List of Publications
There are numbers of autism related research can be found in Malaysia that generally focus on the ASD, learning disorder, communication aids, therapy and many more. The list of publications is provided below:
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2020 |
Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z Factors associated with autism severity among Malaysian children with Autism Spectrum Disorder Journal Article Research in Developmental Disabilities, 100 , 2020, ISSN: 08914222, (cited By 0). Abstract | Links | BibTeX | Tags: Article, Autism, Body Weight, Children, Cross-Sectional Study, Demography, Disease Association, Disease Severity, Employment, Female, Human, Lifestyle, Major Clinical Study, Malaysia, Malaysian, Male, Parents, Preschool Child, School Child, Social Status @article start fusion sticky header wrapper 6, author = start fusion sticky header wrapper 5, url = start fusion sticky header wrapper 4, doi = start fusion sticky header wrapper 3, issn = start fusion sticky header wrapper 2, year = start fusion sticky header wrapper 1, date = start fusion sticky header wrapper 0, journal = standard logo 9, volume = standard logo 8, publisher = standard logo 7, abstract = standard logo 6, note = standard logo 5, keywords = standard logo 4, pubstate = standard logo 3, tppubtype = standard logo 2 } Background: Children with Autism Spectrum Disorder (ASD) of different levels of symptom severity may exhibit a wide range of behaviours and characteristics. There is a limited nutrition-related study on children with ASD of different severity in Malaysia. Aims: This cross-sectional study aims to determine the association between sociodemographic factors, parental factors, and lifestyle factors with autism severity in children with ASD. Methods and procedures: A total of 224 children with ASD were included in this study. Their mothers completed a self-administered questionnaire on sociodemographic characteristics, autism severity, parenting style, parental feeding practices, parenting stress, child's sleep habits and eating behaviours. Outcomes and results: As high as 78.1 % of the children with ASD demonstrated a high level of autism severity. Multiple linear regression showed that father's employment status (B = 6.970, 95 % CI = 3.172, 10.768, p < 0.001) and perceived child weight (B = 3.338, 95 % CI = 1.350, 5.327 |
de Vries, M; Cader, S; Colleer, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E University Students’ Notion of Autism Spectrum Conditions: A Cross-Cultural Study Journal Article Journal of Autism and Developmental Disorders, 50 (4), pp. 1281-1294, 2020, ISSN: 01623257, (cited By 0). Abstract | Links | BibTeX | Tags: Adult, Article, Attitude to Health, Autism, Female, Health Belief, Human, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Malaysian, Male, Priority Journal, Social Acceptance, Social Interactions, Sociology, Student Attitude, Students, United Kingdom, University Student, Young Adult @article standard logo 1, author = standard logo 0, url = sticky header logo 9, doi = sticky header logo 8, issn = sticky header logo 7, year = sticky header logo 6, date = sticky header logo 5, journal = sticky header logo 4, volume = sticky header logo 3, number = sticky header logo 2, pages = sticky header logo 1, publisher = sticky header logo 0, abstract = end fusion sticky header wrapper 9, note = end fusion sticky header wrapper 8, keywords = end fusion sticky header wrapper 7, pubstate = end fusion sticky header wrapper 6, tppubtype = end fusion sticky header wrapper 5 } Cultural background might influence knowledge and attitudes regarding autism, influencing willingness to interact. We studied whether beliefs, knowledge, contact, and attitude differed between the UK and Malaysia. With mediation analyses, we studied how these factors influenced willingness to interact. Autism was more often linked to food in the UK, and to upbringing in Malaysia. Knowledge, contact, and acceptance were greater in the UK. When excluding psychology students, Malaysian students were less willing to interact with autistic people. Knowledge and contact appeared to improve acceptance, but acceptance did not mediate the relation between country, beliefs, knowledge, and experience; and willingness to interact. Knowledge and contact regarding autism might improve acceptance in different cultures, but how acceptance could improve interaction is unclear. © 2020, The Author(s). |
Leong, D; Hedley, D; Uljarević, M Poh-tay-toe, Poh-tah-toe: Autism Diagnosis and Conceptualization Journal Article Journal of Child Neurology, 35 (3), pp. 247-248, 2020, ISSN: 08830738, (cited By 0). Links | BibTeX | Tags: Anxiety, Attention Deficit Disorder, Autism, Caregiver, Children, Clinical Article, Clinical Practice, Disruptive Behavior, DSM-5, Follow Up, Human, Learning Disorder, Letter, Mental Health, Mood Disorder, Multidisciplinary Team, Neuropsychiatry, Priority Journal, Unemployment, Workforce @article end fusion sticky header wrapper 4, author = end fusion sticky header wrapper 3, url = end fusion sticky header wrapper 2, doi = end fusion sticky header wrapper 1, issn = end fusion sticky header wrapper 0, year = fusion-row 9, date = fusion-row 8, journal = fusion-row 7, volume = fusion-row 6, number = fusion-row 5, pages = fusion-row 4, publisher = fusion-row 3, note = fusion-row 2, keywords = fusion-row 1, pubstate = fusion-row 0, tppubtype = #main 9 } |
Taresh, S; Ahmad, N A; Roslan, S; Ma’rof, A M; Zaid, S Brain Sciences, 10 (3), 2020, ISSN: 20763425, (cited By 0). Abstract | Links | BibTeX | Tags: Attitude to Disability, Autism, Cognition, Conceptual Framework, Education, Health Belief, Health Care, Health Care Personnel, Human, Interpersonal Communication, Mental Health, Physiotherapist, Psychological Aspect, Questionnaires, Review, School Teacher, Self Concept, Social Behaviour, Social Cognitive Theory, Social Interactions, Social Stigma, Teaching, Training @article #main 8, author = #main 7, url = #main 6, doi = #main 5, issn = #main 4, year = #main 3, date = #main 2, journal = #main 1, volume = #main 0, number = [if lt IE 9]> publisher = [if lt IE 9]> abstract = [if lt IE 9]> note = [if lt IE 9]> keywords = [if lt IE 9]> pubstate = [if lt IE 9]> tppubtype = [if lt IE 9]> } Recently, the identification and detection of children with autism spectrum disorder (ASD) has become an essential issue under ASD intervention services. The high percentage of ASD among children requires preschool teachers to recognizse children’s abnormal development and identify them at an early stage, followed by referral to specialists. Therefore, this identification calls for a specific ability among preschool teachers, identified as knowledge, belief, identification skills, and self-efficacy (KBISSE). This conceptual framework aims to utilize the current literature to present a discussion on preschool teachers’ KBISSE in identifying children with ASD and making decisions to refer children suspected with ASD to specialists. The conceptual framework is discussed based on social cognitive theory (SCT) and the health belief model (HBM). The conceptual framework emphasizes the need for preschool teachers to be educated in ASD via an educational module that could increase teachers’ self-efficacy in identifying children with ASD. Besides, knowledge in ASD, belief in ASD, and identification skills are also necessary variables for building the educational module. The educational module is useful for guiding future research on preschool teachers’ identification of children with any disability, one of which is ASD, and subsequent specialist referral at an early stage. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
Djatmika, ; Wibowo, A H; Sugini, ; Halim, H; Mohamad, B Multimodal strategies in teaching children with autism: A discourse analysis Journal Article Systematic Reviews in Pharmacy, 11 (2), pp. 219-229, 2020, ISSN: 09758453, (cited By 0). Abstract | Links | BibTeX | Tags: Article, Autism, Body Movement, Children, Discourse Analysis, Gesture, Human, Language, Loudness, Nonverbal Communication, Paralanguage, Priority Journal, Standing, Strategic Planning, Students, Teacher, Teaching, Verbal Behaviour, Verbal Communication @article[if lt IE 9]>
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doi = fusion-columns 9, issn = fusion-columns 8, year = fusion-columns 7, date = fusion-columns 6, journal = fusion-columns 5, volume = fusion-columns 4, number = fusion-columns 3, pages = fusion-columns 2, publisher = fusion-columns 1, abstract = fusion-columns 0, note = fusion-row 9, keywords = fusion-row 8, pubstate = fusion-row 7, tppubtype = fusion-row 6 } The process of teaching and learning involving children with autism requires teachers to be creative in designing special and effective strategies to ensure students' understanding. This is due to the fact that these children have problems in communicating with others, thus need special attention from the teachers. The present research hopes to further understand the needs of these children by examining strategies undertaken by teachers at the Schools for Exceptional Children and Autism Centers in Solo citywhich assist children with autism. Five classes were observed and recorded audio-visually. Data representing the aspects of verbal behaviors, non verbal behaviors, and teaching aids exploitation were collected. Results show that the condition of autism children is a primary influence on the strategy in exploiting multimodal aspects. Thus, teachers must design different approaches in transferring knowledge to these children. In general, teachers always perform verbal exploitation in collaboration with the nonverbal aspects such asfacial gestures, body movements, standing positions, and paralinguistic resources such as intonation and loudness. The study also found thatout the five classes being studied, two classes were supported by an effective use of teaching aids. The findings contributed towards a better understanding for teachers and parents of the needs of autism children during the teaching and learning process. © Advanced Scientific Research. All rights reserved. |
2019 |
Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Sami, F M; Badgujar, S; Govindan, S N; Ansari, M T Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Journal Article Human Vaccines and Immunotherapeutics, 15 (11), pp. 2544-2551, 2019, ISSN: 21645515, (cited By 0). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Attitude, Attitude to Health, Autism, Child Health, Childhood Vaccination, Children, Cross-Sectional Study, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Education, Employment, Ethnicity, Female, Health Knowledge, Human, Immunization Programs, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Mother, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Preschool Child, Preventive Health Service, Psychology, Questionnaires, Seasonal Influenza, Surveys, Vaccination, Young Adult @article fusion-row 5, author = fusion-row 4, url = fusion-row 3, doi = fusion-row 2, issn = fusion-row 1, year = fusion-row 0, date = fusion-footer-widget-area 9, journal = fusion-footer-widget-area 8, volume = fusion-footer-widget-area 7, number = fusion-footer-widget-area 6, pages = fusion-footer-widget-area 5, publisher = fusion-footer-widget-area 4, abstract = fusion-footer-widget-area 3, note = fusion-footer-widget-area 2, keywords = fusion-footer-widget-area 1, pubstate = fusion-footer-widget-area 0, tppubtype = fusion-fusion-copyright-content 9 } Aim: Mothers knowledge and attitude toward childhood vaccination influence uptake is the most adequate tool and preventive aspects to infectious disease epidemics. The present study assesses and measures knowledge and attitude of postnatal mothers toward vaccination. Methods and results: The present study adopted a cross-sectional study design, whereby 200 postnatal mothers were identified during their postnatal visit to clinics. The subjects were accessed using questionnaire to assess the level of knowledge and attitude of mothers regarding vaccination. The objectives were to study the level of knowledge, the attitude, and to find the association between knowledge and attitude of the study subjects. The data were analyzed using SPSS version 16. The results was analyzed through chi-square test. The association between age (p =.031), education (p =.021), occupation (p =.013), and knowledge score toward vaccination was found to be statistically significant. However, ethnicity (p =.127), employment (p =.197), and mode of delivery (p =.750) toward mothers vaccination knowledge were not significant for the study. Mothers education, age, and occupation were found to be associated with attitude toward childhood vaccination. No association was found between ethnicity, employment, and mode of delivery with attitude of childhood vaccination. Conclusion: More than half of the studied mothers had good knowledge scores on vaccination, more than two-thirds of the studied mothers had good attitude scores on vaccination. However, the religious misconception and fear of autism was the main cause of vaccine resistance in Malaysia. © 2019, © 2019 Taylor & Francis Group, LLC. |
Ramachandram, S Medical Journal of Malaysia, 74 (5), pp. 372-376, 2019, ISSN: 03005283, (cited By 0). Abstract | Links | BibTeX | Tags: Adolescent, Article, Asthma, Autism, Birth Weight, Child Development, Children, Chinese, Conception, Demography, Diet Restriction, DSM-5, Eczema, Education, Educational Status, Epilepsy, Female, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Human, Indian, Major Clinical Study, Malay, Male, Medical Record Review, Penang, Prematurity, Speech Disorder, Upper Respiratory Tract Congestion, Wakefulness @article fusion-fusion-copyright-content 8, author = fusion-fusion-copyright-content 7, url = fusion-fusion-copyright-content 6, issn = fusion-fusion-copyright-content 5, year = fusion-fusion-copyright-content 4, date = fusion-fusion-copyright-content 3, journal = fusion-fusion-copyright-content 2, volume = fusion-fusion-copyright-content 1, number = fusion-fusion-copyright-content 0, pages = fusion-row 9, publisher = fusion-row 8, abstract = fusion-row 7, note = fusion-row 6, keywords = fusion-row 5, pubstate = fusion-row 4, tppubtype = fusion-row 3 } Objective: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Results: Out of 331 children with ASD, 82.5% were males, 17.5% females, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 months (SD 31.68 months) with age range from 19 months to 18 years and 4 months. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% and 5.7% respectively. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 and 31.6 years respectively. Conclusion: In this study, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. All rights reserved. |
Ong, J J BMC Complementary and Alternative Medicine, 19 (1), 2019, ISSN: 14726882, (cited By 0). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Alternative Medicine, Autism, Autism Spectrum Disorders, Child Behaviour, Child Parent Relation, Children, Complementary Therapies, Cross-Sectional Study, Female, Human, Infant, Malaysia, Male, Middle Aged, Parents, Personal Satisfaction, Preschool, Preschool Child, Psychology, Questionnaires, Satisfaction, Social Competence, Social Skills, Surveys, Treatment Outcome @article fusion-row 2, author = fusion-row 1, url = fusion-row 0, doi = #footer 9, issn = #footer 8, year = #footer 7, date = #footer 6, journal = #footer 5, volume = #footer 4, number = #footer 3, publisher = #footer 2, abstract = #footer 1, note = #footer 0, keywords = fusion-footer 9, pubstate = fusion-footer 8, tppubtype = fusion-footer 7 } Background: Parents' use of complementary health approaches (CHA) for children with autism spectrum disorder (ASD) are common despite the uncertain evidence of its benefit. Parents often adopt CHA due to dissatisfaction with conventional treatment. This study aimed to examine parents' satisfaction with ASD treatment and their perception of progress in their child's development. Parents' use of CHA among children with ASD and the factors related were also evaluated. Methods: Self-administered questionnaires were completed by 48 parents of children with ASD at a single tertiary referral hospital in Malaysia. Correlation analysis was used to explore associations between parental satisfaction scores, perception of progress scores and use of CHA. Results: Use of CHA was reported by parents for 35.4% of children with ASD in the sample. Parents who were less satisfied with conventional treatment and parents who perceived poorer progress in their child's development were more likely to use CHA. Strong positive relationship was found between parent satisfaction with ASD treatment scores and parent perception of progress scores, which indicates that parents who were satisfied with treatment were more likely to perceive greater progress in their child's development. Improvement in child's progress was most appreciated by parents in their child's behavior (85.5%), social skills (83.3%) and motor skills (77.1%). Conclusion: The use of CHA was common among children with ASD. Parents were more likely to practice CHA when they were less satisfied with conventional treatment and perceived poorer progress. A larger multicenter study is required to further explore the practice of CHA among children with ASD throughout Malaysia. © 2019 The Author(s). |
Sarwar, F; Panatik, S A; Rajab, A; Nordin, N Social support, optimism, parental self-efficacy and wellbeinin mothers of children with autism spectrum disorder Journal Article Indian Journal of Public Health Research and Development, 10 (9), pp. 1824-1829, 2019, ISSN: 09760245, (cited By 0). Abstract | Links | BibTeX | Tags: Adult, Article, Assessment of Humans, Autism, Children, Correlation Analysis, Cross-Sectional Study, Female, Human, Life Orientation Test, Life Satisfaction, Likert Scale, Male, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Perceived Stress Scale, Positive and Negative Affect Schedule, Questionnaires, Satisfaction with Life Scale, Self Concept, Social Support, Wellbeing @article fusion-footer 6, author = fusion-footer 5, url = fusion-footer 4, doi = fusion-footer 3, issn = fusion-footer 2, year = fusion-footer 1, date = fusion-footer 0, journal = wrapper 9, volume = wrapper 8, number = wrapper 7, pages = wrapper 6, publisher = wrapper 5, abstract = wrapper 4, note = wrapper 3, keywords = wrapper 2, pubstate = wrapper 1, tppubtype = wrapper 0 } It was hypothesized that optimism, self-efficacy and social support are positive predictors of life satisfaction and positive affect and negative predictors of perceived stress and negative affect. Data was collected by survey method from 47 mothers of autistic children in Lahore and Faisalabad. Hypotheses were tested on four models of four dependant variables using hierarchical regression analysis. Results depicted that parental self-efficacy was a significant predictor of all four dependant variables, social support was a significant predictor of life satisfaction and perceived stress, while optimism only significantly predicted variance in life satisfaction. The study was first of its type to be done with a sample in Pakistani context and has important implications for clinical psychologist. They can plan interventions to enhance subjective wellbeing and reduce stress directly or indirectly by focusing on antecedents tested in the study. © 2019, Indian Journal of Public Health Research and Development. All rights reserved. |
Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care Journal Article International Journal of Environmental Research and Public Health, 16 (10), 2019, ISSN: 16617827, (cited By 0). Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia @article #boxed-wrapper 9, author = #boxed-wrapper 8, url = #boxed-wrapper 7, doi = #boxed-wrapper 6, issn = #boxed-wrapper 5, year = #boxed-wrapper 4, date = #boxed-wrapper 3, journal = #boxed-wrapper 2, volume = #boxed-wrapper 1, number = #boxed-wrapper 0, publisher = Instagram Feed JS 9, abstract = Instagram Feed JS 8, note = Instagram Feed JS 7, keywords = Instagram Feed JS 6, pubstate = Instagram Feed JS 5, tppubtype = Instagram Feed JS 4 } Background: Caregivers are the initial gatekeepers in the health care management of children with autism spectrum disorder (ASD). Methods: This cross-sectional study aimed to determine the factors associated with caregivers’ satisfaction with different levels of health care services in managing children with ASD in Kelantan. The satisfaction scores of 227 main caregivers of confirmed ASD children were assessed with a modified Parent Satisfaction Scale (PSS) questionnaire. Results: The analysis showed that caregivers who waited longer for a doctor’s consultation in primary care had a reduced PSS score, whereas caregivers who were satisfied with the waiting time in primary care had higher PSS scores. At the secondary care level, caregivers who possessed at least a diploma had reduced PSS scores, whereas caregivers who were satisfied with both doctors’ consultation times and occupational therapy appointments had higher PSS scores. At the tertiary care level, caregivers with an underlying medical problem and who had children undergoing occupational therapy for two months or more had reduced PSS scores. Nevertheless, the analysis showed that caregivers who were concerned with their children’s sleeping problems, who had been informed about parental support, who were satisfied with speech and occupational therapy appointments, who were satisfied with waiting times at tertiary care clinics, and who were satisfied with their doctor’s knowledge and experience had higher PSS scores. Conclusions: This study elucidated the importance of understanding caregivers’ satisfaction in attaining care for their ASD children and highlighted the need to promote factors that would increase caregivers’ satisfaction with current ASD services. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A Perceived stress among caregivers of children with autism spectrum disorder: A state-wide study Journal Article International Journal of Environmental Research and Public Health, 16 (8), 2019, ISSN: 16617827, (cited By 0). Abstract | Links | BibTeX | Tags: Adaptation, Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Caregiver Burden, Child Care, Children, Coping Behaviour, Cross-Sectional Study, Female, Follow Up, Health Care, Health Care Access, Human, Infant, Learning Disorder, Malaysia, Male, Mental Stress, Middle Aged, Multiple Linear Regression Analysis, Newborn, Normal Human, Patient Transport, Perceived Stress Scale, Prediction, Preschool, Preschool Child, Psychological, Psychology, Psychometrics, Psychometry, Quality of Life, Stress, Tertiary Care Center, University Hospital @article Instagram Feed JS 3, author = Instagram Feed JS 2, url = Instagram Feed JS 1, doi = Instagram Feed JS 0, issn = {16617827}, year = {2019}, date = {2019-01-01}, journal = {International Journal of Environmental Research and Public Health}, volume = {16}, number = {8}, publisher = {MDPI AG}, abstract = {Background: Caregivers of children with autism spectrum disorder (ASD) experience increased stress and more significant negative caregiving consequences than those with typically developing children. There is a lack of studies specifically focusing on stress among caregivers with ASD children in Asian countries. The current study examines levels of perceived stress and factors associated with it among caregivers in Kelantan, Malaysia. Methods: In a cross-sectional study, the Malay version of the Perceived Stress Scale (PSS) was administered to 227 caregivers of children with ASD. The caregivers were recruited from ASD databases in four tertiary hospitals in Kelantan and a meeting was set up during the child’s follow-up in the clinic. Multiple linear regression analyses were applied to determine the predictors of perceived stress. Results: The mean total perceived stress score was 20.84 (4.72). This was considered higher than average. Higher perceived stress was significantly predicted among caregivers who live far from the health institution, caregivers who do not own transportation to bring the child to the treatment center, and caregivers who have an ASD child with a learning disability. Conclusion: Caregivers of an ASD child perceived significant stress while taking care of their children. Institutions should alleviate the factors that were predicted to increase the caregivers’ perceived stress to improve the quality of the lives of children and ASD families as a whole. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.}, note = {cited By 0}, keywords = {Adaptation, Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Caregiver Burden, Child Care, Children, Coping Behaviour, Cross-Sectional Study, Female, Follow Up, Health Care, Health Care Access, Human, Infant, Learning Disorder, Malaysia, Male, Mental Stress, Middle Aged, Multiple Linear Regression Analysis, Newborn, Normal Human, Patient Transport, Perceived Stress Scale, Prediction, Preschool, Preschool Child, Psychological, Psychology, Psychometrics, Psychometry, Quality of Life, Stress, Tertiary Care Center, University Hospital}, pubstate = {published}, tppubtype = {article} } Background: Caregivers of children with autism spectrum disorder (ASD) experience increased stress and more significant negative caregiving consequences than those with typically developing children. There is a lack of studies specifically focusing on stress among caregivers with ASD children in Asian countries. The current study examines levels of perceived stress and factors associated with it among caregivers in Kelantan, Malaysia. Methods: In a cross-sectional study, the Malay version of the Perceived Stress Scale (PSS) was administered to 227 caregivers of children with ASD. The caregivers were recruited from ASD databases in four tertiary hospitals in Kelantan and a meeting was set up during the child’s follow-up in the clinic. Multiple linear regression analyses were applied to determine the predictors of perceived stress. Results: The mean total perceived stress score was 20.84 (4.72). This was considered higher than average. Higher perceived stress was significantly predicted among caregivers who live far from the health institution, caregivers who do not own transportation to bring the child to the treatment center, and caregivers who have an ASD child with a learning disability. Conclusion: Caregivers of an ASD child perceived significant stress while taking care of their children. Institutions should alleviate the factors that were predicted to increase the caregivers’ perceived stress to improve the quality of the lives of children and ASD families as a whole. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
Liu, Y -W; Liong, M T; Chung, Y -C E; Huang, H -Y; Peng, W -S; Cheng, Y -F; Lin, Y -S; Wu, Y -Y; Tsai, Y -C Nutrients, 11 (4), 2019, ISSN: 20726643, (cited By 4). Abstract | Links | BibTeX | Tags: Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan @article{Liu2019, title = {Effects of lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial}, author = {Y -W Liu and M T Liong and Y -C E Chung and H -Y Huang and W -S Peng and Y -F Cheng and Y -S Lin and Y -Y Wu and Y -C Tsai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817846&doi=10.3390%2fnu11040820&partnerID=40&md5=ca04462e8710198b821b44f8e73061f3}, doi = {10.3390/nu11040820}, issn = {20726643}, year = {2019}, date = {2019-01-01}, journal = {Nutrients}, volume = {11}, number = {4}, publisher = {MDPI AG}, abstract = {This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.}, note = {cited By 4}, keywords = {Aberrant Behavior Checklist Taiwan version, Adolescent, Age, Age Factors, Aggression, Anxiety, Article, Attention Deficit Disorder, Autism, Autism Behavior Checklist, Autism Diagnostic Interview Revised, Autism Spectrum Disorders, Child Behaviour, Child Behaviour Checklist, Children, Clinical Global Impression Scale, Communication Disorder, Controlled Study, Double Blind Procedure, Double-Blind Method, Female, Generalized Anxiety Disorder, Human, Impulsiveness, Lactobacillus Plantarum, Male, Physiology, Placebo, Placebos, Posttraumatic Stress Disorder, Probiotic Agent, Probiotics, Psychology, Questionnaires, Randomized Controlled Trial, Rating Scale, School Child, Scoring System, Social Behaviour, Social Interactions, Social Problem, Social Responsiveness Scale, Surveys, Swanson Nolan and Pelham IV Assessment, Synaptosomal Associated Protein 23, Taiwan}, pubstate = {published}, tppubtype = {article} } This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T PLoS ONE, 14 (3), 2019, ISSN: 19326203, (cited By 4). Abstract | Links | BibTeX | Tags: Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting @article{Pichitpunpong2019, title = {Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment}, author = {C Pichitpunpong and S Thongkorn and S Kanlayaprasit and W Yuwattana and W Plaingam and S Sangsuthum and W M Aizat and S N Baharum and T Tencomnao and V W Hu and T Sarachana}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371%2fjournal.pone.0214198&partnerID=40&md5=0a4c25481edee56984a59de94fedc414}, doi = {10.1371/journal.pone.0214198}, issn = {19326203}, year = {2019}, date = {2019-01-01}, journal = {PLoS ONE}, volume = {14}, number = {3}, publisher = {Public Library of Science}, abstract = {Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.}, note = {cited By 4}, keywords = {Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting}, pubstate = {published}, tppubtype = {article} } Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Mohamad, F H; Has, A T C The α5-Containing GABA A Receptors—a Brief Summary Journal Article Journal of Molecular Neuroscience, 67 (2), pp. 343-351, 2019, ISSN: 08958696, (cited By 1). Abstract | Links | BibTeX | Tags: 4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Animals, Autism, Brain, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetics, Human, Metabolism, Nonhuman, Protein Subunit, Protein Subunits, Receptors, Review, Schizophrenia, Unclassified Drug @article{Mohamad2019343, title = {The α5-Containing GABA A Receptors—a Brief Summary}, author = {F H Mohamad and A T C Has}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059596842&doi=10.1007%2fs12031-018-1246-4&partnerID=40&md5=7b2ba0dc86c6c3f890f226cad8195ee5}, doi = {10.1007/s12031-018-1246-4}, issn = {08958696}, year = {2019}, date = {2019-01-01}, journal = {Journal of Molecular Neuroscience}, volume = {67}, number = {2}, pages = {343-351}, publisher = {Springer New York LLC}, abstract = {GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Down syndrome, and autism with a possible alternative benzodiazepine binding site. Therefore, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.}, note = {cited By 1}, keywords = {4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Animals, Autism, Brain, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetics, Human, Metabolism, Nonhuman, Protein Subunit, Protein Subunits, Receptors, Review, Schizophrenia, Unclassified Drug}, pubstate = {published}, tppubtype = {article} } GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Down syndrome, and autism with a possible alternative benzodiazepine binding site. Therefore, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, Z Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Journal Article Developmental Medicine and Child Neurology, 61 (2), pp. 135-144, 2019, ISSN: 00121622, (cited By 1). Abstract | Links | BibTeX | Tags: Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability @article{Jaafar2019135, title = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review}, author = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&partnerID=40&md5=d02a2bfcd15a25988b9c23855cd87444}, doi = {10.1111/dmcn.13986}, issn = {00121622}, year = {2019}, date = {2019-01-01}, journal = {Developmental Medicine and Child Neurology}, volume = {61}, number = {2}, pages = {135-144}, publisher = {Blackwell Publishing Ltd}, abstract = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Method: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Results: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, and (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press}, note = {cited By 1}, keywords = {Assessment of Humans, Autism, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Child Behaviour, Child Parent Relation, Childhood Disease, Children, Children's Eating Behaviour Inventory, Complication, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Eating Disorder, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Feeding Behavior, Feeding Difficulty, Food Intake, Human, Nervous System Diseases, Neurologic Disease, Nutritional Assessment, Parents, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Psychometrics, Psychometry, Quality of Life, Receiver Operating Characteristic, Review, Scoring System, Self Disclosure, Sensitivity and Specificity, Syndrome CHARGE, Systematic Review, Test Retest Reliability}, pubstate = {published}, tppubtype = {article} } Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Method: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Results: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, and (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press |
Nor, N K; Ghozali, A H; Ismail, J Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors Journal Article Frontiers in Pediatrics, 7 (FEB), 2019, ISSN: 22962360, (cited By 5). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight @article{Nor2019, title = {Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors}, author = {N K Nor and A H Ghozali and J Ismail}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064414280&doi=10.3389%2ffped.2019.00038&partnerID=40&md5=4bb61b1df043a4adf79618e223d77f26}, doi = {10.3389/fped.2019.00038}, issn = {22962360}, year = {2019}, date = {2019-01-01}, journal = {Frontiers in Pediatrics}, volume = {7}, number = {FEB}, publisher = {Frontiers Media S.A.}, abstract = {Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.}, note = {cited By 5}, keywords = {Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight}, pubstate = {published}, tppubtype = {article} } Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail. |
Khan, N A; Soopramanien, M; Siddiqui, R Crocodiles and alligators: Physicians’ answer to cancer? Journal Article Current Oncology, 26 (3), pp. 186, 2019, ISSN: 11980052, (cited By 1). Links | BibTeX | Tags: Allergic Disease, Alligators and Crocodiles, Animal Product, Animals, Antineoplastic Activity, Antineoplastic Agent, Article, Atopic Dermatitis, Autism, Cancer Growth, Cancer Therapy, Carcinogen, Contaminated Organism, Crocodilian, End Cretaceous Mass Extinction, Environmental Factor, Environmental Stress, Gastrointestinal Microbiome, Health Behaviour, Heavy Metal, Human, Immune System, Inflammatory Bowel Disease, Intestine Flora, Longevity, Metabolic Disorder, Microbiology, Neoplasm, Neoplasms, Nerve Cell Differentiation, Physician, Schizophrenia, Survival Analysis, Terminal Disease @article{Khan2019186, title = {Crocodiles and alligators: Physicians’ answer to cancer?}, author = {N A Khan and M Soopramanien and R Siddiqui}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069313377&doi=10.3747%2fco.26.4855&partnerID=40&md5=6a266208d5fe14a1c888bb1db397d744}, doi = {10.3747/co.26.4855}, issn = {11980052}, year = {2019}, date = {2019-01-01}, journal = {Current Oncology}, volume = {26}, number = {3}, pages = {186}, publisher = {Multimed Inc.}, note = {cited By 1}, keywords = {Allergic Disease, Alligators and Crocodiles, Animal Product, Animals, Antineoplastic Activity, Antineoplastic Agent, Article, Atopic Dermatitis, Autism, Cancer Growth, Cancer Therapy, Carcinogen, Contaminated Organism, Crocodilian, End Cretaceous Mass Extinction, Environmental Factor, Environmental Stress, Gastrointestinal Microbiome, Health Behaviour, Heavy Metal, Human, Immune System, Inflammatory Bowel Disease, Intestine Flora, Longevity, Metabolic Disorder, Microbiology, Neoplasm, Neoplasms, Nerve Cell Differentiation, Physician, Schizophrenia, Survival Analysis, Terminal Disease}, pubstate = {published}, tppubtype = {article} } |
2018 |
Al-Hiyali, M I; Ishak, A J; Harun, H; Ahmad, S A; Sulaiman, Wan W A A review in modification food-intake behavior by brain stimulation: Excess weight cases Journal Article NeuroQuantology, 16 (12), pp. 86-97, 2018, ISSN: 13035150, (cited By 2). Abstract | Links | BibTeX | Tags: Amygdala, Anoxia, Article, Autism, Binge Eating Disorder, Body Mass, Body Weight, Brain Depth Stimulation, Depolarization, Dietary Intake, Drug Craving, Eating Disorder, Electric Current, Electroencephalogram, Electroencephalography, Energy Consumption, Energy Expenditure, Feeding Behavior, Food Intake, Functional Magnetic Resonance Imaging, Gender, Health Status, Homeostasis, Human, Hunger, Lifestyle, Nerve Cell Membrane Steady Potential, Nerve Excitability, Neurofeedback, Neuromodulation, Nutritional Assessment, Outcome Assessment, Questionnaires, Repetitive Transcranial Magnetic Stimulation, Signal Processing, Training, Transcranial Direct Current Stimulation, Transcranial Magnetic Stimulation, Underweight @article{Al-Hiyali201886, title = {A review in modification food-intake behavior by brain stimulation: Excess weight cases}, author = {M I Al-Hiyali and A J Ishak and H Harun and S A Ahmad and W A Wan Sulaiman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062843670&doi=10.14704%2fnq.2018.16.12.1894&partnerID=40&md5=235f66cef05a144be23472641f70bd1d}, doi = {10.14704/nq.2018.16.12.1894}, issn = {13035150}, year = {2018}, date = {2018-01-01}, journal = {NeuroQuantology}, volume = {16}, number = {12}, pages = {86-97}, publisher = {Anka Publishers}, abstract = {Obesity and overweight are frequently prescribed for dysfunction in food-intake behavior. Due to the widely prevalence of obesity in last year’s, there is demand for more studies which are aimed to modify the food-intake behavior. For the past decades many researches has applied in modify food-intake by brain training or stimulation. This review for neuroscience studies in modifying food-intake behavior, it’s involved three sections; The first section explained the role of brain activity in food-intake regulation, general ideas about biomedical devices in food-intake behavior are discussed in second section and third section focused on brain-stimulation systems. Finally, this paper concluded with main points that need to be taken into account when designing experimental study for modification food-intake behavior by brain stimulation according to previous studies recommendation and challenges. © 2018, Anka Publishers. All Rights Reserved.}, note = {cited By 2}, keywords = {Amygdala, Anoxia, Article, Autism, Binge Eating Disorder, Body Mass, Body Weight, Brain Depth Stimulation, Depolarization, Dietary Intake, Drug Craving, Eating Disorder, Electric Current, Electroencephalogram, Electroencephalography, Energy Consumption, Energy Expenditure, Feeding Behavior, Food Intake, Functional Magnetic Resonance Imaging, Gender, Health Status, Homeostasis, Human, Hunger, Lifestyle, Nerve Cell Membrane Steady Potential, Nerve Excitability, Neurofeedback, Neuromodulation, Nutritional Assessment, Outcome Assessment, Questionnaires, Repetitive Transcranial Magnetic Stimulation, Signal Processing, Training, Transcranial Direct Current Stimulation, Transcranial Magnetic Stimulation, Underweight}, pubstate = {published}, tppubtype = {article} } Obesity and overweight are frequently prescribed for dysfunction in food-intake behavior. Due to the widely prevalence of obesity in last year’s, there is demand for more studies which are aimed to modify the food-intake behavior. For the past decades many researches has applied in modify food-intake by brain training or stimulation. This review for neuroscience studies in modifying food-intake behavior, it’s involved three sections; The first section explained the role of brain activity in food-intake regulation, general ideas about biomedical devices in food-intake behavior are discussed in second section and third section focused on brain-stimulation systems. Finally, this paper concluded with main points that need to be taken into account when designing experimental study for modification food-intake behavior by brain stimulation according to previous studies recommendation and challenges. © 2018, Anka Publishers. All Rights Reserved. |
Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N GRIN2D variants in three cases of developmental and epileptic encephalopathy Journal Article Clinical Genetics, 94 (6), pp. 538-547, 2018, ISSN: 00099163, (cited By 4). Abstract | Links | BibTeX | Tags: Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing @article{Tsuchida2018538, title = {GRIN2D variants in three cases of developmental and epileptic encephalopathy}, author = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&partnerID=40&md5=f0d32670db57261820bc244943cffd62}, doi = {10.1111/cge.13454}, issn = {00099163}, year = {2018}, date = {2018-01-01}, journal = {Clinical Genetics}, volume = {94}, number = {6}, pages = {538-547}, publisher = {Blackwell Publishing Ltd}, abstract = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd}, note = {cited By 4}, keywords = {Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing}, pubstate = {published}, tppubtype = {article} } N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Arifin, W N International Journal of Environmental Research and Public Health, 15 (11), 2018, ISSN: 16617827, (cited By 2). Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia @article{Adib2018, title = {Translation and validation of the malay version of the parents’ satisfaction scale (Pss-m) for assessment of caregivers’ satisfaction with health care services for children with autism spectrum disorder}, author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N Arifin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056090545&doi=10.3390%2fijerph15112455&partnerID=40&md5=53650806d46343cc3e95c9b30442f79c}, doi = {10.3390/ijerph15112455}, issn = {16617827}, year = {2018}, date = {2018-01-01}, journal = {International Journal of Environmental Research and Public Health}, volume = {15}, number = {11}, publisher = {MDPI AG}, abstract = {Background: A Malay version of Parent Satisfaction Scale (PSS-M) is needed to investigate the factors contributing to the Malay caregivers’ satisfaction with health care management for children with autism spectrum disorder (ASD). The aim of the study is to translate and validate the questionnaire to assess the caregivers’ satisfaction on health care services. Methods: A cross-sectional study was conducted among 110 caregivers of children with ASD aged between 2 and 17 years old that received treatment at two tertiary care centres in Kelantan. Permission to use the original version of the PSS questionnaire was obtained. The original English version of the PSS was translated into a Malay version following the 10 steps proposed by an established guideline. Pre-testing of the PSS was carried out with 30 caregivers before confirmatory factor analysis (CFA) was established using 110 caregivers. They were asked to assess their understanding of the questionnaire. The one-dimensional questionnaire consists of 11 items, including staff attitudes, availability of staff, supportiveness, and helpfulness. The 5-point Likert scale provided ratings from 1 (strongly disagree) to 5 (strongly agree). Confirmatory factor analysis was performed using a robust maximum likelihood estimator. Results: The analysis showed model fit data with good reliability. Conclusion: The PSS-M shows overall model fitness based on specific indices, with good construct validity and excellent absolute reliability to determine the satisfaction level of caregivers of children with ASD with respect to health care services. © 2018, MDPI AG. All rights reserved.}, note = {cited By 2}, keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Child Parent Relation, Children, Cross-Sectional Study, Factor Analysis, Female, Guideline, Health Personnel Attitude, Health Service, Health Worker, Human, Kelantan, Likelihood Functions, Likert Scale, Malaysia, Male, Maximum Likelihood Analysis, Mental Health, Mental Health Service, Parents, Parents Satisfaction Scale Malay Version, Personal Satisfaction, Practice Guideline, Psychological Rating Scale, Psychology, Publication, Questionnaires, Reproducibility, Reproducibility of Results, Satisfaction, Statistical Model, Statistics, Surveys, Tertiary Care Center, Translations, Validation Study, West Malaysia}, pubstate = {published}, tppubtype = {article} } Background: A Malay version of Parent Satisfaction Scale (PSS-M) is needed to investigate the factors contributing to the Malay caregivers’ satisfaction with health care management for children with autism spectrum disorder (ASD). The aim of the study is to translate and validate the questionnaire to assess the caregivers’ satisfaction on health care services. Methods: A cross-sectional study was conducted among 110 caregivers of children with ASD aged between 2 and 17 years old that received treatment at two tertiary care centres in Kelantan. Permission to use the original version of the PSS questionnaire was obtained. The original English version of the PSS was translated into a Malay version following the 10 steps proposed by an established guideline. Pre-testing of the PSS was carried out with 30 caregivers before confirmatory factor analysis (CFA) was established using 110 caregivers. They were asked to assess their understanding of the questionnaire. The one-dimensional questionnaire consists of 11 items, including staff attitudes, availability of staff, supportiveness, and helpfulness. The 5-point Likert scale provided ratings from 1 (strongly disagree) to 5 (strongly agree). Confirmatory factor analysis was performed using a robust maximum likelihood estimator. Results: The analysis showed model fit data with good reliability. Conclusion: The PSS-M shows overall model fitness based on specific indices, with good construct validity and excellent absolute reliability to determine the satisfaction level of caregivers of children with ASD with respect to health care services. © 2018, MDPI AG. All rights reserved. |
Paudel, Y N; Shaikh, M F; Shah, S; Kumari, Y; Othman, I Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy Journal Article European Journal of Pharmacology, 837 , pp. 145-155, 2018, ISSN: 00142999, (cited By 14). Abstract | Links | BibTeX | Tags: 3 Dioxygenase, Acetylsalicylic Acid, Adalimumab, Anakinra, Animals, Anti-Inflammatory Agents, Anxiety, Autacoid, Autism, Autism Spectrum Disorders, Behaviour Disorder, Belnacasan, Celecoxib, Cognition, Comorbidity, Complication, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitor, Cytokine, Cytokines, Depression, Dexmedetomidine, Disease Association, Dopaminergic Transmission, Electroencephalogram, Electroencephalography, Epilepsy, Epileptogenesis, Esculetin, High Mobility Group B1 Protein, Human, Ibuprofen, Icariin, IImmunoglobulin Enhancer Binding Protein, Immunology, Indoleamine 2, Inflammation, Inflammation Mediators, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Nerve Cell Plasticity, Nervous System Development, Nervous System Inflammation, Neuroendocrine Regulation, Neurotransmitter Release, Nonhuman, Palmidrol, Paracetamol, Physiology, Priority Journal, Prostaglandin E2, Psychology, Review, SC 51089, Schizophrenia, Toll-Like Receptor 4, Transforming Growth Factor Beta, Tryptophan Hydroxylase, Tumor Necrosis Factor, Unclassified Drug @article{Paudel2018145, title = {Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy}, author = {Y N Paudel and M F Shaikh and S Shah and Y Kumari and I Othman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053082063&doi=10.1016%2fj.ejphar.2018.08.020&partnerID=40&md5=27ff0199bae72f156425637a7ad02228}, doi = {10.1016/j.ejphar.2018.08.020}, issn = {00142999}, year = {2018}, date = {2018-01-01}, journal = {European Journal of Pharmacology}, volume = {837}, pages = {145-155}, publisher = {Elsevier B.V.}, abstract = {Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover, the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities. The neurobehavioral comorbidities discussed herein share a reciprocal and complex relationship with epilepsy, which ultimately complicates the treatment process in PWE. Understanding the mechanistic pathway by which these comorbidities are associated with epilepsy might be instrumental in developing therapeutic interventions. Inflammatory cytokine signaling in the brain regulates important brain functions including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, dopaminergic transmission, the kynurenine pathway, and affects neurogenesis as well as the neural circuitry of moods. In this review, we hypothesize that the complex relationship between epilepsy and its related comorbidities (cognitive impairment, depression, anxiety, autism, and schizophrenia) can be unraveled through the inflammatory mechanism that plays a prominent role in all these individual conditions. An ample amount of evidence is available reporting the role of inflammation in epilepsy and all individual comorbid condition but their complex relationship with epilepsy has not yet been explored through the prospective of inflammatory pathway. Our review suggests that epilepsy and its neurobehavioral comorbidities are associated with elevated levels of several key inflammatory markers. This review also sheds light on the mechanistic association between epilepsy and its neurobehavioral comorbidities. Moreover, we analyzed several anti-inflammatory therapies available for epilepsy and its neurobehavioral comorbidities. We suggest, these anti-inflammatory therapies might be a possible intervention and could be a promising strategy for preventing epileptogenesis and its related neurobehavioral comorbidities. © 2018 Elsevier B.V.}, note = {cited By 14}, keywords = {3 Dioxygenase, Acetylsalicylic Acid, Adalimumab, Anakinra, Animals, Anti-Inflammatory Agents, Anxiety, Autacoid, Autism, Autism Spectrum Disorders, Behaviour Disorder, Belnacasan, Celecoxib, Cognition, Comorbidity, Complication, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitor, Cytokine, Cytokines, Depression, Dexmedetomidine, Disease Association, Dopaminergic Transmission, Electroencephalogram, Electroencephalography, Epilepsy, Epileptogenesis, Esculetin, High Mobility Group B1 Protein, Human, Ibuprofen, Icariin, IImmunoglobulin Enhancer Binding Protein, Immunology, Indoleamine 2, Inflammation, Inflammation Mediators, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Nerve Cell Plasticity, Nervous System Development, Nervous System Inflammation, Neuroendocrine Regulation, Neurotransmitter Release, Nonhuman, Palmidrol, Paracetamol, Physiology, Priority Journal, Prostaglandin E2, Psychology, Review, SC 51089, Schizophrenia, Toll-Like Receptor 4, Transforming Growth Factor Beta, Tryptophan Hydroxylase, Tumor Necrosis Factor, Unclassified Drug}, pubstate = {published}, tppubtype = {article} } Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover, the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities. The neurobehavioral comorbidities discussed herein share a reciprocal and complex relationship with epilepsy, which ultimately complicates the treatment process in PWE. Understanding the mechanistic pathway by which these comorbidities are associated with epilepsy might be instrumental in developing therapeutic interventions. Inflammatory cytokine signaling in the brain regulates important brain functions including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, dopaminergic transmission, the kynurenine pathway, and affects neurogenesis as well as the neural circuitry of moods. In this review, we hypothesize that the complex relationship between epilepsy and its related comorbidities (cognitive impairment, depression, anxiety, autism, and schizophrenia) can be unraveled through the inflammatory mechanism that plays a prominent role in all these individual conditions. An ample amount of evidence is available reporting the role of inflammation in epilepsy and all individual comorbid condition but their complex relationship with epilepsy has not yet been explored through the prospective of inflammatory pathway. Our review suggests that epilepsy and its neurobehavioral comorbidities are associated with elevated levels of several key inflammatory markers. This review also sheds light on the mechanistic association between epilepsy and its neurobehavioral comorbidities. Moreover, we analyzed several anti-inflammatory therapies available for epilepsy and its neurobehavioral comorbidities. We suggest, these anti-inflammatory therapies might be a possible intervention and could be a promising strategy for preventing epileptogenesis and its related neurobehavioral comorbidities. © 2018 Elsevier B.V. |
Kho, Z Y; Lal, S K The human gut microbiome - A potential controller of wellness and disease Journal Article Frontiers in Microbiology, 9 (AUG), 2018, ISSN: 1664302X, (cited By 80). Abstract | Links | BibTeX | Tags: Acetylcholine, Autism, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Human, Hydrocortisone, Immunity, Immunoglobulin A, Inflammatory Bowel Disease, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Intestine Flora, Leptin, Membrane Protein, Metabolism, Metabolite, Nervous System, Nonhuman, Obesity, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Protein Expression, Protein ZO1, Review, RNA 16S, Toll-Like Receptor 4, Transcription Factor FOXP3, Tumor Necrosis Factor, Unclassified Drug, Unindexed Drug, Uvomorulin, Vasculotropin @article{Kho2018, title = {The human gut microbiome - A potential controller of wellness and disease}, author = {Z Y Kho and S K Lal}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051459505&doi=10.3389%2ffmicb.2018.01835&partnerID=40&md5=d89097ac9c0963d8ef7666aa99cff46f}, doi = {10.3389/fmicb.2018.01835}, issn = {1664302X}, year = {2018}, date = {2018-01-01}, journal = {Frontiers in Microbiology}, volume = {9}, number = {AUG}, publisher = {Frontiers Media S.A.}, abstract = {Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. In this review, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal.}, note = {cited By 80}, keywords = {Acetylcholine, Autism, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Human, Hydrocortisone, Immunity, Immunoglobulin A, Inflammatory Bowel Disease, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Intestine Flora, Leptin, Membrane Protein, Metabolism, Metabolite, Nervous System, Nonhuman, Obesity, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Protein Expression, Protein ZO1, Review, RNA 16S, Toll-Like Receptor 4, Transcription Factor FOXP3, Tumor Necrosis Factor, Unclassified Drug, Unindexed Drug, Uvomorulin, Vasculotropin}, pubstate = {published}, tppubtype = {article} } Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. In this review, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal. |
Low, H M; Zailan, F Medical students’ perceptions, awareness, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia Journal Article International Journal of Developmental Disabilities, 64 (2), pp. 86-95, 2018, ISSN: 20473869, (cited By 1). Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Awareness, Behaviour, Exploratory Research, Female, Human, Knowledge, Malaysia, Male, Medical Student, Student Attitude, Students, Symptom @article{Low201886, title = {Medical students’ perceptions, awareness, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia}, author = {H M Low and F Zailan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002273499&doi=10.1080%2f20473869.2016.1264663&partnerID=40&md5=4b1b16448e16172b2dce10eacf1c3f3d}, doi = {10.1080/20473869.2016.1264663}, issn = {20473869}, year = {2018}, date = {2018-01-01}, journal = {International Journal of Developmental Disabilities}, volume = {64}, number = {2}, pages = {86-95}, publisher = {Taylor and Francis Ltd.}, abstract = {Objectives: This study aimed to investigate the perception, awareness, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Methods: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, awareness, societal attitude, and their recognition of ASD symptoms. Results: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Specifically, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Conclusion: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016.}, note = {cited By 1}, keywords = {Adult, Article, Autism, Awareness, Behaviour, Exploratory Research, Female, Human, Knowledge, Malaysia, Male, Medical Student, Student Attitude, Students, Symptom}, pubstate = {published}, tppubtype = {article} } Objectives: This study aimed to investigate the perception, awareness, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Methods: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, awareness, societal attitude, and their recognition of ASD symptoms. Results: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Specifically, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Conclusion: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016. |
Hariharan, M; Sindhu, R; Vijean, V; Yazid, H; Nadarajaw, T; Yaacob, S; Polat, K Improved binary dragonfly optimization algorithm and wavelet packet based non-linear features for infant cry classification Journal Article Computer Methods and Programs in Biomedicine, 155 , pp. 39-51, 2018, ISSN: 01692607, (cited By 21). Abstract | Links | BibTeX | Tags: Accidents, Algorithms, Article, Artificial Neural Network, Asphyxia, Binary Dragonfly Optimization Aalgorithm, Classification (of information), Classification Algorithm, Classifier, Coding, Computer-Assisted, Constants and Coefficients, Crying, Database Systems, Databases, Deafness, Diagnosis, Energy, Entropy, Extraction, Extreme Learning Machine, Factual, Factual Database, Feature Extraction, Feature Selection Methods, Fuzzy System, Hearing Impairment, Human, Hunger, Infant, Infant Cry, Infant Cry Classifications, Jaundice, Kernel Method, Learning, Linear Predictive Coding, Machine Learning, Mathematical Transformations, Mel Frequency Cepstral Coefficient, Mel Frequency Cepstral Coefficients, Multi-Class Classification, Neural Networks, Nonlinear Dynamics, Nonlinear System, Optimization, Pain, Pathophysiology, Prematurity, Reproducibility, Reproducibility of Results, Signal Processing, Speech Recognition, Wavelet Analysis, Wavelet Packet, Wavelet Packet Transforms @article{Hariharan201839, title = {Improved binary dragonfly optimization algorithm and wavelet packet based non-linear features for infant cry classification}, author = {M Hariharan and R Sindhu and V Vijean and H Yazid and T Nadarajaw and S Yaacob and K Polat}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85036611215&doi=10.1016%2fj.cmpb.2017.11.021&partnerID=40&md5=1f3b17817b00f07cadad6eb61c0f4bf9}, doi = {10.1016/j.cmpb.2017.11.021}, issn = {01692607}, year = {2018}, date = {2018-01-01}, journal = {Computer Methods and Programs in Biomedicine}, volume = {155}, pages = {39-51}, publisher = {Elsevier Ireland Ltd}, abstract = {Background and objective Infant cry signal carries several levels of information about the reason for crying (hunger, pain, sleepiness and discomfort) or the pathological status (asphyxia, deaf, jaundice, premature condition and autism, etc.) of an infant and therefore suited for early diagnosis. In this work, combination of wavelet packet based features and Improved Binary Dragonfly Optimization based feature selection method was proposed to classify the different types of infant cry signals. Methods Cry signals from 2 different databases were utilized. First database contains 507 cry samples of normal (N), 340 cry samples of asphyxia (A), 879 cry samples of deaf (D), 350 cry samples of hungry (H) and 192 cry samples of pain (P). Second database contains 513 cry samples of jaundice (J), 531 samples of premature (Prem) and 45 samples of normal (N). Wavelet packet transform based energy and non-linear entropies (496 features), Linear Predictive Coding (LPC) based cepstral features (56 features), Mel-frequency Cepstral Coefficients (MFCCs) were extracted (16 features). The combined feature set consists of 568 features. To overcome the curse of dimensionality issue, improved binary dragonfly optimization algorithm (IBDFO) was proposed to select the most salient attributes or features. Finally, Extreme Learning Machine (ELM) kernel classifier was used to classify the different types of infant cry signals using all the features and highly informative features as well. Results Several experiments of two-class and multi-class classification of cry signals were conducted. In binary or two-class experiments, maximum accuracy of 90.18% for H Vs P, 100% for A Vs N, 100% for D Vs N and 97.61% J Vs Prem was achieved using the features selected (only 204 features out of 568) by IBDFO. For the classification of multiple cry signals (multi-class problem), the selected features could differentiate between three classes (N, A & D) with the accuracy of 100% and seven classes with the accuracy of 97.62%. Conclusion The experimental results indicated that the proposed combination of feature extraction and selection method offers suitable classification accuracy and may be employed to detect the subtle changes in the cry signals. © 2017 Elsevier B.V.}, note = {cited By 21}, keywords = {Accidents, Algorithms, Article, Artificial Neural Network, Asphyxia, Binary Dragonfly Optimization Aalgorithm, Classification (of information), Classification Algorithm, Classifier, Coding, Computer-Assisted, Constants and Coefficients, Crying, Database Systems, Databases, Deafness, Diagnosis, Energy, Entropy, Extraction, Extreme Learning Machine, Factual, Factual Database, Feature Extraction, Feature Selection Methods, Fuzzy System, Hearing Impairment, Human, Hunger, Infant, Infant Cry, Infant Cry Classifications, Jaundice, Kernel Method, Learning, Linear Predictive Coding, Machine Learning, Mathematical Transformations, Mel Frequency Cepstral Coefficient, Mel Frequency Cepstral Coefficients, Multi-Class Classification, Neural Networks, Nonlinear Dynamics, Nonlinear System, Optimization, Pain, Pathophysiology, Prematurity, Reproducibility, Reproducibility of Results, Signal Processing, Speech Recognition, Wavelet Analysis, Wavelet Packet, Wavelet Packet Transforms}, pubstate = {published}, tppubtype = {article} } Background and objective Infant cry signal carries several levels of information about the reason for crying (hunger, pain, sleepiness and discomfort) or the pathological status (asphyxia, deaf, jaundice, premature condition and autism, etc.) of an infant and therefore suited for early diagnosis. In this work, combination of wavelet packet based features and Improved Binary Dragonfly Optimization based feature selection method was proposed to classify the different types of infant cry signals. Methods Cry signals from 2 different databases were utilized. First database contains 507 cry samples of normal (N), 340 cry samples of asphyxia (A), 879 cry samples of deaf (D), 350 cry samples of hungry (H) and 192 cry samples of pain (P). Second database contains 513 cry samples of jaundice (J), 531 samples of premature (Prem) and 45 samples of normal (N). Wavelet packet transform based energy and non-linear entropies (496 features), Linear Predictive Coding (LPC) based cepstral features (56 features), Mel-frequency Cepstral Coefficients (MFCCs) were extracted (16 features). The combined feature set consists of 568 features. To overcome the curse of dimensionality issue, improved binary dragonfly optimization algorithm (IBDFO) was proposed to select the most salient attributes or features. Finally, Extreme Learning Machine (ELM) kernel classifier was used to classify the different types of infant cry signals using all the features and highly informative features as well. Results Several experiments of two-class and multi-class classification of cry signals were conducted. In binary or two-class experiments, maximum accuracy of 90.18% for H Vs P, 100% for A Vs N, 100% for D Vs N and 97.61% J Vs Prem was achieved using the features selected (only 204 features out of 568) by IBDFO. For the classification of multiple cry signals (multi-class problem), the selected features could differentiate between three classes (N, A & D) with the accuracy of 100% and seven classes with the accuracy of 97.62%. Conclusion The experimental results indicated that the proposed combination of feature extraction and selection method offers suitable classification accuracy and may be employed to detect the subtle changes in the cry signals. © 2017 Elsevier B.V. |
Masiran, R Stimming behaviour in a 4-year-old girl with autism spectrum disorder Journal Article BMJ Case Reports, 2018 , 2018, ISSN: 1757790X, (cited By 0). Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Biscuit, Biting Hard Object, Case Report, Chew Toy, Child Safety, Children, Clinical Article, Female, Food, Food Texture, Hot Food, Human, Language Disability, Note, Preschool, Preschool Child, Priority Journal, Psychology, Self Stimulation, Spicy Food, Stereotyped Behaviour, Stereotypy, Stimming Behaviour, Teething Biscuit, Vegetable @article{Masiran2018, title = {Stimming behaviour in a 4-year-old girl with autism spectrum disorder}, author = {R Masiran}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042604824&doi=10.1136%2fbcr-2017-223671&partnerID=40&md5=c7b6514a4758257be1360250bf120de3}, doi = {10.1136/bcr-2017-223671}, issn = {1757790X}, year = {2018}, date = {2018-01-01}, journal = {BMJ Case Reports}, volume = {2018}, publisher = {BMJ Publishing Group}, note = {cited By 0}, keywords = {Autism, Autism Spectrum Disorders, Biscuit, Biting Hard Object, Case Report, Chew Toy, Child Safety, Children, Clinical Article, Female, Food, Food Texture, Hot Food, Human, Language Disability, Note, Preschool, Preschool Child, Priority Journal, Psychology, Self Stimulation, Spicy Food, Stereotyped Behaviour, Stereotypy, Stimming Behaviour, Teething Biscuit, Vegetable}, pubstate = {published}, tppubtype = {article} } |
Toh, T -H; Tan, V W -Y; Lau, P S -T; Kiyu, A Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9). Abstract | Links | BibTeX | Tags: Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler @article{Toh201828, title = {Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics}, author = {T -H Toh and V W -Y Tan and P S -T Lau and A Kiyu}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028764085&doi=10.1007%2fs10803-017-3287-x&partnerID=40&md5=21bce2407197b8b1e43b4420d274861b}, doi = {10.1007/s10803-017-3287-x}, issn = {01623257}, year = {2018}, date = {2018-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {48}, number = {1}, pages = {28-35}, publisher = {Springer New York LLC}, abstract = {This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC.}, note = {cited By 9}, keywords = {Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler}, pubstate = {published}, tppubtype = {article} } This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC. |
Nor, Md Z; Isa, Md Z; Yusof, S N; Ghazi, H F; Jaafar, M H The development and validation of questionnaire on autism spectrum disorders and its association with plastic-based food contact materials Journal Article Journal of Nepal Paediatric Society, 38 (3), pp. 182-189, 2018, ISSN: 19907974, (cited By 0). Abstract | Links | BibTeX | Tags: 4' Isopropylidenediphenol, Article, Autism, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Environmental Factor, Exploratory Factor Analysis, Food Packaging, Human, Internal Consistency, Phthalic Acid, Plastic, Process Development, Questionnaires, Test Retest Reliability, Validation Process @article{MdNor2018182, title = {The development and validation of questionnaire on autism spectrum disorders and its association with plastic-based food contact materials}, author = {Z Md Nor and Z Md Isa and S N Yusof and H F Ghazi and M H Jaafar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083863826&doi=10.3126%2fjnps.v38i3.20671&partnerID=40&md5=13ffb01477ac798ebd7d430305d0a73a}, doi = {10.3126/jnps.v38i3.20671}, issn = {19907974}, year = {2018}, date = {2018-01-01}, journal = {Journal of Nepal Paediatric Society}, volume = {38}, number = {3}, pages = {182-189}, publisher = {Nepal Paediatric Society (NEPAS)}, abstract = {Introduction: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic-based food contact materials (FCM) as a proxy for exposure to this group of EDCs. Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done. Results: The questionnaire achieved kappa value ranged between 0.800 to 0.900 for knowledge, 0.610 to 0.815 for perception and 0.607 to 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 to 0.780. Conclusions: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items. © 2020, Nepal Paediatric Society (NEPAS). All rights reserved.}, note = {cited By 0}, keywords = {4' Isopropylidenediphenol, Article, Autism, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Environmental Factor, Exploratory Factor Analysis, Food Packaging, Human, Internal Consistency, Phthalic Acid, Plastic, Process Development, Questionnaires, Test Retest Reliability, Validation Process}, pubstate = {published}, tppubtype = {article} } Introduction: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic-based food contact materials (FCM) as a proxy for exposure to this group of EDCs. Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done. Results: The questionnaire achieved kappa value ranged between 0.800 to 0.900 for knowledge, 0.610 to 0.815 for perception and 0.607 to 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 to 0.780. Conclusions: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items. © 2020, Nepal Paediatric Society (NEPAS). All rights reserved. |
Masiran, R Autism and trichotillomania in an adolescent boy Journal Article BMJ Case Reports, 2018 , 2018, ISSN: 1757790X, (cited By 0). Abstract | Links | BibTeX | Tags: Adolescent, Alopecia, Anxiety, Article, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Autism, Autism Spectrum Disorders, Behaviour Disorder, Body Mass, Case Report, Central Nervous System Stimulants, Child Behaviour Checklist, Clinical Article, Comorbidity, Complication, Diagnosis, Differential, Differential Diagnosis, Drug Dose Titration, Drug Tolerance, DSM-5, Echolalia, Fluvoxamine, Follow Up, Human, Hyperactivity, Intellectual Impairment, Male, Methylphenidate, Obesity, Occupational Therapy, Perceptual Reasoning Index, Priority Journal, Processing Speed Index, Psychiatric Status Rating Scales, Psychological Rating Scale, Rating Scale, Restlessness, Reward, Serotonin Uptake Inhibitor, Serotonin Uptake Inhibitors, Special Education, Speech Delay, Speech Disorder, Speech Therapy, Trichotillomania, Verbal Comprehension Index, Wechsler Intelligence Scale, Working Memory Index @article{Masiran2018b, title = {Autism and trichotillomania in an adolescent boy}, author = {R Masiran}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053164449&doi=10.1136%2fbcr-2018-226270&partnerID=40&md5=7eed3f6af717df527dce73838feab571}, doi = {10.1136/bcr-2018-226270}, issn = {1757790X}, year = {2018}, date = {2018-01-01}, journal = {BMJ Case Reports}, volume = {2018}, publisher = {BMJ Publishing Group}, abstract = {An adolescent with autism spectrum disorder and improperly treated attention deficit hyperactivity disorder presented with recurrent hair pulling. Treatment with selective serotonin reuptake inhibitor and stimulant improved these conditions. © © BMJ Publishing Group Limited 2018.}, note = {cited By 0}, keywords = {Adolescent, Alopecia, Anxiety, Article, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Autism, Autism Spectrum Disorders, Behaviour Disorder, Body Mass, Case Report, Central Nervous System Stimulants, Child Behaviour Checklist, Clinical Article, Comorbidity, Complication, Diagnosis, Differential, Differential Diagnosis, Drug Dose Titration, Drug Tolerance, DSM-5, Echolalia, Fluvoxamine, Follow Up, Human, Hyperactivity, Intellectual Impairment, Male, Methylphenidate, Obesity, Occupational Therapy, Perceptual Reasoning Index, Priority Journal, Processing Speed Index, Psychiatric Status Rating Scales, Psychological Rating Scale, Rating Scale, Restlessness, Reward, Serotonin Uptake Inhibitor, Serotonin Uptake Inhibitors, Special Education, Speech Delay, Speech Disorder, Speech Therapy, Trichotillomania, Verbal Comprehension Index, Wechsler Intelligence Scale, Working Memory Index}, pubstate = {published}, tppubtype = {article} } An adolescent with autism spectrum disorder and improperly treated attention deficit hyperactivity disorder presented with recurrent hair pulling. Treatment with selective serotonin reuptake inhibitor and stimulant improved these conditions. © © BMJ Publishing Group Limited 2018. |
Thu, Ei H; Hussain, Z; Shuid, A N Current Drug Targets, 19 (8), pp. 865-876, 2018, ISSN: 13894501, (cited By 2). Abstract | Links | BibTeX | Tags: Amisulpride, Amitriptyline, Animals, Antipsychotic Agents, Anxiety, Aripiprazole, Autism, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Chemistry, Clonazepam, Clozapine, Depression, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Health Care, Human, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Mental Disorders, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Pathophysiology, Permeability, Physical Chemistry, Psychosis, Review, Risperidone, Schizophrenia, Solubility, Sulpiride, Treatment Outcome, Venlafaxine, Ziprasidone @article{EiThu2018865, title = {New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects}, author = {H Ei Thu and Z Hussain and A N Shuid}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048981535&doi=10.2174%2f1389450117666161125174625&partnerID=40&md5=d32e5bc9766ff9d68dd79f082b9ca4bc}, doi = {10.2174/1389450117666161125174625}, issn = {13894501}, year = {2018}, date = {2018-01-01}, journal = {Current Drug Targets}, volume = {19}, number = {8}, pages = {865-876}, publisher = {Bentham Science Publishers B.V.}, abstract = {Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. To date, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, anxiety, bipolar disorders and autism spectrum problems. However, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Therefore, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers.}, note = {cited By 2}, keywords = {Amisulpride, Amitriptyline, Animals, Antipsychotic Agents, Anxiety, Aripiprazole, Autism, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Chemistry, Clonazepam, Clozapine, Depression, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Health Care, Human, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Mental Disorders, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Pathophysiology, Permeability, Physical Chemistry, Psychosis, Review, Risperidone, Schizophrenia, Solubility, Sulpiride, Treatment Outcome, Venlafaxine, Ziprasidone}, pubstate = {published}, tppubtype = {article} } Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. To date, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, anxiety, bipolar disorders and autism spectrum problems. However, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Therefore, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers. |
2017 |
Hnoonual, A; Thammachote, W; Tim-Aroon, T; Rojnueangnit, K; Hansakunachai, T; Sombuntham, T; Roongpraiwan, R; Worachotekamjorn, J; Chuthapisith, J; Fucharoen, S; Wattanasirichaigoon, D; Ruangdaraganon, N; Limprasert, P; Jinawath, N Scientific Reports, 7 (1), 2017, ISSN: 20452322, (cited By 6). Abstract | Links | BibTeX | Tags: Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism @article{Hnoonual2017, title = {Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder}, author = {A Hnoonual and W Thammachote and T Tim-Aroon and K Rojnueangnit and T Hansakunachai and T Sombuntham and R Roongpraiwan and J Worachotekamjorn and J Chuthapisith and S Fucharoen and D Wattanasirichaigoon and N Ruangdaraganon and P Limprasert and N Jinawath}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029864969&doi=10.1038%2fs41598-017-12317-3&partnerID=40&md5=3c1b6a0c064665aab8ace8e8f58c2b01}, doi = {10.1038/s41598-017-12317-3}, issn = {20452322}, year = {2017}, date = {2017-01-01}, journal = {Scientific Reports}, volume = {7}, number = {1}, publisher = {Nature Publishing Group}, abstract = {Chromosomal microarray (CMA) is now recognized as the first-tier genetic test for detection of copy number variations (CNVs) in patients with autism spectrum disorder (ASD). The aims of this study were to identify known and novel ASD associated-CNVs and to evaluate the diagnostic yield of CMA in Thai patients with ASD. The Infinium CytoSNP-850K BeadChip was used to detect CNVs in 114 Thai patients comprised of 68 retrospective ASD patients (group 1) with the use of CMA as a second line test and 46 prospective ASD and developmental delay patients (group 2) with the use of CMA as the first-tier test. We identified 7 (6.1%) pathogenic CNVs and 22 (19.3%) variants of uncertain clinical significance (VOUS). A total of 29 patients with pathogenic CNVs and VOUS were found in 22% (15/68) and 30.4% (14/46) of the patients in groups 1 and 2, respectively. The difference in detected CNV frequencies between the 2 groups was not statistically significant (Chi square = 1.02}, note = {cited By 6}, keywords = {Adolescent, Autism, Autism Spectrum Disorders, Children, Chromosomal Mapping, Chromosome Mapping, Cohort Analysis, Cohort Studies, Copy Number Variation, DNA Copy Number Variations, Female, Genetic Predisposition, Genetic Predisposition to Disease, Genetics, Human, Infant, Male, Membrane Protein, Membrane Proteins, Microarray Analysis, Polymorphism, Preschool, Preschool Child, Procedures, SERINC2 Protein, Single Nucleotide, Single Nucleotide Polymorphism}, pubstate = {published}, tppubtype = {article} } Chromosomal microarray (CMA) is now recognized as the first-tier genetic test for detection of copy number variations (CNVs) in patients with autism spectrum disorder (ASD). The aims of this study were to identify known and novel ASD associated-CNVs and to evaluate the diagnostic yield of CMA in Thai patients with ASD. The Infinium CytoSNP-850K BeadChip was used to detect CNVs in 114 Thai patients comprised of 68 retrospective ASD patients (group 1) with the use of CMA as a second line test and 46 prospective ASD and developmental delay patients (group 2) with the use of CMA as the first-tier test. We identified 7 (6.1%) pathogenic CNVs and 22 (19.3%) variants of uncertain clinical significance (VOUS). A total of 29 patients with pathogenic CNVs and VOUS were found in 22% (15/68) and 30.4% (14/46) of the patients in groups 1 and 2, respectively. The difference in detected CNV frequencies between the 2 groups was not statistically significant (Chi square = 1.02 |
Hameed, S S; Hassan, R; Muhammad, F F Selection and classification of gene expression in autism disorder: Use of a combination of statistical filters and a GBPSO-SVM algorithm Journal Article PLoS ONE, 12 (11), 2017, ISSN: 19326203, (cited By 11). Abstract | Links | BibTeX | Tags: Accuracy, Algorithms, Article, Autism, Autism Spectrum Disorders, CAPS2 Gene, Classification (of information), Classifier, Experimental Study, Gene, Gene Expression, Gene Identification, Genetic Association, Genetic Procedures, Genetic Risk, Genetics, Geometric Binary Particle Swarm Optimization Support Vector Machine Algorithm, Human, RIsk Assessment, Standardization, Statistical Filter, Statistical Parameters, Statistics, Support Vector Machines @article{Hameed2017, title = {Selection and classification of gene expression in autism disorder: Use of a combination of statistical filters and a GBPSO-SVM algorithm}, author = {S S Hameed and R Hassan and F F Muhammad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033361187&doi=10.1371%2fjournal.pone.0187371&partnerID=40&md5=f9260d41165145f229a3cf157699635e}, doi = {10.1371/journal.pone.0187371}, issn = {19326203}, year = {2017}, date = {2017-01-01}, journal = {PLoS ONE}, volume = {12}, number = {11}, publisher = {Public Library of Science}, abstract = {In this work, gene expression in autism spectrum disorder (ASD) is analyzed with the goal of selecting the most attributed genes and performing classification. The objective was achieved by utilizing a combination of various statistical filters and a wrapper-based geometric binary particle swarm optimization-support vector machine (GBPSO-SVM) algorithm. The utilization of different filters was accentuated by incorporating a mean and median ratio criterion to remove very similar genes. The results showed that the most discriminative genes that were identified in the first and last selection steps included the presence of a repetitive gene (CAPS2), which was assigned as the gene most highly related to ASD risk. The merged gene subset that was selected by the GBPSO-SVM algorithm was able to enhance the classification accuracy. © 2017 Hameed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.}, note = {cited By 11}, keywords = {Accuracy, Algorithms, Article, Autism, Autism Spectrum Disorders, CAPS2 Gene, Classification (of information), Classifier, Experimental Study, Gene, Gene Expression, Gene Identification, Genetic Association, Genetic Procedures, Genetic Risk, Genetics, Geometric Binary Particle Swarm Optimization Support Vector Machine Algorithm, Human, RIsk Assessment, Standardization, Statistical Filter, Statistical Parameters, Statistics, Support Vector Machines}, pubstate = {published}, tppubtype = {article} } In this work, gene expression in autism spectrum disorder (ASD) is analyzed with the goal of selecting the most attributed genes and performing classification. The objective was achieved by utilizing a combination of various statistical filters and a wrapper-based geometric binary particle swarm optimization-support vector machine (GBPSO-SVM) algorithm. The utilization of different filters was accentuated by incorporating a mean and median ratio criterion to remove very similar genes. The results showed that the most discriminative genes that were identified in the first and last selection steps included the presence of a repetitive gene (CAPS2), which was assigned as the gene most highly related to ASD risk. The merged gene subset that was selected by the GBPSO-SVM algorithm was able to enhance the classification accuracy. © 2017 Hameed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Wo, S W; Ong, L C; Low, W Y; Lai, P S M The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review Journal Article Epilepsy Research, 136 , pp. 35-45, 2017, ISSN: 09201211, (cited By 8). Abstract | Links | BibTeX | Tags: Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement @article{Wo201735, title = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review}, author = {S W Wo and L C Ong and W Y Low and P S M Lai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&partnerID=40&md5=f34a0aada2cc5dc6e4d6beab18ac779c}, doi = {10.1016/j.eplepsyres.2017.07.009}, issn = {09201211}, year = {2017}, date = {2017-01-01}, journal = {Epilepsy Research}, volume = {136}, pages = {35-45}, publisher = {Elsevier B.V.}, abstract = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.}, note = {cited By 8}, keywords = {Academic Achievement, Academic Success, Achievement, Attitude to Health, Autism, Benign Childhood Epilepsy, Children, Children with Epilepsy, Cohort Analysis, Comorbidity, Cross-Sectional Study, English (Language), Epilepsy, Human, Intellectual Impairment, Intelligence, Intelligence Quotient, Learning Disorder, Observational Study, Parenting Education, Priority Journal, Psychology, Recurrent Disease, Recurrent Epilepsy, Review, Scoring System, Systematic Review, Underachievement}, pubstate = {published}, tppubtype = {article} } Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) of normal intelligence, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, intellectual disabilities (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V. |
Hasan, C Z C; Jailani, R; Tahir, Md N; Ilias, S The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders Journal Article Research in Developmental Disabilities, 66 , pp. 55-63, 2017, ISSN: 08914222, (cited By 8). Abstract | Links | BibTeX | Tags: Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking @article{Hasan201755, title = {The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders}, author = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi=10.1016%2fj.ridd.2017.02.015&partnerID=40&md5=d6a9839cda7f62bcce9bdcca33d3d33b}, doi = {10.1016/j.ridd.2017.02.015}, issn = {08914222}, year = {2017}, date = {2017-01-01}, journal = {Research in Developmental Disabilities}, volume = {66}, pages = {55-63}, publisher = {Elsevier Inc.}, abstract = {Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd}, note = {cited By 8}, keywords = {Age Distribution, Article, Autism, Autism Spectrum Disorders, Biomechanical Phenomena, Biomechanics, Body Equilibrium, Body Height, Body Mass, Body Weight, Children, Clinical Article, Controlled Study, Disease Assessment, Female, Gait, Gait Analysis, Gait Disorder, Ground Reaction Forces, Human, Imaging, Leg Length, Malaysia, Male, Neurologic Examination, Pathophysiology, Physiology, Postural Balance, Procedures, Psychology, Statistics, Three-Dimensional, Three-Dimensional Imaging, Three-Dimentional Ground Reaction Force, Walking}, pubstate = {published}, tppubtype = {article} } Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd |
Singh, Joginder S; Hussein, N H; Kamal, Mustaffa R; Hassan, F H Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Journal Article AAC: Augmentative and Alternative Communication, 33 (2), pp. 110-120, 2017, ISSN: 07434618, (cited By 10). Abstract | Links | BibTeX | Tags: Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research @article{JoginderSingh2017110, title = {Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC}, author = {S Joginder Singh and N H Hussein and R Mustaffa Kamal and F H Hassan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131769&doi=10.1080%2f07434618.2017.1309457&partnerID=40&md5=067c39e0c318e76caff96b29bb4dbb21}, doi = {10.1080/07434618.2017.1309457}, issn = {07434618}, year = {2017}, date = {2017-01-01}, journal = {AAC: Augmentative and Alternative Communication}, volume = {33}, number = {2}, pages = {110-120}, publisher = {Taylor and Francis Ltd}, abstract = {Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. To date, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. For this study, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, and (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication.}, note = {cited By 10}, keywords = {Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research}, pubstate = {published}, tppubtype = {article} } Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. To date, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. For this study, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, and (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication. |
Shuib, S; Saaid, N N; Zakaria, Z; Ismail, J; Latiff, Abdul Z Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay Journal Article Malaysian Journal of Pathology, 39 (1), pp. 77-81, 2017, ISSN: 01268635, (cited By 0). Abstract | Links | BibTeX | Tags: Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry @article{Shuib201777, title = {Duplication 17p11.2 (Potocki-Lupski syndrome) in a child with developmental delay}, author = {S Shuib and N N Saaid and Z Zakaria and J Ismail and Z Abdul Latiff}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037028880&partnerID=40&md5=624b87d1e9ebac2d1bf66b4d30c0f6e9}, issn = {01268635}, year = {2017}, date = {2017-01-01}, journal = {Malaysian Journal of Pathology}, volume = {39}, number = {1}, pages = {77-81}, publisher = {Malaysian Society of Pathologists}, abstract = {Potocki-Lupski syndrome (PTLS), also known as duplication 17p11.2 syndrome, trisomy 17p11.2 or dup(17)(p11.2p11.2) syndrome, is a developmental disorder and a rare contiguous gene syndrome affecting 1 in 20,000 live births. Among the key features of such patients are autism spectrum disorder, learning disabilities, developmental delay, attention-deficit disorder, infantile hypotonia and cardiovascular abnormalities. Previous studies using microarray identified variations in the size and extent of the duplicated region of chromosome 17p11.2. However, there are a few genes which are considered as candidates for PTLS which include RAI1, SREBF1, DRG2, LLGL1, SHMT1 and ZFP179. In this report, we investigated a case of a 3-year-old girl who has developmental delay. Her chromosome analysis showed a normal karyotype (46,XX). Analysis using array CGH (4X44 K, Agilent USA) identified an ~4.2 Mb de novo duplication in chromosome 17p11.2. The result was confirmed by fluorescence in situ hybridization (FISH) using probes in the critical PTLS region. This report demonstrates the importance of microarray and FISH in the diagnosis of PTLS. © 2017, Malaysian Society of Pathologists. All rights reserved.}, note = {cited By 0}, keywords = {Abnormalities, Agarose, Article, Autism, Autism Spectrum Disorders, Blood Culture, Case Report, Children, Chromosome 17, Chromosome Analysis, Chromosome Disorder, Chromosome Duplication, Chromosomes, Clinical Article, Comparative Genomic Hybridization, Developmental Delay, Electrophoresis, Female, Fluorescence, Fluorescence in Situ Hybridization, Gene, Gene Identification, Genetics, Genomic DNA, Human, In Situ Hybridization, Lymphocyte Culture, Microarray Analysis, Multiple, Multiple Malformation Syndrome, Pair 17, Phenotype, Potocki Lupski Syndrome, Preschool, Preschool Child, Procedures, RAI1 Gene, Ultraviolet Spectrophotometry}, pubstate = {published}, tppubtype = {article} } Potocki-Lupski syndrome (PTLS), also known as duplication 17p11.2 syndrome, trisomy 17p11.2 or dup(17)(p11.2p11.2) syndrome, is a developmental disorder and a rare contiguous gene syndrome affecting 1 in 20,000 live births. Among the key features of such patients are autism spectrum disorder, learning disabilities, developmental delay, attention-deficit disorder, infantile hypotonia and cardiovascular abnormalities. Previous studies using microarray identified variations in the size and extent of the duplicated region of chromosome 17p11.2. However, there are a few genes which are considered as candidates for PTLS which include RAI1, SREBF1, DRG2, LLGL1, SHMT1 and ZFP179. In this report, we investigated a case of a 3-year-old girl who has developmental delay. Her chromosome analysis showed a normal karyotype (46,XX). Analysis using array CGH (4X44 K, Agilent USA) identified an ~4.2 Mb de novo duplication in chromosome 17p11.2. The result was confirmed by fluorescence in situ hybridization (FISH) using probes in the critical PTLS region. This report demonstrates the importance of microarray and FISH in the diagnosis of PTLS. © 2017, Malaysian Society of Pathologists. All rights reserved. |
Bhagat, V; Haque, M; Simbak, N B; Husain, R Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education Journal Article Journal of Global Pharma Technology, 9 (7), pp. 32-43, 2017, ISSN: 09758542, (cited By 0). Abstract | Links | BibTeX | Tags: Adaptive Behavior, Amygdala, Autism, Awareness, Cognition, Comorbidity, Conceptual Framework, Cost Benefit Analysis, Education, Emotion, Emotional Disorder, Emotionality, Health Care, Health Promotion, Human, Impulsiveness, Learning, Motivation, Parent Education, Perception, Practice Guideline, Prefrontal Cortex, Prevalence, Problem Behavior, Psychoeducation, Psychological Well Being, Review, Sex Difference, Social Behaviour, Social Cognition, Social Competence, Social Learning @article{Bhagat201732, title = {Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education}, author = {V Bhagat and M Haque and N B Simbak and R Husain}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021786235&partnerID=40&md5=ece2d7c28018f0c4526810e08e314461}, issn = {09758542}, year = {2017}, date = {2017-01-01}, journal = {Journal of Global Pharma Technology}, volume = {9}, number = {7}, pages = {32-43}, publisher = {Journal of Global Pharma Technology}, abstract = {Autism spectrum disorders (ASD) may affect all spheres of a child's life. One of the areas of the behavioral spectrum need to be focused is affected. Thus, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Thus, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT.}, note = {cited By 0}, keywords = {Adaptive Behavior, Amygdala, Autism, Awareness, Cognition, Comorbidity, Conceptual Framework, Cost Benefit Analysis, Education, Emotion, Emotional Disorder, Emotionality, Health Care, Health Promotion, Human, Impulsiveness, Learning, Motivation, Parent Education, Perception, Practice Guideline, Prefrontal Cortex, Prevalence, Problem Behavior, Psychoeducation, Psychological Well Being, Review, Sex Difference, Social Behaviour, Social Cognition, Social Competence, Social Learning}, pubstate = {published}, tppubtype = {article} } Autism spectrum disorders (ASD) may affect all spheres of a child's life. One of the areas of the behavioral spectrum need to be focused is affected. Thus, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Thus, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT. |
Hasan, C Z C; Jailani, R; Tahir, Md N Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder Journal Article International Journal of Biology and Biomedical Engineering, 11 , pp. 74-79, 2017, ISSN: 19984510, (cited By 1). Abstract | Links | BibTeX | Tags: Article, Artificial Neural Network, Autism, Body Height, Body Mass, Children, Clinical Article, Controlled Study, Discriminant Analysis, Early Diagnosis, Female, Gait, Gait Analysis, Gait Disorder, Human, Learning, Male, Pediatrics, School Child, Statistical Analysis, Statistics, Time Series Analysis @article{Hasan201774, title = {Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder}, author = {C Z C Hasan and R Jailani and N Md Tahir}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043500605&partnerID=40&md5=6f2ffe7c2f5daf9fd02d4456acb94438}, issn = {19984510}, year = {2017}, date = {2017-01-01}, journal = {International Journal of Biology and Biomedical Engineering}, volume = {11}, pages = {74-79}, publisher = {North Atlantic University Union NAUN}, abstract = {Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% accuracy, 93.3% sensitivity, and 90.0% specificity. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. All Rights Reserved.}, note = {cited By 1}, keywords = {Article, Artificial Neural Network, Autism, Body Height, Body Mass, Children, Clinical Article, Controlled Study, Discriminant Analysis, Early Diagnosis, Female, Gait, Gait Analysis, Gait Disorder, Human, Learning, Male, Pediatrics, School Child, Statistical Analysis, Statistics, Time Series Analysis}, pubstate = {published}, tppubtype = {article} } Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% accuracy, 93.3% sensitivity, and 90.0% specificity. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. All Rights Reserved. |
Hakim, N H A; Majlis, B Y; Suzuki, H; Tsukahara, T Neuron-specific splicing Journal Article BioScience Trends, 11 (1), pp. 16-22, 2017, ISSN: 18817815, (cited By 0). Abstract | Links | BibTeX | Tags: Alternative RNA Splicing, Alternative Splicing, Animals, Antibody Specificity, Biological, Biological Model, Diseases, Genetics, Human, Metabolism, Models, Nerve Cell, Neurons, Organ Specificity, RNA Splicing @article{Hakim201716, title = {Neuron-specific splicing}, author = {N H A Hakim and B Y Majlis and H Suzuki and T Tsukahara}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014435502&doi=10.5582%2fbst.2016.01169&partnerID=40&md5=8a5044dbf3b905fc2553520a048bcd59}, doi = {10.5582/bst.2016.01169}, issn = {18817815}, year = {2017}, date = {2017-01-01}, journal = {BioScience Trends}, volume = {11}, number = {1}, pages = {16-22}, publisher = {International Advancement Center for Medicine and Health Research Co., Ltd.}, abstract = {During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.}, note = {cited By 0}, keywords = {Alternative RNA Splicing, Alternative Splicing, Animals, Antibody Specificity, Biological, Biological Model, Diseases, Genetics, Human, Metabolism, Models, Nerve Cell, Neurons, Organ Specificity, RNA Splicing}, pubstate = {published}, tppubtype = {article} } During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated. |
Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Vos, T; Daoud, F; Wang, H; Bcheraoui, C E; Khalil, I; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Ali, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Ali, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, I A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Defo, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, O A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, A K; Mitchell, P B; Patton, G; Sagar, R; Satpathy, M; Savuon, K; Seedat, S; Shiue, I; Skogen, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H The burden of mental disorders in the eastern mediterranean region, 1990-2013 Journal Article PLoS ONE, 12 (1), 2017, ISSN: 19326203, (cited By 30). Abstract | Links | BibTeX | Tags: 80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult @article{Charara2017, title = {The burden of mental disorders in the eastern mediterranean region, 1990-2013}, author = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371%2fjournal.pone.0169575&partnerID=40&md5=471830ec1239e37c6fc4681bed5698f6}, doi = {10.1371/journal.pone.0169575}, issn = {19326203}, year = {2017}, date = {2017-01-01}, journal = {PLoS ONE}, volume = {12}, number = {1}, publisher = {Public Library of Science}, abstract = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.}, note = {cited By 30}, keywords = {80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult}, pubstate = {published}, tppubtype = {article} } The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
2016 |
Tan, M L; Ho, J J; Teh, K H Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders Journal Article Cochrane Database of Systematic Reviews, 2016 (9), 2016, ISSN: 1469493X, (cited By 6). Abstract | Links | BibTeX | Tags: Attention Deficit Disorder, Autism, Carnosine, Children, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Human, Learning Disorder, Meta Analysis, Outcome Assessment, Placebo, Polyunsaturated Fatty Acid, Priority Journal, Randomized Controlled Trial, Review, Systematic Review @article{Tan2016, title = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders}, author = {M L Tan and J J Ho and K H Teh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988922340&doi=10.1002%2f14651858.CD009398.pub3&partnerID=40&md5=3460f403b8829b4692a0b6f795f4a2a3}, doi = {10.1002/14651858.CD009398.pub3}, issn = {1469493X}, year = {2016}, date = {2016-01-01}, journal = {Cochrane Database of Systematic Reviews}, volume = {2016}, number = {9}, publisher = {John Wiley and Sons Ltd}, abstract = {Background: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objectives: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 children, mainly boys between 10 and 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. In addition, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, writing, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 to 8.15; two studies, 116 children). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.}, note = {cited By 6}, keywords = {Attention Deficit Disorder, Autism, Carnosine, Children, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Human, Learning Disorder, Meta Analysis, Outcome Assessment, Placebo, Polyunsaturated Fatty Acid, Priority Journal, Randomized Controlled Trial, Review, Systematic Review}, pubstate = {published}, tppubtype = {article} } Background: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objectives: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 children, mainly boys between 10 and 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. In addition, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, writing, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 to 8.15; two studies, 116 children). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration. |
Ooi, K L; Ong, Y S; Jacob, S A; Khan, T M A meta-synthesis on parenting a child with autism Journal Article Neuropsychiatric Disease and Treatment, 12 , pp. 745-762, 2016, ISSN: 11766328, (cited By 44). Abstract | Links | BibTeX | Tags: Adaptation, Article, Attitude to Health, Attitude to Mental Illness, Autism, Child Care, Child Parent Relation, Childhood, Family, Family Centered Care, Health Care, Health Care Delivery, Health Education, Human, Parental Attitude, Parental Stress, Quality of Life, Social Aspect, Systematic Review, Wellbeing @article{Ooi2016745, title = {A meta-synthesis on parenting a child with autism}, author = {K L Ooi and Y S Ong and S A Jacob and T M Khan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962625349&doi=10.2147%2fNDT.S100634&partnerID=40&md5=48b432dc361f8f3c373ed3b481e01e4c}, doi = {10.2147/NDT.S100634}, issn = {11766328}, year = {2016}, date = {2016-01-01}, journal = {Neuropsychiatric Disease and Treatment}, volume = {12}, pages = {745-762}, publisher = {Dove Medical Press Ltd.}, abstract = {Background: The lifelong nature of autism in a child has deep implications on parents as they are faced with a range of challenges and emotional consequences in raising the child. The aim of this meta-synthesis was to explore the perspectives of parents in raising a child with autism in the childhood period to gain an insight of the adaptations and beliefs of parents toward autism, their family and social experiences, as well as their perceptions toward health and educational services. Methods: A systematic search of six databases (PubMed, EMBASE, PsychInfo, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects [DARE]) was conducted from inception up to September 30, 2014. Full-text English articles of qualitative studies describing parents’ perceptions relating to the care of children younger than 12 years of age and diagnosed with a sole disorder of autism were included. Results: A total of 50 eligible articles were appraised and analyzed, identifying four core themes encompassing all thoughts, emotions, and experiences commonly expressed by parents: 1) The Parent, 2) Impact on the Family, 3) Social Impact, and 4) Health and Educational Services. Findings revealed that parents who have a child with autism experienced multiple challenges in different aspects of care, impacting on parents’ stress and adaptation. Conclusion: Health care provision should be family centered, addressing and supporting the needs of the whole family and not just the affected child, to ensure the family’s well-being and quality of life in the face of a diagnosis of autism. © 2016 Ooi et al.}, note = {cited By 44}, keywords = {Adaptation, Article, Attitude to Health, Attitude to Mental Illness, Autism, Child Care, Child Parent Relation, Childhood, Family, Family Centered Care, Health Care, Health Care Delivery, Health Education, Human, Parental Attitude, Parental Stress, Quality of Life, Social Aspect, Systematic Review, Wellbeing}, pubstate = {published}, tppubtype = {article} } Background: The lifelong nature of autism in a child has deep implications on parents as they are faced with a range of challenges and emotional consequences in raising the child. The aim of this meta-synthesis was to explore the perspectives of parents in raising a child with autism in the childhood period to gain an insight of the adaptations and beliefs of parents toward autism, their family and social experiences, as well as their perceptions toward health and educational services. Methods: A systematic search of six databases (PubMed, EMBASE, PsychInfo, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects [DARE]) was conducted from inception up to September 30, 2014. Full-text English articles of qualitative studies describing parents’ perceptions relating to the care of children younger than 12 years of age and diagnosed with a sole disorder of autism were included. Results: A total of 50 eligible articles were appraised and analyzed, identifying four core themes encompassing all thoughts, emotions, and experiences commonly expressed by parents: 1) The Parent, 2) Impact on the Family, 3) Social Impact, and 4) Health and Educational Services. Findings revealed that parents who have a child with autism experienced multiple challenges in different aspects of care, impacting on parents’ stress and adaptation. Conclusion: Health care provision should be family centered, addressing and supporting the needs of the whole family and not just the affected child, to ensure the family’s well-being and quality of life in the face of a diagnosis of autism. © 2016 Ooi et al. |
Sheppard, E; Pillai, D; Wong, G T -L; Ropar, D; Mitchell, P How Easy is it to Read the Minds of People with Autism Spectrum Disorder? Journal Article Journal of Autism and Developmental Disorders, 46 (4), pp. 1247-1254, 2016, ISSN: 01623257, (cited By 37). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Decision Making, Emotion, Facial Expression, Female, Human, Male, Mental Health, Nonverbal Communication, Pathophysiology, Priority Journal, Psychology, Video Recording, Young Adult @article{Sheppard20161247, title = {How Easy is it to Read the Minds of People with Autism Spectrum Disorder?}, author = {E Sheppard and D Pillai and G T -L Wong and D Ropar and P Mitchell}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961215349&doi=10.1007%2fs10803-015-2662-8&partnerID=40&md5=d39b6bdebe3c2f33e304eb4d4c09b6fd}, doi = {10.1007/s10803-015-2662-8}, issn = {01623257}, year = {2016}, date = {2016-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {46}, number = {4}, pages = {1247-1254}, publisher = {Springer New York LLC}, abstract = {How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science+Business Media New York.}, note = {cited By 37}, keywords = {Adolescent, Adult, Article, Autism, Autism Spectrum Disorders, Decision Making, Emotion, Facial Expression, Female, Human, Male, Mental Health, Nonverbal Communication, Pathophysiology, Priority Journal, Psychology, Video Recording, Young Adult}, pubstate = {published}, tppubtype = {article} } How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science+Business Media New York. |
Bhagat, V; Mat, Khairi Che H J; Husain, R; Haque, M International Journal of Pharmaceutical Sciences Review and Research, 36 (1), pp. 54-62, 2016, ISSN: 0976044X, (cited By 0). Abstract | Links | BibTeX | Tags: Autism, Children, Disease Severity, Emotion, Emotionality, Evidence-based Practice, Human, Human Relation, Intervention Study, Negative Emotionality, Parent Counseling, Parental Attitude, Parenting Education, Personality Assessment, Review, Social Status, Stress @article{Bhagat201654, title = {Parent’s negative emotionality impacting parenting and involvement in the intervention of their child with autism spectrum disorder: A review proposed the new model for intervention}, author = {V Bhagat and H J Khairi Che Mat and R Husain and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957597820&partnerID=40&md5=40212e84a1b6be6ade2617d5c9df29a9}, issn = {0976044X}, year = {2016}, date = {2016-01-01}, journal = {International Journal of Pharmaceutical Sciences Review and Research}, volume = {36}, number = {1}, pages = {54-62}, publisher = {Global Research Online}, abstract = {Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Indeed, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Indeed, their negative emotions disturb their focus on the treatment of their ASD child. Thus, the management of ASD child incapacitates their parents to bring out the best. Therefore, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. However, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. All rights reserved.}, note = {cited By 0}, keywords = {Autism, Children, Disease Severity, Emotion, Emotionality, Evidence-based Practice, Human, Human Relation, Intervention Study, Negative Emotionality, Parent Counseling, Parental Attitude, Parenting Education, Personality Assessment, Review, Social Status, Stress}, pubstate = {published}, tppubtype = {article} } Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Indeed, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Indeed, their negative emotions disturb their focus on the treatment of their ASD child. Thus, the management of ASD child incapacitates their parents to bring out the best. Therefore, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. However, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. All rights reserved. |
2015 |
Banire, B; Jomhari, N; Ahmad, R Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism Journal Article Journal of Autism and Developmental Disorders, 45 (10), pp. 3069-3084, 2015, ISSN: 01623257, (cited By 7). Abstract | Links | BibTeX | Tags: Article, Attention, Autism, Autism Spectrum Disorders, Children, Computer Interface, Education, Education of Intellectually Disabled, Educational Model, Feedback System, Female, Human, Learning, Male, Models, Occupational Therapist, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Quality of Life, Treatment Duration, User Interfaces, Visual Hybrid Development Learning System, Visual Stimulation @article{Banire20153069, title = {Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism}, author = {B Banire and N Jomhari and R Ahmad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941942795&doi=10.1007%2fs10803-015-2469-7&partnerID=40&md5=3c5ecc776725aea4e585e17a1ae805c7}, doi = {10.1007/s10803-015-2469-7}, issn = {01623257}, year = {2015}, date = {2015-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {45}, number = {10}, pages = {3069-3084}, publisher = {Springer New York LLC}, abstract = {The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. In this study, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science+Business Media New York.}, note = {cited By 7}, keywords = {Article, Attention, Autism, Autism Spectrum Disorders, Children, Computer Interface, Education, Education of Intellectually Disabled, Educational Model, Feedback System, Female, Human, Learning, Male, Models, Occupational Therapist, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Quality of Life, Treatment Duration, User Interfaces, Visual Hybrid Development Learning System, Visual Stimulation}, pubstate = {published}, tppubtype = {article} } The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. In this study, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science+Business Media New York. |
Bhagat, V; Simbak, Bin N; Haque, M Journal of Young Pharmacists, 7 (4), pp. 403-414, 2015, ISSN: 09751483, (cited By 0). Abstract | Links | BibTeX | Tags: Autism, Coping Behaviour, Decision Making, Disease Severity, Economic Aspect, Emotion, Emotionality, Experience, Human, Human Relation, Intervention Study, Parental Attitude, Parental Stress, Priority Journal, Psychological Well Being, Review, Satisfaction, Social Behaviour, Strategic Planning @article{Bhagat2015403, title = {The peripheral focus on the psychological parameters of parents of autistic children in the intervention methods: A review and recommending the strategy, focusing psychological parameters of parents of autistic children in intervention methods}, author = {V Bhagat and N Bin Simbak and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959853109&doi=10.5530%2fjyp.2015.4s.1&partnerID=40&md5=ed5b5faede6650d1249a902d7201ed43}, doi = {10.5530/jyp.2015.4s.1}, issn = {09751483}, year = {2015}, date = {2015-01-01}, journal = {Journal of Young Pharmacists}, volume = {7}, number = {4}, pages = {403-414}, publisher = {EManuscript Services}, abstract = {The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Indeed, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Thus, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Thus, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them.}, note = {cited By 0}, keywords = {Autism, Coping Behaviour, Decision Making, Disease Severity, Economic Aspect, Emotion, Emotionality, Experience, Human, Human Relation, Intervention Study, Parental Attitude, Parental Stress, Priority Journal, Psychological Well Being, Review, Satisfaction, Social Behaviour, Strategic Planning}, pubstate = {published}, tppubtype = {article} } The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Indeed, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Thus, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Thus, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them. |
Khowaja, K; Salim, S S Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD) Journal Article PLoS ONE, 10 (7), 2015, ISSN: 19326203, (cited By 12). Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Bibliographic Database, Children, Computer Interface, Computer Program, Controlled Study, Evaluation Study, Female, Heuristics, Human, Information System, Interactive System, Interrater Reliability, Male, Practice Guideline, Questionnaires, Software, Surveys @article{Khowaja2015, title = {Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD)}, author = {K Khowaja and S S Salim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941313427&doi=10.1371%2fjournal.pone.0132187&partnerID=40&md5=60f3ee4a32fd71be4b842755a58527cf}, doi = {10.1371/journal.pone.0132187}, issn = {19326203}, year = {2015}, date = {2015-01-01}, journal = {PLoS ONE}, volume = {10}, number = {7}, publisher = {Public Library of Science}, abstract = {In this paper, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim.}, note = {cited By 12}, keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Bibliographic Database, Children, Computer Interface, Computer Program, Controlled Study, Evaluation Study, Female, Heuristics, Human, Information System, Interactive System, Interrater Reliability, Male, Practice Guideline, Questionnaires, Software, Surveys}, pubstate = {published}, tppubtype = {article} } In this paper, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim. |
Roffeei, Mohd S H; Abdullah, N; Basar, S K R Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs) Journal Article International Journal of Medical Informatics, 84 (5), pp. 375-385, 2015, ISSN: 13865056, (cited By 43). Abstract | Links | BibTeX | Tags: Article, ASD, Autism, Autism Spectrum Disorders, Caregiver, Children, Consumer Health Information, Content Analysis, Diseases, E-mail, Facebook, Family, Friendship, Human, Internet, Parents, Patient Referral, Priority Journal, Psychology, Qualitative Analysis, Self Esteem, Social Media, Social Networking, Social Support, Statistics, Support Group, Telemedicine, Utilization @article{MohdRoffeei2015375, title = {Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs)}, author = {S H Mohd Roffeei and N Abdullah and S K R Basar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924517643&doi=10.1016%2fj.ijmedinf.2015.01.015&partnerID=40&md5=7296825093cbf87388b5b65023e59371}, doi = {10.1016/j.ijmedinf.2015.01.015}, issn = {13865056}, year = {2015}, date = {2015-01-01}, journal = {International Journal of Medical Informatics}, volume = {84}, number = {5}, pages = {375-385}, publisher = {Elsevier Ireland Ltd}, abstract = {Purpose: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (AM) and Autism Children Club (ACA). Method: A total of 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% and 20.2%, respectively. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Conclusion: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd.}, note = {cited By 43}, keywords = {Article, ASD, Autism, Autism Spectrum Disorders, Caregiver, Children, Consumer Health Information, Content Analysis, Diseases, E-mail, Facebook, Family, Friendship, Human, Internet, Parents, Patient Referral, Priority Journal, Psychology, Qualitative Analysis, Self Esteem, Social Media, Social Networking, Social Support, Statistics, Support Group, Telemedicine, Utilization}, pubstate = {published}, tppubtype = {article} } Purpose: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (AM) and Autism Children Club (ACA). Method: A total of 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% and 20.2%, respectively. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Conclusion: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd. |
Alwi, N; Harun, D; Jh, L Multidisciplinary Parent Education for Caregivers of Children With Autism Spectrum Disorders (ASD): Implications for Clinical Practice Journal Article Archives of Psychiatric Nursing, 29 (1), pp. 5, 2015, ISSN: 08839417, (cited By 0). Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Caregiver, Child Development Disorders, Children, Human, Parents, Pervasive @article{Alwi20155, title = {Multidisciplinary Parent Education for Caregivers of Children With Autism Spectrum Disorders (ASD): Implications for Clinical Practice}, author = {N Alwi and D Harun and L Jh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921463937&doi=10.1016%2fj.apnu.2014.09.010&partnerID=40&md5=afc618a09a89f9461c587ab56a96559a}, doi = {10.1016/j.apnu.2014.09.010}, issn = {08839417}, year = {2015}, date = {2015-01-01}, journal = {Archives of Psychiatric Nursing}, volume = {29}, number = {1}, pages = {5}, publisher = {W.B. Saunders}, note = {cited By 0}, keywords = {Autism, Autism Spectrum Disorders, Caregiver, Child Development Disorders, Children, Human, Parents, Pervasive}, pubstate = {published}, tppubtype = {article} } |
Alwi, N; Harun, D; Leonard, J H Clinical application of sensory integration therapy for children with autism Journal Article Egyptian Journal of Medical Human Genetics, 16 (4), pp. 393-394, 2015, ISSN: 11108630, (cited By 1). Links | BibTeX | Tags: Autism, Disease Severity, Groups by Age, Human, Letter, Motor Performance, Outcome Assessment, Sensorimotor Integration, Therapy, Therapy Effect, Treatment Indication, Treatment Response @article{Alwi2015393, title = {Clinical application of sensory integration therapy for children with autism}, author = {N Alwi and D Harun and J H Leonard}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940898525&doi=10.1016%2fj.ejmhg.2015.05.009&partnerID=40&md5=5548f0db22520a480f09da9aaf4c872e}, doi = {10.1016/j.ejmhg.2015.05.009}, issn = {11108630}, year = {2015}, date = {2015-01-01}, journal = {Egyptian Journal of Medical Human Genetics}, volume = {16}, number = {4}, pages = {393-394}, publisher = {Egyptian Society of Human Genetics}, note = {cited By 1}, keywords = {Autism, Disease Severity, Groups by Age, Human, Letter, Motor Performance, Outcome Assessment, Sensorimotor Integration, Therapy, Therapy Effect, Treatment Indication, Treatment Response}, pubstate = {published}, tppubtype = {article} } |
Haque, S; Haque, M Art therapy and autism Journal Article Asian Journal of Pharmaceutical and Clinical Research, 8 (6), pp. 202-203, 2015, ISSN: 09742441, (cited By 0). Links | BibTeX | Tags: Art Therapy, Article, Autism, Child Behaviour, Human, Human Relation, Interpersonal Communication, Nonverbal Communication, Social Interactions @article{Haque2015202, title = {Art therapy and autism}, author = {S Haque and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947426821&partnerID=40&md5=735d495bc1b2ce0c6370c265bb1a4802}, issn = {09742441}, year = {2015}, date = {2015-01-01}, journal = {Asian Journal of Pharmaceutical and Clinical Research}, volume = {8}, number = {6}, pages = {202-203}, publisher = {Asian Journal of Pharmaceutical and Clinical Research}, note = {cited By 0}, keywords = {Art Therapy, Article, Autism, Child Behaviour, Human, Human Relation, Interpersonal Communication, Nonverbal Communication, Social Interactions}, pubstate = {published}, tppubtype = {article} } |