Senarai Penerbitan
Terdapat sebilangan besar penyelidikan berkaitan autisme yang boleh dijumpai di Malaysia yang umumnya menumpukan pada ASD, gangguan pembelajaran, alat bantu komunikasi, terapi dan banyak lagi. Senarai penerbitan disediakan di bawah:
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2020 |
Taresh, S; Ahmad, N A; Roslan, S; Ma'rof, Seorang M; Zaid, S Sains Otak, 10 (3), 2020, ISSN: 20763425, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Sikap Kurang Upaya, Autisme, Kognisi, Kerangka Konseptual, Pendidikan, Kepercayaan Kesihatan, Penjagaan Kesihatan, Kakitangan Penjagaan Kesihatan, Manusia, Komunikasi Interpersonal, Kesihatan mental, Ahli Fisioterapi, Aspek Psikologi, Soal selidik, Kaji semula, Cikgu sekolah, Konsep Kendiri, Kelakuan Sosial, Teori Kognitif Sosial, Interaksi Sosial, Stigma Sosial, Mengajar, Latihan @artikel{Taresh2020, tajuk = {Pengetahuan guru prasekolah, kepercayaan, kemahiran mengenal pasti, dan keberkesanan diri dalam mengenal pasti gangguan spektrum autisme (ASD): Kerangka konsep untuk mengenal pasti kanak-kanak dengan ASD}, pengarang = {S Taresh dan N A Ahmad dan S Roslan dan A M Ma'rof dan S Zaid}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85082661960&doi = 10.3390% 2fbrainsci10030165&rakan kongsi = 40&md5 = 806c3d699ffc9bd518bc0397b07598a8}, doi = {10.3390/brainsci10030165}, terbitan = {20763425}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Sains Otak}, isi padu = {10}, nombor = {3}, penerbit = {MDPI AG}, abstrak = {Baru-baru ini, pengenalpastian dan pengesanan kanak-kanak dengan gangguan spektrum autisme (ASD) telah menjadi isu penting dalam perkhidmatan campur tangan ASD. Peratusan ASD yang tinggi di kalangan kanak-kanak memerlukan guru prasekolah untuk mengenali perkembangan abnormal kanak-kanak dan mengenal pasti mereka pada peringkat awal, diikuti dengan rujukan kepada pakar. Oleh itu, pengenalan ini memerlukan kemampuan khusus di kalangan guru prasekolah, dikenal pasti sebagai pengetahuan, kepercayaan, kemahiran mengenal pasti, dan keberkesanan diri (KBISSE). Kerangka konseptual ini bertujuan untuk menggunakan literatur semasa untuk menyampaikan perbincangan mengenai KBISSE guru prasekolah dalam mengenal pasti kanak-kanak dengan ASD dan membuat keputusan untuk merujuk kanak-kanak yang disyaki dengan ASD kepada pakar. Kerangka konsep dibincangkan berdasarkan teori kognitif sosial (SCT) dan model kepercayaan kesihatan (HBM). Kerangka konsep menekankan perlunya guru prasekolah dididik di ASD melalui modul pendidikan yang dapat meningkatkan keberkesanan diri guru dalam mengenal pasti kanak-kanak dengan ASD. Selain itu, pengetahuan dalam ASD, kepercayaan terhadap ASD, dan kemahiran mengenal pasti juga pemboleh ubah yang diperlukan untuk membina modul pendidikan. Modul pendidikan berguna untuk membimbing penyelidikan masa depan mengenai pengenalan guru prasekolah kanak-kanak dengan sebarang kecacatan, salah satunya adalah ASD, dan rujukan pakar seterusnya pada peringkat awal. © 2020 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.}, nota = {dipetik oleh 0}, kata kunci = {Sikap Kurang Upaya, Autisme, Kognisi, Kerangka Konseptual, Pendidikan, Kepercayaan Kesihatan, Penjagaan Kesihatan, Kakitangan Penjagaan Kesihatan, Manusia, Komunikasi Interpersonal, Kesihatan mental, Ahli Fisioterapi, Aspek Psikologi, Soal selidik, Kaji semula, Cikgu sekolah, Konsep Kendiri, Kelakuan Sosial, Teori Kognitif Sosial, Interaksi Sosial, Stigma Sosial, Mengajar, Latihan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Baru-baru ini, pengenalpastian dan pengesanan kanak-kanak dengan gangguan spektrum autisme (ASD) telah menjadi isu penting dalam perkhidmatan campur tangan ASD. Peratusan ASD yang tinggi di kalangan kanak-kanak memerlukan guru prasekolah untuk mengenali perkembangan abnormal kanak-kanak dan mengenal pasti mereka pada peringkat awal, diikuti dengan rujukan kepada pakar. Oleh itu, pengenalan ini memerlukan kemampuan khusus di kalangan guru prasekolah, dikenal pasti sebagai pengetahuan, kepercayaan, kemahiran mengenal pasti, dan keberkesanan diri (KBISSE). Kerangka konseptual ini bertujuan untuk menggunakan literatur semasa untuk menyampaikan perbincangan mengenai KBISSE guru prasekolah dalam mengenal pasti kanak-kanak dengan ASD dan membuat keputusan untuk merujuk kanak-kanak yang disyaki dengan ASD kepada pakar. Kerangka konsep dibincangkan berdasarkan teori kognitif sosial (SCT) dan model kepercayaan kesihatan (HBM). Kerangka konsep menekankan perlunya guru prasekolah dididik di ASD melalui modul pendidikan yang dapat meningkatkan keberkesanan diri guru dalam mengenal pasti kanak-kanak dengan ASD. Selain itu, pengetahuan dalam ASD, kepercayaan terhadap ASD, dan kemahiran mengenal pasti juga pemboleh ubah yang diperlukan untuk membina modul pendidikan. Modul pendidikan berguna untuk membimbing penyelidikan masa depan mengenai pengenalan guru prasekolah kanak-kanak dengan sebarang kecacatan, salah satunya adalah ASD, dan rujukan pakar seterusnya pada peringkat awal. © 2020 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
2019 |
Mohamad, F H; Telah, A T C The α5-Containing GABA A Receptors—a Brief Summary Artikel Jurnal Journal of Molecular Neuroscience, 67 (2), hlm. 343-351, 2019, ISSN: 08958696, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: 4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Haiwan, Autisme, Otak, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetik, Manusia, Metabolisme, Bukan Manusia, Protein Subunit, Protein Subunits, Receptors, Kaji semula, Skizofrenia, Dadah yang tidak dikelaskan @artikel{Mohamad2019343, tajuk = {The α5-Containing GABA A Receptors—a Brief Summary}, pengarang = {F H Mohamad and A T C Has}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059596842&doi=10.1007%2fs12031-018-1246-4&rakan kongsi = 40&md5=7b2ba0dc86c6c3f890f226cad8195ee5}, doi = {10.1007/s12031-018-1246-4}, terbitan = {08958696}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Journal of Molecular Neuroscience}, isi padu = {67}, nombor = {2}, halaman = {343-351}, penerbit = {Springer New York LLC}, abstrak = {GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Sindrom Down, and autism with a possible alternative benzodiazepine binding site. Oleh itu, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science + Media Perniagaan, LLC, bahagian dari Springer Nature.}, nota = {dipetik oleh 1}, kata kunci = {4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Haiwan, Autisme, Otak, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetik, Manusia, Metabolisme, Bukan Manusia, Protein Subunit, Protein Subunits, Receptors, Kaji semula, Skizofrenia, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Sindrom Down, and autism with a possible alternative benzodiazepine binding site. Oleh itu, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science + Media Perniagaan, LLC, bahagian dari Springer Nature. |
Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, DENGAN Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Artikel Jurnal Developmental Medicine and Child Neurology, 61 (2), hlm. 135-144, 2019, ISSN: 00121622, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability @artikel{Jaafar2019135, tajuk = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review}, pengarang = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&rakan kongsi = 40&md5=d02a2bfcd15a25988b9c23855cd87444}, doi = {10.1111/dmcn.13986}, terbitan = {00121622}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Developmental Medicine and Child Neurology}, isi padu = {61}, nombor = {2}, halaman = {135-144}, penerbit = {Blackwell Publishing Ltd}, abstrak = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press}, nota = {dipetik oleh 1}, kata kunci = {Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability}, pubstate = {diterbitkan}, tppubtype = {artikel} } Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press |
2018 |
Paudel, Y N; Syeikh, M F; Shah, S; Kumari, Y; Othman, Saya Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi Artikel Jurnal Jurnal Farmakologi Eropah, 837 , hlm. 145-155, 2018, ISSN: 00142999, (dipetik oleh 14). Abstrak | Pautan | BibTeX | Tag: 3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan @artikel{Paudel2018145, tajuk = {Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi}, pengarang = {Y N Paudel dan MF Shaikh dan S Shah dan Y Kumari dan I Othman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053082063&doi = 10.1016% 2fj.ejphar.2018.08.020&rakan kongsi = 40&md5=27ff0199bae72f156425637a7ad02228}, doi = {10.1016/j.ejphar.2018.08.020}, terbitan = {00142999}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Farmakologi Eropah}, isi padu = {837}, halaman = {145-155}, penerbit = {Elsevier B.V.}, abstrak = {Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V.}, nota = {dipetik oleh 14}, kata kunci = {3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V. |
Gudang, Dengan Y; Lal, S K The human gut microbiome - A potential controller of wellness and disease Artikel Jurnal Frontiers in Microbiology, 9 (AUG), 2018, ISSN: 1664302X, (dipetik oleh 80). Abstrak | Pautan | BibTeX | Tag: Acetylcholine, Autisme, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Manusia, Hydrocortisone, Immunity, Immunoglobulin A, Penyakit Usus Keradangan, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Flora usus, Leptin, Protein Membran, Metabolisme, Metabolite, Nervous System, Bukan Manusia, Obesiti, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Ekspresi Protein, Protein ZO1, Kaji semula, RNA 16S, Reseptor Seperti Tol 4, Transcription Factor FOXP3, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan, Unindexed Drug, Uvomorulin, Vasculotropin @artikel{Kho2018, tajuk = {The human gut microbiome - A potential controller of wellness and disease}, pengarang = {Z Y Kho and S K Lal}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051459505&doi=10.3389%2ffmicb.2018.01835&rakan kongsi = 40&md5=d89097ac9c0963d8ef7666aa99cff46f}, doi = {10.3389/fmicb.2018.01835}, terbitan = {1664302X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Frontiers in Microbiology}, isi padu = {9}, nombor = {AUG}, penerbit = {Frontiers Media S.A.}, abstrak = {Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. Dalam ulasan ini, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal.}, nota = {dipetik oleh 80}, kata kunci = {Acetylcholine, Autisme, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Manusia, Hydrocortisone, Immunity, Immunoglobulin A, Penyakit Usus Keradangan, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Flora usus, Leptin, Protein Membran, Metabolisme, Metabolite, Nervous System, Bukan Manusia, Obesiti, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Ekspresi Protein, Protein ZO1, Kaji semula, RNA 16S, Reseptor Seperti Tol 4, Transcription Factor FOXP3, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan, Unindexed Drug, Uvomorulin, Vasculotropin}, pubstate = {diterbitkan}, tppubtype = {artikel} } Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. Dalam ulasan ini, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal. |
Thu, Tidak H; Hussain, DENGAN; Shuid, A N Current Drug Targets, 19 (8), hlm. 865-876, 2018, ISSN: 13894501, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Amisulpride, Amitriptyline, Haiwan, Antipsychotic Agents, Keresahan, Aripiprazole, Autisme, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Kimia, Clonazepam, Clozapine, Kemurungan, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Penjagaan Kesihatan, Manusia, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Gangguan Mental, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Patofisiologi, Kebolehtelapan, Physical Chemistry, Psychosis, Kaji semula, Risperidone, Skizofrenia, Solubility, Sulpiride, Hasil Rawatan, Venlafaxine, Ziprasidone @artikel{EiThu2018865, tajuk = {New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects}, pengarang = {H Ei Thu and Z Hussain and A N Shuid}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048981535&doi=10.2174%2f1389450117666161125174625&rakan kongsi = 40&md5=d32e5bc9766ff9d68dd79f082b9ca4bc}, doi = {10.2174/1389450117666161125174625}, terbitan = {13894501}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Current Drug Targets}, isi padu = {19}, nombor = {8}, halaman = {865-876}, penerbit = {Bentham Science Publishers B.V.}, abstrak = {Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. Sehingga kini, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, kegelisahan, bipolar disorders and autism spectrum problems. Walau bagaimanapun, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Oleh itu, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers.}, nota = {dipetik oleh 2}, kata kunci = {Amisulpride, Amitriptyline, Haiwan, Antipsychotic Agents, Keresahan, Aripiprazole, Autisme, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Kimia, Clonazepam, Clozapine, Kemurungan, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Penjagaan Kesihatan, Manusia, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Gangguan Mental, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Patofisiologi, Kebolehtelapan, Physical Chemistry, Psychosis, Kaji semula, Risperidone, Skizofrenia, Solubility, Sulpiride, Hasil Rawatan, Venlafaxine, Ziprasidone}, pubstate = {diterbitkan}, tppubtype = {artikel} } Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. Sehingga kini, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, kegelisahan, bipolar disorders and autism spectrum problems. Walau bagaimanapun, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Oleh itu, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers. |
Hashim, R; Yussof, H Feasibility of care robots for children with special needs: A review Persidangan 2018-Januari , Institut Jurutera Elektrik dan Elektronik Inc., 2018, ISBN: 9781538613429, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Pengasuh, humanoid, Kawalan Pintar, Kaji semula, Robotik, Robot, Sensor Pintar, Robotik Sosial, Special Needs @ persidangan{Hashim2018379, tajuk = {Feasibility of care robots for children with special needs: A review}, pengarang = {R Hashim dan H Yussof}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047391087&doi=10.1109%2fIRIS.2017.8250152&rakan kongsi = 40&md5=01f785951837849962044510db789d8d}, doi = {10.1109/IRIS.2017.8250152}, isbn = {9781538613429}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Prosiding - 2017 IEEE 5th International Symposium on Robotics and Intelligent Sensors, IRIS 2017}, isi padu = {2018-Januari}, halaman = {379-382}, penerbit = {Institut Jurutera Elektrik dan Elektronik Inc.}, abstrak = {In caring for special needs children, sebagai contoh, those with autism, there should be alternatives for the parents and guardians of these children. In this instance, aside from fellow humans, care robots should be considered. Oleh itu, this review paper synthesizes the results from several primary literature on the feasibility of using robots to care for children with special needs. Digesting and summarizing on the literature reviewed within this scope, it is not currently feasible for robots to care for children much so for those with special needs. More concrete evidences are required for parents and guardians to put faith in a machine as a replacement for a human care giver. © 2017 IEEE.}, nota = {dipetik oleh 1}, kata kunci = {Pengasuh, humanoid, Kawalan Pintar, Kaji semula, Robotik, Robot, Sensor Pintar, Robotik Sosial, Special Needs}, pubstate = {diterbitkan}, tppubtype = {persidangan} } In caring for special needs children, sebagai contoh, those with autism, there should be alternatives for the parents and guardians of these children. In this instance, aside from fellow humans, care robots should be considered. Oleh itu, this review paper synthesizes the results from several primary literature on the feasibility of using robots to care for children with special needs. Digesting and summarizing on the literature reviewed within this scope, it is not currently feasible for robots to care for children much so for those with special needs. More concrete evidences are required for parents and guardians to put faith in a machine as a replacement for a human care giver. © 2017 IEEE. |
2017 |
Di mana, S W; Ong, L C; Rendah, W Y; Lai, P S M Epilepsy Research, 136 , hlm. 35-45, 2017, ISSN: 09201211, (dipetik oleh 8). Abstrak | Pautan | BibTeX | Tag: Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement @artikel{Wo201735, tajuk = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: Kajian semula yang sistematik}, pengarang = {S W Wo and L C Ong and W Y Low and P S M Lai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&rakan kongsi = 40&md5=f34a0aada2cc5dc6e4d6beab18ac779c}, doi = {10.1016/j.eplepsyres.2017.07.009}, terbitan = {09201211}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Epilepsy Research}, isi padu = {136}, halaman = {35-45}, penerbit = {Elsevier B.V.}, abstrak = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.}, nota = {dipetik oleh 8}, kata kunci = {Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement}, pubstate = {diterbitkan}, tppubtype = {artikel} } Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V. |
Bhagat, V; Haque, M; Simbak, N B; Husain, R Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education Artikel Jurnal Journal of Global Pharma Technology, 9 (7), hlm. 32-43, 2017, ISSN: 09758542, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Adaptive Behavior, Amygdala, Autisme, Awareness, Kognisi, komorbiditi, Kerangka Konseptual, Cost Benefit Analysis, Pendidikan, Emosi, Emotional Disorder, Emotionality, Penjagaan Kesihatan, Health Promotion, Manusia, Impulsif, Belajar, Motivasi, Parent Education, Persepsi, Garis Panduan Amalan, Prefrontal Cortex, Kelaziman, Problem Behavior, Psychoeducation, Psychological Well Being, Kaji semula, Sex Difference, Kelakuan Sosial, Kognisi Sosial, Kecekapan Sosial, Social Learning @artikel{Bhagat201732, tajuk = {Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education}, pengarang = {V Bhagat and M Haque and N B Simbak and R Husain}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021786235&rakan kongsi = 40&md5=ece2d7c28018f0c4526810e08e314461}, terbitan = {09758542}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Journal of Global Pharma Technology}, isi padu = {9}, nombor = {7}, halaman = {32-43}, penerbit = {Journal of Global Pharma Technology}, abstrak = {Autism spectrum disorders (ASD) boleh menjejaskan semua bidang kehidupan kanak-kanak. One of the areas of the behavioral spectrum need to be focused is affected. Oleh itu, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Oleh itu, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT.}, nota = {dipetik oleh 0}, kata kunci = {Adaptive Behavior, Amygdala, Autisme, Awareness, Kognisi, komorbiditi, Kerangka Konseptual, Cost Benefit Analysis, Pendidikan, Emosi, Emotional Disorder, Emotionality, Penjagaan Kesihatan, Health Promotion, Manusia, Impulsif, Belajar, Motivasi, Parent Education, Persepsi, Garis Panduan Amalan, Prefrontal Cortex, Kelaziman, Problem Behavior, Psychoeducation, Psychological Well Being, Kaji semula, Sex Difference, Kelakuan Sosial, Kognisi Sosial, Kecekapan Sosial, Social Learning}, pubstate = {diterbitkan}, tppubtype = {artikel} } Autism spectrum disorders (ASD) boleh menjejaskan semua bidang kehidupan kanak-kanak. One of the areas of the behavioral spectrum need to be focused is affected. Oleh itu, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Oleh itu, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT. |
2016 |
Tan, M L; Ho, BUKAN PERKATAAN; Teh, K H Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders Artikel Jurnal Pangkalan Data Cochrane dari Ulasan Sistematik, 2016 (9), 2016, ISSN: 1469493X, (dipetik oleh 6). Abstrak | Pautan | BibTeX | Tag: Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik @artikel{Tan2016, tajuk = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders}, pengarang = {M L Tan and J J Ho and K H Teh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988922340&doi=10.1002%2f14651858.CD009398.pub3&rakan kongsi = 40&md5=3460f403b8829b4692a0b6f795f4a2a3}, doi = {10.1002/14651858.CD009398.pub3}, terbitan = {1469493X}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Pangkalan Data Cochrane dari Ulasan Sistematik}, isi padu = {2016}, nombor = {9}, penerbit = {John Wiley and Sons Ltd}, abstrak = {Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.}, nota = {dipetik oleh 6}, kata kunci = {Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration. |
Bhagat, V; Mat, Khairi Che H J; Husain, R; Haque, M International Journal of Pharmaceutical Sciences Review and Research, 36 (1), hlm. 54-62, 2016, ISSN: 0976044X, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Autisme, Anak-anak, Keterukan Penyakit, Emosi, Emotionality, Amalan Berasaskan Bukti, Manusia, Perhubungan Manusia, Intervention Study, Negative Emotionality, Parent Counseling, Sikap Ibu Bapa, Parenting Education, Personality Assessment, Kaji semula, Status sosial, Tekanan @artikel{Bhagat201654, tajuk = {Parent’s negative emotionality impacting parenting and involvement in the intervention of their child with autism spectrum disorder: A review proposed the new model for intervention}, pengarang = {V Bhagat and H J Khairi Che Mat and R Husain and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957597820&rakan kongsi = 40&md5=40212e84a1b6be6ade2617d5c9df29a9}, terbitan = {0976044X}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {International Journal of Pharmaceutical Sciences Review and Research}, isi padu = {36}, nombor = {1}, halaman = {54-62}, penerbit = {Global Research Online}, abstrak = {Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Sesungguhnya, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, their negative emotions disturb their focus on the treatment of their ASD child. Oleh itu, the management of ASD child incapacitates their parents to bring out the best. Oleh itu, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. Walau bagaimanapun, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Anak-anak, Keterukan Penyakit, Emosi, Emotionality, Amalan Berasaskan Bukti, Manusia, Perhubungan Manusia, Intervention Study, Negative Emotionality, Parent Counseling, Sikap Ibu Bapa, Parenting Education, Personality Assessment, Kaji semula, Status sosial, Tekanan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Sesungguhnya, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, their negative emotions disturb their focus on the treatment of their ASD child. Oleh itu, the management of ASD child incapacitates their parents to bring out the best. Oleh itu, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. Walau bagaimanapun, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. Hak cipta terpelihara. |
2015 |
Bhagat, V; Simbak, Bin N; Haque, M Journal of Young Pharmacists, 7 (4), hlm. 403-414, 2015, ISSN: 09751483, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik @artikel{Bhagat2015403, tajuk = {The peripheral focus on the psychological parameters of parents of autistic children in the intervention methods: A review and recommending the strategy, focusing psychological parameters of parents of autistic children in intervention methods}, pengarang = {V Bhagat and N Bin Simbak and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959853109&doi=10.5530%2fjyp.2015.4s.1&rakan kongsi = 40&md5=ed5b5faede6650d1249a902d7201ed43}, doi = {10.5530/jyp.2015.4s.1}, terbitan = {09751483}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Journal of Young Pharmacists}, isi padu = {7}, nombor = {4}, halaman = {403-414}, penerbit = {EManuscript Services}, abstrak = {The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them.}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik}, pubstate = {diterbitkan}, tppubtype = {artikel} } The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them. |
Bhagat, V; Jayaraj, J; Haque, M International Journal of Pharmacy and Pharmaceutical Sciences, 7 (11), hlm. 7-12, 2015, ISSN: 09751491, (dipetik oleh 3). Abstrak | Pautan | BibTeX | Tag: Keresahan, Autisme, Pengasuh, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Kognisi, Tingkah Laku Menghadapi, Distress Syndrome, Emosi, Emotionality, Manusia, Intelligence, Mental Capacity, Tekanan Ibu Bapa, Ibu bapa, Fenotip, Kaji semula, Konsep Kendiri @artikel{Bhagat20157, tajuk = {Parent’s self-efficacy, emotionality, and intellectual ability impacting the intervention of autism spectrum disorders: A review proposed model for appraisal of intervention}, pengarang = {V Bhagat and J Jayaraj and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946575464&rakan kongsi = 40&md5=7384d5557b767097e456dee7c79128f7}, terbitan = {09751491}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {International Journal of Pharmacy and Pharmaceutical Sciences}, isi padu = {7}, nombor = {11}, halaman = {7-12}, penerbit = {International Journal of Pharmacy and Pharmaceutical Science}, abstrak = {Gangguan spektrum autisme (ASD) may affect all domains of a child’s life. Sesungguhnya, it impacts not only the child but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be devastating; they have a demanding need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, thus, nudging them into distress which in turn incapacitate them and lowers their efficiency to deal with these situations thereby reducing their self-efficacy. These parents are found with disturbances in emotional and intellectual components of their personalities. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress rank lower in position and the focus rests on the treatment of ASD. Oleh itu, the management of ASD incapacitating the parents of the deficit children to reach their fullest abilities remains questionable. Oleh itu, the objectives of this study are a) to examine the impact of emotionality, intellectual ability and self-efficacy of the intervention of autism spectrum disorder. b) To propose a new intervention model for ASD incorporating self-efficacy, emotional and mental ability c) To suggest the integration of this new model with the current intervention regimens to ensure better efficacy. This study, based on past evidence has keenly, examined the correlation of intellectual ability, emotionality and self-efficacy with the intervention of autism spectrum disorder. The results reveal that emotional and intellectual disturbances and impaired self-efficacy in the parents of children with ASD have an adverse impact on the intervention of ASD. A new model of intervention for ASD encompassing the above-mentioned essential components of parents’ personality has been proposed, and its integration with the existing treatment regimens has been suggested to reap an improved outcome. The study concludes by observing the fact that considerable improvement in the diagnosed child may not ameliorate the parent and family distress already present, especially at the time and expense of intervention can be even more detrimental to the overall personality of the parents. The new proposed model of intervention can pave the way for further research in this regard. © 2015, International Journal of Pharmacy and Pharmaceutical Science. Hak cipta terpelihara.}, nota = {dipetik oleh 3}, kata kunci = {Keresahan, Autisme, Pengasuh, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Kognisi, Tingkah Laku Menghadapi, Distress Syndrome, Emosi, Emotionality, Manusia, Intelligence, Mental Capacity, Tekanan Ibu Bapa, Ibu bapa, Fenotip, Kaji semula, Konsep Kendiri}, pubstate = {diterbitkan}, tppubtype = {artikel} } Gangguan spektrum autisme (ASD) may affect all domains of a child’s life. Sesungguhnya, it impacts not only the child but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be devastating; they have a demanding need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, thus, nudging them into distress which in turn incapacitate them and lowers their efficiency to deal with these situations thereby reducing their self-efficacy. These parents are found with disturbances in emotional and intellectual components of their personalities. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress rank lower in position and the focus rests on the treatment of ASD. Oleh itu, the management of ASD incapacitating the parents of the deficit children to reach their fullest abilities remains questionable. Oleh itu, the objectives of this study are a) to examine the impact of emotionality, intellectual ability and self-efficacy of the intervention of autism spectrum disorder. b) To propose a new intervention model for ASD incorporating self-efficacy, emotional and mental ability c) To suggest the integration of this new model with the current intervention regimens to ensure better efficacy. This study, based on past evidence has keenly, examined the correlation of intellectual ability, emotionality and self-efficacy with the intervention of autism spectrum disorder. The results reveal that emotional and intellectual disturbances and impaired self-efficacy in the parents of children with ASD have an adverse impact on the intervention of ASD. A new model of intervention for ASD encompassing the above-mentioned essential components of parents’ personality has been proposed, and its integration with the existing treatment regimens has been suggested to reap an improved outcome. The study concludes by observing the fact that considerable improvement in the diagnosed child may not ameliorate the parent and family distress already present, especially at the time and expense of intervention can be even more detrimental to the overall personality of the parents. The new proposed model of intervention can pave the way for further research in this regard. © 2015, International Journal of Pharmacy and Pharmaceutical Science. Hak cipta terpelihara. |
2014 |
Rasool, M; Malik, A; Shahid, CIK; Manan, A; Pushparaj, P N; Asif, M; Hakim, M H; Hakim, Seorang M; Kamal, M A; Gan, S H; Syeikh, Saya A Recent updates in the treatment of neurodegenerative disorders using natural compounds Artikel Jurnal Evidence-based Complementary and Alternative Medicine, 2014 , 2014, ISSN: 1741427X, (dipetik oleh 49). Abstrak | Pautan | BibTeX | Tag: Antiinflammatory Activity, Antioxidant Activity, Blood Brain Barrier, Cholinesterase, Degenerative Disease, Enzyme Inhibition, Manusia, Natural Product, Kaji semula @artikel{Rasool2014, tajuk = {Recent updates in the treatment of neurodegenerative disorders using natural compounds}, pengarang = {M Rasool and A Malik and M S Qureshi and A Manan and P N Pushparaj and M Asif and M H Qazi and A M Qazi and M A Kamal and S H Gan and I A Sheikh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901278946&doi=10.1155%2f2014%2f979730&rakan kongsi = 40&md5=c16e01bd0289ca547ae6afb7704ed5d6}, doi = {10.1155/2014/979730}, terbitan = {1741427X}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {Evidence-based Complementary and Alternative Medicine}, isi padu = {2014}, penerbit = {Oxford University Press}, abstrak = {Neurodegenerative diseases are characterized by protein aggregates and inflammation as well as oxidative stress in the central nervous system (CNS). Multiple biological processes are linked to neurodegenerative diseases such as depletion or insufficient synthesis of neurotransmitters, oxidative stress, abnormal ubiquitination. Selanjutnya, damaging of blood brain barrier (BBB) in the CNS also leads to various CNS-related diseases. Even though synthetic drugs are used for the management of Alzheimer's disease, Parkinson's disease, autisme, and many other chronic illnesses, they are not without side effects. The attentions of researchers have been inclined towards the phytochemicals, many of which have minimal side effects. Phytochemicals are promising therapeutic agents because many phytochemicals have anti-inflammatory, antioxidative as well as anticholinesterase activities. Various drugs of either synthetic or natural origin applied in the treatment of brain disorders need to cross the BBB before they can be used. This paper covers various researches related to phytochemicals used in the management of neurodegenerative disorders. © 2014 Mahmood Rasool et al.}, nota = {dipetik oleh 49}, kata kunci = {Antiinflammatory Activity, Antioxidant Activity, Blood Brain Barrier, Cholinesterase, Degenerative Disease, Enzyme Inhibition, Manusia, Natural Product, Kaji semula}, pubstate = {diterbitkan}, tppubtype = {artikel} } Neurodegenerative diseases are characterized by protein aggregates and inflammation as well as oxidative stress in the central nervous system (CNS). Multiple biological processes are linked to neurodegenerative diseases such as depletion or insufficient synthesis of neurotransmitters, oxidative stress, abnormal ubiquitination. Selanjutnya, damaging of blood brain barrier (BBB) in the CNS also leads to various CNS-related diseases. Even though synthetic drugs are used for the management of Alzheimer's disease, Parkinson's disease, autisme, and many other chronic illnesses, they are not without side effects. The attentions of researchers have been inclined towards the phytochemicals, many of which have minimal side effects. Phytochemicals are promising therapeutic agents because many phytochemicals have anti-inflammatory, antioxidative as well as anticholinesterase activities. Various drugs of either synthetic or natural origin applied in the treatment of brain disorders need to cross the BBB before they can be used. This paper covers various researches related to phytochemicals used in the management of neurodegenerative disorders. © 2014 Mahmood Rasool et al. |
2013 |
Khowaja, K; Salim, S S Kajian sistematik mengenai strategi dan intervensi berasaskan komputer (CBI) untuk membaca pemahaman kanak-kanak dengan autisme Artikel Jurnal Penyelidikan dalam Gangguan Spektrum Autisme, 7 (9), hlm. 1111-1121, 2013, ISSN: 17509467, (dipetik oleh 28). Abstrak | Pautan | BibTeX | Tag: Perhatian, Autisme, Pangkalan Data Bibliografi, Anak-anak, Keberkesanan Klinikal, Pemerhatian Klinikal, Kognisi, Kefahaman, Terapi Berbantukan Komputer, Intervensi Berasaskan Komputer, Ingatan Eksplisit, Manusia, Belajar, Linguistik, Motivasi, Multimedia, Reka Bentuk Posttest Pretest, Jurnal Keutamaan, Membaca, Pemahaman bacaan, Kaji semula, Kajian Sistematik, Hasil Rawatan @artikel{Khowaja20131111, tajuk = {Kajian sistematik mengenai strategi dan intervensi berasaskan komputer (CBI) untuk membaca pemahaman kanak-kanak dengan autisme}, pengarang = {K Khowaja dan S S Salim}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84879609907&doi=10.1016/j.rasd.2013.05.009&rakan kongsi = 40&md5 = 6ba3e9315ee8b3cecb6248b97198313d}, doi = {10.1016/j.rasd.2013.05.009}, terbitan = {17509467}, tahun = {2013}, tarikh = {2013-01-01}, jurnal = {Penyelidikan dalam Gangguan Spektrum Autisme}, isi padu = {7}, nombor = {9}, halaman = {1111-1121}, abstrak = {Makalah ini membentangkan tinjauan sistematik mengenai kajian yang diterbitkan yang berkaitan mengenai pemahaman membaca untuk kanak-kanak dengan autisme, memberi tumpuan kepada arahan perbendaharaan kata dan pengajaran pemahaman teks dari tahun 2000 ke 2011. Kajian sistematik ini cuba menangani tiga persoalan kajian khusus: strategi pengajaran kosa kata dan arahan pemahaman teks yang digunakan, campur tangan berasaskan komputer (CBI) digunakan atau dikembangkan semasa belajar, dan keberkesanan penggunaan CBI untuk mengajar kanak-kanak dengan autisme. Terdapat lima strategi pengajaran kosa kata dan tujuh strategi pengajaran pemahaman teks. Hasil menunjukkan bahawa dua strategi pengajaran kosa kata, kaedah multimedia dan arahan eksplisit didapati lebih biasa digunakan daripada tiga kaedah lain. Pada nota yang sama, strategi menjawab soalan pengajaran pemahaman teks didapati digunakan lebih kerap daripada enam yang lain. Hasilnya juga menunjukkan bahawa kanak-kanak dengan autisme dapat memanfaatkan strategi pemahaman membaca dan penggunaan CBI sebagai kaedah pengajaran untuk pemahaman membaca meningkatkan pembelajaran anak-anak. Ini jelas dilihat dari prestasi kanak-kanak antara ujian pra dan ujian pasca kajian di mana CBI digunakan. Walau bagaimanapun, kerana heterogenitas peserta, ini tidak selalu berlaku; beberapa kajian melaporkan tiada peningkatan dalam pembelajaran kanak-kanak dengan autisme. © 2013 Elsevier Ltd.. Hak cipta terpelihara.}, nota = {dipetik oleh 28}, kata kunci = {Perhatian, Autisme, Pangkalan Data Bibliografi, Anak-anak, Keberkesanan Klinikal, Pemerhatian Klinikal, Kognisi, Kefahaman, Terapi Berbantukan Komputer, Intervensi Berasaskan Komputer, Ingatan Eksplisit, Manusia, Belajar, Linguistik, Motivasi, Multimedia, Reka Bentuk Posttest Pretest, Jurnal Keutamaan, Membaca, Pemahaman bacaan, Kaji semula, Kajian Sistematik, Hasil Rawatan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Makalah ini membentangkan tinjauan sistematik mengenai kajian yang diterbitkan yang berkaitan mengenai pemahaman membaca untuk kanak-kanak dengan autisme, memberi tumpuan kepada arahan perbendaharaan kata dan pengajaran pemahaman teks dari tahun 2000 ke 2011. Kajian sistematik ini cuba menangani tiga persoalan kajian khusus: strategi pengajaran kosa kata dan arahan pemahaman teks yang digunakan, campur tangan berasaskan komputer (CBI) digunakan atau dikembangkan semasa belajar, dan keberkesanan penggunaan CBI untuk mengajar kanak-kanak dengan autisme. Terdapat lima strategi pengajaran kosa kata dan tujuh strategi pengajaran pemahaman teks. Hasil menunjukkan bahawa dua strategi pengajaran kosa kata, kaedah multimedia dan arahan eksplisit didapati lebih biasa digunakan daripada tiga kaedah lain. Pada nota yang sama, strategi menjawab soalan pengajaran pemahaman teks didapati digunakan lebih kerap daripada enam yang lain. Hasilnya juga menunjukkan bahawa kanak-kanak dengan autisme dapat memanfaatkan strategi pemahaman membaca dan penggunaan CBI sebagai kaedah pengajaran untuk pemahaman membaca meningkatkan pembelajaran anak-anak. Ini jelas dilihat dari prestasi kanak-kanak antara ujian pra dan ujian pasca kajian di mana CBI digunakan. Walau bagaimanapun, kerana heterogenitas peserta, ini tidak selalu berlaku; beberapa kajian melaporkan tiada peningkatan dalam pembelajaran kanak-kanak dengan autisme. © 2013 Elsevier Ltd.. Hak cipta terpelihara. |
2012 |
Tan, M L; Ho, BUKAN PERKATAAN; Teh, K H Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders. Artikel Jurnal Cochrane database of systematic reviews (Online), 12 , hlm. CD009398, 2012, ISSN: 1469493X, (dipetik oleh 10). Abstrak | Pautan | BibTeX | Tag: Anak-anak, Fatty Acids, Manusia, Gangguan Pembelajaran, Omega 3 Fatty Acid, Omega 6 Fatty Acid, Omega-3, Omega-6, Kaji semula, Unsaturated, Unsaturated Fatty Acid @artikel{Tan2012c, tajuk = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.}, pengarang = {M L Tan and J J Ho and K H Teh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874188414&rakan kongsi = 40&md5=e6f01e2e67a98a878ea3a2d8fc954a7b}, terbitan = {1469493X}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Cochrane database of systematic reviews (Online)}, isi padu = {12}, halaman = {CD009398}, abstrak = {About 5% of schoolchildren have a specific learning disorder, defined as an unexpected failure to acquire adequate abilities in reading, writing or mathematic skills not as a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular omega-3 and omega-6 fatty acids, which are found abundantly in the brain and retina are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. To assess the effects of polyunsaturated fatty acids (PUFAs) supplementation for children with specific learning disorders, on learning outcomes. We searched the following databases in April 2012: CENTRAL (2012, Issue 4), MEDLINE (1948 to April Week 2 2012), ASAS (1980 ke 2012 Week 16), PsycINFO (1806 to April 2012), ERIC (1966 to April 2012), Science Citation Index (1970 ke 20 April 2012), Social Science Citation Index (1970 ke 20 April 2012), Conference Proceedings Citation Index-Science (1970 ke 20 April 2012), Conference Proceedings Citation Index-Social Sciences and Humanites (1970 ke 20 April 2012), Pangkalan Data Cochrane dari Ulasan Sistematik (2012, Issue 4), BERANI (2012, Issue 2) , ZETOC (24 April 2012) and WorldCat (24 April 2012). We searched the WHO International Clinical Trials Registry Platform and ClinicalTrials.gov on 24 April 2012. We also searched the reference lists of relevant articles identified by the searches. Randomised or quasi-randomised controlled trials comparing polyunsaturated fatty acids (PUFAs) with placebo or no treatment in children aged below 18 years with specific learning disabilities diagnosed using DSM-IV, ICD-10 or equivalent criteria. We intended to include participants with co-existing developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Two authors (ML and KH) independently screened the titles and abstracts of the search results and eliminated all studies that did not meet the inclusion criteria. Authors were contacted for missing information and clarifications when needed. We did not find any studies suitable for inclusion in the review. One study is awaiting classification as we were unable to get any information from the study author. There is insufficient evidence to draw any conclusion about the use of PUFAs for children with specific learning disorders. There is a need for well designed randomised studies to support or refute the use of PUFAs in this group of children.}, nota = {dipetik oleh 10}, kata kunci = {Anak-anak, Fatty Acids, Manusia, Gangguan Pembelajaran, Omega 3 Fatty Acid, Omega 6 Fatty Acid, Omega-3, Omega-6, Kaji semula, Unsaturated, Unsaturated Fatty Acid}, pubstate = {diterbitkan}, tppubtype = {artikel} } About 5% of schoolchildren have a specific learning disorder, defined as an unexpected failure to acquire adequate abilities in reading, writing or mathematic skills not as a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular omega-3 and omega-6 fatty acids, which are found abundantly in the brain and retina are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. To assess the effects of polyunsaturated fatty acids (PUFAs) supplementation for children with specific learning disorders, on learning outcomes. We searched the following databases in April 2012: CENTRAL (2012, Issue 4), MEDLINE (1948 to April Week 2 2012), ASAS (1980 ke 2012 Week 16), PsycINFO (1806 to April 2012), ERIC (1966 to April 2012), Science Citation Index (1970 ke 20 April 2012), Social Science Citation Index (1970 ke 20 April 2012), Conference Proceedings Citation Index-Science (1970 ke 20 April 2012), Conference Proceedings Citation Index-Social Sciences and Humanites (1970 ke 20 April 2012), Pangkalan Data Cochrane dari Ulasan Sistematik (2012, Issue 4), BERANI (2012, Issue 2) , ZETOC (24 April 2012) and WorldCat (24 April 2012). We searched the WHO International Clinical Trials Registry Platform and ClinicalTrials.gov on 24 April 2012. We also searched the reference lists of relevant articles identified by the searches. Randomised or quasi-randomised controlled trials comparing polyunsaturated fatty acids (PUFAs) with placebo or no treatment in children aged below 18 years with specific learning disabilities diagnosed using DSM-IV, ICD-10 or equivalent criteria. We intended to include participants with co-existing developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Two authors (ML and KH) independently screened the titles and abstracts of the search results and eliminated all studies that did not meet the inclusion criteria. Authors were contacted for missing information and clarifications when needed. We did not find any studies suitable for inclusion in the review. One study is awaiting classification as we were unable to get any information from the study author. There is insufficient evidence to draw any conclusion about the use of PUFAs for children with specific learning disorders. There is a need for well designed randomised studies to support or refute the use of PUFAs in this group of children. |
2007 |
Pandi-Perumal, S R; Srinivasan, V; Spence, D W; Kardinal, D P Role of the melatonin system in the control of sleep: Therapeutic implications Artikel Jurnal CNS Drugs, 21 (12), hlm. 995-1018, 2007, ISSN: 11727047, (dipetik oleh 90). Abstrak | Pautan | BibTeX | Tag: Absence of Side Effects, Acetylserotonin Methyltransferase, Advanced Sleep Phase Syndrome, Agomelatine, Alpha Tocopherol, Alzheimer Disease, Haiwan, Ascorbic Acid, Beta Adrenergic Receptor Blocking Agent, Biosynthesis, Circadian Rhythm, Circadian Rhythm Sleep Disorder, Clinical Trial, Confusion, Delayed Sleep Phase Syndrome, Drowsiness, Drug Dose Comparison, Drug Efficacy, Drug Half Life, Drug Mechanism, Fatigue, Fluvoxamine, Headache, Hormone Metabolism, Manusia, Hypnosis, Hypothalamus, Insomnia, Jet Lag, Macaca, Melatonin, Melatonin Receptor, Muscle Cramp, Nausea, Non-24-Hour Sleep-Wake Syndrome, Bukan Manusia, Noradrenalin, Pineal Body, Jurnal Keutamaan, Ekspresi Protein, Ramelteon, Rat Strain, Receptor Density, Receptors, REM Sleep, Retina Ganglion Cell, Kaji semula, Serotonin, Shift Worker, Sleep, Gangguan Tidur, Sleep Waking Cycle, Smith Magenis Syndrome, Suprachiasmatic Nucleus, Sustained Drug Release, Vomiting @artikel{Pandi-Perumal2007995, tajuk = {Role of the melatonin system in the control of sleep: Therapeutic implications}, pengarang = {S R Pandi-Perumal and V Srinivasan and D W Spence and D P Cardinali}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-36248949004&doi=10.2165%2f00023210-200721120-00004&rakan kongsi = 40&md5=489ee976fa444beb95b26cdb77b722c2}, doi = {10.2165/00023210-200721120-00004}, terbitan = {11727047}, tahun = {2007}, tarikh = {2007-01-01}, jurnal = {CNS Drugs}, isi padu = {21}, nombor = {12}, halaman = {995-1018}, abstrak = {The circadian rhythm of pineal melatonin secretion, which is controlled by the suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control of the sleep/wake cycle. Melatonin can influence sleep-promoting and sleep/wake rhythm-regulating actions through the specific activation of MT1 (melatonin 1a) and MT2 (melatonin 1b) receptors, the two major melatonin receptor subtypes found in mammals. Both receptors are highly concentrated in the SCN. In diurnal animals, exogenous melatonin induces sleep over a wide range of doses. In healthy humans, melatonin also induces sleep, although its maximum hypnotic effectiveness, as shown by studies of the timing of dose administration, is influenced by the circadian phase. In both young and elderly individuals with primary insomnia, nocturnal plasma melatonin levels tend to be lower than those in healthy controls. There are data indicating that, in affected individuals, melatonin therapy may be beneficial for ameliorating insomnia symptoms. Melatonin has been successfully used to treat insomnia in children with attention-deficit hyperactivity disorder or autism, as well as in other neurodevelopmental disorders in which sleep disturbance is commonly reported. In circadian rhythm sleep disorders, such as delayed sleep-phase syndrome, melatonin can significantly advance the phase of the sleep/wake rhythm. Begitu juga, among shift workers or individuals experiencing jet lag, melatonin is beneficial for promoting adjustment to work schedules and improving sleep quality. The hypnotic and rhythm-regulating properties of melatonin and its agonists (ramelteon, agomelatine) make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders. © 2007 Adis Data Information BV. Hak cipta terpelihara.}, nota = {dipetik oleh 90}, kata kunci = {Absence of Side Effects, Acetylserotonin Methyltransferase, Advanced Sleep Phase Syndrome, Agomelatine, Alpha Tocopherol, Alzheimer Disease, Haiwan, Ascorbic Acid, Beta Adrenergic Receptor Blocking Agent, Biosynthesis, Circadian Rhythm, Circadian Rhythm Sleep Disorder, Clinical Trial, Confusion, Delayed Sleep Phase Syndrome, Drowsiness, Drug Dose Comparison, Drug Efficacy, Drug Half Life, Drug Mechanism, Fatigue, Fluvoxamine, Headache, Hormone Metabolism, Manusia, Hypnosis, Hypothalamus, Insomnia, Jet Lag, Macaca, Melatonin, Melatonin Receptor, Muscle Cramp, Nausea, Non-24-Hour Sleep-Wake Syndrome, Bukan Manusia, Noradrenalin, Pineal Body, Jurnal Keutamaan, Ekspresi Protein, Ramelteon, Rat Strain, Receptor Density, Receptors, REM Sleep, Retina Ganglion Cell, Kaji semula, Serotonin, Shift Worker, Sleep, Gangguan Tidur, Sleep Waking Cycle, Smith Magenis Syndrome, Suprachiasmatic Nucleus, Sustained Drug Release, Vomiting}, pubstate = {diterbitkan}, tppubtype = {artikel} } The circadian rhythm of pineal melatonin secretion, which is controlled by the suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control of the sleep/wake cycle. Melatonin can influence sleep-promoting and sleep/wake rhythm-regulating actions through the specific activation of MT1 (melatonin 1a) and MT2 (melatonin 1b) receptors, the two major melatonin receptor subtypes found in mammals. Both receptors are highly concentrated in the SCN. In diurnal animals, exogenous melatonin induces sleep over a wide range of doses. In healthy humans, melatonin also induces sleep, although its maximum hypnotic effectiveness, as shown by studies of the timing of dose administration, is influenced by the circadian phase. In both young and elderly individuals with primary insomnia, nocturnal plasma melatonin levels tend to be lower than those in healthy controls. There are data indicating that, in affected individuals, melatonin therapy may be beneficial for ameliorating insomnia symptoms. Melatonin has been successfully used to treat insomnia in children with attention-deficit hyperactivity disorder or autism, as well as in other neurodevelopmental disorders in which sleep disturbance is commonly reported. In circadian rhythm sleep disorders, such as delayed sleep-phase syndrome, melatonin can significantly advance the phase of the sleep/wake rhythm. Begitu juga, among shift workers or individuals experiencing jet lag, melatonin is beneficial for promoting adjustment to work schedules and improving sleep quality. The hypnotic and rhythm-regulating properties of melatonin and its agonists (ramelteon, agomelatine) make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders. © 2007 Adis Data Information BV. Hak cipta terpelihara. |