Kemahiran sosial, Tinjauan, Hasil Rawatan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Sarwar, F; fanatik, S A; Rajab, A; Nordin, N

Sokongan sosial, optimisme, efikasi kendiri ibu bapa dan kesejahteraan ibu kanak-kanak dengan gangguan spektrum autisme Artikel Jurnal

Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam, 10 (9), hlm. 1824-1829, 2019, ISSN: 09760245, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Assessment of Humans, Autisme, Anak-anak, Correlation Analysis, Kajian Lintas Bahagian, Perempuan, Manusia, Life Orientation Test, Kepuasan Hidup, Skala Likert, Lelaki, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Skala Tekanan yang Diperhatikan, Positive and Negative Affect Schedule, Soal selidik, Satisfaction with Life Scale, Konsep Kendiri, Sokongan Sosial, Kesejahteraan

@artikel{Sarwar20191824,
tajuk = {Sokongan sosial, optimisme, efikasi kendiri ibu bapa dan kesejahteraan ibu kanak-kanak dengan gangguan spektrum autisme},
pengarang = {F Sarwar dan S A Panatik dan A Rajab dan N Nordin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074977478&doi = 10.5958% 2f0976-5506.2019.02719.0&rakan kongsi = 40&md5=6760a63e9eca52a1bb463dc10bd5abe6},
doi = {10.5958/0976-5506.2019.02719.0},
terbitan = {09760245},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam},
isi padu = {10},
nombor = {9},
halaman = {1824-1829},
penerbit = {Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam},
abstrak = {Ia telah dihipotesiskan bahawa optimisme, efikasi kendiri dan sokongan sosial adalah peramal positif kepuasan hidup dan kesan positif dan peramal negatif tekanan yang dirasakan dan kesan negatif. Data dikumpul dengan kaedah tinjauan daripada 47 ibu kepada kanak-kanak autisme di Lahore dan Faisalabad. Hipotesis telah diuji pada empat model empat pembolehubah bersandar menggunakan analisis regresi hierarki. Keputusan menggambarkan bahawa efikasi kendiri ibu bapa adalah peramal yang signifikan bagi keempat-empat pembolehubah bersandar, sokongan sosial adalah peramal penting kepuasan hidup dan tekanan yang dirasakan, manakala keyakinan hanya meramalkan varians secara signifikan dalam kepuasan hidup. Kajian itu adalah yang pertama dari jenisnya yang akan dilakukan dengan sampel dalam konteks Pakistan dan mempunyai implikasi penting untuk ahli psikologi klinikal. Mereka boleh merancang intervensi untuk meningkatkan kesejahteraan subjektif dan mengurangkan tekanan secara langsung atau tidak langsung dengan memberi tumpuan kepada anteseden yang diuji dalam kajian.. © 2019, Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam. Hak cipta terpelihara.},
nota = {dipetik oleh 0},
kata kunci = {Dewasa, Artikel, Assessment of Humans, Autisme, Anak-anak, Correlation Analysis, Kajian Lintas Bahagian, Perempuan, Manusia, Life Orientation Test, Kepuasan Hidup, Skala Likert, Lelaki, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Skala Tekanan yang Diperhatikan, Positive and Negative Affect Schedule, Soal selidik, Satisfaction with Life Scale, Konsep Kendiri, Sokongan Sosial, Kesejahteraan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Peramal kepuasan penjaga terhadap pengurusan kanak-kanak dengan gangguan spektrum autisme: Kajian di pelbagai peringkat penjagaan kesihatan Artikel Jurnal

Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 16 (10), 2019, ISSN: 16617827, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Anak-anak, komorbiditi, Perundingan, Kajian Terkawal, Kajian Lintas Bahagian, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Sistem penjagaan kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kepuasan kerja, Kelantan, Kajian Klinikal Utama, Malaysia, Lelaki, Pengurusan, Kesihatan mental, Pertengahan umur, Terapi pekerjaan, Soal Selidik Skala Kepuasan Ibu Bapa, Persepsi, Kepuasan Peribadi, Penjagaan Kesihatan Utama, Penjagaan Perubatan Utama, Psikologi, Soal selidik, Kepuasan hati, Penjagaan Kesihatan Sekunder, Terapi ucapan, Tinjauan, Penjagaan Kesihatan Tertiari, West Malaysia

@artikel{Adib2019,
tajuk = {Peramal kepuasan penjaga terhadap pengurusan kanak-kanak dengan gangguan spektrum autisme: Kajian di pelbagai peringkat penjagaan kesihatan},
pengarang = {N A N Adib dan M I Ibrahim dan A A Rahman dan R S Bakar dan N A Yahaya dan S Hussin dan W N A Wan Mansor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066861959&doi=10.3390/ijerph16101684&rakan kongsi = 40&md5=7f7b4ccd7484a6dcc6e2f03375b1ffb7},
doi = {10.3390/ijerph16101684},
terbitan = {16617827},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam},
isi padu = {16},
nombor = {10},
penerbit = {MDPI AG},
abstrak = {Latar belakang: Pengasuh adalah penjaga pintu awal dalam pengurusan penjagaan kesihatan kanak-kanak dengan gangguan spektrum autisme (ASD). Kaedah: Kajian keratan rentas ini bertujuan untuk menentukan faktor-faktor yang berkaitan dengan kepuasan penjaga terhadap tahap perkhidmatan penjagaan kesihatan yang berbeza dalam menguruskan kanak-kanak ASD di Kelantan.. Markah kepuasan daripada 227 penjaga utama kanak-kanak ASD yang disahkan telah dinilai dengan Skala Kepuasan Ibu Bapa yang diubah suai (PSS) soal selidik. Keputusan: Analisis menunjukkan bahawa penjaga yang menunggu lebih lama untuk perundingan doktor dalam penjagaan primer mempunyai skor PSS yang berkurangan, manakala penjaga yang berpuas hati dengan masa menunggu di jagaan primer mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan menengah, penjaga yang memiliki sekurang-kurangnya diploma telah mengurangkan markah PSS, manakala penjaga yang berpuas hati dengan masa konsultasi doktor dan pelantikan terapi pekerjaan mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan tertiari, penjaga yang mempunyai masalah perubatan yang mendasari dan yang mempunyai anak yang menjalani terapi pekerjaan selama dua bulan atau lebih telah mengurangkan markah PSS. Namun begitu, analisis menunjukkan bahawa penjaga yang prihatin dengan masalah tidur anak-anak mereka, yang telah dimaklumkan tentang sokongan ibu bapa, yang berpuas hati dengan pelantikan terapi pertuturan dan pekerjaan, yang berpuas hati dengan masa menunggu di klinik penjagaan tertiari, dan yang berpuas hati dengan pengetahuan dan pengalaman doktor mereka mempunyai markah PSS yang lebih tinggi. Kesimpulannya: Kajian ini menjelaskan kepentingan memahami kepuasan penjaga dalam mendapatkan penjagaan untuk anak ASD mereka dan menekankan keperluan untuk mempromosikan faktor yang akan meningkatkan kepuasan penjaga terhadap perkhidmatan ASD semasa.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.},
nota = {dipetik oleh 0},
kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Anak-anak, komorbiditi, Perundingan, Kajian Terkawal, Kajian Lintas Bahagian, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Sistem penjagaan kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kepuasan kerja, Kelantan, Kajian Klinikal Utama, Malaysia, Lelaki, Pengurusan, Kesihatan mental, Pertengahan umur, Terapi pekerjaan, Soal Selidik Skala Kepuasan Ibu Bapa, Persepsi, Kepuasan Peribadi, Penjagaan Kesihatan Utama, Penjagaan Perubatan Utama, Psikologi, Soal selidik, Kepuasan hati, Penjagaan Kesihatan Sekunder, Terapi ucapan, Tinjauan, Penjagaan Kesihatan Tertiari, West Malaysia},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Tekanan yang dirasakan dalam kalangan penjaga kanak-kanak yang mengalami gangguan spektrum autisme: Kajian seluruh negeri Artikel Jurnal

Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 16 (8), 2019, ISSN: 16617827, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Adaptasi, Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Beban Penjaga, Penjagaan Kanak-kanak, Anak-anak, Tingkah Laku Menghadapi, Kajian Lintas Bahagian, Perempuan, Susulan, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Manusia, Bayi, Gangguan Pembelajaran, Malaysia, Lelaki, Tekanan Mental, Pertengahan umur, Analisis Regresi Linear Berganda, Baru lahir, Manusia Biasa, Pengangkutan Pesakit, Skala Tekanan yang Diperhatikan, Ramalan, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Tekanan, Pusat Jagaan Tertiari, Hospital Universiti

@artikel{Adib2019b,
tajuk = {Tekanan yang dirasakan dalam kalangan penjaga kanak-kanak yang mengalami gangguan spektrum autisme: Kajian seluruh negeri},
pengarang = {N A N Adib dan M I Ibrahim dan A A Rahman dan R S Bakar dan N A Yahaya dan S Hussin dan W N A Wan Mansor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065303613&doi = 10.3390% 2fijerph16081468&rakan kongsi = 40&md5=fc871375f0d307a95820cd87c57ea270},
doi = {10.3390/ijerph16081468},
terbitan = {16617827},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam},
isi padu = {16},
nombor = {8},
penerbit = {MDPI AG},
abstrak = {Latar belakang: Penjaga kanak-kanak yang mengalami gangguan spektrum autisme (ASD) mengalami tekanan yang meningkat dan akibat pengasuhan negatif yang lebih ketara daripada mereka yang mempunyai kanak-kanak yang sedang membangun. Terdapat kekurangan kajian yang khusus memfokuskan kepada tekanan dalam kalangan penjaga yang mempunyai kanak-kanak ASD di negara Asia. Kajian semasa mengkaji tahap tekanan yang dirasakan dan faktor yang dikaitkan dengannya dalam kalangan penjaga di Kelantan, Malaysia. Kaedah: Dalam kajian keratan rentas, versi Bahasa Melayu bagi Skala Tekanan Yang Diperhatikan (PSS) telah ditadbirkan kepada 227 penjaga kanak-kanak dengan ASD. Pengasuh telah diambil daripada pangkalan data ASD di empat hospital tertiari di Kelantan dan satu mesyuarat telah diadakan semasa susulan kanak-kanak itu di klinik.. Analisis regresi linear berbilang telah digunakan untuk menentukan peramal tekanan yang dirasakan. Keputusan: Purata jumlah skor tekanan yang dirasakan ialah 20.84 (4.72). Ini dianggap lebih tinggi daripada purata. Tekanan yang dirasakan lebih tinggi telah diramalkan dengan ketara dalam kalangan penjaga yang tinggal jauh dari institusi kesihatan, penjaga yang tidak memiliki pengangkutan untuk membawa anak ke pusat rawatan, dan penjaga yang mempunyai anak ASD dengan masalah pembelajaran. Kesimpulannya: Pengasuh kanak-kanak ASD merasakan tekanan yang ketara semasa menjaga anak-anak mereka. Institusi harus mengurangkan faktor-faktor yang diramalkan meningkatkan tekanan pengasuh untuk meningkatkan kualiti kehidupan kanak-kanak dan keluarga ASD secara keseluruhan.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.},
nota = {dipetik oleh 0},
kata kunci = {Adaptasi, Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Beban Penjaga, Penjagaan Kanak-kanak, Anak-anak, Tingkah Laku Menghadapi, Kajian Lintas Bahagian, Perempuan, Susulan, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Manusia, Bayi, Gangguan Pembelajaran, Malaysia, Lelaki, Tekanan Mental, Pertengahan umur, Analisis Regresi Linear Berganda, Baru lahir, Manusia Biasa, Pengangkutan Pesakit, Skala Tekanan yang Diperhatikan, Ramalan, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Tekanan, Pusat Jagaan Tertiari, Hospital Universiti},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Liu, Y-W; Liong, M T; Am, Y -C E; Huang, H -Y; Peng, W -S; Cheng, Y -F; Lin, Y -S; Wu, Y-Y; Tsai, Y -C

Kesan lactobacillus plantarum PS128 pada kanak-kanak dengan gangguan spektrum autisme di Taiwan: A rawak, buta dua, percubaan terkawal plasebo Artikel Jurnal

Nutrien, 11 (4), 2019, ISSN: 20726643, (dipetik oleh 4).

Abstrak | Pautan | BibTeX | Tag: Senarai Semak Tingkah Laku Aberrant versi Taiwan, Remaja, umur, Faktor Umur, Keagresifan, Keresahan, Artikel, Gangguan Defisit Perhatian, Autisme, Senarai Semak Tingkah Laku Autisme, Temuduga Diagnostik Autisme Disemak, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Senarai Semak Tingkah Laku Kanak-kanak, Anak-anak, Skala Teraan Global Klinikal, Gangguan Komunikasi, Kajian Terkawal, Prosedur Double Blind, Kaedah Double-Blind, Perempuan, Gangguan Kebimbangan Umum, Manusia, Impulsif, Lactobacillus delbrueckii, Lelaki, Fisiologi, Placebo, Placebo, Gangguan Tekanan Selepas Traumatik, Agen Probiotik, Probiotik, Psikologi, Soal selidik, Percubaan Terkawal Rawak, Skala penilaian, Budak sekolah, Sistem Pemarkahan, Kelakuan Sosial, Interaksi Sosial, Masalah Sosial, Skala Responsif Sosial, Tinjauan, Penilaian Swanson Nolan dan Pelham IV, Protein Berkaitan Sinaptosomal 23, Taiwan

@artikel{Liu2019,
tajuk = {Kesan lactobacillus plantarum PS128 pada kanak-kanak dengan gangguan spektrum autisme di Taiwan: A rawak, buta dua, percubaan terkawal plasebo},
pengarang = {Y -W Liu dan M T Liong dan Y -C E Chung dan H -Y Huang dan W -S Peng dan Y -F Cheng dan Y -S Lin dan Y -Y Wu dan Y -C Tsai},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817846&doi=10.3390/nu11040820&rakan kongsi = 40&md5=ca04462e8710198b821b44f8e73061f3},
doi = {10.3390/nu11040820},
terbitan = {20726643},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Nutrien},
isi padu = {11},
nombor = {4},
penerbit = {MDPI AG},
abstrak = {Empat minggu ini, rawak, buta dua, kajian terkawal plasebo menyiasat kesan Lactobacillus plantarum PS128 (PS128) pada kanak-kanak lelaki dengan gangguan spektrum autisme (ASD) berumur 7-15 di Taiwan. Semua subjek memenuhi kriteria untuk diagnosis ASD DSM-V dan Temuduga Diagnostik Autisme-Disemak (ADI-R). Soal selidik yang digunakan untuk ukuran hasil utama termasuk versi Senarai Semak Tingkah Laku Autisme-Taiwan (ABC-T), Skala Responsif Sosial (SRS) dan Senarai Semak Tingkah Laku Kanak-kanak (CBCL). Swanson, Nolan, dan versi Pelham-IV-Taiwan (SNAP-IV) dan Penambahbaikan Tera Global Klinikal (CGI-I) digunakan untuk ukuran hasil sekunder. Keputusan menunjukkan bahawa PS128 memperbaiki tingkah laku pembangkang/menentang, dan bahawa jumlah skor SNAP-IV untuk kanak-kanak yang lebih muda (berumur 7−12) meningkat dengan ketara berbanding dengan kumpulan plasebo. Selain itu, beberapa elemen juga telah dipertingkatkan dengan ketara dalam kumpulan PS128 selepas penggunaan PS128 selama 28 hari. Kajian lanjut diperlukan untuk menjelaskan dengan lebih baik kesan PS128 untuk kanak-kanak yang lebih muda dengan ASD pada gejala yang lebih luas. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.},
nota = {dipetik oleh 4},
kata kunci = {Senarai Semak Tingkah Laku Aberrant versi Taiwan, Remaja, umur, Faktor Umur, Keagresifan, Keresahan, Artikel, Gangguan Defisit Perhatian, Autisme, Senarai Semak Tingkah Laku Autisme, Temuduga Diagnostik Autisme Disemak, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Senarai Semak Tingkah Laku Kanak-kanak, Anak-anak, Skala Teraan Global Klinikal, Gangguan Komunikasi, Kajian Terkawal, Prosedur Double Blind, Kaedah Double-Blind, Perempuan, Gangguan Kebimbangan Umum, Manusia, Impulsif, Lactobacillus delbrueckii, Lelaki, Fisiologi, Placebo, Placebo, Gangguan Tekanan Selepas Traumatik, Agen Probiotik, Probiotik, Psikologi, Soal selidik, Percubaan Terkawal Rawak, Skala penilaian, Budak sekolah, Sistem Pemarkahan, Kelakuan Sosial, Interaksi Sosial, Masalah Sosial, Skala Responsif Sosial, Tinjauan, Penilaian Swanson Nolan dan Pelham IV, Protein Berkaitan Sinaptosomal 23, Taiwan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T

Analisis subkumpulan fenotip dan multi-omik mendedahkan perencat pengikat diazepam yang berkurangan (DBI) tahap protein dalam gangguan spektrum autisme dengan gangguan bahasa yang teruk Artikel Jurnal

PLoS SATU, 14 (3), 2019, ISSN: 19326203, (dipetik oleh 4).

Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat

@artikel{Pichitpunpong2019,
tajuk = {Analisis subkumpulan fenotip dan multi-omik mendedahkan perencat pengikat diazepam yang berkurangan (DBI) tahap protein dalam gangguan spektrum autisme dengan gangguan bahasa yang teruk},
pengarang = {C Pichitpunpong dan S Thongkorn dan S Kanlayaprasit dan W Yuwattana dan W Plaingam dan S Sangsuthum dan W M Aizat dan SN Baharum dan T Tencomnao dan V W Hu dan T Sarachana},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371/journal.pone.0214198&rakan kongsi = 40&md5=0a4c25481edee56984a59de94fedc414},
doi = {10.1371/jurnal.pone.0214198},
terbitan = {19326203},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {PLoS SATU},
isi padu = {14},
nombor = {3},
penerbit = {Perpustakaan Awam Sains},
abstrak = {Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan
Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.},
nota = {dipetik oleh 4},
kata kunci = {Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan
Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.

Tutup

Tidak juga, N K; Ghozali, A H; Ismail, J

Kelebihan berat badan berlebihan dan obesiti di kalangan kanak-kanak dan remaja dengan gangguan spektrum autisme dan faktor risiko yang berkaitan Artikel Jurnal

Sempadan dalam Pediatrik, 7 (FEB), 2019, ISSN: 22962360, (dipetik oleh 5).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang

@artikel{Nor2019,
tajuk = {Kelebihan berat badan berlebihan dan obesiti di kalangan kanak-kanak dan remaja dengan gangguan spektrum autisme dan faktor risiko yang berkaitan},
pengarang = {N K Nor dan A H Ghozali dan J Ismail},
url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85064414280&dua = 10.3389% 2kurang.2019.00038&rakan kongsi = 40&md5 = 4bb61b1df043a4adf79618e223d77f26},
doi = {10.3389/fped.2019.00038},
terbitan = {22962360},
tahun = {2019},
tarikh = {2019-01-01},
jurnal = {Sempadan dalam Pediatrik},
isi padu = {7},
nombor = {FEB},
penerbit = {Frontiers Media S.A.},
abstrak = {Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.},
nota = {dipetik oleh 5},
kata kunci = {Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95persentil ke-) adalah 11.3% dan berlakunya kegemukan (BMI persentil ke-95) adalah 21.9%. Umur rata-rata kanak-kanak ASD yang berlebihan berat badan / gemuk lebih tinggi pada 8.5 tahun (IQR 5.81-10.13) berbanding dengan kumpulan normal / kurang berat badan 6.33 tahun (IQR 4.75-7.7) dengan nilai p 0.001. Kedua-dua kumpulan juga berbeza secara signifikan untuk BMI ibu dan usia bapa. BMI ibu rata-rata dalam kumpulan berat badan berlebihan / gemuk adalah 26.05 (IQR 23.35-32.25), secara statistik lebih tinggi secara signifikan (p = 0.003) berbanding kumpulan yang tidak berlebihan berat badan / gemuk, 24.7 (IQR 21-27.9). Umur bapa median pada 40 tahun (IQR 37-44) secara statistik lebih tinggi secara signifikan (p = 0.039) dalam kumpulan berlebihan berat badan / gemuk, berbanding dengan usia bapa rata-rata pada kumpulan bukan berat badan berlebihan / obes 38 (IQR 35-42). Kanak-kanak lelaki yang berlebihan berat badan / gemuk mempunyai skor PAQ-C median 2.44 (IQR 2.00-3.00) lwn. 2.89 (IQR 2.35-3.53) dalam kumpulan rakan niaga dengan nilai p 0.01. Menggunakan kaedah regresi linear berganda, tiga peramal yang berkaitan dengan persentil BMI mencapai tahap kepentingan statistik; Skor PAQ-C pada lelaki (hlm < 0.001), domain BAMBI dari Penolakan Makanan (p = 0.001) dan Pelbagai Jenis Makanan yang Terhad (p = 0.001). Kesimpulannya: Kelaziman obesiti dan berat badan berlebihan adalah tinggi di kalangan kanak-kanak dan remaja ASD Malaysia. Umur kanak-kanak yang lebih tua, BMI ibu yang tinggi, usia bapa yang lebih tua, aktiviti fizikal yang rendah, kemungkinan rendahnya penolakan makanan dan kemungkinan tinggi pemilihan makanan didapati menjadi faktor risiko BMI tinggi pada kanak-kanak ini. © 2019 Kamal Nor, Ghozali and Ismail.

Tutup

Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N

GRIN2D variants in three cases of developmental and epileptic encephalopathy Artikel Jurnal

Clinical Genetics, 94 (6), hlm. 538-547, 2018, ISSN: 00099163, (dipetik oleh 4).

Abstrak | Pautan | BibTeX | Tag: Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing

@artikel{Tsuchida2018538,
tajuk = {GRIN2D variants in three cases of developmental and epileptic encephalopathy},
pengarang = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&rakan kongsi = 40&md5=f0d32670db57261820bc244943cffd62},
doi = {10.1111/cge.13454},
terbitan = {00099163},
tahun = {2018},
tarikh = {2018-01-01},
jurnal = {Clinical Genetics},
isi padu = {94},
nombor = {6},
halaman = {538-547},
penerbit = {Blackwell Publishing Ltd},
abstrak = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Baru-baru ini, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. Dalam kajian ini, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd},
nota = {dipetik oleh 4},
kata kunci = {Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Arifin, W N

Terjemahan dan pengesahan skala kepuasan ibu bapa versi bahasa melayu (Pss-m) untuk penilaian kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme Artikel Jurnal

Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 15 (11), 2018, ISSN: 16617827, (dipetik oleh 2).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Kajian Lintas Bahagian, Analisis Faktor, Perempuan, Garis panduan, Sikap Kakitangan Kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kelantan, Fungsi Kemungkinan, Skala Likert, Malaysia, Lelaki, Analisis Kemungkinan Maksimum, Kesihatan mental, Perkhidmatan Kesihatan Mental, Ibu bapa, Skala Kepuasan Ibu Bapa Versi Bahasa Melayu, Kepuasan Peribadi, Garis Panduan Amalan, Skala Penarafan Psikologi, Psikologi, Penerbitan, Soal selidik, Kebolehulangan, Kebolehulangan Keputusan, Kepuasan hati, Model Statistik, Statistik, Tinjauan, Pusat Jagaan Tertiari, Terjemahan, Kajian Pengesahan, West Malaysia

@artikel{Adib2018,
tajuk = {Terjemahan dan pengesahan skala kepuasan ibu bapa versi bahasa melayu (Pss-m) untuk penilaian kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme},
pengarang = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N Arifin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056090545&doi=10.3390/ijerph15112455&rakan kongsi = 40&md5=53650806d46343cc3e95c9b30442f79c},
doi = {10.3390/ijerph15112455},
terbitan = {16617827},
tahun = {2018},
tarikh = {2018-01-01},
jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam},
isi padu = {15},
nombor = {11},
penerbit = {MDPI AG},
abstrak = {Latar belakang: Skala Kepuasan Ibu Bapa versi Bahasa Melayu (PSS-M) diperlukan untuk menyiasat faktor-faktor yang menyumbang kepada kepuasan pengasuh Melayu terhadap pengurusan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme. (ASD). Matlamat kajian adalah untuk menterjemah dan mengesahkan soal selidik untuk menilai kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan. Kaedah: Kajian keratan rentas telah dijalankan di kalangan 110 penjaga kanak-kanak dengan ASD berumur antara 2 dan 17 tahun yang menerima rawatan di dua pusat jagaan tinggi di Kelantan. Kebenaran untuk menggunakan borang soal selidik PSS versi asal telah diperolehi. Versi Inggeris asal PSS telah diterjemahkan ke dalam versi Bahasa Melayu berikutan 10 langkah yang dicadangkan oleh garis panduan yang ditetapkan. Pra-ujian PSS telah dijalankan dengan 30 penjaga sebelum analisis faktor pengesahan (CFA) ditubuhkan menggunakan 110 penjaga. Mereka diminta menilai kefahaman mereka terhadap soal selidik. Soal selidik satu dimensi terdiri daripada 11 barang, termasuk sikap kakitangan, ketersediaan kakitangan, sokongan, dan suka menolong. Skala Likert 5 mata memberikan penilaian daripada 1 (sangat tidak setuju) ke 5 (sangat bersetuju). Analisis faktor pengesahan dilakukan menggunakan penganggar kemungkinan maksimum yang teguh. Keputusan: Analisis menunjukkan data kesesuaian model dengan kebolehpercayaan yang baik. Kesimpulannya: PSS-M menunjukkan kecergasan model keseluruhan berdasarkan indeks tertentu, dengan kesahan konstruk yang baik dan kebolehpercayaan mutlak yang sangat baik untuk menentukan tahap kepuasan penjaga kanak-kanak dengan ASD berkenaan dengan perkhidmatan penjagaan kesihatan. © 2018, MDPI AG. Hak cipta terpelihara.},
nota = {dipetik oleh 2},
kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Kajian Lintas Bahagian, Analisis Faktor, Perempuan, Garis panduan, Sikap Kakitangan Kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kelantan, Fungsi Kemungkinan, Skala Likert, Malaysia, Lelaki, Analisis Kemungkinan Maksimum, Kesihatan mental, Perkhidmatan Kesihatan Mental, Ibu bapa, Skala Kepuasan Ibu Bapa Versi Bahasa Melayu, Kepuasan Peribadi, Garis Panduan Amalan, Skala Penarafan Psikologi, Psikologi, Penerbitan, Soal selidik, Kebolehulangan, Kebolehulangan Keputusan, Kepuasan hati, Model Statistik, Statistik, Tinjauan, Pusat Jagaan Tertiari, Terjemahan, Kajian Pengesahan, West Malaysia},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Rendah, H M; Zailan, F

Medical students’ perceptions, kesedaran, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia Artikel Jurnal

International Journal of Developmental Disabilities, 64 (2), hlm. 86-95, 2018, ISSN: 20473869, (dipetik oleh 1).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Awareness, Kelakuan, Exploratory Research, Perempuan, Manusia, Pengetahuan, Malaysia, Lelaki, Medical Student, Sikap Pelajar, Pelajar, Symptom

@artikel{Low201886,
tajuk = {Medical students’ perceptions, kesedaran, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia},
pengarang = {H M Low and F Zailan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002273499&doi=10.1080%2f20473869.2016.1264663&rakan kongsi = 40&md5=4b1b16448e16172b2dce10eacf1c3f3d},
doi = {10.1080/20473869.2016.1264663},
terbitan = {20473869},
tahun = {2018},
tarikh = {2018-01-01},
jurnal = {International Journal of Developmental Disabilities},
isi padu = {64},
nombor = {2},
halaman = {86-95},
penerbit = {Taylor and Francis Ltd.},
abstrak = {Objektif: This study aimed to investigate the perception, kesedaran, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Kaedah: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, kesedaran, societal attitude, and their recognition of ASD symptoms. Keputusan: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Secara khusus, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Kesimpulannya: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016.},
nota = {dipetik oleh 1},
kata kunci = {Dewasa, Artikel, Autisme, Awareness, Kelakuan, Exploratory Research, Perempuan, Manusia, Pengetahuan, Malaysia, Lelaki, Medical Student, Sikap Pelajar, Pelajar, Symptom},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Toh, T -H; Tan, V W -Y; Lau, PST; Kiyu, A

Ketepatan Senarai Semak Perubahan untuk Autisme pada Kanak-kanak (M-CHAT) dalam Mengesan Autisme dan Gangguan Perkembangan Lain di Klinik Komuniti Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 48 (1), hlm. 28-35, 2018, ISSN: 01623257, (dipetik oleh 9).

Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil

@artikel{Toh201828,
tajuk = {Ketepatan Senarai Semak Perubahan untuk Autisme pada Kanak-kanak (M-CHAT) dalam Mengesan Autisme dan Gangguan Perkembangan Lain di Klinik Komuniti},
pengarang = {T -H Toh dan V W -Y Tan dan P S -T Lau dan A Kiyu},
url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85028764085&doi=10.1007/s10803-017-3287-x&rakan kongsi = 40&md5 = 21bce2407197b8b1e43b4420d274861b},
doi = {10.1007/s10803-017-3287-x},
terbitan = {01623257},
tahun = {2018},
tarikh = {2018-01-01},
jurnal = {Jurnal Autisme dan Gangguan Perkembangan},
isi padu = {48},
nombor = {1},
halaman = {28-35},
penerbit = {Springer New York LLC},
abstrak = {Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC.},
nota = {dipetik oleh 9},
kata kunci = {Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Diurut, R

Autisme dan trikotilomania dalam remaja lelaki Artikel Jurnal

Laporan Kes BMJ, 2018 , 2018, ISSN: 1757790X, (dipetik oleh 0).

Abstrak | Pautan | BibTeX | Tag: Remaja, Alopecia, Keresahan, Artikel, Gangguan Defisit Perhatian, Gangguan Hiperaktifan Kekurangan Perhatian, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Berat badan, Laporan kes, Perangsang Sistem Saraf Pusat, Senarai Semak Tingkah Laku Kanak-kanak, Artikel Klinikal, komorbiditi, Komplikasi, Diagnosis, Berbeza, Diagnosis pembezaan, Pentitratan Dos Ubat, Toleransi Dadah, DSM-5, Echolalia, Fluvoxamine, Susulan, Manusia, Hiperaktif, Kemerosotan Intelektual, Lelaki, Metilfenidat, Obesiti, Terapi pekerjaan, Indeks Penaakulan Persepsi, Jurnal Keutamaan, Indeks Kelajuan Pemprosesan, Skala Penarafan Status Psikiatri, Skala Penarafan Psikologi, Skala penilaian, Kegelisahan, Ganjaran, Perencat Serapan Serotonin, Perencat Serapan Serotonin, Pendidikan Khas, Kelewatan Pertuturan, Gangguan Pertuturan, Terapi ucapan, Trikotilomania, Indeks Kefahaman Lisan, Skala Kepintaran Wechsler, Indeks Memori Bekerja

Hnoonual, A; Thammachote, W; Tim-Aroon, T; Rojnueangnit, K; Hansakunachai, T; Sombuntham, T; Roongpraiwan, R; Vorachotekamjorn, J; Chuthapisith, J; Fucharoen, S; Wattanasirichaigoon, D; Ruangdaraganon, N; Limprasert, P; Jinawath, N

Analisis microarray kromosom dalam kohort populasi yang kurang diwakili mengenal pasti SERINC2 sebagai gen calon baru untuk gangguan spektrum autisme Artikel Jurnal

Laporan Saintifik, 7 (1), 2017, ISSN: 20452322, (dipetik oleh 6).

Abstrak | Pautan | BibTeX | Tag: Remaja, Autisme, Gangguan Spektrum Autisme, Anak-anak, Pemetaan Kromosom, Pemetaan Kromosom, Analisis Kohort, Kajian Kohort, Variasi Nombor Salin, Variasi Nombor Salinan DNA, Perempuan, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Genetik, Manusia, Bayi, Lelaki, Protein Membran, Protein Membran, Analisis Mikroarray, Polimorfisme, Prasekolah, Kanak-kanak Prasekolah, Prosedur, SERINC2 Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal

@artikel{Hnoual2017,
tajuk = {Analisis microarray kromosom dalam kohort populasi yang kurang diwakili mengenal pasti SERINC2 sebagai gen calon baru untuk gangguan spektrum autisme},
pengarang = {A Hnoonual dan W Thammachote dan T Tim-Aroon dan K Rojnueangnit dan T Hansakunachai dan T Sombuntham dan R Roongpraiwan dan J Worachotekamjorn dan J Chuthapisith dan S Fucharoen dan D Wattanasirichaigoon dan N Ruangdaraganon dan P Limprasert dan N Jinawath},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029864969&doi=10.1038/s41598-017-12317-3&rakan kongsi = 40&md5=3c1b6a0c064665aab8ace8e8f58c2b01},
doi = {10.1038/s41598-017-12317-3},
terbitan = {20452322},
tahun = {2017},
tarikh = {2017-01-01},
jurnal = {Laporan Saintifik},
isi padu = {7},
nombor = {1},
penerbit = {Kumpulan Penerbitan Alam},
abstrak = {Mikroarray kromosom (CMA) kini diiktiraf sebagai ujian genetik peringkat pertama untuk pengesanan variasi nombor salinan (CNV) pada pesakit dengan gangguan spektrum autisme (ASD). Matlamat kajian ini adalah untuk mengenal pasti ASD-CNV yang diketahui dan baru yang berkaitan dan untuk menilai hasil diagnostik CMA dalam pesakit Thai dengan ASD. Infinium CytoSNP-850K BeadChip telah digunakan untuk mengesan CNV dalam 114 Pesakit Thai terdiri daripada 68 pesakit ASD retrospektif (kumpulan 1) dengan penggunaan CMA sebagai ujian baris kedua dan 46 bakal pesakit ASD dan kelewatan perkembangan (kumpulan 2) dengan penggunaan CMA sebagai ujian peringkat pertama. Kami mengenal pasti 7 (6.1%) CNV patogenik dan 22 (19.3%) varian kepentingan klinikal yang tidak pasti (ANDA). Sejumlah 29 pesakit dengan CNV patogen dan VOUS ditemui di 22% (15/68) dan 30.4% (14/46) daripada pesakit dalam kumpulan 1 dan 2, masing-masing. Perbezaan frekuensi CNV yang dikesan antara 2 kumpulan tidak signifikan secara statistik (Chi kuasa dua = 1.02},
nota = {dipetik oleh 6},
kata kunci = {Remaja, Autisme, Gangguan Spektrum Autisme, Anak-anak, Pemetaan Kromosom, Pemetaan Kromosom, Analisis Kohort, Kajian Kohort, Variasi Nombor Salin, Variasi Nombor Salinan DNA, Perempuan, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Genetik, Manusia, Bayi, Lelaki, Protein Membran, Protein Membran, Analisis Mikroarray, Polimorfisme, Prasekolah, Kanak-kanak Prasekolah, Prosedur, SERINC2 Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Hasan, C Z C; Jailani, R; Tahir, Md N; Ilias, S

Analisis daya tindak balas tanah tiga dimensi semasa berjalan pada kanak-kanak dengan gangguan spektrum autisme Artikel Jurnal

Penyelidikan Ketidakupayaan Pembangunan, 66 , hlm. 55-63, 2017, ISSN: 08914222, (dipetik oleh 8).

Abstrak | Pautan | BibTeX | Tag: Taburan Umur, Artikel, Autisme, Gangguan Spektrum Autisme, Fenomena Biomekanikal, Biomekanik, Keseimbangan Badan, Tinggi Badan, Berat badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Penilaian Penyakit, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Angkatan Tindak Balas Tanah, Manusia, Pengimejan, Panjang Kaki, Malaysia, Lelaki, Pemeriksaan Neurologi, Patofisiologi, Fisiologi, Keseimbangan Postur, Prosedur, Psikologi, Statistik, Tiga Dimensi, Pengimejan Tiga Dimensi, Daya Tindak Balas Tanah Tiga Dimensi, berjalan

@artikel{Hasan201755,
tajuk = {Analisis daya tindak balas tanah tiga dimensi semasa berjalan pada kanak-kanak dengan gangguan spektrum autisme},
pengarang = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi = 10.1016% 2fj.ridd.2017.02.015&rakan kongsi = 40&md5=d6a9839cda7f62bcce9bdcca33d3d33b},
doi = {10.1016/j.ridd.2017.02.015},
terbitan = {08914222},
tahun = {2017},
tarikh = {2017-01-01},
jurnal = {Penyelidikan Ketidakupayaan Pembangunan},
isi padu = {66},
halaman = {55-63},
penerbit = {Elsevier Inc.},
abstrak = {Maklumat minimum diketahui tentang tiga dimensi (3D) daya tindak balas tanah (GRF) mengenai corak gaya berjalan individu yang mengalami gangguan spektrum autisme (ASD). Tujuan kajian ini adalah untuk menyiasat sama ada komponen GRF 3D berbeza secara signifikan antara kanak-kanak dengan ASD dan kawalan rakan sebaya.. 15 kanak-kanak dengan ASD dan 25 biasanya berkembang (TD) kanak-kanak telah mengambil bahagian dalam kajian ini. Dua plat daya digunakan untuk mengukur data GRF 3D semasa berjalan. Teknik parameterisasi siri masa telah digunakan untuk mengekstrak 17 ciri diskret daripada bentuk gelombang GRF 3D. Dengan menggunakan ujian-t bebas dan ujian Mann-Whitney U, perbezaan yang ketara (hlm < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd},
nota = {dipetik oleh 8},
kata kunci = {Taburan Umur, Artikel, Autisme, Gangguan Spektrum Autisme, Fenomena Biomekanikal, Biomekanik, Keseimbangan Badan, Tinggi Badan, Berat badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Penilaian Penyakit, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Angkatan Tindak Balas Tanah, Manusia, Pengimejan, Panjang Kaki, Malaysia, Lelaki, Pemeriksaan Neurologi, Patofisiologi, Fisiologi, Keseimbangan Postur, Prosedur, Psikologi, Statistik, Tiga Dimensi, Pengimejan Tiga Dimensi, Daya Tindak Balas Tanah Tiga Dimensi, berjalan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Singh, Joginder S; Hussein, N H; Kamal, Mustaffa R; Hassan, F H

Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Artikel Jurnal

AAC: Augmentative and Alternative Communication, 33 (2), hlm. 110-120, 2017, ISSN: 07434618, (dipetik oleh 10).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Sikap Terhadap Kesihatan, Augmentative and Alternative Communication, Anak-anak, Communication Aid, Communication Aids for Disabled, Gangguan Komunikasi, Communication Disorders, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Disabilities, Penyakit, Keluarga, Perempuan, Manusia, Human Rehabilitation Engineering, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Prasekolah, Kanak-kanak Prasekolah, Qualitative Research

@artikel{JoginderSingh2017110,
tajuk = {Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC},
pengarang = {S Joginder Singh and N H Hussein and R Mustaffa Kamal and F H Hassan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131769&doi=10.1080%2f07434618.2017.1309457&rakan kongsi = 40&md5=067c39e0c318e76caff96b29bb4dbb21},
doi = {10.1080/07434618.2017.1309457},
terbitan = {07434618},
tahun = {2017},
tarikh = {2017-01-01},
jurnal = {AAC: Augmentative and Alternative Communication},
isi padu = {33},
nombor = {2},
halaman = {110-120},
penerbit = {Taylor and Francis Ltd},
abstrak = {Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. Sehingga kini, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. Untuk kajian ini, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, dan (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication.},
nota = {dipetik oleh 10},
kata kunci = {Dewasa, Sikap Terhadap Kesihatan, Augmentative and Alternative Communication, Anak-anak, Communication Aid, Communication Aids for Disabled, Gangguan Komunikasi, Communication Disorders, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Disabilities, Penyakit, Keluarga, Perempuan, Manusia, Human Rehabilitation Engineering, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Prasekolah, Kanak-kanak Prasekolah, Qualitative Research},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Hasan, C Z C; Jailani, R; Tahir, Md N

Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder Artikel Jurnal

International Journal of Biology and Biomedical Engineering, 11 , hlm. 74-79, 2017, ISSN: 19984510, (dipetik oleh 1).

Abstrak | Pautan | BibTeX | Tag: Artikel, Artificial Neural Network, Autisme, Tinggi Badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Analisis Diskriminan, Early Diagnosis, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Manusia, Belajar, Lelaki, Pediatrics, Budak sekolah, Statistical Analysis, Statistik, Time Series Analysis

@artikel{Hasan201774,
tajuk = {Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder},
pengarang = {C Z C Hasan and R Jailani and N Md Tahir},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043500605&rakan kongsi = 40&md5=6f2ffe7c2f5daf9fd02d4456acb94438},
terbitan = {19984510},
tahun = {2017},
tarikh = {2017-01-01},
jurnal = {International Journal of Biology and Biomedical Engineering},
isi padu = {11},
halaman = {74-79},
penerbit = {North Atlantic University Union NAUN},
abstrak = {Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% ketepatan, 93.3% kepekaan, dan 90.0% kekhususan. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. Hak cipta terpelihara.},
nota = {dipetik oleh 1},
kata kunci = {Artikel, Artificial Neural Network, Autisme, Tinggi Badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Analisis Diskriminan, Early Diagnosis, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Manusia, Belajar, Lelaki, Pediatrics, Budak sekolah, Statistical Analysis, Statistik, Time Series Analysis},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Anda, T; Daoud, F; Wang, H; Bcheraoui, TERDAPAT; Khalil, Saya; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Tetapi, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Tetapi, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, Saya A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Lalai, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, Wahai A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, Seorang K; Mitchell, P B; Patton, G; Sagar, R; Satpati, M; Savuon, K; Seedat, S; Shiue, Saya; Hutan, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H

The burden of mental disorders in the eastern mediterranean region, 1990-2013 Artikel Jurnal

PLoS SATU, 12 (1), 2017, ISSN: 19326203, (dipetik oleh 30).

Abstrak | Pautan | BibTeX | Tag: 80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda

@artikel{Charara2017,
tajuk = {The burden of mental disorders in the eastern mediterranean region, 1990-2013},
pengarang = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371/journal.pone.0169575&rakan kongsi = 40&md5=471830ec1239e37c6fc4681bed5698f6},
doi = {10.1371/jurnal.pone.0169575},
terbitan = {19326203},
tahun = {2017},
tarikh = {2017-01-01},
jurnal = {PLoS SATU},
isi padu = {12},
nombor = {1},
penerbit = {Perpustakaan Awam Sains},
abstrak = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.},
nota = {dipetik oleh 30},
kata kunci = {80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.

Tutup

Sheppard, E; Pillai, D; Wong, G T -L; Panggil, D; Mitchell, P

How Easy is it to Read the Minds of People with Autism Spectrum Disorder? Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 46 (4), hlm. 1247-1254, 2016, ISSN: 01623257, (dipetik oleh 37).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Membuat keputusan, Emosi, Ekspresi wajah, Perempuan, Manusia, Lelaki, Kesihatan mental, Perhubungan tanpa percakapan, Patofisiologi, Jurnal Keutamaan, Psikologi, Video Recording, Dewasa Muda

Pelik, B; Jomhari, N; Ahmad, R

Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 45 (10), hlm. 3069-3084, 2015, ISSN: 01623257, (dipetik oleh 7).

Abstrak | Pautan | BibTeX | Tag: Artikel, Perhatian, Autisme, Gangguan Spektrum Autisme, Anak-anak, Computer Interface, Pendidikan, Education of Intellectually Disabled, Educational Model, Feedback System, Perempuan, Manusia, Belajar, Lelaki, Models, Occupational Therapist, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kualiti hidup, Treatment Duration, Antara Muka Pengguna, Visual Hybrid Development Learning System, Visual Stimulation

Khowaja, K; Salim, S S

Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD) Artikel Jurnal

PLoS SATU, 10 (7), 2015, ISSN: 19326203, (dipetik oleh 12).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pangkalan Data Bibliografi, Anak-anak, Computer Interface, Program komputer, Kajian Terkawal, Evaluation Study, Perempuan, Heuristics, Manusia, Information System, Interactive System, Interrater Reliability, Lelaki, Garis Panduan Amalan, Soal selidik, Software, Tinjauan

@artikel{Khowaja2015,
tajuk = {Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD)},
pengarang = {K Khowaja dan S S Salim},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941313427&doi=10.1371/journal.pone.0132187&rakan kongsi = 40&md5=60f3ee4a32fd71be4b842755a58527cf},
doi = {10.1371/jurnal.pone.0132187},
terbitan = {19326203},
tahun = {2015},
tarikh = {2015-01-01},
jurnal = {PLoS SATU},
isi padu = {10},
nombor = {7},
penerbit = {Perpustakaan Awam Sains},
abstrak = {Dalam kertas ini, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim.},
nota = {dipetik oleh 12},
kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pangkalan Data Bibliografi, Anak-anak, Computer Interface, Program komputer, Kajian Terkawal, Evaluation Study, Perempuan, Heuristics, Manusia, Information System, Interactive System, Interrater Reliability, Lelaki, Garis Panduan Amalan, Soal selidik, Software, Tinjauan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Siah, P -C; Tan, S -H

Sense of coherence and WHOQoL among parents of children with ASD in Malaysia Artikel Jurnal

International Journal on Disability and Human Development, 14 (1), hlm. 59-66, 2015, ISSN: 21911231, (dipetik oleh 2).

Abstrak | Pautan | BibTeX | Tag: Dewasa, umur, Artikel, Autisme, Anak-anak, Kefahaman, Pendidikan, Pekerjaan, Faktor Persekitaran, Perempuan, Jantina, Han Chinese, Health, Housewife, Manusia, Income, Orang India, Kajian Klinikal Utama, Malay, Malaysia, Lelaki, Marriage, Kesihatan mental, Sikap Ibu Bapa, Pensioner, Aspek Psikologi, Kualiti hidup, Religion, Sampling, Sense of Coherence, Interaksi Sosial

@artikel{Siah201559,
tajuk = {Sense of coherence and WHOQoL among parents of children with ASD in Malaysia},
pengarang = {P -C Siah and S -H Tan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922567900&doi=10.1515%2fijdhd-2013-0039&rakan kongsi = 40&md5=a909c24c26550aebe2c8922063d70001},
doi = {10.1515/ijdhd-2013-0039},
terbitan = {21911231},
tahun = {2015},
tarikh = {2015-01-01},
jurnal = {International Journal on Disability and Human Development},
isi padu = {14},
nombor = {1},
halaman = {59-66},
penerbit = {Walter de Gruyter GmbH},
abstrak = {Studies have shown that most parents of children with autism spectrum disorder (ASD) face more stress and have a poorer quality of life (QoL) than other parents. Walaupun begitu, there are still some parents of children with ASD who are able to maintain or even improve their QoL. This study is aimed to explore the relationship between SoC and WHOQoL among parents of children with ASD. Kaedah: Sejumlah 96 parents of children with ASD were invited to participate using a purposive sampling method. Keputusan: The results suggested that participants in the high SoC group had better QoL in the four domains than those in the low SoC group. More importantly, not all types of SoC were relevant to QoL. Comprehensibility was relevant to all the four QoL domains and manageability was relevant to physical and psychological health, while meaningfulness was not relevant to any of the QoL domains. Kesimpulannya: NGOs may improve the QoL of these parents by providing trainings to improve their SOC, especially in comprehensibility and manageability. © 2015 by De Gruyter.},
nota = {dipetik oleh 2},
kata kunci = {Dewasa, umur, Artikel, Autisme, Anak-anak, Kefahaman, Pendidikan, Pekerjaan, Faktor Persekitaran, Perempuan, Jantina, Han Chinese, Health, Housewife, Manusia, Income, Orang India, Kajian Klinikal Utama, Malay, Malaysia, Lelaki, Marriage, Kesihatan mental, Sikap Ibu Bapa, Pensioner, Aspek Psikologi, Kualiti hidup, Religion, Sampling, Sense of Coherence, Interaksi Sosial},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Haerian, B S; Shaári, H M; Tan, H J; Fong, C Y; Wong, S W; Ong, L C; Raymond, A A; Tan, C T; Mohamed, DENGAN

RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia Artikel Jurnal

Genomics, 105 (4), hlm. 229-236, 2015, ISSN: 08887543, (dipetik oleh 5).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda

@artikel{Haerian2015229,
tajuk = {RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia},
pengarang = {B S Haerian and H M Shaári and H J Tan and C Y Fong and S W Wong and L C Ong and A A Raymond and C T Tan and Z Mohamed},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924135981&doi=10.1016%2fj.ygeno.2015.02.001&rakan kongsi = 40&md5=209a1720cddfd76bfa515ee8940749d5},
doi = {10.1016/j.ygeno.2015.02.001},
terbitan = {08887543},
tahun = {2015},
tarikh = {2015-01-01},
jurnal = {Genomics},
isi padu = {105},
nombor = {4},
halaman = {229-236},
penerbit = {Academic Press Inc.},
abstrak = {RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Oleh itu, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.},
nota = {dipetik oleh 5},
kata kunci = {Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Brett, M; McPherson, J; Vokal, Z J; Lai, A; Tan, E -S; Ng, Saya; Ong, L -C; Cham, B; Tan, P; Bunga mawar, S; Tan, DAN -C

Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel Artikel Jurnal

PLoS SATU, 9 (4), 2014, ISSN: 19326203, (dipetik oleh 20).

Abstrak | Pautan | BibTeX | Tag: Artikel, ATRX Gene, Autisme, Gangguan Spektrum Autisme, Anak-anak, Artikel Klinikal, Congenital Abnormalities, Congenital Malformation, Kajian Terkawal, Diagnostic Test, DNA Mutational Analysis, Perempuan, Gen, Profil Ekspresi Gen, Gene Mutation, Penyasaran Gen, Persatuan Genetik, Genetic Association Studies, Genetic Disorder, Genetic Variability, Genetic Variation, Genetik, Genome-Wide Association Study, High Throughput Sequencing, High-Throughput Nucleotide Sequencing, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Karyotype, L1CAM Gene, Lelaki, Mutation, Nonsense Mutation, Nucleotide Sequence, Fenotip, Polimorfisme, RNA Splice Sites, RNA Splicing, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal

@artikel{Brett2014,
tajuk = {Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel},
pengarang = {M Brett and J McPherson and Z J Zang and A Lai and E -S Tan and I Ng and L -C Ong and B Cham and P Tan and S Rozen and E -C Tan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898625023&doi=10.1371/journal.pone.0093409&rakan kongsi = 40&md5=f673e204a009bf84de81ea69dcd026db},
doi = {10.1371/jurnal.pone.0093409},
terbitan = {19326203},
tahun = {2014},
tarikh = {2014-01-01},
jurnal = {PLoS SATU},
isi padu = {9},
nombor = {4},
penerbit = {Perpustakaan Awam Sains},
abstrak = {Developmental delay and/or intellectual disability (DD/ID) affects 1-3% of all children. At least half of these are thought to have a genetic etiology. Recent studies have shown that massively parallel sequencing (MPS) using a targeted gene panel is particularly suited for diagnostic testing for genetically heterogeneous conditions. We report on our experiences with using massively parallel sequencing of a targeted gene panel of 355 genes for investigating the genetic etiology of eight patients with a wide range of phenotypes including DD/ID, congenital anomalies and/or autism spectrum disorder. Targeted sequence enrichment was performed using the Agilent SureSelect Target Enrichment Kit and sequenced on the Illumina HiSeq2000 using paired-end reads. For all eight patients, 81-84% of the targeted regions achieved read depths of at least 20×, with average read depths overlapping targets ranging from 322 × to 798 ×. Causative variants were successfully identified in two of the eight patients: a nonsense mutation in the ATRX gene and a canonical splice site mutation in the L1CAM gene. In a third patient, a canonical splice site variant in the USP9X gene could likely explain all or some of her clinical phenotypes. These results confirm the value of targeted MPS for investigating DD/ID in children for diagnostic purposes. Walau bagaimanapun, targeted gene MPS was less likely to provide a genetic diagnosis for children whose phenotype includes autism. © 2014 Brett et al.},
nota = {dipetik oleh 20},
kata kunci = {Artikel, ATRX Gene, Autisme, Gangguan Spektrum Autisme, Anak-anak, Artikel Klinikal, Congenital Abnormalities, Congenital Malformation, Kajian Terkawal, Diagnostic Test, DNA Mutational Analysis, Perempuan, Gen, Profil Ekspresi Gen, Gene Mutation, Penyasaran Gen, Persatuan Genetik, Genetic Association Studies, Genetic Disorder, Genetic Variability, Genetic Variation, Genetik, Genome-Wide Association Study, High Throughput Sequencing, High-Throughput Nucleotide Sequencing, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Karyotype, L1CAM Gene, Lelaki, Mutation, Nonsense Mutation, Nucleotide Sequence, Fenotip, Polimorfisme, RNA Splice Sites, RNA Splicing, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Shobana, M; Saravanan, C

Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Artikel Jurnal

East Asian Archives of Psychiatry, 24 (1), hlm. 16-22, 2014, ISSN: 20789947, (dipetik oleh 6).

Abstrak | Pautan | BibTeX | Tag: Dewasa, Keresahan, Artikel, Attitude, Autisme, Gangguan Spektrum Autisme, Anak-anak, Kajian Perbandingan, Kemurungan, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Sindrom Down, Pendidikan, Perempuan, General Health Questionnaire 28, Home Care, Hostility, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kajian Klinikal Utama, Malaysia, Lelaki, Gangguan Mental, Mother Child Relation, Mothers, Named Inventories, Sikap Ibu Bapa, Parental Attitude Scale, Kelaziman, Psychological Well Being, Soal selidik, Skala penilaian, Budak sekolah, Social Disability

@artikel{Shobana201416,
tajuk = {Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability},
pengarang = {M Shobana and C Saravanan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898619897&rakan kongsi = 40&md5=e877e03b868d1a11ed8f859a33057d5d},
terbitan = {20789947},
tahun = {2014},
tarikh = {2014-01-01},
jurnal = {East Asian Archives of Psychiatry},
isi padu = {24},
nombor = {1},
halaman = {16-22},
penerbit = {Hong Kong Academy of Medicine Press},
abstrak = {Objektif: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Kaedah: Dalam kajian ini, 112 mothers of children having mild and moderate levels of autism disorder, Sindrom Down, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Keputusan: Secara keseluruhan, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, kegelisahan, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Kesimpulannya: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists.},
nota = {dipetik oleh 6},
kata kunci = {Dewasa, Keresahan, Artikel, Attitude, Autisme, Gangguan Spektrum Autisme, Anak-anak, Kajian Perbandingan, Kemurungan, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Sindrom Down, Pendidikan, Perempuan, General Health Questionnaire 28, Home Care, Hostility, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kajian Klinikal Utama, Malaysia, Lelaki, Gangguan Mental, Mother Child Relation, Mothers, Named Inventories, Sikap Ibu Bapa, Parental Attitude Scale, Kelaziman, Psychological Well Being, Soal selidik, Skala penilaian, Budak sekolah, Social Disability},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Cassidy, S; Panggil, D; Mitchell, P; Kapten, P

Can adults with autism spectrum disorders infer what happened to someone from their emotional response? Artikel Jurnal

Penyelidikan Autisme, 7 (1), hlm. 112-123, 2014, ISSN: 19393792, (dipetik oleh 21).

Abstrak | Pautan | BibTeX | Tag: Ketepatan, Dewasa, Aged, Artikel, Sindrom Asperger, Perhatian, Autisme, Kelakuan, Cacao, Gangguan Perkembangan Kanak-kanak, Artikel Klinikal, Concept Formation, Kajian Terkawal, Deception, Discrimination (Psikologi), Emosi, Pergerakan Mata, Eye Tracking, Face Processing, Ekspresi wajah, Perempuan, Manusia, Interpersonal Relations, Lelaki, Pertengahan umur, Money, Meresap, Jurnal Keutamaan, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Dewasa Muda

@artikel{Cassidy2014112,
tajuk = {Can adults with autism spectrum disorders infer what happened to someone from their emotional response?},
pengarang = {S Cassidy and D Ropar and P Mitchell and P Chapman},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894307909&doi=10.1002%2faur.1351&rakan kongsi = 40&md5=8c6736bc006e9eebde29427879d023c3},
doi = {10.1002/aur.1351},
terbitan = {19393792},
tahun = {2014},
tarikh = {2014-01-01},
jurnal = {Penyelidikan Autisme},
isi padu = {7},
nombor = {1},
halaman = {112-123},
penerbit = {John Wiley and Sons Inc.},
abstrak = {Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. © 2013 International Society for Autism Research, Berkala Wiley, Inc.},
nota = {dipetik oleh 21},
kata kunci = {Ketepatan, Dewasa, Aged, Artikel, Sindrom Asperger, Perhatian, Autisme, Kelakuan, Cacao, Gangguan Perkembangan Kanak-kanak, Artikel Klinikal, Concept Formation, Kajian Terkawal, Deception, Discrimination (Psikologi), Emosi, Pergerakan Mata, Eye Tracking, Face Processing, Ekspresi wajah, Perempuan, Manusia, Interpersonal Relations, Lelaki, Pertengahan umur, Money, Meresap, Jurnal Keutamaan, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Dewasa Muda},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Pillai, D; Sheppard, E; Panggil, D; Marsh, L; Pearson, A; Mitchell, P

Using other minds as a window onto the world: Guessing what happened from clues in behaviour Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 44 (10), hlm. 2430-2439, 2014, ISSN: 01623257, (dipetik oleh 17).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kognisi, Kajian Terkawal, Pergerakan Mata, Eye Tracking, Ekspresi wajah, Gaze, Manusia, Intelligence Quotient, Lelaki, Measurement Accuracy, Mouth, Patofisiologi, Meresap, Fisiologi, Aspek Psikologi, Psikologi, Retrodiction, Task Performance, Theory of Mind, Komunikasi Lisan, Video Recording, Videotape Recording, Dewasa Muda

@artikel{Pillai20142430,
tajuk = {Using other minds as a window onto the world: Guessing what happened from clues in behaviour},
pengarang = {D Pillai and E Sheppard and D Ropar and L Marsh and A Pearson and P Mitchell},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84912053354&doi=10.1007%2fs10803-014-2106-x&rakan kongsi = 40&md5=c3396f6f468e37e253c657f998993859},
doi = {10.1007/s10803-014-2106-x},
terbitan = {01623257},
tahun = {2014},
tarikh = {2014-01-01},
jurnal = {Jurnal Autisme dan Gangguan Perkembangan},
isi padu = {44},
nombor = {10},
halaman = {2430-2439},
penerbit = {Springer New York LLC},
abstrak = {It has been proposed that mentalising involves retrodicting as well as predicting behaviour, by inferring previous mental states of a target. This study investigated whether retrodiction is impaired in individuals with autism spectrum disorders (ASD). Participants watched videos of real people reacting to the researcher behaving in one of four possible ways. Their task was to decide which of these four ‘‘scenarios’’ each person responded to. Participants’ eye movements were recorded. Participants with ASD were poorer than comparison participants at identifying the scenario to which people in the videos were responding. There were no group differences in time spent looking at the eyes or mouth. The findings imply those with ASD are impaired in using mentalising skills for retrodiction. © Springer Science+Business Media New York 2014.},
nota = {dipetik oleh 17},
kata kunci = {Remaja, Dewasa, Artikel, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kognisi, Kajian Terkawal, Pergerakan Mata, Eye Tracking, Ekspresi wajah, Gaze, Manusia, Intelligence Quotient, Lelaki, Measurement Accuracy, Mouth, Patofisiologi, Meresap, Fisiologi, Aspek Psikologi, Psikologi, Retrodiction, Task Performance, Theory of Mind, Komunikasi Lisan, Video Recording, Videotape Recording, Dewasa Muda},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Chen, B C; Rawi, Mohd R; Meinsma, R; Meijer, J; Hennekam, R C M; Kuilenburg, Van A B P

Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings Artikel Jurnal

Molecular Syndromology, 5 (6), hlm. 299-303, 2014, ISSN: 16618769, (dipetik oleh 4).

Abstrak | Pautan | BibTeX | Tag: Alanine, Artikel, Asymptomatic Disease, Autisme, Autosomal Recessive Disorder, Laporan kes, Cerebellum Atrophy, Anak-anak, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Keterukan Penyakit, DPYD Gene, Eye Malformation, Perempuan, Gen, Gene Mutation, Homozygosity, Manusia, Kemerosotan Intelektual, Orang Malaysia, Lelaki, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Kanak-kanak Prasekolah, Pyrimidine, Pyrimidine Metabolism, Budak sekolah, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil

@artikel{Chen2014299,
tajuk = {Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings},
pengarang = {B C Chen and R Mohd Rawi and R Meinsma and J Meijer and R C M Hennekam and A B P Van Kuilenburg},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919783242&doi=10.1159%2f000366074&rakan kongsi = 40&md5=1ebfb9aedb7cb64e3423811b41b6aa7c},
doi = {10.1159/000366074},
terbitan = {16618769},
tahun = {2014},
tarikh = {2014-01-01},
jurnal = {Molecular Syndromology},
isi padu = {5},
nombor = {6},
halaman = {299-303},
penerbit = {S. Karger AG},
abstrak = {Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine metabolism. Deficiency of this enzyme leads to an accumulation of thymine and uracil and a deficiency of metabolites distal to the catabolic enzyme. The disorder presents with a wide clinical spectrum, ranging from asymptomatic to severe neurological manifestations, termasuk kecacatan intelektual, seizures, microcephaly, autistic behavior, and eye abnormalities. Di sini, we report on an 11-year-old Malaysian girl and her 6-year-old brother with DPD deficiency who presented with intellectual disability, microcephaly, and hypotonia. Brain MRI scans showed generalized cerebral and cerebellar atrophy and callosal body dysgenesis in the boy. Urine analysis showed strongly elevated levels of uracil in the girl and boy (571 dan 578 mmol/mol creatinine, masing-masing) and thymine (425 dan 427 mmol/mol creatinine, masing-masing). Sequence analysis of the DPYD gene showed that both siblings were homozygous for the mutation c.1651G>A (pAla551Thr). © 2014 S. Karger AG, Basel.},
nota = {dipetik oleh 4},
kata kunci = {Alanine, Artikel, Asymptomatic Disease, Autisme, Autosomal Recessive Disorder, Laporan kes, Cerebellum Atrophy, Anak-anak, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Keterukan Penyakit, DPYD Gene, Eye Malformation, Perempuan, Gen, Gene Mutation, Homozygosity, Manusia, Kemerosotan Intelektual, Orang Malaysia, Lelaki, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Kanak-kanak Prasekolah, Pyrimidine, Pyrimidine Metabolism, Budak sekolah, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Freeth, M; Sheppard, E; Ramachandran, R; Milne, E

Perbandingan silang budaya ciri autistik di UK, India and Malaysia Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 43 (11), hlm. 2569-2583, 2013, ISSN: 01623257, (dipetik oleh 39).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Kumpulan Leluhur Benua Asia, Perhatian, Autisme, Gangguan Spektrum Autisme, Kuantiti Spektrum Autisme, Kemahiran komunikasi, Kajian Perbandingan, Perbandingan Merentas Budaya, Faktor Budaya, Etnik, Perempuan, Great Britain, Manusia, Eksperimen Manusia, Khayalan, India, Orang India, Malaysia, Lelaki, Keperibadian, Fenotip, Pelajar Pascasiswazah, Jurnal Keutamaan, Psikometri, Soal selidik, Faktor Seks, Penyesuaian Sosial, Spektrum, Pelajar, Pelajar Prasiswazah, United Kingdom, Dewasa Muda

@artikel{Freeth20132569,
tajuk = {Perbandingan silang budaya ciri autistik di UK, India and Malaysia},
pengarang = {M Freeth dan E Sheppard dan R Ramachandran dan E Milne},
url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84886802970&doi = 10.1007% 2fs10803-013-1808-9&rakan kongsi = 40&md5 = d8acde51c0626be3862facc1d6bc493c},
doi = {10.1007/s10803-013-1808-9},
terbitan = {01623257},
tahun = {2013},
tarikh = {2013-01-01},
jurnal = {Jurnal Autisme dan Gangguan Perkembangan},
isi padu = {43},
nombor = {11},
halaman = {2569-2583},
abstrak = {Gangguan autisme dikenali secara meluas di seluruh dunia. Walau bagaimanapun, kriteria diagnostik dan teori autisme didasarkan pada penyelidikan yang kebanyakannya dilakukan dalam budaya Barat. Di sini kita membandingkan ekspresi sifat autistik dalam sampel individu neurotipikal dari satu budaya Barat (UK) dan dua budaya Timur (India and Malaysia), menggunakan Autisme-spektrum Quotient (AQ) untuk mengenal pasti kemungkinan perbezaan budaya dalam penyataan sifat autistik. Tingkah laku yang berkaitan dengan sifat autistik dilaporkan pada tahap yang lebih besar dalam budaya Timur daripada budaya Barat. Lelaki mendapat markah lebih tinggi daripada pelajar perempuan dan pelajar sains mendapat markah lebih tinggi daripada pelajar bukan sains dalam setiap budaya. Pelajar India mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub-skala Imaginasi, Pelajar Malaysia mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub skala Attention Switching. Struktur faktor asas AQ untuk setiap populasi diperoleh dan dibincangkan. © 2013 Springer Science + Business Media New York.},
nota = {dipetik oleh 39},
kata kunci = {Remaja, Dewasa, Artikel, Kumpulan Leluhur Benua Asia, Perhatian, Autisme, Gangguan Spektrum Autisme, Kuantiti Spektrum Autisme, Kemahiran komunikasi, Kajian Perbandingan, Perbandingan Merentas Budaya, Faktor Budaya, Etnik, Perempuan, Great Britain, Manusia, Eksperimen Manusia, Khayalan, India, Orang India, Malaysia, Lelaki, Keperibadian, Fenotip, Pelajar Pascasiswazah, Jurnal Keutamaan, Psikometri, Soal selidik, Faktor Seks, Penyesuaian Sosial, Spektrum, Pelajar, Pelajar Prasiswazah, United Kingdom, Dewasa Muda},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Assaf, M; Hyatt, C J; Wong, C G; Johnson, ENCIK; Schultz, R T; Hendler, T; Pearlson, G D

Mentalizing and motivation neural function during social interactions in autism spectrum disorders Artikel Jurnal

NeuroImage: klinikal, 3 , hlm. 321-331, 2013, ISSN: 22131582, (dipetik oleh 28).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan

@artikel{Assaf2013321,
tajuk = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders},
pengarang = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&rakan kongsi = 40&md5=b63630c997b658167792266e40e855b6},
doi = {10.1016/j.nicl.2013.09.005},
terbitan = {22131582},
tahun = {2013},
tarikh = {2013-01-01},
jurnal = {NeuroImage: klinikal},
isi padu = {3},
halaman = {321-331},
abstrak = {Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis.},
nota = {dipetik oleh 28},
kata kunci = {Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis.

Tutup

Modugumudi, Y R; Santhosh, J; Anand, S

Efficacy of collaborative virtual environment intervention programs in emotion expression of children with autism Artikel Jurnal

Journal of Medical Imaging and Health Informatics, 3 (2), hlm. 321-325, 2013, ISSN: 21567018, (dipetik oleh 4).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Anak-anak, Artikel Klinikal, Collaborative Virtual Environment, Kajian Terkawal, DSM-IV, Elektroencephalogram, Elektroensefalografi, Electrooculogram, Emosi, Ketua Penolong Pengarah, Event Related Potential, Ekspresi wajah, Perempuan, Manusia, Latent Period, Lelaki, Recognition, Budak sekolah

Tan, E H; Razak, S A; Abdullah, J M; Yusoff, Mohamed A A

De-novo mutations and genetic variation in the SCN1A gene in Malaysian patients with generalized epilepsy with febrile seizures plus (GEFS+) Artikel Jurnal

Epilepsy Research, 102 (3), hlm. 210-215, 2012, ISSN: 09201211, (dipetik oleh 2).

Abstrak | Pautan | BibTeX | Tag: Alanine, Amino Acid Substitution, Arginine, Artikel, Asparagine, Aspartic Acid, Anak-anak, Artikel Klinikal, Clinical Feature, Kajian Terkawal, Persatuan Penyakit, DNA Mutational Analysis, DNA Sequence, Elektroensefalografi, Epilepsi, Febrile, Febrile Convulsion, Perempuan, Gen, Gene Frequency, Pengenalan Gen, Generalized, Generalized Epilepsy, Persatuan Genetik, Kecenderungan Genetik, Genetic Screening, Genetic Variability, Glycine, Histidine, Manusia, Bayi, Malaysia, Lelaki, Missense Mutation, Molecular Pathology, Mutation, Mutational Analysis, Mutator Gene, Nav1.1 Voltage-Gated Sodium Channel, Onset Age, Patient Assessment, Polimorfisme, Kanak-kanak Prasekolah, Jurnal Keutamaan, Promoter Region, Budak sekolah, Seizure, Sequence Analysis, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Voltage Gated Sodium Channel Alpha1 Subunit Gene

@artikel{Tan2012210,
tajuk = {De-novo mutations and genetic variation in the SCN1A gene in Malaysian patients with generalized epilepsy with febrile seizures plus (GEFS+)},
pengarang = {E H Tan and S A Razak and J M Abdullah and A A Mohamed Yusoff},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870296042&doi=10.1016%2fj.eplepsyres.2012.08.004&rakan kongsi = 40&md5=25cc4eeb07db2492a7c04c6b3b3b2167},
doi = {10.1016/j.eplepsyres.2012.08.004},
terbitan = {09201211},
tahun = {2012},
tarikh = {2012-01-01},
jurnal = {Epilepsy Research},
isi padu = {102},
nombor = {3},
halaman = {210-215},
abstrak = {Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Di sini, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty seven sequence variants (missense mutation and silent polymorphism also intronic polymorphism), as well as 2 novel de-novo mutations were found in our patients at coding regions, c.5197A>G (N1733D) and c.4748A>G (H1583R). Our findings provide potential genetic insights into the pathogenesis of GEFS+ in Malaysian populations concerning the SCN1A gene mutations. © 2012 Elsevier B.V.},
nota = {dipetik oleh 2},
kata kunci = {Alanine, Amino Acid Substitution, Arginine, Artikel, Asparagine, Aspartic Acid, Anak-anak, Artikel Klinikal, Clinical Feature, Kajian Terkawal, Persatuan Penyakit, DNA Mutational Analysis, DNA Sequence, Elektroensefalografi, Epilepsi, Febrile, Febrile Convulsion, Perempuan, Gen, Gene Frequency, Pengenalan Gen, Generalized, Generalized Epilepsy, Persatuan Genetik, Kecenderungan Genetik, Genetic Screening, Genetic Variability, Glycine, Histidine, Manusia, Bayi, Malaysia, Lelaki, Missense Mutation, Molecular Pathology, Mutation, Mutational Analysis, Mutator Gene, Nav1.1 Voltage-Gated Sodium Channel, Onset Age, Patient Assessment, Polimorfisme, Kanak-kanak Prasekolah, Jurnal Keutamaan, Promoter Region, Budak sekolah, Seizure, Sequence Analysis, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Voltage Gated Sodium Channel Alpha1 Subunit Gene},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Salih, M R M; Laut, M B; Hassali, M A A; Shafie, A A; Al-Lela, Wahai Q B; Abd, Ke dan; Ganesan, V M

Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Artikel Jurnal

Journal of Neurosciences in Rural Practice, 3 (3), hlm. 244-250, 2012, ISSN: 09763147, (dipetik oleh 1).

Abstrak | Pautan | BibTeX | Tag: Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease

@artikel{Salih2012244,
tajuk = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy},
pengarang = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&rakan kongsi = 40&md5=039bd22d6c38366ebfdd00a4254c20f0},
doi = {10.4103/0976-3147.102596},
terbitan = {09763147},
tahun = {2012},
tarikh = {2012-01-01},
jurnal = {Journal of Neurosciences in Rural Practice},
isi padu = {3},
nombor = {3},
halaman = {244-250},
abstrak = {Pengenalan: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 bulan, the required data were extracted from the medical records using a pre-designed data collection form. Keputusan: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. Walau bagaimanapun, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.},
nota = {dipetik oleh 1},
kata kunci = {Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Tan, E H; Yusoff, A A M; Abdullah, J M; Razak, S A

Generalized epilepsy with febrile seizure plus (GEFS+) spectrum: Novel de novo mutation of SCN1A detected in a Malaysian patient Artikel Jurnal

Journal of Pediatric Neurosciences, 7 (2), hlm. 123-125, 2012, ISSN: 18171745, (dipetik oleh 3).

Abstrak | Pautan | BibTeX | Tag: Remaja, Anxiety Disorder, Artikel, Autisme, Carbamazepine, Laporan kes, Computer Assisted Tomography, Elektroencephalogram, Elektroensefalografi, Febrile Convulsion, Gen, Generalized Epilepsy, Generalized Epilepsy with Febrile Seizure Plus, Manusia, Karyotype, Malaysia, Lelaki, Medical History, Mental Deficiency, Missense Mutation, Nuclear Magnetic Resonance Imaging, Fenotip, SCN1A Gene, Tonic Clonic Seizure, Topiramate, Valproic Acid

@artikel{Tan2012123,
tajuk = {Generalized epilepsy with febrile seizure plus (GEFS+) spectrum: Novel de novo mutation of SCN1A detected in a Malaysian patient},
pengarang = {E H Tan and A A M Yusoff and J M Abdullah and S A Razak},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870194979&doi=10.4103%2f1817-1745.102575&rakan kongsi = 40&md5=b73f0bdb583e84404e0fff232faf30cb},
doi = {10.4103/1817-1745.102575},
terbitan = {18171745},
tahun = {2012},
tarikh = {2012-01-01},
jurnal = {Journal of Pediatric Neurosciences},
isi padu = {7},
nombor = {2},
halaman = {123-125},
abstrak = {Dalam laporan ini, we describe a 15-year-old Malaysian male patient with a de novo SCN1A mutation who experienced prolonged febrile seizures after his first seizure at 6 months of age. This boy had generalized tonic clonic seizure (GTCS) which occurred with and without fever. Sequencing analysis of voltage-gated sodium channel a1-subunit gene, SCN1A, confirmed a homozygous A to G change at nucleotide 5197 (c.5197A > G) in exon 26 resulting in amino acid substitution of asparagines to aspartate at codon 1733 of sodium channel. The mutation identified in this patient is located in the pore-forming loop of SCN1A and this case report suggests missense mutation in pore-forming loop causes generalized epilepsy with febrile seizure plus (GEFS+) with clinically more severe neurologic phenotype including intellectual disabilities (mental retardation and autism features) and neuropsychiatric disease (anxiety disorder).},
nota = {dipetik oleh 3},
kata kunci = {Remaja, Anxiety Disorder, Artikel, Autisme, Carbamazepine, Laporan kes, Computer Assisted Tomography, Elektroencephalogram, Elektroensefalografi, Febrile Convulsion, Gen, Generalized Epilepsy, Generalized Epilepsy with Febrile Seizure Plus, Manusia, Karyotype, Malaysia, Lelaki, Medical History, Mental Deficiency, Missense Mutation, Nuclear Magnetic Resonance Imaging, Fenotip, SCN1A Gene, Tonic Clonic Seizure, Topiramate, Valproic Acid},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Cheah, P -S; Ramshaw, H S; Thomas, P; Toyo-Oka, K; Syiling, X; Martin, S; Coyle, P; Guthridge, M A; Stomski, F; Tetapi, Van Den M; Wynshaw-Boris, A; Lopez, A F; Schwarz, Q

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency Artikel Jurnal

Molecular Psychiatry, 17 (4), hlm. 451-466, 2012, ISSN: 13594184, (dipetik oleh 58).

Abstrak | Pautan | BibTeX | Tag: 14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan

@artikel{Cheah2012451,
tajuk = {Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency},
pengarang = {P -S Cheah and H S Ramshaw and P Q Thomas and K Toyo-Oka and X Xu and S Martin and P Coyle and M A Guthridge and F Stomski and M Van Den Buuse and A Wynshaw-Boris and A F Lopez and Q P Schwarz},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859007028&doi=10.1038%2fmp.2011.158&rakan kongsi = 40&md5=7f507fef31a192a10b3cde7bf69b5442},
doi = {10.1038/mp.2011.158},
terbitan = {13594184},
tahun = {2012},
tarikh = {2012-01-01},
jurnal = {Molecular Psychiatry},
isi padu = {17},
nombor = {4},
halaman = {451-466},
abstrak = {Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Di sini, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved.},
nota = {dipetik oleh 58},
kata kunci = {14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Clark, M; Coklat, R; Karrapaya, R

Pandangan awal mengenai kualiti hidup keluarga Malaysia yang merangkumi kanak-kanak kurang upaya Artikel Jurnal

Jurnal Penyelidikan Kecacatan Intelektual, 56 (1), hlm. 45-60, 2012, ISSN: 09642633, (dipetik oleh 16).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Pengasuh, Cerebral Palsy, Anak-anak, Kos Penyakit, Perbandingan Merentas Budaya, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Kesihatan Keluarga, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Tinjauan Kesihatan, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kepuasan Hidup, Malaysia, Lelaki, Ibu bapa, Dasar, Prasekolah, Kanak-kanak Prasekolah, Psikometrik, Kualiti hidup, Soal selidik, Budak sekolah, Sokongan Sosial, Faktor Sosioekonomi

@artikel{Clark201245,
tajuk = {Pandangan awal mengenai kualiti hidup keluarga Malaysia yang merangkumi kanak-kanak kurang upaya},
pengarang = {M Clark dan R Brown dan R Karrapaya},
url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-83855165819&doi=10.1111/j.1365-2788.2011.01408.x&rakan kongsi = 40&md5 = 4822406179501d1b0b93c5374e383637},
doi = {10.1111/j.1365-2788.2011.01408.x},
terbitan = {09642633},
tahun = {2012},
tarikh = {2012-01-01},
jurnal = {Jurnal Penyelidikan Kecacatan Intelektual},
isi padu = {56},
nombor = {1},
halaman = {45-60},
abstrak = {Latar Belakang Walaupun terdapat banyak literatur dalam kualiti hidup keluarga yang merangkumi anak-anak kurang upaya, majoriti penyelidikan telah dilakukan di negara-negara barat. Kajian ini memberikan penerokaan awal mengenai kualiti hidup keluarga Malaysia yang merangkumi anak-anak yang kurang upaya perkembangan / intelektual. Dinamika yang mencirikan masyarakat Malaysia digambarkan sebagai perkembangan dalam dasar sosial dan penyediaan perkhidmatan yang menyokong orang kurang upaya dan keluarga mereka. Data Kaedah Soal Selidik dikumpulkan menggunakan Tinjauan Kualiti Hidup Keluarga - Versi pendek. Anggota 52 keluarga yang merangkumi satu atau dua kanak-kanak kurang upaya ditemu ramah. Respons mereka memberikan persepsi mereka dalam enam dimensi kualiti hidup keluarga di sembilan domain kehidupan yang dinilai. Hasil Dapatan menunjukkan corak penilaian 'penting' yang dirasakan kuat pada setiap domain kehidupan berbanding dengan penilaian min untuk dimensi kualiti hidup keluarga yang lain. Beberapa dimensi kualiti hidup keluarga, khususnya 'peluang', ínitiative 'dan áttainment', menunjukkan hubungan yang sangat kuat antara satu sama lain. Keseluruhan cara kepuasan dengan dan pencapaian kualiti hidup keluarga serta penilaian global terhadap kualiti hidup dan kepuasan semua menunjukkan hubungan yang signifikan, walaupun setiap korelasi ini menyumbang kurang daripada 50% dari varians biasa. Kesimpulan Peringkat kepentingan dapat dilihat sebagai faktor penentu dari segi kualiti hidup, dan memainkan peranan penting dalam menyokong pencapaian, dan kepuasan dengan, kualiti hidup keluarga, menanggung peluang, inisiatif dan kestabilan mencukupi. Keperluan untuk sampel yang lebih luas termasuk keluarga yang tidak menerima perkhidmatan diperhatikan. Soalan penyelidikan masa depan berdasarkan hasil kajian semasa dan beberapa dinamika yang mempengaruhi masyarakat Malaysia juga dicadangkan. © 2011 Penulis. Jurnal Penyelidikan Kecacatan Intelektual © 2011 Blackwell Publishing Ltd.},
nota = {dipetik oleh 16},
kata kunci = {Remaja, Dewasa, Artikel, Autisme, Pengasuh, Cerebral Palsy, Anak-anak, Kos Penyakit, Perbandingan Merentas Budaya, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Kesihatan Keluarga, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Tinjauan Kesihatan, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kepuasan Hidup, Malaysia, Lelaki, Ibu bapa, Dasar, Prasekolah, Kanak-kanak Prasekolah, Psikometrik, Kualiti hidup, Soal selidik, Budak sekolah, Sokongan Sosial, Faktor Sosioekonomi},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Latar Belakang Walaupun terdapat banyak literatur dalam kualiti hidup keluarga yang merangkumi anak-anak kurang upaya, majoriti penyelidikan telah dilakukan di negara-negara barat. Kajian ini memberikan penerokaan awal mengenai kualiti hidup keluarga Malaysia yang merangkumi anak-anak yang kurang upaya perkembangan / intelektual. Dinamika yang mencirikan masyarakat Malaysia digambarkan sebagai perkembangan dalam dasar sosial dan penyediaan perkhidmatan yang menyokong orang kurang upaya dan keluarga mereka. Data Kaedah Soal Selidik dikumpulkan menggunakan Tinjauan Kualiti Hidup Keluarga - Versi pendek. Anggota 52 keluarga yang merangkumi satu atau dua kanak-kanak kurang upaya ditemu ramah. Respons mereka memberikan persepsi mereka dalam enam dimensi kualiti hidup keluarga di sembilan domain kehidupan yang dinilai. Hasil Dapatan menunjukkan corak penilaian 'penting' yang dirasakan kuat pada setiap domain kehidupan berbanding dengan penilaian min untuk dimensi kualiti hidup keluarga yang lain. Beberapa dimensi kualiti hidup keluarga, khususnya 'peluang', ínitiative 'dan áttainment', menunjukkan hubungan yang sangat kuat antara satu sama lain. Keseluruhan cara kepuasan dengan dan pencapaian kualiti hidup keluarga serta penilaian global terhadap kualiti hidup dan kepuasan semua menunjukkan hubungan yang signifikan, walaupun setiap korelasi ini menyumbang kurang daripada 50% dari varians biasa. Kesimpulan Peringkat kepentingan dapat dilihat sebagai faktor penentu dari segi kualiti hidup, dan memainkan peranan penting dalam menyokong pencapaian, dan kepuasan dengan, kualiti hidup keluarga, menanggung peluang, inisiatif dan kestabilan mencukupi. Keperluan untuk sampel yang lebih luas termasuk keluarga yang tidak menerima perkhidmatan diperhatikan. Soalan penyelidikan masa depan berdasarkan hasil kajian semasa dan beberapa dinamika yang mempengaruhi masyarakat Malaysia juga dicadangkan. © 2011 Penulis. Jurnal Penyelidikan Kecacatan Intelektual © 2011 Blackwell Publishing Ltd.

Tutup

Freeth, M; Panggil, D; Mitchell, P; Kapten, P; Loher, S

Brief report: How adolescents with ASD process social information in complex scenes. Combining evidence from eye movements and verbal descriptions Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 41 (3), hlm. 364-371, 2011, ISSN: 01623257, (dipetik oleh 21).

Abstrak | Pautan | BibTeX | Tag: Remaja, Artikel, Association, Perhatian, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kajian Terkawal, Cues, Emosi, Eye Fixation, Pergerakan Mata, Eye Tracking, Perempuan, Gaze, Manusia, Intelligence Quotient, Lelaki, Mental Function, Kesihatan mental, Persepsi, Meresap, Photic Stimulation, Photostimulation, Jurnal Keutamaan, Aspek Psikologi, Budak sekolah, Aspek Sosial, Social Perception, Stimulus Response, Komunikasi Lisan, Penglihatan, Persepsi Visual, Visual Stimulation

@artikel{Freeth2011364,
tajuk = {Brief report: How adolescents with ASD process social information in complex scenes. Combining evidence from eye movements and verbal descriptions},
pengarang = {M Freeth and D Ropar and P Mitchell and P Chapman and S Loher},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79956006659&doi=10.1007%2fs10803-010-1053-4&rakan kongsi = 40&md5=35b5c8dd813f7eab2963b27081f11e78},
doi = {10.1007/s10803-010-1053-4},
terbitan = {01623257},
tahun = {2011},
tarikh = {2011-01-01},
jurnal = {Jurnal Autisme dan Gangguan Perkembangan},
isi padu = {41},
nombor = {3},
halaman = {364-371},
abstrak = {We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (berumur 11-16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Namun begitu, the verbal descriptions revealed that participants with ASD frequently processed the observed person's emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed. © Springer Science+Business Media, LLC 2010.},
nota = {dipetik oleh 21},
kata kunci = {Remaja, Artikel, Association, Perhatian, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kajian Terkawal, Cues, Emosi, Eye Fixation, Pergerakan Mata, Eye Tracking, Perempuan, Gaze, Manusia, Intelligence Quotient, Lelaki, Mental Function, Kesihatan mental, Persepsi, Meresap, Photic Stimulation, Photostimulation, Jurnal Keutamaan, Aspek Psikologi, Budak sekolah, Aspek Sosial, Social Perception, Stimulus Response, Komunikasi Lisan, Penglihatan, Persepsi Visual, Visual Stimulation},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup

Sheppard, E; Panggil, D; Di bawah kayu, G; Loon, Dari E

Brief report: Driving hazard perception in autism Artikel Jurnal

Jurnal Autisme dan Gangguan Perkembangan, 40 (4), hlm. 504-508, 2010, ISSN: 01623257, (dipetik oleh 42).

Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Association, Autisme, Gangguan Spektrum Autisme, Automobile Driving, Car Driving, Case-Control Studies, Artikel Klinikal, Kajian Terkawal, Hazard Assessment, Manusia, Information Processing, Intelligence Quotient, Lelaki, Kesihatan mental, Motor Dysfunction, Neuropsychological Tests, Persepsi, Photic Stimulation, Jurnal Keutamaan, Reaction Time, Social Perception, Traffic Accident, Traffic Safety, Visual Impairment, Persepsi Visual, Visual Stimulation, Dewasa Muda

Tan, K L; Yadav, H

Reassessment on the development of children with disability in Malaysia Artikel Jurnal

Medical Journal of Malaysia, 63 (1), hlm. 17-20, 2008, ISSN: 03005283, (dipetik oleh 5).

Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Pembangunan kanak-kanak, Anak-anak, Clinical Assessment Tool, Analisis Kohort, Kajian Terkawal, Gangguan Perkembangan, Developmental Screening, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Perempuan, Susulan, Manusia, Bayi, Gangguan Pembelajaran, Kajian Klinikal Utama, Malaysia, Lelaki, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Prasekolah, Penjagaan Kesihatan Utama, Register, Gangguan Pertuturan, Statistical Significance

@artikel{Tan200817,
tajuk = {Reassessment on the development of children with disability in Malaysia},
pengarang = {K L Tan and H Yadav},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649115291&rakan kongsi = 40&md5=8838ddaa3d9906d8b696be13e88f1baa},
terbitan = {03005283},
tahun = {2008},
tarikh = {2008-01-01},
jurnal = {Medical Journal of Malaysia},
isi padu = {63},
nombor = {1},
halaman = {17-20},
abstrak = {This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. Sejumlah 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autisme, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment.},
nota = {dipetik oleh 5},
kata kunci = {Artikel, Autisme, Pembangunan kanak-kanak, Anak-anak, Clinical Assessment Tool, Analisis Kohort, Kajian Terkawal, Gangguan Perkembangan, Developmental Screening, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Perempuan, Susulan, Manusia, Bayi, Gangguan Pembelajaran, Kajian Klinikal Utama, Malaysia, Lelaki, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Prasekolah, Penjagaan Kesihatan Utama, Register, Gangguan Pertuturan, Statistical Significance},
pubstate = {diterbitkan},
tppubtype = {artikel}
}

Tutup