@article{Eow2020,
title = {Factors associated with autism severity among Malaysian children with Autism Spectrum Disorder},
author = {S Y Eow and W Y Gan and P Y Lim and H Awang and Z Mohd Shariff},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081212440&doi=10.1016%2fj.ridd.2020.103632&partnerID=40&md5=a2814a66b9d649278ea7f764ed7e4125},
doi = {10.1016/j.ridd.2020.103632},
issn = {08914222},
year = {2020},
date = {2020-01-01},
journal = {Research in Developmental Disabilities},
volume = {100},
publisher = {Elsevier Inc.},
abstract = {Background: Children with Autism Spectrum Disorder (ASD) of different levels of symptom severity may exhibit a wide range of behaviours and characteristics. There is a limited nutrition-related study on children with ASD of different severity in Malaysia. Aims: This cross-sectional study aims to determine the association between sociodemographic factors, parental factors, and lifestyle factors with autism severity in children with ASD. Methods and procedures: A total of 224 children with ASD were included in this study. Their mothers completed a self-administered questionnaire on sociodemographic characteristics, autism severity, parenting style, parental feeding practices, parenting stress, child's sleep habits and eating behaviours. Outcomes and results: As high as 78.1 % of the children with ASD demonstrated a high level of autism severity. Multiple linear regression showed that father's employment status (B = 6.970, 95 % CI = 3.172, 10.768, p < 0.001) and perceived child weight (B = 3.338, 95 % CI = 1.350, 5.327},
note = {cited By 0},
keywords = {Article, Autism, Body Weight, Children, Cross-Sectional Study, Demography, Disease Association, Disease Severity, Employment, Female, Human, Lifestyle, Major Clinical Study, Malaysia, Malaysian, Male, Parents, Preschool Child, School Child, Social Status},
pubstate = {published},
tppubtype = {article}
}

@article{Prabhakar201918,
title = {Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1},
author = {S Prabhakar and P S Cheah and X Zhang and M Zinter and M Gianatasio and E Hudry and R T Bronson and D J Kwiatkowski and A Stemmer-Rachamimov and C A Maguire and M Sena-Esteves and B A Tannous and X O Breakefield},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070908794&doi=10.1016%2fj.omtm.2019.08.003&partnerID=40&md5=b169187dde0d3b05f8a9d5295a4ad8c4},
doi = {10.1016/j.omtm.2019.08.003},
issn = {23290501},
year = {2019},
date = {2019-01-01},
journal = {Molecular Therapy - Methods and Clinical Development},
volume = {15},
pages = {18-26},
publisher = {Cell Press},
abstract = {Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, respectively. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth and proliferation. Loss of either protein leads to overgrowth in many organs, including subependymal nodules, subependymal giant cell astrocytomas, and cortical tubers in the human brain. Neurological manifestations in TSC include intellectual disability, autism, hydrocephalus, and epilepsy. In a stochastic mouse model of TSC1 brain lesions, complete loss of Tsc1 is achieved in homozygous Tsc1-floxed mice in a subpopulation of neural cells in the brain by intracerebroventricular (i.c.v.) injection at birth of an adeno-associated virus (AAV) vector encoding Cre recombinase. This results in median survival of 38 days and brain pathology, including subependymal lesions and enlargement of neuronal cells. Remarkably, when these mice were injected intravenously on day 21 with an AAV9 vector encoding hamartin, most survived at least up to 429 days in apparently healthy condition with marked reduction in brain pathology. Thus, a single intravenous administration of an AAV vector encoding hamartin restored protein function in enough cells in the brain to extend lifespan in this TSC1 mouse model. © 2019},
note = {cited By 2},
keywords = {Adeno Associated Virus, Adeno Associated Virus Vector, Animal Experiment, Animal Model, Article, Beta Actin, Blood Brain Barrier, Body Weight, Body Weight Gain, Brain Nerve Cell, Brain Ventricle, Cell Proliferation, Complementary DNA, Controlled Study, Cre Recombinase, Drug Efficacy, Female, Gene, Gene Replacement Therapy, Hamartin, HEK293 Cell Line, Hydrocephalus, Immunohistochemistry, Inverted Terminal Repeat, Long Term Care, Male, Motor Activity, Motor Performance, Mouse, Nonhuman, Priority Journal, Promoter Region, Protein Function, Protein Phosphorylation, Quantitative Analysis, Subventricular Zone, Survival Time, Tuberous Sclerosis, Tuberous Sclerosis Type 1, Vascularization, Viral Gene Delivery System},
pubstate = {published},
tppubtype = {article}
}

@article{Al-Hiyali201886,
title = {A review in modification food-intake behavior by brain stimulation: Excess weight cases},
author = {M I Al-Hiyali and A J Ishak and H Harun and S A Ahmad and W A Wan Sulaiman},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062843670&doi=10.14704%2fnq.2018.16.12.1894&partnerID=40&md5=235f66cef05a144be23472641f70bd1d},
doi = {10.14704/nq.2018.16.12.1894},
issn = {13035150},
year = {2018},
date = {2018-01-01},
journal = {NeuroQuantology},
volume = {16},
number = {12},
pages = {86-97},
publisher = {Anka Publishers},
abstract = {Obesity and overweight are frequently prescribed for dysfunction in food-intake behavior. Due to the widely prevalence of obesity in last year’s, there is demand for more studies which are aimed to modify the food-intake behavior. For the past decades many researches has applied in modify food-intake by brain training or stimulation. This review for neuroscience studies in modifying food-intake behavior, it’s involved three sections; The first section explained the role of brain activity in food-intake regulation, general ideas about biomedical devices in food-intake behavior are discussed in second section and third section focused on brain-stimulation systems. Finally, this paper concluded with main points that need to be taken into account when designing experimental study for modification food-intake behavior by brain stimulation according to previous studies recommendation and challenges. © 2018, Anka Publishers. All Rights Reserved.},
note = {cited By 2},
keywords = {Amygdala, Anoxia, Article, Autism, Binge Eating Disorder, Body Mass, Body Weight, Brain Depth Stimulation, Depolarization, Dietary Intake, Drug Craving, Eating Disorder, Electric Current, Electroencephalogram, Electroencephalography, Energy Consumption, Energy Expenditure, Feeding Behavior, Food Intake, Functional Magnetic Resonance Imaging, Gender, Health Status, Homeostasis, Human, Hunger, Lifestyle, Nerve Cell Membrane Steady Potential, Nerve Excitability, Neurofeedback, Neuromodulation, Nutritional Assessment, Outcome Assessment, Questionnaires, Repetitive Transcranial Magnetic Stimulation, Signal Processing, Training, Transcranial Direct Current Stimulation, Transcranial Magnetic Stimulation, Underweight},
pubstate = {published},
tppubtype = {article}
}

@article{Hasan201755,
title = {The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders},
author = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi=10.1016%2fj.ridd.2017.02.015&partnerID=40&md5=d6a9839cda7f62bcce9bdcca33d3d33b},
doi = {10.1016/j.ridd.2017.02.015},
issn = {08914222},
year = {2017},
date = {2017-01-01},
journal = {Research in Developmental Disabilities},
volume = {66},
pages = {55-63},
publisher = {Elsevier Inc.},
abstract = {Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd},
note = {cited By 8},
keywords = {Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking},
pubstate = {published},
tppubtype = {article}
}