Senarai Penerbitan
Terdapat sebilangan besar penyelidikan berkaitan autisme yang boleh dijumpai di Malaysia yang umumnya menumpukan pada ASD, gangguan pembelajaran, alat bantu komunikasi, terapi dan banyak lagi. Senarai penerbitan disediakan di bawah:
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2020 |
Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z Faktor-faktor yang berkaitan dengan keparahan autisme di kalangan kanak-kanak Malaysia dengan Autism Spectrum Disorder Artikel Jurnal Penyelidikan Ketidakupayaan Pembangunan, 100 , 2020, ISSN: 08914222, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Berat badan, Anak-anak, Kajian Lintas Bahagian, Demografi, Persatuan Penyakit, Keterukan Penyakit, Pekerjaan, Perempuan, Manusia, Gaya hidup, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Ibu bapa, Kanak-kanak Prasekolah, Budak sekolah, Status sosial @artikel mulakan pembungkus pengepala melekit gabungan 6, pengarang = mulakan fusion sticky header wrapper 5, url = start fusion sticky header wrapper 4, doi = mulakan fusion sticky header wrapper 3, issn = mulakan fusion sticky header wrapper 2, tahun = mulakan fusion sticky header wrapper 1, tarikh = mulakan fusion sticky header wrapper 0, jurnal = logo standard 9, volum = logo standard 8, penerbit = logo standard 7, abstrak = logo standard 6, note = standard logo 5, kata kunci = logo standard 4, pubstate = logo standard 3, tppubtype = logo standard 2 } Latar belakang: Kanak-kanak dengan Gangguan Spektrum Autisme (ASD) tahap keparahan gejala yang berlainan boleh menunjukkan pelbagai tingkah laku dan ciri. Terdapat kajian berkaitan pemakanan terhad pada kanak-kanak dengan ASD dengan tahap keparahan yang berbeza di Malaysia. Matlamat: Kajian keratan rentas ini bertujuan untuk mengetahui perkaitan antara faktor sosiodemografi, faktor ibu bapa, dan faktor gaya hidup dengan keparahan autisme pada kanak-kanak dengan ASD. Kaedah dan prosedur: Sejumlah 224 kanak-kanak dengan ASD dimasukkan dalam kajian ini. Ibu mereka melengkapkan borang soal selidik mengenai ciri sosiodemografi, keterukan autisme, gaya keibubapaan, amalan memberi makan ibu bapa, tekanan keibubapaan, tabiat tidur anak dan tingkah laku makan. Hasil dan hasil: Setinggi 78.1 % kanak-kanak dengan ASD menunjukkan tahap keparahan autisme yang tinggi. Regresi linear berganda menunjukkan bahawa status pekerjaan bapa (B = 6.970, 95 % CI = 3.172, 10.768, hlm < 0.001) dan berat badan anak yang dirasakan (B = 3.338, 95 % CI = 1.350, 5.327 |
de Vries, M; Cader, S; Rakan sekerja, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 50 (4), hlm. 1281-1294, 2020, ISSN: 01623257, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda @article standard logo 1, author = standard logo 0, url = sticky header logo 9, doi = sticky header logo 8, issn = sticky header logo 7, year = sticky header logo 6, date = sticky header logo 5, journal = sticky header logo 4, volume = sticky header logo 3, number = sticky header logo 2, pages = sticky header logo 1, publisher = sticky header logo 0, abstract = end fusion sticky header wrapper 9, note = end fusion sticky header wrapper 8, keywords = end fusion sticky header wrapper 7, pubstate = end fusion sticky header wrapper 6, tppubtype = end fusion sticky header wrapper 5 } Latar belakang budaya mungkin mempengaruhi pengetahuan dan sikap mengenai autisme, mempengaruhi kesediaan untuk berinteraksi. Kami mengkaji sama ada kepercayaan, pengetahuan, kenalan, dan sikap berbeza antara Inggeris dan Malaysia. Dengan analisis mediasi, kami mengkaji bagaimana faktor-faktor ini mempengaruhi kesediaan untuk berinteraksi. Autisme lebih kerap dikaitkan dengan makanan di UK, dan asuhan di Malaysia. Pengetahuan, kenalan, dan penerimaan lebih besar di UK. Semasa tidak termasuk pelajar psikologi, Pelajar Malaysia kurang bersedia untuk berinteraksi dengan orang autistik. Pengetahuan dan hubungan muncul untuk meningkatkan penerimaan, tetapi penerimaan tidak menjadi perantara hubungan antara negara, kepercayaan, pengetahuan, dan pengalaman; dan kesediaan untuk berinteraksi. Pengetahuan dan hubungan mengenai autisme dapat meningkatkan penerimaan dalam budaya yang berbeza, tetapi bagaimana penerimaan dapat meningkatkan interaksi tidak jelas. © 2020, Pengarang(s). |
Leong, D; Hedley, D; Uljarevic, M Poh-tay-toe, Poh-tah-toe: Diagnosis dan Konseptualisasi Autisme Artikel Jurnal Jurnal Neurologi Kanak-kanak, 35 (3), hlm. 247-248, 2020, ISSN: 08830738, (dipetik oleh 0). Pautan | BibTeX | Tag: Keresahan, Gangguan Defisit Perhatian, Autisme, Pengasuh, Anak-anak, Artikel Klinikal, Amalan Klinikal, Kelakuan Mengganggu, DSM-5, Susulan, Manusia, Gangguan Pembelajaran, Surat, Kesihatan mental, Gangguan Mood, Pasukan Pelbagai Disiplin, Neuropsychiatry, Jurnal Keutamaan, Pengangguran, Tenaga kerja @pembungkus pengepala melekit gabungan akhir artikel 4, pengarang = pembalut kepala melekit gabungan hujung 3, url = pembungkus pengepala melekit gabungan akhir 2, doi = pembalut kepala melekit gabungan hujung 1, issn = pembalut kepala melekit gabungan hujung 0, tahun = barisan gabungan 9, tarikh = barisan gabungan 8, jurnal = barisan gabungan 7, isi padu = barisan gabungan 6, nombor = barisan gabungan 5, halaman = barisan gabungan 4, penerbit = fusion-row 3, nota = barisan gabungan 2, kata kunci = baris gabungan 1, pubstate = barisan gabungan 0, tppubtype = #utama 9 } |
Taresh, S; Ahmad, N A; Roslan, S; Ma'rof, Seorang M; Zaid, S Sains Otak, 10 (3), 2020, ISSN: 20763425, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Sikap Kurang Upaya, Autisme, Kognisi, Kerangka Konseptual, Pendidikan, Kepercayaan Kesihatan, Penjagaan Kesihatan, Kakitangan Penjagaan Kesihatan, Manusia, Komunikasi Interpersonal, Kesihatan mental, Ahli Fisioterapi, Aspek Psikologi, Soal selidik, Kaji semula, Cikgu sekolah, Konsep Kendiri, Kelakuan Sosial, Teori Kognitif Sosial, Interaksi Sosial, Stigma Sosial, Mengajar, Latihan @artikel #hand 8, pengarang = #main 7, url = #tangan 6, doi = #main 5, Issn = #main 4, tahun = #utama 3, tarikh = #utama 2, jurnal = #utama 1, isipadu = #utama 0, nombor = [sekiranya IE 9]> penerbit = [sekiranya IE 9]> abstrak = [sekiranya IE 9]> nota = [sekiranya IE 9]> kata kunci = [sekiranya IE 9]> pubstate = [sekiranya IE 9]> tppubtype = [sekiranya IE 9]> } Baru-baru ini, pengenalpastian dan pengesanan kanak-kanak dengan gangguan spektrum autisme (ASD) telah menjadi isu penting dalam perkhidmatan campur tangan ASD. Peratusan ASD yang tinggi di kalangan kanak-kanak memerlukan guru prasekolah untuk mengenali perkembangan abnormal kanak-kanak dan mengenal pasti mereka pada peringkat awal, diikuti dengan rujukan kepada pakar. Oleh itu, pengenalan ini memerlukan kemampuan khusus di kalangan guru prasekolah, dikenal pasti sebagai pengetahuan, kepercayaan, kemahiran mengenal pasti, dan keberkesanan diri (KBISSE). Kerangka konseptual ini bertujuan untuk menggunakan literatur semasa untuk menyampaikan perbincangan mengenai KBISSE guru prasekolah dalam mengenal pasti kanak-kanak dengan ASD dan membuat keputusan untuk merujuk kanak-kanak yang disyaki dengan ASD kepada pakar. Kerangka konsep dibincangkan berdasarkan teori kognitif sosial (SCT) dan model kepercayaan kesihatan (HBM). Kerangka konsep menekankan perlunya guru prasekolah dididik di ASD melalui modul pendidikan yang dapat meningkatkan keberkesanan diri guru dalam mengenal pasti kanak-kanak dengan ASD. Selain itu, pengetahuan dalam ASD, kepercayaan terhadap ASD, dan kemahiran mengenal pasti juga pemboleh ubah yang diperlukan untuk membina modul pendidikan. Modul pendidikan berguna untuk membimbing penyelidikan masa depan mengenai pengenalan guru prasekolah kanak-kanak dengan sebarang kecacatan, salah satunya adalah ASD, dan rujukan pakar seterusnya pada peringkat awal. © 2020 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
Djatmika, ; Wibowo, A H; Sugini, ; Halim, H; Mohamad, B Strategi multimodal dalam mengajar kanak-kanak dengan autisme: Analisis wacana Artikel Jurnal Ulasan Sistematik di Farmasi, 11 (2), hlm. 219-229, 2020, ISSN: 09758453, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Pergerakan Badan, Anak-anak, Analisis Wacana, Gerak isyarat, Manusia, Bahasa, Kesunyian, Perhubungan tanpa percakapan, Paralanguage, Jurnal Keutamaan, Berdiri, Perancangan strategik, Pelajar, Cikgu, Mengajar, Tingkah laku Lisan, Komunikasi Lisan @artikel[sekiranya IE 9]>
pengarang = [sekiranya IE 9]>
url = [sekiranya IE 9]>
doi = lajur gabungan 9, issn = lajur gabungan 8, tahun = lajur gabungan 7, tarikh = lajur gabungan 6, jurnal = lajur gabungan 5, isipadu = gabungan-lajur 4, nombor = gabungan-lajur 3, pages = fusion-columns 2, penerbit = lajur gabungan 1, abstrak = gabungan-lajur 0, nota = barisan gabungan 9, kata kunci = baris gabungan 8, pubstate = barisan gabungan 7, tppubtype = gabungan-baris 6 } Proses pengajaran dan pembelajaran yang melibatkan kanak-kanak autisme memerlukan guru untuk kreatif dalam merancang strategi khas dan berkesan untuk memastikan pemahaman pelajar. Ini disebabkan oleh fakta bahawa kanak-kanak ini mempunyai masalah dalam berkomunikasi dengan orang lain, oleh itu memerlukan perhatian khusus dari para guru. Penyelidikan ini bertujuan untuk lebih memahami keperluan anak-anak ini dengan meneliti strategi yang dilakukan oleh guru-guru di Sekolah-sekolah untuk Kanak-kanak Luar Biasa dan Pusat Autisme di bandar Solo yang membantu kanak-kanak dengan autisme. Lima kelas diperhatikan dan dirakam secara audio-visual. Data yang mewakili aspek tingkah laku verbal, tingkah laku bukan lisan, dan eksploitasi alat bantu mengajar dikumpulkan. Hasil kajian menunjukkan bahawa keadaan kanak-kanak autisme adalah pengaruh utama strategi dalam mengeksploitasi aspek multimodal. Oleh itu, guru mesti merancang pendekatan yang berbeza dalam memindahkan pengetahuan kepada kanak-kanak ini. Secara umum, guru selalu melakukan eksploitasi secara lisan bekerjasama dengan aspek bukan lisan seperti gerak tubuh, pergerakan badan, kedudukan berdiri, dan sumber daya paralinguistik seperti intonasi dan kelantangan. Kajian ini juga mendapati bahawa dari lima kelas yang sedang dikaji, dua kelas disokong oleh penggunaan alat bantu mengajar yang berkesan. Penemuan ini menyumbang kepada pemahaman yang lebih baik bagi guru dan ibu bapa mengenai keperluan kanak-kanak autisme semasa proses pengajaran dan pembelajaran. © Penyelidikan Ilmiah Lanjutan. Hak cipta terpelihara. |
2019 |
Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Bersendirian, F M; Badgujar, S; Govindan, S N; Ansari, M T Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Artikel Jurnal Human Vaccines and Immunotherapeutics, 15 (11), hlm. 2544-2551, 2019, ISSN: 21645515, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Attitude, Sikap Terhadap Kesihatan, Autisme, Child Health, Childhood Vaccination, Anak-anak, Kajian Lintas Bahagian, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Pendidikan, Pekerjaan, Etnik, Perempuan, Health Knowledge, Manusia, Immunization Programs, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Ibu, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Kanak-kanak Prasekolah, Preventive Health Service, Psikologi, Soal selidik, Seasonal Influenza, Tinjauan, Vaccination, Dewasa Muda @artikel fusion-baris 5, pengarang = gabungan-baris 4, url = baris gabungan 3, doi = barisan gabungan 2, issn = barisan gabungan 1, tahun = barisan gabungan 0, tarikh = kawasan fusion-footer-widget 9, jurnal = kawasan fusion-footer-widget-area 8, isipadu = kawasan fusion-footer-widget-area 7, number = kawasan fusion-footer-widget 6, halaman = kawasan fusion-footer-widget-area 5, penerbit = kawasan fusion-footer-widget-area 4, abstrak = kawasan fusion-footer-widget 3, note = kawasan fusion-footer-widget 2, kata kunci = kawasan fusion-footer-widget 1, pubstate = kawasan fusion-footer-widget-kawasan 0, tppubtype = fusion-fusion-copyright-content 9 } Aim: Mothers knowledge and attitude toward childhood vaccination influence uptake is the most adequate tool and preventive aspects to infectious disease epidemics. The present study assesses and measures knowledge and attitude of postnatal mothers toward vaccination. Methods and results: The present study adopted a cross-sectional study design, whereby 200 postnatal mothers were identified during their postnatal visit to clinics. The subjects were accessed using questionnaire to assess the level of knowledge and attitude of mothers regarding vaccination. The objectives were to study the level of knowledge, the attitude, and to find the association between knowledge and attitude of the study subjects. The data were analyzed using SPSS version 16. The results was analyzed through chi-square test. The association between age (p =.031), pendidikan (p =.021), occupation (p =.013), and knowledge score toward vaccination was found to be statistically significant. Walau bagaimanapun, ethnicity (p =.127), employment (p =.197), and mode of delivery (p =.750) toward mothers vaccination knowledge were not significant for the study. Mothers education, umur, and occupation were found to be associated with attitude toward childhood vaccination. No association was found between ethnicity, employment, and mode of delivery with attitude of childhood vaccination. Kesimpulannya: More than half of the studied mothers had good knowledge scores on vaccination, more than two-thirds of the studied mothers had good attitude scores on vaccination. Walau bagaimanapun, the religious misconception and fear of autism was the main cause of vaccine resistance in Malaysia. © 2019, © 2019 Taylor & Kumpulan Francis, LLC. |
Ramachandram, S Medical Journal of Malaysia, 74 (5), hlm. 372-376, 2019, ISSN: 03005283, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Artikel, Asthma, Autisme, Birth Weight, Pembangunan kanak-kanak, Anak-anak, Chinese, Conception, Demografi, Diet Restriction, DSM-5, Eczema, Pendidikan, Educational Status, Epilepsi, Perempuan, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Manusia, Orang India, Kajian Klinikal Utama, Malay, Lelaki, Medical Record Review, Pulau Pinang, Prematurity, Gangguan Pertuturan, Upper Respiratory Tract Congestion, Wakefulness @artikel fusion-fusion-hak cipta-kandungan 8, pengarang = fusion-fusion-copyright-content 7, url = kandungan fusion-fusion-copyright-copyright 6, issn = kandungan fusion-fusion-copyright-copyright 5, tahun = fusion-fusion-hak cipta-kandungan 4, tarikh = kandungan fusion-fusion-copyright-copyright 3, jurnal = fusion-fusion-copyright-content 2, isi padu = kandungan fusion-fusion-copyright-copyright 1, nombor = fusion-fusion-hak cipta-kandungan 0, halaman = barisan gabungan 9, penerbit = fusion-row 8, abstrak = gabungan-baris 7, nota = barisan gabungan 6, kata kunci = baris gabungan 5, pubstate = barisan gabungan 4, tppubtype = gabungan-baris 3 } Objektif: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Keputusan: Daripada 331 children with ASD, 82.5% were males, 17.5% perempuan, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 bulan (SD 31.68 bulan) with age range from 19 months to 18 years and 4 bulan. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% dan 5.7% masing-masing. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 dan 31.6 years respectively. Kesimpulannya: Dalam kajian ini, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. Hak cipta terpelihara. |
Ong, BUKAN PERKATAAN Perubatan Komplementari dan Alternatif BMC, 19 (1), 2019, ISSN: 14726882, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Ubatan alternatif, Autisme, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Terapi Pelengkap, Kajian Lintas Bahagian, Perempuan, Manusia, Bayi, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Kepuasan Peribadi, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Soal selidik, Kepuasan hati, Kecekapan Sosial, Kemahiran sosial, Tinjauan, Hasil Rawatan @artikel fusion-baris 2, pengarang = gabungan-baris 1, url = baris gabungan 0, doi = #kaki 9, issn = #kaki 8, tahun = #kaki 7, tarikh = #kaki 6, jurnal = #footer 5, isipadu = #kaki 4, nombor = #kaki 3, penerbit = #footer 2, abstrak = #kaki 1, nota = #kaki 0, kata kunci = fusion-footer 9, pubstate = fusion-footer 8, tppubtype = fusion-footer 7 } Latar belakang: Penggunaan pendekatan kesihatan pelengkap oleh ibu bapa (TIDAK) untuk kanak-kanak yang mengalami gangguan spektrum autisme (ASD) adalah perkara biasa walaupun terdapat bukti yang tidak pasti tentang manfaatnya. Ibu bapa sering mengamalkan CHA kerana tidak berpuas hati dengan rawatan konvensional. Kajian ini bertujuan untuk mengkaji kepuasan ibu bapa terhadap rawatan ASD dan persepsi mereka terhadap kemajuan dalam perkembangan anak mereka.. Penggunaan CHA oleh ibu bapa dalam kalangan kanak-kanak dengan ASD dan faktor-faktor yang berkaitan juga dinilai. Kaedah: Soal selidik yang ditadbir sendiri telah dilengkapkan oleh 48 ibu bapa yang mempunyai anak ASD di hospital rujukan tertiari tunggal di Malaysia. Analisis korelasi digunakan untuk meneroka perkaitan antara skor kepuasan ibu bapa, persepsi skor kemajuan dan penggunaan CHA. Keputusan: Penggunaan CHA dilaporkan oleh ibu bapa untuk 35.4% kanak-kanak dengan ASD dalam sampel. Ibu bapa yang kurang berpuas hati dengan rawatan konvensional dan ibu bapa yang merasakan kemajuan yang lebih lemah dalam perkembangan anak mereka lebih cenderung menggunakan CHA. Hubungan positif yang kukuh didapati antara kepuasan ibu bapa dengan skor rawatan ASD dan persepsi ibu bapa terhadap skor kemajuan, yang menunjukkan bahawa ibu bapa yang berpuas hati dengan rawatan lebih cenderung untuk melihat kemajuan yang lebih besar dalam perkembangan anak mereka. Peningkatan dalam kemajuan anak amat dihargai oleh ibu bapa dalam tingkah laku anak mereka (85.5%), kemahiran sosial (83.3%) dan kemahiran motor (77.1%). Kesimpulannya: Penggunaan CHA adalah biasa di kalangan kanak-kanak dengan ASD. Ibu bapa lebih cenderung untuk mengamalkan CHA apabila mereka kurang berpuas hati dengan rawatan konvensional dan merasakan kemajuan yang lebih buruk. Kajian berbilang pusat yang lebih besar diperlukan untuk meneroka lebih lanjut amalan CHA dalam kalangan kanak-kanak ASD di seluruh Malaysia. © 2019 Pengarang(s). |
Sarwar, F; fanatik, S A; Rajab, A; Nordin, N Sokongan sosial, optimisme, efikasi kendiri ibu bapa dan kesejahteraan ibu kanak-kanak dengan gangguan spektrum autisme Artikel Jurnal Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam, 10 (9), hlm. 1824-1829, 2019, ISSN: 09760245, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Assessment of Humans, Autisme, Anak-anak, Correlation Analysis, Kajian Lintas Bahagian, Perempuan, Manusia, Life Orientation Test, Kepuasan Hidup, Skala Likert, Lelaki, Maternal Behavior, Multidimensional Scale of Percieved Social Support, Optimism, Parenting Sense of Competence, Skala Tekanan yang Diperhatikan, Positive and Negative Affect Schedule, Soal selidik, Satisfaction with Life Scale, Konsep Kendiri, Sokongan Sosial, Kesejahteraan @artikel fusion-footer 6, pengarang = fusion-footer 5, url = fusion-footer 4, doi = fusion-footer 3, issn = fusion-footer 2, tahun = fusion-footer 1, tarikh = fusion-footer 0, jurnal = pembungkus 9, isipadu = pembungkus 8, nombor = pembungkus 7, halaman = pembungkus 6, penerbit = pembungkus 5, abstrak = pembungkus 4, nota = pembungkus 3, kata kunci = pembungkus 2, pubstate = pembungkus 1, tppubtype = pembungkus 0 } Ia telah dihipotesiskan bahawa optimisme, efikasi kendiri dan sokongan sosial adalah peramal positif kepuasan hidup dan kesan positif dan peramal negatif tekanan yang dirasakan dan kesan negatif. Data dikumpul dengan kaedah tinjauan daripada 47 ibu kepada kanak-kanak autisme di Lahore dan Faisalabad. Hipotesis telah diuji pada empat model empat pembolehubah bersandar menggunakan analisis regresi hierarki. Keputusan menggambarkan bahawa efikasi kendiri ibu bapa adalah peramal yang signifikan bagi keempat-empat pembolehubah bersandar, sokongan sosial adalah peramal penting kepuasan hidup dan tekanan yang dirasakan, manakala keyakinan hanya meramalkan varians secara signifikan dalam kepuasan hidup. Kajian itu adalah yang pertama dari jenisnya yang akan dilakukan dengan sampel dalam konteks Pakistan dan mempunyai implikasi penting untuk ahli psikologi klinikal. Mereka boleh merancang intervensi untuk meningkatkan kesejahteraan subjektif dan mengurangkan tekanan secara langsung atau tidak langsung dengan memberi tumpuan kepada anteseden yang diuji dalam kajian.. © 2019, Jurnal India Penyelidikan dan Pembangunan Kesihatan Awam. Hak cipta terpelihara. |
Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 16 (10), 2019, ISSN: 16617827, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Anak-anak, komorbiditi, Perundingan, Kajian Terkawal, Kajian Lintas Bahagian, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Sistem penjagaan kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kepuasan kerja, Kelantan, Kajian Klinikal Utama, Malaysia, Lelaki, Pengurusan, Kesihatan mental, Pertengahan umur, Terapi pekerjaan, Soal Selidik Skala Kepuasan Ibu Bapa, Persepsi, Kepuasan Peribadi, Penjagaan Kesihatan Utama, Penjagaan Perubatan Utama, Psikologi, Soal selidik, Kepuasan hati, Penjagaan Kesihatan Sekunder, Terapi ucapan, Tinjauan, Penjagaan Kesihatan Tertiari, West Malaysia @artikel # pembungkus kotak 9, pengarang = # kotak-pembungkus 8, url = # pembungkus kotak 7, doi = # pembungkus kotak 6, issn = # pembungkus kotak 5, tahun = # pembungkus kotak 4, tarikh = # pembungkus kotak 3, jurnal = # kotak-pembungkus 2, isi padu = # pembungkus kotak 1, nombor = # pembungkus kotak 0, publisher = Instagram Feed JS 9, abstract = Instagram Feed JS 8, note = Instagram Feed JS 7, keywords = Instagram Feed JS 6, pubstate = Instagram Feed JS 5, tppubtype = Instagram Feed JS 4 } Latar belakang: Pengasuh adalah penjaga pintu awal dalam pengurusan penjagaan kesihatan kanak-kanak dengan gangguan spektrum autisme (ASD). Kaedah: Kajian keratan rentas ini bertujuan untuk menentukan faktor-faktor yang berkaitan dengan kepuasan penjaga terhadap tahap perkhidmatan penjagaan kesihatan yang berbeza dalam menguruskan kanak-kanak ASD di Kelantan.. Markah kepuasan daripada 227 penjaga utama kanak-kanak ASD yang disahkan telah dinilai dengan Skala Kepuasan Ibu Bapa yang diubah suai (PSS) soal selidik. Keputusan: Analisis menunjukkan bahawa penjaga yang menunggu lebih lama untuk perundingan doktor dalam penjagaan primer mempunyai skor PSS yang berkurangan, manakala penjaga yang berpuas hati dengan masa menunggu di jagaan primer mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan menengah, penjaga yang memiliki sekurang-kurangnya diploma telah mengurangkan markah PSS, manakala penjaga yang berpuas hati dengan masa konsultasi doktor dan pelantikan terapi pekerjaan mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan tertiari, penjaga yang mempunyai masalah perubatan yang mendasari dan yang mempunyai anak yang menjalani terapi pekerjaan selama dua bulan atau lebih telah mengurangkan markah PSS. Namun begitu, analisis menunjukkan bahawa penjaga yang prihatin dengan masalah tidur anak-anak mereka, yang telah dimaklumkan tentang sokongan ibu bapa, yang berpuas hati dengan pelantikan terapi pertuturan dan pekerjaan, yang berpuas hati dengan masa menunggu di klinik penjagaan tertiari, dan yang berpuas hati dengan pengetahuan dan pengalaman doktor mereka mempunyai markah PSS yang lebih tinggi. Kesimpulannya: Kajian ini menjelaskan kepentingan memahami kepuasan penjaga dalam mendapatkan penjagaan untuk anak ASD mereka dan menekankan keperluan untuk mempromosikan faktor yang akan meningkatkan kepuasan penjaga terhadap perkhidmatan ASD semasa.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A Tekanan yang dirasakan dalam kalangan penjaga kanak-kanak yang mengalami gangguan spektrum autisme: Kajian seluruh negeri Artikel Jurnal Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 16 (8), 2019, ISSN: 16617827, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Adaptasi, Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Beban Penjaga, Penjagaan Kanak-kanak, Anak-anak, Tingkah Laku Menghadapi, Kajian Lintas Bahagian, Perempuan, Susulan, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Manusia, Bayi, Gangguan Pembelajaran, Malaysia, Lelaki, Tekanan Mental, Pertengahan umur, Analisis Regresi Linear Berganda, Baru lahir, Manusia Biasa, Pengangkutan Pesakit, Skala Tekanan yang Diperhatikan, Ramalan, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Tekanan, Pusat Jagaan Tertiari, Hospital Universiti @article Instagram Feed JS 3, author = Instagram Feed JS 2, url = Instagram Feed JS 1, doi = Instagram Feed JS 0, terbitan = {16617827}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam}, isi padu = {16}, nombor = {8}, penerbit = {MDPI AG}, abstrak = {Latar belakang: Penjaga kanak-kanak yang mengalami gangguan spektrum autisme (ASD) mengalami tekanan yang meningkat dan akibat pengasuhan negatif yang lebih ketara daripada mereka yang mempunyai kanak-kanak yang sedang membangun. Terdapat kekurangan kajian yang khusus memfokuskan kepada tekanan dalam kalangan penjaga yang mempunyai kanak-kanak ASD di negara Asia. Kajian semasa mengkaji tahap tekanan yang dirasakan dan faktor yang dikaitkan dengannya dalam kalangan penjaga di Kelantan, Malaysia. Kaedah: Dalam kajian keratan rentas, versi Bahasa Melayu bagi Skala Tekanan Yang Diperhatikan (PSS) telah ditadbirkan kepada 227 penjaga kanak-kanak dengan ASD. Pengasuh telah diambil daripada pangkalan data ASD di empat hospital tertiari di Kelantan dan satu mesyuarat telah diadakan semasa susulan kanak-kanak itu di klinik.. Analisis regresi linear berbilang telah digunakan untuk menentukan peramal tekanan yang dirasakan. Keputusan: Purata jumlah skor tekanan yang dirasakan ialah 20.84 (4.72). Ini dianggap lebih tinggi daripada purata. Tekanan yang dirasakan lebih tinggi telah diramalkan dengan ketara dalam kalangan penjaga yang tinggal jauh dari institusi kesihatan, penjaga yang tidak memiliki pengangkutan untuk membawa anak ke pusat rawatan, dan penjaga yang mempunyai anak ASD dengan masalah pembelajaran. Kesimpulannya: Pengasuh kanak-kanak ASD merasakan tekanan yang ketara semasa menjaga anak-anak mereka. Institusi harus mengurangkan faktor-faktor yang diramalkan meningkatkan tekanan pengasuh untuk meningkatkan kualiti kehidupan kanak-kanak dan keluarga ASD secara keseluruhan.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.}, nota = {dipetik oleh 0}, kata kunci = {Adaptasi, Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Beban Penjaga, Penjagaan Kanak-kanak, Anak-anak, Tingkah Laku Menghadapi, Kajian Lintas Bahagian, Perempuan, Susulan, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Manusia, Bayi, Gangguan Pembelajaran, Malaysia, Lelaki, Tekanan Mental, Pertengahan umur, Analisis Regresi Linear Berganda, Baru lahir, Manusia Biasa, Pengangkutan Pesakit, Skala Tekanan yang Diperhatikan, Ramalan, Prasekolah, Kanak-kanak Prasekolah, Psikologi, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Tekanan, Pusat Jagaan Tertiari, Hospital Universiti}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: Penjaga kanak-kanak yang mengalami gangguan spektrum autisme (ASD) mengalami tekanan yang meningkat dan akibat pengasuhan negatif yang lebih ketara daripada mereka yang mempunyai kanak-kanak yang sedang membangun. Terdapat kekurangan kajian yang khusus memfokuskan kepada tekanan dalam kalangan penjaga yang mempunyai kanak-kanak ASD di negara Asia. Kajian semasa mengkaji tahap tekanan yang dirasakan dan faktor yang dikaitkan dengannya dalam kalangan penjaga di Kelantan, Malaysia. Kaedah: Dalam kajian keratan rentas, versi Bahasa Melayu bagi Skala Tekanan Yang Diperhatikan (PSS) telah ditadbirkan kepada 227 penjaga kanak-kanak dengan ASD. Pengasuh telah diambil daripada pangkalan data ASD di empat hospital tertiari di Kelantan dan satu mesyuarat telah diadakan semasa susulan kanak-kanak itu di klinik.. Analisis regresi linear berbilang telah digunakan untuk menentukan peramal tekanan yang dirasakan. Keputusan: Purata jumlah skor tekanan yang dirasakan ialah 20.84 (4.72). Ini dianggap lebih tinggi daripada purata. Tekanan yang dirasakan lebih tinggi telah diramalkan dengan ketara dalam kalangan penjaga yang tinggal jauh dari institusi kesihatan, penjaga yang tidak memiliki pengangkutan untuk membawa anak ke pusat rawatan, dan penjaga yang mempunyai anak ASD dengan masalah pembelajaran. Kesimpulannya: Pengasuh kanak-kanak ASD merasakan tekanan yang ketara semasa menjaga anak-anak mereka. Institusi harus mengurangkan faktor-faktor yang diramalkan meningkatkan tekanan pengasuh untuk meningkatkan kualiti kehidupan kanak-kanak dan keluarga ASD secara keseluruhan.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
Liu, Y-W; Liong, M T; Am, Y -C E; Huang, H -Y; Peng, W -S; Cheng, Y -F; Lin, Y -S; Wu, Y-Y; Tsai, Y -C Nutrien, 11 (4), 2019, ISSN: 20726643, (dipetik oleh 4). Abstrak | Pautan | BibTeX | Tag: Senarai Semak Tingkah Laku Aberrant versi Taiwan, Remaja, umur, Faktor Umur, Keagresifan, Keresahan, Artikel, Gangguan Defisit Perhatian, Autisme, Senarai Semak Tingkah Laku Autisme, Temuduga Diagnostik Autisme Disemak, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Senarai Semak Tingkah Laku Kanak-kanak, Anak-anak, Skala Teraan Global Klinikal, Gangguan Komunikasi, Kajian Terkawal, Prosedur Double Blind, Kaedah Double-Blind, Perempuan, Gangguan Kebimbangan Umum, Manusia, Impulsif, Lactobacillus delbrueckii, Lelaki, Fisiologi, Placebo, Placebo, Gangguan Tekanan Selepas Traumatik, Agen Probiotik, Probiotik, Psikologi, Soal selidik, Percubaan Terkawal Rawak, Skala penilaian, Budak sekolah, Sistem Pemarkahan, Kelakuan Sosial, Interaksi Sosial, Masalah Sosial, Skala Responsif Sosial, Tinjauan, Penilaian Swanson Nolan dan Pelham IV, Protein Berkaitan Sinaptosomal 23, Taiwan @artikel{Liu2019, tajuk = {Kesan lactobacillus plantarum PS128 pada kanak-kanak dengan gangguan spektrum autisme di Taiwan: A rawak, buta dua, percubaan terkawal plasebo}, pengarang = {Y -W Liu dan M T Liong dan Y -C E Chung dan H -Y Huang dan W -S Peng dan Y -F Cheng dan Y -S Lin dan Y -Y Wu dan Y -C Tsai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064817846&doi=10.3390/nu11040820&rakan kongsi = 40&md5=ca04462e8710198b821b44f8e73061f3}, doi = {10.3390/nu11040820}, terbitan = {20726643}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Nutrien}, isi padu = {11}, nombor = {4}, penerbit = {MDPI AG}, abstrak = {Empat minggu ini, rawak, buta dua, kajian terkawal plasebo menyiasat kesan Lactobacillus plantarum PS128 (PS128) pada kanak-kanak lelaki dengan gangguan spektrum autisme (ASD) berumur 7-15 di Taiwan. Semua subjek memenuhi kriteria untuk diagnosis ASD DSM-V dan Temuduga Diagnostik Autisme-Disemak (ADI-R). Soal selidik yang digunakan untuk ukuran hasil utama termasuk versi Senarai Semak Tingkah Laku Autisme-Taiwan (ABC-T), Skala Responsif Sosial (SRS) dan Senarai Semak Tingkah Laku Kanak-kanak (CBCL). Swanson, Nolan, dan versi Pelham-IV-Taiwan (SNAP-IV) dan Penambahbaikan Tera Global Klinikal (CGI-I) digunakan untuk ukuran hasil sekunder. Keputusan menunjukkan bahawa PS128 memperbaiki tingkah laku pembangkang/menentang, dan bahawa jumlah skor SNAP-IV untuk kanak-kanak yang lebih muda (berumur 7−12) meningkat dengan ketara berbanding dengan kumpulan plasebo. Selain itu, beberapa elemen juga telah dipertingkatkan dengan ketara dalam kumpulan PS128 selepas penggunaan PS128 selama 28 hari. Kajian lanjut diperlukan untuk menjelaskan dengan lebih baik kesan PS128 untuk kanak-kanak yang lebih muda dengan ASD pada gejala yang lebih luas. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.}, nota = {dipetik oleh 4}, kata kunci = {Senarai Semak Tingkah Laku Aberrant versi Taiwan, Remaja, umur, Faktor Umur, Keagresifan, Keresahan, Artikel, Gangguan Defisit Perhatian, Autisme, Senarai Semak Tingkah Laku Autisme, Temuduga Diagnostik Autisme Disemak, Gangguan Spektrum Autisme, Tingkah Laku Kanak-kanak, Senarai Semak Tingkah Laku Kanak-kanak, Anak-anak, Skala Teraan Global Klinikal, Gangguan Komunikasi, Kajian Terkawal, Prosedur Double Blind, Kaedah Double-Blind, Perempuan, Gangguan Kebimbangan Umum, Manusia, Impulsif, Lactobacillus delbrueckii, Lelaki, Fisiologi, Placebo, Placebo, Gangguan Tekanan Selepas Traumatik, Agen Probiotik, Probiotik, Psikologi, Soal selidik, Percubaan Terkawal Rawak, Skala penilaian, Budak sekolah, Sistem Pemarkahan, Kelakuan Sosial, Interaksi Sosial, Masalah Sosial, Skala Responsif Sosial, Tinjauan, Penilaian Swanson Nolan dan Pelham IV, Protein Berkaitan Sinaptosomal 23, Taiwan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Empat minggu ini, rawak, buta dua, kajian terkawal plasebo menyiasat kesan Lactobacillus plantarum PS128 (PS128) pada kanak-kanak lelaki dengan gangguan spektrum autisme (ASD) berumur 7-15 di Taiwan. Semua subjek memenuhi kriteria untuk diagnosis ASD DSM-V dan Temuduga Diagnostik Autisme-Disemak (ADI-R). Soal selidik yang digunakan untuk ukuran hasil utama termasuk versi Senarai Semak Tingkah Laku Autisme-Taiwan (ABC-T), Skala Responsif Sosial (SRS) dan Senarai Semak Tingkah Laku Kanak-kanak (CBCL). Swanson, Nolan, dan versi Pelham-IV-Taiwan (SNAP-IV) dan Penambahbaikan Tera Global Klinikal (CGI-I) digunakan untuk ukuran hasil sekunder. Keputusan menunjukkan bahawa PS128 memperbaiki tingkah laku pembangkang/menentang, dan bahawa jumlah skor SNAP-IV untuk kanak-kanak yang lebih muda (berumur 7−12) meningkat dengan ketara berbanding dengan kumpulan plasebo. Selain itu, beberapa elemen juga telah dipertingkatkan dengan ketara dalam kumpulan PS128 selepas penggunaan PS128 selama 28 hari. Kajian lanjut diperlukan untuk menjelaskan dengan lebih baik kesan PS128 untuk kanak-kanak yang lebih muda dengan ASD pada gejala yang lebih luas. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T PLoS SATU, 14 (3), 2019, ISSN: 19326203, (dipetik oleh 4). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat @artikel{Pichitpunpong2019, tajuk = {Analisis subkumpulan fenotip dan multi-omik mendedahkan perencat pengikat diazepam yang berkurangan (DBI) tahap protein dalam gangguan spektrum autisme dengan gangguan bahasa yang teruk}, pengarang = {C Pichitpunpong dan S Thongkorn dan S Kanlayaprasit dan W Yuwattana dan W Plaingam dan S Sangsuthum dan W M Aizat dan SN Baharum dan T Tencomnao dan V W Hu dan T Sarachana}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371/journal.pone.0214198&rakan kongsi = 40&md5=0a4c25481edee56984a59de94fedc414}, doi = {10.1371/jurnal.pone.0214198}, terbitan = {19326203}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {PLoS SATU}, isi padu = {14}, nombor = {3}, penerbit = {Perpustakaan Awam Sains}, abstrak = {Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.}, nota = {dipetik oleh 4}, kata kunci = {Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan. |
Mohamad, F H; Telah, A T C The α5-Containing GABA A Receptors—a Brief Summary Artikel Jurnal Journal of Molecular Neuroscience, 67 (2), hlm. 343-351, 2019, ISSN: 08958696, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: 4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Haiwan, Autisme, Otak, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetik, Manusia, Metabolisme, Bukan Manusia, Protein Subunit, Protein Subunits, Receptors, Kaji semula, Skizofrenia, Dadah yang tidak dikelaskan @artikel{Mohamad2019343, tajuk = {The α5-Containing GABA A Receptors—a Brief Summary}, pengarang = {F H Mohamad and A T C Has}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059596842&doi=10.1007%2fs12031-018-1246-4&rakan kongsi = 40&md5=7b2ba0dc86c6c3f890f226cad8195ee5}, doi = {10.1007/s12031-018-1246-4}, terbitan = {08958696}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Journal of Molecular Neuroscience}, isi padu = {67}, nombor = {2}, halaman = {343-351}, penerbit = {Springer New York LLC}, abstrak = {GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Sindrom Down, and autism with a possible alternative benzodiazepine binding site. Oleh itu, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science + Media Perniagaan, LLC, bahagian dari Springer Nature.}, nota = {dipetik oleh 1}, kata kunci = {4 Aminobutyric Acid, 4 Aminobutyric Acid A Receptor, Alpha5 Containing 4 Aminobutyric Acid A Receptor, Haiwan, Autisme, Otak, Cognitive Defect, Cognitive Dysfunction, Drug Effect, GABA Agents, GABA-A, GABAergic Receptor Affecting Agent, Genetik, Manusia, Metabolisme, Bukan Manusia, Protein Subunit, Protein Subunits, Receptors, Kaji semula, Skizofrenia, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } GABA A receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1–6, β1–3, γ1–3, ρ1–3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA A subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. The receptors also possess binding sites for various unrelated substances including benzodiazepines, barbiturates, and anesthetics. The α5-containing GABA A Rs only make up ≤ 5% of the entire receptor population, but up to 25% of the receptor subtype is located in the crucial learning and memory-associated area of the brain—the hippocampus, which has ignited myriads of hypotheses and theories in regard to its role. As well as exhibiting synaptic phasic inhibition, the α5-containing receptors are also extrasynaptic and mediate tonic inhibition with continuously occurring smaller amplitude. Studies on negative-allosteric modulators for reducing this tonic inhibition have been shown to enhance learning and memory in neurological disorders such as schizophrenia, Sindrom Down, and autism with a possible alternative benzodiazepine binding site. Oleh itu, a few α5 subunit-specific compounds have been developed to address these pharmacological needs. With its small population, the α5-containing receptors could be the key and also the answer for many untreated cognitive dysfunctions and disorders. © 2019, Springer Science + Media Perniagaan, LLC, bahagian dari Springer Nature. |
Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, DENGAN Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Artikel Jurnal Developmental Medicine and Child Neurology, 61 (2), hlm. 135-144, 2019, ISSN: 00121622, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability @artikel{Jaafar2019135, tajuk = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review}, pengarang = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&rakan kongsi = 40&md5=d02a2bfcd15a25988b9c23855cd87444}, doi = {10.1111/dmcn.13986}, terbitan = {00121622}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Developmental Medicine and Child Neurology}, isi padu = {61}, nombor = {2}, halaman = {135-144}, penerbit = {Blackwell Publishing Ltd}, abstrak = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press}, nota = {dipetik oleh 1}, kata kunci = {Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability}, pubstate = {diterbitkan}, tppubtype = {artikel} } Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press |
Tidak juga, N K; Ghozali, A H; Ismail, J Sempadan dalam Pediatrik, 7 (FEB), 2019, ISSN: 22962360, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang @artikel{Nor2019, tajuk = {Kelebihan berat badan berlebihan dan obesiti di kalangan kanak-kanak dan remaja dengan gangguan spektrum autisme dan faktor risiko yang berkaitan}, pengarang = {N K Nor dan A H Ghozali dan J Ismail}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85064414280&dua = 10.3389% 2kurang.2019.00038&rakan kongsi = 40&md5 = 4bb61b1df043a4adf79618e223d77f26}, doi = {10.3389/fped.2019.00038}, terbitan = {22962360}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Sempadan dalam Pediatrik}, isi padu = {7}, nombor = {FEB}, penerbit = {Frontiers Media S.A.}, abstrak = {Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.}, nota = {dipetik oleh 5}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95persentil ke-) adalah 11.3% dan berlakunya kegemukan (BMI persentil ke-95) adalah 21.9%. Umur rata-rata kanak-kanak ASD yang berlebihan berat badan / gemuk lebih tinggi pada 8.5 tahun (IQR 5.81-10.13) berbanding dengan kumpulan normal / kurang berat badan 6.33 tahun (IQR 4.75-7.7) dengan nilai p 0.001. Kedua-dua kumpulan juga berbeza secara signifikan untuk BMI ibu dan usia bapa. BMI ibu rata-rata dalam kumpulan berat badan berlebihan / gemuk adalah 26.05 (IQR 23.35-32.25), secara statistik lebih tinggi secara signifikan (p = 0.003) berbanding kumpulan yang tidak berlebihan berat badan / gemuk, 24.7 (IQR 21-27.9). Umur bapa median pada 40 tahun (IQR 37-44) secara statistik lebih tinggi secara signifikan (p = 0.039) dalam kumpulan berlebihan berat badan / gemuk, berbanding dengan usia bapa rata-rata pada kumpulan bukan berat badan berlebihan / obes 38 (IQR 35-42). Kanak-kanak lelaki yang berlebihan berat badan / gemuk mempunyai skor PAQ-C median 2.44 (IQR 2.00-3.00) lwn. 2.89 (IQR 2.35-3.53) dalam kumpulan rakan niaga dengan nilai p 0.01. Menggunakan kaedah regresi linear berganda, tiga peramal yang berkaitan dengan persentil BMI mencapai tahap kepentingan statistik; Skor PAQ-C pada lelaki (hlm < 0.001), domain BAMBI dari Penolakan Makanan (p = 0.001) dan Pelbagai Jenis Makanan yang Terhad (p = 0.001). Kesimpulannya: Kelaziman obesiti dan berat badan berlebihan adalah tinggi di kalangan kanak-kanak dan remaja ASD Malaysia. Umur kanak-kanak yang lebih tua, BMI ibu yang tinggi, usia bapa yang lebih tua, aktiviti fizikal yang rendah, kemungkinan rendahnya penolakan makanan dan kemungkinan tinggi pemilihan makanan didapati menjadi faktor risiko BMI tinggi pada kanak-kanak ini. © 2019 Kamal Nor, Ghozali and Ismail. |
Khan, N A; Soopramanien, M; Siddiqui, R Buaya dan buaya: Jawapan doktor untuk barah? Artikel Jurnal Onkologi Semasa, 26 (3), hlm. 186, 2019, ISSN: 11980052, (dipetik oleh 1). Pautan | BibTeX | Tag: Penyakit Alergi, Buaya dan Buaya, Produk Haiwan, Haiwan, Aktiviti Antineoplastik, Ejen Antineoplastik, Artikel, Dermatitis Atopik, Autisme, Pertumbuhan Barah, Terapi Barah, Karsinogen, Organisma yang tercemar, Buaya, Kepupusan Massa Cretaceous Akhir, Faktor Persekitaran, Tekanan Alam Sekitar, Mikrobioma gastrousus, Tingkah laku Kesihatan, Logam berat, Manusia, Sistem Imun, Penyakit Usus Keradangan, Flora usus, Panjang umur, Gangguan Metabolik, Mikrobiologi, Neoplasma, Neoplasma, Pembezaan Sel Saraf, Pakar Perubatan, Skizofrenia, Analisis Survival, Penyakit Terminal @artikel{Khan2019186, tajuk = {Buaya dan buaya: Jawapan doktor untuk barah?}, pengarang = {N A Khan dan M Soopramanien dan R Siddiqui}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85069313377&dua = 10.3747% 2fco.26.4855&rakan kongsi = 40&md5 = 6a266208d5fe14a1c888bb1db397d744}, doi = {10.3747/bersama.26.4855}, terbitan = {11980052}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Onkologi Semasa}, isi padu = {26}, nombor = {3}, halaman = {186}, penerbit = {Multimed Inc.}, nota = {dipetik oleh 1}, kata kunci = {Penyakit Alergi, Buaya dan Buaya, Produk Haiwan, Haiwan, Aktiviti Antineoplastik, Ejen Antineoplastik, Artikel, Dermatitis Atopik, Autisme, Pertumbuhan Barah, Terapi Barah, Karsinogen, Organisma yang tercemar, Buaya, Kepupusan Massa Cretaceous Akhir, Faktor Persekitaran, Tekanan Alam Sekitar, Mikrobioma gastrousus, Tingkah laku Kesihatan, Logam berat, Manusia, Sistem Imun, Penyakit Usus Keradangan, Flora usus, Panjang umur, Gangguan Metabolik, Mikrobiologi, Neoplasma, Neoplasma, Pembezaan Sel Saraf, Pakar Perubatan, Skizofrenia, Analisis Survival, Penyakit Terminal}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
2018 |
Al-Hiyali, M Saya; Ishak, A J; Harun, H; Ahmad, S A; Sulaiman, Wan W A Tinjauan dalam mengubah suai tingkah laku pengambilan makanan oleh rangsangan otak: Kes berat badan berlebihan Artikel Jurnal Kuantologi Neuro, 16 (12), hlm. 86-97, 2018, ISSN: 13035150, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Amygdala, Anoksia, Artikel, Autisme, Gangguan pesta minum-minum makan, Berat badan, Berat badan, Rangsangan Kedalaman Otak, Depolarisasi, Pengambilan diet, Keinginan Dadah, Gangguan Makan, Arus elektrik, Elektroencephalogram, Elektroensefalografi, Penggunaan tenaga, Penggunaan tenaga, Tingkah Laku Makan, Pengambilan makanan, Pengimejan Resonans Magnetik Berfungsi, Jantina, Status kesihatan, Homeostasis, Manusia, Kelaparan, Gaya hidup, Potensi Mantap Membran Sel Saraf, Keseronokan Saraf, Neurofeedback, Neuromodulasi, Penilaian Pemakanan, Penilaian Hasil, Soal selidik, Rangsangan Magnetik Transkranial Berulang, Pemprosesan isyarat, Latihan, Rangsangan Arus Langsung Transkranial, Rangsangan Magnetik Transkranial, Berat badan kurang @artikel{Al-Hiyali201886, tajuk = {Tinjauan dalam mengubah suai tingkah laku pengambilan makanan oleh rangsangan otak: Kes berat badan berlebihan}, pengarang = {M I Al-Hiyali dan A J Ishak dan H Harun dan S A Ahmad dan W A Wan Sulaiman}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85062843670&doi = 10.14704% 2fnq.2018.16.12.1894&rakan kongsi = 40&md5 = 235f66cef05a144be23472641f70bd1d}, doi = {10.14704/nq.2018.16.12.1894}, terbitan = {13035150}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Kuantologi Neuro}, isi padu = {16}, nombor = {12}, halaman = {86-97}, penerbit = {Penerbit Anka}, abstrak = {Obesiti dan berat badan berlebihan sering ditetapkan untuk disfungsi dalam tingkah laku pengambilan makanan. Kerana banyaknya kegemukan pada tahun lalu, terdapat permintaan untuk lebih banyak kajian yang bertujuan untuk mengubah tingkah laku pengambilan makanan. Selama beberapa dekad yang lalu, banyak kajian telah dilakukan untuk mengubah pengambilan makanan melalui latihan otak atau rangsangan. Ulasan ini untuk kajian neurosains dalam mengubah tingkah laku pengambilan makanan, ia melibatkan tiga bahagian; Bahagian pertama menjelaskan peranan aktiviti otak dalam peraturan pengambilan makanan, idea umum mengenai alat bioperubatan dalam tingkah laku pengambilan makanan dibincangkan di bahagian kedua dan bahagian ketiga yang difokuskan pada sistem rangsangan otak. Akhirnya, makalah ini disimpulkan dengan perkara utama yang perlu diambil kira semasa merancang kajian eksperimental untuk mengubah tingkah laku pengambilan makanan oleh rangsangan otak mengikut cadangan dan cabaran kajian sebelumnya. © 2018, Penerbit Anka. Hak cipta terpelihara.}, nota = {dipetik oleh 2}, kata kunci = {Amygdala, Anoksia, Artikel, Autisme, Gangguan pesta minum-minum makan, Berat badan, Berat badan, Rangsangan Kedalaman Otak, Depolarisasi, Pengambilan diet, Keinginan Dadah, Gangguan Makan, Arus elektrik, Elektroencephalogram, Elektroensefalografi, Penggunaan tenaga, Penggunaan tenaga, Tingkah Laku Makan, Pengambilan makanan, Pengimejan Resonans Magnetik Berfungsi, Jantina, Status kesihatan, Homeostasis, Manusia, Kelaparan, Gaya hidup, Potensi Mantap Membran Sel Saraf, Keseronokan Saraf, Neurofeedback, Neuromodulasi, Penilaian Pemakanan, Penilaian Hasil, Soal selidik, Rangsangan Magnetik Transkranial Berulang, Pemprosesan isyarat, Latihan, Rangsangan Arus Langsung Transkranial, Rangsangan Magnetik Transkranial, Berat badan kurang}, pubstate = {diterbitkan}, tppubtype = {artikel} } Obesiti dan berat badan berlebihan sering ditetapkan untuk disfungsi dalam tingkah laku pengambilan makanan. Kerana banyaknya kegemukan pada tahun lalu, terdapat permintaan untuk lebih banyak kajian yang bertujuan untuk mengubah tingkah laku pengambilan makanan. Selama beberapa dekad yang lalu, banyak kajian telah dilakukan untuk mengubah pengambilan makanan melalui latihan otak atau rangsangan. Ulasan ini untuk kajian neurosains dalam mengubah tingkah laku pengambilan makanan, ia melibatkan tiga bahagian; Bahagian pertama menjelaskan peranan aktiviti otak dalam peraturan pengambilan makanan, idea umum mengenai alat bioperubatan dalam tingkah laku pengambilan makanan dibincangkan di bahagian kedua dan bahagian ketiga yang difokuskan pada sistem rangsangan otak. Akhirnya, makalah ini disimpulkan dengan perkara utama yang perlu diambil kira semasa merancang kajian eksperimental untuk mengubah tingkah laku pengambilan makanan oleh rangsangan otak mengikut cadangan dan cabaran kajian sebelumnya. © 2018, Penerbit Anka. Hak cipta terpelihara. |
Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N GRIN2D variants in three cases of developmental and epileptic encephalopathy Artikel Jurnal Clinical Genetics, 94 (6), hlm. 538-547, 2018, ISSN: 00099163, (dipetik oleh 4). Abstrak | Pautan | BibTeX | Tag: Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing @artikel{Tsuchida2018538, tajuk = {GRIN2D variants in three cases of developmental and epileptic encephalopathy}, pengarang = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&rakan kongsi = 40&md5=f0d32670db57261820bc244943cffd62}, doi = {10.1111/cge.13454}, terbitan = {00099163}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Clinical Genetics}, isi padu = {94}, nombor = {6}, halaman = {538-547}, penerbit = {Blackwell Publishing Ltd}, abstrak = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Baru-baru ini, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. Dalam kajian ini, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd}, nota = {dipetik oleh 4}, kata kunci = {Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing}, pubstate = {diterbitkan}, tppubtype = {artikel} } N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Baru-baru ini, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. Dalam kajian ini, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Arifin, W N Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 15 (11), 2018, ISSN: 16617827, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Kajian Lintas Bahagian, Analisis Faktor, Perempuan, Garis panduan, Sikap Kakitangan Kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kelantan, Fungsi Kemungkinan, Skala Likert, Malaysia, Lelaki, Analisis Kemungkinan Maksimum, Kesihatan mental, Perkhidmatan Kesihatan Mental, Ibu bapa, Skala Kepuasan Ibu Bapa Versi Bahasa Melayu, Kepuasan Peribadi, Garis Panduan Amalan, Skala Penarafan Psikologi, Psikologi, Penerbitan, Soal selidik, Kebolehulangan, Kebolehulangan Keputusan, Kepuasan hati, Model Statistik, Statistik, Tinjauan, Pusat Jagaan Tertiari, Terjemahan, Kajian Pengesahan, West Malaysia @artikel{Adib2018, tajuk = {Terjemahan dan pengesahan skala kepuasan ibu bapa versi bahasa melayu (Pss-m) untuk penilaian kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme}, pengarang = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N Arifin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056090545&doi=10.3390/ijerph15112455&rakan kongsi = 40&md5=53650806d46343cc3e95c9b30442f79c}, doi = {10.3390/ijerph15112455}, terbitan = {16617827}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam}, isi padu = {15}, nombor = {11}, penerbit = {MDPI AG}, abstrak = {Latar belakang: Skala Kepuasan Ibu Bapa versi Bahasa Melayu (PSS-M) diperlukan untuk menyiasat faktor-faktor yang menyumbang kepada kepuasan pengasuh Melayu terhadap pengurusan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme. (ASD). Matlamat kajian adalah untuk menterjemah dan mengesahkan soal selidik untuk menilai kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan. Kaedah: Kajian keratan rentas telah dijalankan di kalangan 110 penjaga kanak-kanak dengan ASD berumur antara 2 dan 17 tahun yang menerima rawatan di dua pusat jagaan tinggi di Kelantan. Kebenaran untuk menggunakan borang soal selidik PSS versi asal telah diperolehi. Versi Inggeris asal PSS telah diterjemahkan ke dalam versi Bahasa Melayu berikutan 10 langkah yang dicadangkan oleh garis panduan yang ditetapkan. Pra-ujian PSS telah dijalankan dengan 30 penjaga sebelum analisis faktor pengesahan (CFA) ditubuhkan menggunakan 110 penjaga. Mereka diminta menilai kefahaman mereka terhadap soal selidik. Soal selidik satu dimensi terdiri daripada 11 barang, termasuk sikap kakitangan, ketersediaan kakitangan, sokongan, dan suka menolong. Skala Likert 5 mata memberikan penilaian daripada 1 (sangat tidak setuju) ke 5 (sangat bersetuju). Analisis faktor pengesahan dilakukan menggunakan penganggar kemungkinan maksimum yang teguh. Keputusan: Analisis menunjukkan data kesesuaian model dengan kebolehpercayaan yang baik. Kesimpulannya: PSS-M menunjukkan kecergasan model keseluruhan berdasarkan indeks tertentu, dengan kesahan konstruk yang baik dan kebolehpercayaan mutlak yang sangat baik untuk menentukan tahap kepuasan penjaga kanak-kanak dengan ASD berkenaan dengan perkhidmatan penjagaan kesihatan. © 2018, MDPI AG. Hak cipta terpelihara.}, nota = {dipetik oleh 2}, kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Anak-anak, Kajian Lintas Bahagian, Analisis Faktor, Perempuan, Garis panduan, Sikap Kakitangan Kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kelantan, Fungsi Kemungkinan, Skala Likert, Malaysia, Lelaki, Analisis Kemungkinan Maksimum, Kesihatan mental, Perkhidmatan Kesihatan Mental, Ibu bapa, Skala Kepuasan Ibu Bapa Versi Bahasa Melayu, Kepuasan Peribadi, Garis Panduan Amalan, Skala Penarafan Psikologi, Psikologi, Penerbitan, Soal selidik, Kebolehulangan, Kebolehulangan Keputusan, Kepuasan hati, Model Statistik, Statistik, Tinjauan, Pusat Jagaan Tertiari, Terjemahan, Kajian Pengesahan, West Malaysia}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: Skala Kepuasan Ibu Bapa versi Bahasa Melayu (PSS-M) diperlukan untuk menyiasat faktor-faktor yang menyumbang kepada kepuasan pengasuh Melayu terhadap pengurusan penjagaan kesihatan untuk kanak-kanak yang mengalami gangguan spektrum autisme. (ASD). Matlamat kajian adalah untuk menterjemah dan mengesahkan soal selidik untuk menilai kepuasan penjaga terhadap perkhidmatan penjagaan kesihatan. Kaedah: Kajian keratan rentas telah dijalankan di kalangan 110 penjaga kanak-kanak dengan ASD berumur antara 2 dan 17 tahun yang menerima rawatan di dua pusat jagaan tinggi di Kelantan. Kebenaran untuk menggunakan borang soal selidik PSS versi asal telah diperolehi. Versi Inggeris asal PSS telah diterjemahkan ke dalam versi Bahasa Melayu berikutan 10 langkah yang dicadangkan oleh garis panduan yang ditetapkan. Pra-ujian PSS telah dijalankan dengan 30 penjaga sebelum analisis faktor pengesahan (CFA) ditubuhkan menggunakan 110 penjaga. Mereka diminta menilai kefahaman mereka terhadap soal selidik. Soal selidik satu dimensi terdiri daripada 11 barang, termasuk sikap kakitangan, ketersediaan kakitangan, sokongan, dan suka menolong. Skala Likert 5 mata memberikan penilaian daripada 1 (sangat tidak setuju) ke 5 (sangat bersetuju). Analisis faktor pengesahan dilakukan menggunakan penganggar kemungkinan maksimum yang teguh. Keputusan: Analisis menunjukkan data kesesuaian model dengan kebolehpercayaan yang baik. Kesimpulannya: PSS-M menunjukkan kecergasan model keseluruhan berdasarkan indeks tertentu, dengan kesahan konstruk yang baik dan kebolehpercayaan mutlak yang sangat baik untuk menentukan tahap kepuasan penjaga kanak-kanak dengan ASD berkenaan dengan perkhidmatan penjagaan kesihatan. © 2018, MDPI AG. Hak cipta terpelihara. |
Paudel, Y N; Syeikh, M F; Shah, S; Kumari, Y; Othman, Saya Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi Artikel Jurnal Jurnal Farmakologi Eropah, 837 , hlm. 145-155, 2018, ISSN: 00142999, (dipetik oleh 14). Abstrak | Pautan | BibTeX | Tag: 3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan @artikel{Paudel2018145, tajuk = {Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi}, pengarang = {Y N Paudel dan MF Shaikh dan S Shah dan Y Kumari dan I Othman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053082063&doi = 10.1016% 2fj.ejphar.2018.08.020&rakan kongsi = 40&md5=27ff0199bae72f156425637a7ad02228}, doi = {10.1016/j.ejphar.2018.08.020}, terbitan = {00142999}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Farmakologi Eropah}, isi padu = {837}, halaman = {145-155}, penerbit = {Elsevier B.V.}, abstrak = {Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V.}, nota = {dipetik oleh 14}, kata kunci = {3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V. |
Gudang, Dengan Y; Lal, S K The human gut microbiome - A potential controller of wellness and disease Artikel Jurnal Frontiers in Microbiology, 9 (AUG), 2018, ISSN: 1664302X, (dipetik oleh 80). Abstrak | Pautan | BibTeX | Tag: Acetylcholine, Autisme, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Manusia, Hydrocortisone, Immunity, Immunoglobulin A, Penyakit Usus Keradangan, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Flora usus, Leptin, Protein Membran, Metabolisme, Metabolite, Nervous System, Bukan Manusia, Obesiti, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Ekspresi Protein, Protein ZO1, Kaji semula, RNA 16S, Reseptor Seperti Tol 4, Transcription Factor FOXP3, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan, Unindexed Drug, Uvomorulin, Vasculotropin @artikel{Kho2018, tajuk = {The human gut microbiome - A potential controller of wellness and disease}, pengarang = {Z Y Kho and S K Lal}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051459505&doi=10.3389%2ffmicb.2018.01835&rakan kongsi = 40&md5=d89097ac9c0963d8ef7666aa99cff46f}, doi = {10.3389/fmicb.2018.01835}, terbitan = {1664302X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Frontiers in Microbiology}, isi padu = {9}, nombor = {AUG}, penerbit = {Frontiers Media S.A.}, abstrak = {Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. Dalam ulasan ini, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal.}, nota = {dipetik oleh 80}, kata kunci = {Acetylcholine, Autisme, Blood Clotting Factor 13, CD14 Antigen, Celiac Disease, Clostridium Difficile Infection, Colorectal Cancer, Cyanocobalamin, Dysbiosis, Enterotoxin, G Protein Coupled Bile Acid Receptor 1, G Protein Coupled Receptor 41, Gamma Interferon, Manusia, Hydrocortisone, Immunity, Immunoglobulin A, Penyakit Usus Keradangan, Interleukin 10, Interleukin 12, Interleukin 15, Interleukin 17, Interleukin 1beta, Interleukin 22, Interleukin 6, Interleukin 8, Flora usus, Leptin, Protein Membran, Metabolisme, Metabolite, Nervous System, Bukan Manusia, Obesiti, Pantothenic Acid, Pathogenesis, Protein Bcl-2, Ekspresi Protein, Protein ZO1, Kaji semula, RNA 16S, Reseptor Seperti Tol 4, Transcription Factor FOXP3, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan, Unindexed Drug, Uvomorulin, Vasculotropin}, pubstate = {diterbitkan}, tppubtype = {artikel} } Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. Dalam ulasan ini, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them. © 2018 Kho and Lal. |
Rendah, H M; Zailan, F International Journal of Developmental Disabilities, 64 (2), hlm. 86-95, 2018, ISSN: 20473869, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Awareness, Kelakuan, Exploratory Research, Perempuan, Manusia, Pengetahuan, Malaysia, Lelaki, Medical Student, Sikap Pelajar, Pelajar, Symptom @artikel{Low201886, tajuk = {Medical students’ perceptions, kesedaran, societal attitudes and knowledge of autism spectrum disorder: an exploratory study in Malaysia}, pengarang = {H M Low and F Zailan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002273499&doi=10.1080%2f20473869.2016.1264663&rakan kongsi = 40&md5=4b1b16448e16172b2dce10eacf1c3f3d}, doi = {10.1080/20473869.2016.1264663}, terbitan = {20473869}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {International Journal of Developmental Disabilities}, isi padu = {64}, nombor = {2}, halaman = {86-95}, penerbit = {Taylor and Francis Ltd.}, abstrak = {Objektif: This study aimed to investigate the perception, kesedaran, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Kaedah: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, kesedaran, societal attitude, and their recognition of ASD symptoms. Keputusan: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Secara khusus, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Kesimpulannya: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016.}, nota = {dipetik oleh 1}, kata kunci = {Dewasa, Artikel, Autisme, Awareness, Kelakuan, Exploratory Research, Perempuan, Manusia, Pengetahuan, Malaysia, Lelaki, Medical Student, Sikap Pelajar, Pelajar, Symptom}, pubstate = {diterbitkan}, tppubtype = {artikel} } Objektif: This study aimed to investigate the perception, kesedaran, societal attitude, and knowledge about Autism Spectrum Disorder (ASD) in Malaysian medical students. Kaedah: An exploratory survey was conducted with 83 medical students in Malaysia. In the survey, the medical students were required to rate their perception, kesedaran, societal attitude, and their recognition of ASD symptoms. Keputusan: The results showed the senior medical students had increased knowledge about ASD symptoms compared to the juniors, but there was no clear indicator that they had obtained the knowledge through formal training. Secara khusus, the medical students could better identify symptoms related to restrictive and fixation behavioral patterns than social communicative deficits. While considering the effects of societal attitude, year of study, perception about ASD course and other demographic variables, the year of study emerged as the sole predictor of the medical students’ knowledge about ASD. Kesimpulannya: The findings from this study provided evidence for the need of compulsory training on ASD in medical schools in improve the knowledge and skills of prospective medical practitioners to identify individuals with ASD. Such effort is fundamental for the early identification and intervention of ASD in developing countries such as Malaysia. © 2016, © The British Society of Developmental Disabilities 2016. |
Hariharan, M; Sindhu, R; Vijean, V; Yazid, H; Nadarajaw, T; Yaacob, S; Polat, K Improved binary dragonfly optimization algorithm and wavelet packet based non-linear features for infant cry classification Artikel Jurnal Computer Methods and Programs in Biomedicine, 155 , hlm. 39-51, 2018, ISSN: 01692607, (dipetik oleh 21). Abstrak | Pautan | BibTeX | Tag: Accidents, Algoritma, Artikel, Artificial Neural Network, Asphyxia, Binary Dragonfly Optimization Aalgorithm, Pengelasan (maklumat), Classification Algorithm, Pengelas, Coding, Computer-Assisted, Constants and Coefficients, Crying, Database Systems, Databases, Deafness, Diagnosis, Energy, Entropy, Pengekstrakan, Extreme Learning Machine, Factual, Factual Database, Pengekstrakan Ciri, Kaedah Pemilihan Ciri, Fuzzy System, Hearing Impairment, Manusia, Kelaparan, Bayi, Infant Cry, Infant Cry Classifications, Jaundice, Kernel Method, Belajar, Linear Predictive Coding, Pembelajaran Mesin, Mathematical Transformations, Mel Frequency Cepstral Coefficient, Pekali Cepstral Frekuensi Mel, Multi-Class Classification, Rangkaian Neural, Nonlinear Dynamics, Nonlinear System, Optimization, Pain, Patofisiologi, Prematurity, Kebolehulangan, Kebolehulangan Keputusan, Pemprosesan isyarat, Pengenalan suara, Wavelet Analysis, Wavelet Packet, Paket Wavelet Berubah @artikel{Hariharan201839, tajuk = {Improved binary dragonfly optimization algorithm and wavelet packet based non-linear features for infant cry classification}, pengarang = {M Hariharan and R Sindhu and V Vijean and H Yazid and T Nadarajaw and S Yaacob and K Polat}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85036611215&doi=10.1016%2fj.cmpb.2017.11.021&rakan kongsi = 40&md5=1f3b17817b00f07cadad6eb61c0f4bf9}, doi = {10.1016/j.cmpb.2017.11.021}, terbitan = {01692607}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Computer Methods and Programs in Biomedicine}, isi padu = {155}, halaman = {39-51}, penerbit = {Elsevier Ireland Ltd}, abstrak = {Background and objective Infant cry signal carries several levels of information about the reason for crying (hunger, pain, sleepiness and discomfort) or the pathological status (asphyxia, deaf, jaundice, premature condition and autism, etc.) of an infant and therefore suited for early diagnosis. Dalam kerja ini, combination of wavelet packet based features and Improved Binary Dragonfly Optimization based feature selection method was proposed to classify the different types of infant cry signals. Methods Cry signals from 2 different databases were utilized. First database contains 507 cry samples of normal (N), 340 cry samples of asphyxia (A), 879 cry samples of deaf (D), 350 cry samples of hungry (H) dan 192 cry samples of pain (P). Second database contains 513 cry samples of jaundice (J), 531 samples of premature (Prem) dan 45 samples of normal (N). Wavelet packet transform based energy and non-linear entropies (496 ciri-ciri), Linear Predictive Coding (LPC) based cepstral features (56 ciri-ciri), Mel-frequency Cepstral Coefficients (MFCCs) were extracted (16 ciri-ciri). The combined feature set consists of 568 ciri-ciri. To overcome the curse of dimensionality issue, improved binary dragonfly optimization algorithm (IBDFO) was proposed to select the most salient attributes or features. Akhirnya, Extreme Learning Machine (ELM) kernel classifier was used to classify the different types of infant cry signals using all the features and highly informative features as well. Results Several experiments of two-class and multi-class classification of cry signals were conducted. In binary or two-class experiments, maximum accuracy of 90.18% for H Vs P, 100% for A Vs N, 100% for D Vs N and 97.61% J Vs Prem was achieved using the features selected (only 204 features out of 568) by IBDFO. For the classification of multiple cry signals (multi-class problem), the selected features could differentiate between three classes (N, A & D) with the accuracy of 100% and seven classes with the accuracy of 97.62%. Conclusion The experimental results indicated that the proposed combination of feature extraction and selection method offers suitable classification accuracy and may be employed to detect the subtle changes in the cry signals. © 2017 Elsevier B.V.}, nota = {dipetik oleh 21}, kata kunci = {Accidents, Algoritma, Artikel, Artificial Neural Network, Asphyxia, Binary Dragonfly Optimization Aalgorithm, Pengelasan (maklumat), Classification Algorithm, Pengelas, Coding, Computer-Assisted, Constants and Coefficients, Crying, Database Systems, Databases, Deafness, Diagnosis, Energy, Entropy, Pengekstrakan, Extreme Learning Machine, Factual, Factual Database, Pengekstrakan Ciri, Kaedah Pemilihan Ciri, Fuzzy System, Hearing Impairment, Manusia, Kelaparan, Bayi, Infant Cry, Infant Cry Classifications, Jaundice, Kernel Method, Belajar, Linear Predictive Coding, Pembelajaran Mesin, Mathematical Transformations, Mel Frequency Cepstral Coefficient, Pekali Cepstral Frekuensi Mel, Multi-Class Classification, Rangkaian Neural, Nonlinear Dynamics, Nonlinear System, Optimization, Pain, Patofisiologi, Prematurity, Kebolehulangan, Kebolehulangan Keputusan, Pemprosesan isyarat, Pengenalan suara, Wavelet Analysis, Wavelet Packet, Paket Wavelet Berubah}, pubstate = {diterbitkan}, tppubtype = {artikel} } Background and objective Infant cry signal carries several levels of information about the reason for crying (hunger, pain, sleepiness and discomfort) or the pathological status (asphyxia, deaf, jaundice, premature condition and autism, etc.) of an infant and therefore suited for early diagnosis. Dalam kerja ini, combination of wavelet packet based features and Improved Binary Dragonfly Optimization based feature selection method was proposed to classify the different types of infant cry signals. Methods Cry signals from 2 different databases were utilized. First database contains 507 cry samples of normal (N), 340 cry samples of asphyxia (A), 879 cry samples of deaf (D), 350 cry samples of hungry (H) dan 192 cry samples of pain (P). Second database contains 513 cry samples of jaundice (J), 531 samples of premature (Prem) dan 45 samples of normal (N). Wavelet packet transform based energy and non-linear entropies (496 ciri-ciri), Linear Predictive Coding (LPC) based cepstral features (56 ciri-ciri), Mel-frequency Cepstral Coefficients (MFCCs) were extracted (16 ciri-ciri). The combined feature set consists of 568 ciri-ciri. To overcome the curse of dimensionality issue, improved binary dragonfly optimization algorithm (IBDFO) was proposed to select the most salient attributes or features. Akhirnya, Extreme Learning Machine (ELM) kernel classifier was used to classify the different types of infant cry signals using all the features and highly informative features as well. Results Several experiments of two-class and multi-class classification of cry signals were conducted. In binary or two-class experiments, maximum accuracy of 90.18% for H Vs P, 100% for A Vs N, 100% for D Vs N and 97.61% J Vs Prem was achieved using the features selected (only 204 features out of 568) by IBDFO. For the classification of multiple cry signals (multi-class problem), the selected features could differentiate between three classes (N, A & D) with the accuracy of 100% and seven classes with the accuracy of 97.62%. Conclusion The experimental results indicated that the proposed combination of feature extraction and selection method offers suitable classification accuracy and may be employed to detect the subtle changes in the cry signals. © 2017 Elsevier B.V. |
Diurut, R Tingkah laku merangsang dalam kanak-kanak perempuan berusia 4 tahun dengan gangguan spektrum autisme Artikel Jurnal Laporan Kes BMJ, 2018 , 2018, ISSN: 1757790X, (dipetik oleh 0). Pautan | BibTeX | Tag: Autisme, Gangguan Spektrum Autisme, biskut, Menggigit Objek Keras, Laporan kes, Mainan Kunyah, Keselamatan Kanak-kanak, Anak-anak, Artikel Klinikal, Perempuan, Makanan, Tekstur Makanan, Makanan panas, Manusia, Ketidakupayaan Bahasa, Nota, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psikologi, Rangsangan Diri, Makanan pedas, Kelakuan Stereotaip, Stereotaip, Tingkah Laku Merangsang, Biskut Tumbuh Gigi, sayur @artikel{Masiran2018, tajuk = {Tingkah laku merangsang dalam kanak-kanak perempuan berusia 4 tahun dengan gangguan spektrum autisme}, pengarang = {R Diurut}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042604824&doi = 10.1136% 2fbcr-2017-223671&rakan kongsi = 40&md5=c7b6514a4758257be1360250bf120de3}, doi = {10.1136/bcr-2017-223671}, terbitan = {1757790X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Laporan Kes BMJ}, isi padu = {2018}, penerbit = {Kumpulan Penerbitan BMJ}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Gangguan Spektrum Autisme, biskut, Menggigit Objek Keras, Laporan kes, Mainan Kunyah, Keselamatan Kanak-kanak, Anak-anak, Artikel Klinikal, Perempuan, Makanan, Tekstur Makanan, Makanan panas, Manusia, Ketidakupayaan Bahasa, Nota, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psikologi, Rangsangan Diri, Makanan pedas, Kelakuan Stereotaip, Stereotaip, Tingkah Laku Merangsang, Biskut Tumbuh Gigi, sayur}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Toh, T -H; Tan, V W -Y; Lau, PST; Kiyu, A Jurnal Autisme dan Gangguan Perkembangan, 48 (1), hlm. 28-35, 2018, ISSN: 01623257, (dipetik oleh 9). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil @artikel{Toh201828, tajuk = {Ketepatan Senarai Semak Perubahan untuk Autisme pada Kanak-kanak (M-CHAT) dalam Mengesan Autisme dan Gangguan Perkembangan Lain di Klinik Komuniti}, pengarang = {T -H Toh dan V W -Y Tan dan P S -T Lau dan A Kiyu}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85028764085&doi=10.1007/s10803-017-3287-x&rakan kongsi = 40&md5 = 21bce2407197b8b1e43b4420d274861b}, doi = {10.1007/s10803-017-3287-x}, terbitan = {01623257}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {48}, nombor = {1}, halaman = {28-35}, penerbit = {Springer New York LLC}, abstrak = {Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC.}, nota = {dipetik oleh 9}, kata kunci = {Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil}, pubstate = {diterbitkan}, tppubtype = {artikel} } Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 bulan dan kohort umur 27–36 bulan (54.5–64.3%). Walaupun nilai ramalan positif (PPV) miskin untuk ASD, terutamanya kohort yang lebih muda, positif M-CHAT membantu dalam mengesan semua DD (PPV = 81.6%). Ini mencadangkan M-CHAT untuk pemeriksaan ASD adalah tepat untuk kohort yang lebih tua (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC. |
Tidak juga, Cik Z; Ialah, Cik Z; Yusof, S N; Ghazi, H F; Jaafar, M H Journal of Nepal Paediatric Society, 38 (3), hlm. 182-189, 2018, ISSN: 19907974, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: 4' Isopropylidenediphenol, Artikel, Autisme, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Faktor Persekitaran, Exploratory Factor Analysis, Food Packaging, Manusia, Ketekalan Dalaman, Phthalic Acid, Plastic, Process Development, Soal selidik, Test Retest Reliability, Validation Process @artikel{MdNor2018182, tajuk = {The development and validation of questionnaire on autism spectrum disorders and its association with plastic-based food contact materials}, pengarang = {Z Md Nor and Z Md Isa and S N Yusof and H F Ghazi and M H Jaafar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083863826&doi=10.3126%2fjnps.v38i3.20671&rakan kongsi = 40&md5=13ffb01477ac798ebd7d430305d0a73a}, doi = {10.3126/jnps.v38i3.20671}, terbitan = {19907974}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Journal of Nepal Paediatric Society}, isi padu = {38}, nombor = {3}, halaman = {182-189}, penerbit = {Nepal Paediatric Society (NEPAS)}, abstrak = {Pengenalan: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic-based food contact materials (FCM) as a proxy for exposure to this group of EDCs. Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done. Keputusan: The questionnaire achieved kappa value ranged between 0.800 ke 0.900 for knowledge, 0.610 ke 0.815 for perception and 0.607 ke 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 ke 0.780. Kesimpulannya: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items. © 2020, Nepal Paediatric Society (NEPAS). Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {4' Isopropylidenediphenol, Artikel, Autisme, Confirmatory Factor Analysis, Cronbach Alpha Coefficient, Endocrine Disruptor, Environmental Exposure, Faktor Persekitaran, Exploratory Factor Analysis, Food Packaging, Manusia, Ketekalan Dalaman, Phthalic Acid, Plastic, Process Development, Soal selidik, Test Retest Reliability, Validation Process}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic-based food contact materials (FCM) as a proxy for exposure to this group of EDCs. Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done. Keputusan: The questionnaire achieved kappa value ranged between 0.800 ke 0.900 for knowledge, 0.610 ke 0.815 for perception and 0.607 ke 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 ke 0.780. Kesimpulannya: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items. © 2020, Nepal Paediatric Society (NEPAS). Hak cipta terpelihara. |
Diurut, R Autisme dan trikotilomania dalam remaja lelaki Artikel Jurnal Laporan Kes BMJ, 2018 , 2018, ISSN: 1757790X, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Alopecia, Keresahan, Artikel, Gangguan Defisit Perhatian, Gangguan Hiperaktifan Kekurangan Perhatian, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Berat badan, Laporan kes, Perangsang Sistem Saraf Pusat, Senarai Semak Tingkah Laku Kanak-kanak, Artikel Klinikal, komorbiditi, Komplikasi, Diagnosis, Berbeza, Diagnosis pembezaan, Pentitratan Dos Ubat, Toleransi Dadah, DSM-5, Echolalia, Fluvoxamine, Susulan, Manusia, Hiperaktif, Kemerosotan Intelektual, Lelaki, Metilfenidat, Obesiti, Terapi pekerjaan, Indeks Penaakulan Persepsi, Jurnal Keutamaan, Indeks Kelajuan Pemprosesan, Skala Penarafan Status Psikiatri, Skala Penarafan Psikologi, Skala penilaian, Kegelisahan, Ganjaran, Perencat Serapan Serotonin, Perencat Serapan Serotonin, Pendidikan Khas, Kelewatan Pertuturan, Gangguan Pertuturan, Terapi ucapan, Trikotilomania, Indeks Kefahaman Lisan, Skala Kepintaran Wechsler, Indeks Memori Bekerja @artikel{Masiran2018b, tajuk = {Autisme dan trikotilomania dalam remaja lelaki}, pengarang = {R Diurut}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053164449&doi = 10.1136% 2fbcr-2018-226270&rakan kongsi = 40&md5=7eed3f6af717df527dce73838feab571}, doi = {10.1136/bcr-2018-226270}, terbitan = {1757790X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Laporan Kes BMJ}, isi padu = {2018}, penerbit = {Kumpulan Penerbitan BMJ}, abstrak = {Remaja yang mengalami gangguan spektrum autisme dan gangguan hiperaktif kekurangan perhatian yang tidak dirawat dengan betul ditunjukkan dengan tarikan rambut berulang. Rawatan dengan perencat pengambilan semula serotonin terpilih dan perangsang memperbaiki keadaan ini. © © BMJ Publishing Group Limited 2018.}, nota = {dipetik oleh 0}, kata kunci = {Remaja, Alopecia, Keresahan, Artikel, Gangguan Defisit Perhatian, Gangguan Hiperaktifan Kekurangan Perhatian, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Berat badan, Laporan kes, Perangsang Sistem Saraf Pusat, Senarai Semak Tingkah Laku Kanak-kanak, Artikel Klinikal, komorbiditi, Komplikasi, Diagnosis, Berbeza, Diagnosis pembezaan, Pentitratan Dos Ubat, Toleransi Dadah, DSM-5, Echolalia, Fluvoxamine, Susulan, Manusia, Hiperaktif, Kemerosotan Intelektual, Lelaki, Metilfenidat, Obesiti, Terapi pekerjaan, Indeks Penaakulan Persepsi, Jurnal Keutamaan, Indeks Kelajuan Pemprosesan, Skala Penarafan Status Psikiatri, Skala Penarafan Psikologi, Skala penilaian, Kegelisahan, Ganjaran, Perencat Serapan Serotonin, Perencat Serapan Serotonin, Pendidikan Khas, Kelewatan Pertuturan, Gangguan Pertuturan, Terapi ucapan, Trikotilomania, Indeks Kefahaman Lisan, Skala Kepintaran Wechsler, Indeks Memori Bekerja}, pubstate = {diterbitkan}, tppubtype = {artikel} } Remaja yang mengalami gangguan spektrum autisme dan gangguan hiperaktif kekurangan perhatian yang tidak dirawat dengan betul ditunjukkan dengan tarikan rambut berulang. Rawatan dengan perencat pengambilan semula serotonin terpilih dan perangsang memperbaiki keadaan ini. © © BMJ Publishing Group Limited 2018. |
Thu, Tidak H; Hussain, DENGAN; Shuid, A N Current Drug Targets, 19 (8), hlm. 865-876, 2018, ISSN: 13894501, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Amisulpride, Amitriptyline, Haiwan, Antipsychotic Agents, Keresahan, Aripiprazole, Autisme, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Kimia, Clonazepam, Clozapine, Kemurungan, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Penjagaan Kesihatan, Manusia, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Gangguan Mental, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Patofisiologi, Kebolehtelapan, Physical Chemistry, Psychosis, Kaji semula, Risperidone, Skizofrenia, Solubility, Sulpiride, Hasil Rawatan, Venlafaxine, Ziprasidone @artikel{EiThu2018865, tajuk = {New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects}, pengarang = {H Ei Thu and Z Hussain and A N Shuid}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048981535&doi=10.2174%2f1389450117666161125174625&rakan kongsi = 40&md5=d32e5bc9766ff9d68dd79f082b9ca4bc}, doi = {10.2174/1389450117666161125174625}, terbitan = {13894501}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Current Drug Targets}, isi padu = {19}, nombor = {8}, halaman = {865-876}, penerbit = {Bentham Science Publishers B.V.}, abstrak = {Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. Sehingga kini, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, kegelisahan, bipolar disorders and autism spectrum problems. Walau bagaimanapun, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Oleh itu, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers.}, nota = {dipetik oleh 2}, kata kunci = {Amisulpride, Amitriptyline, Haiwan, Antipsychotic Agents, Keresahan, Aripiprazole, Autisme, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Kimia, Clonazepam, Clozapine, Kemurungan, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Penjagaan Kesihatan, Manusia, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Gangguan Mental, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Patofisiologi, Kebolehtelapan, Physical Chemistry, Psychosis, Kaji semula, Risperidone, Skizofrenia, Solubility, Sulpiride, Hasil Rawatan, Venlafaxine, Ziprasidone}, pubstate = {diterbitkan}, tppubtype = {artikel} } Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. Sehingga kini, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, kegelisahan, bipolar disorders and autism spectrum problems. Walau bagaimanapun, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Oleh itu, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers. |
2017 |
Hnoonual, A; Thammachote, W; Tim-Aroon, T; Rojnueangnit, K; Hansakunachai, T; Sombuntham, T; Roongpraiwan, R; Vorachotekamjorn, J; Chuthapisith, J; Fucharoen, S; Wattanasirichaigoon, D; Ruangdaraganon, N; Limprasert, P; Jinawath, N Laporan Saintifik, 7 (1), 2017, ISSN: 20452322, (dipetik oleh 6). Abstrak | Pautan | BibTeX | Tag: Remaja, Autisme, Gangguan Spektrum Autisme, Anak-anak, Pemetaan Kromosom, Pemetaan Kromosom, Analisis Kohort, Kajian Kohort, Variasi Nombor Salin, Variasi Nombor Salinan DNA, Perempuan, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Genetik, Manusia, Bayi, Lelaki, Protein Membran, Protein Membran, Analisis Mikroarray, Polimorfisme, Prasekolah, Kanak-kanak Prasekolah, Prosedur, SERINC2 Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal @artikel{Hnoual2017, tajuk = {Analisis microarray kromosom dalam kohort populasi yang kurang diwakili mengenal pasti SERINC2 sebagai gen calon baru untuk gangguan spektrum autisme}, pengarang = {A Hnoonual dan W Thammachote dan T Tim-Aroon dan K Rojnueangnit dan T Hansakunachai dan T Sombuntham dan R Roongpraiwan dan J Worachotekamjorn dan J Chuthapisith dan S Fucharoen dan D Wattanasirichaigoon dan N Ruangdaraganon dan P Limprasert dan N Jinawath}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029864969&doi=10.1038/s41598-017-12317-3&rakan kongsi = 40&md5=3c1b6a0c064665aab8ace8e8f58c2b01}, doi = {10.1038/s41598-017-12317-3}, terbitan = {20452322}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Laporan Saintifik}, isi padu = {7}, nombor = {1}, penerbit = {Kumpulan Penerbitan Alam}, abstrak = {Mikroarray kromosom (CMA) kini diiktiraf sebagai ujian genetik peringkat pertama untuk pengesanan variasi nombor salinan (CNV) pada pesakit dengan gangguan spektrum autisme (ASD). Matlamat kajian ini adalah untuk mengenal pasti ASD-CNV yang diketahui dan baru yang berkaitan dan untuk menilai hasil diagnostik CMA dalam pesakit Thai dengan ASD. Infinium CytoSNP-850K BeadChip telah digunakan untuk mengesan CNV dalam 114 Pesakit Thai terdiri daripada 68 pesakit ASD retrospektif (kumpulan 1) dengan penggunaan CMA sebagai ujian baris kedua dan 46 bakal pesakit ASD dan kelewatan perkembangan (kumpulan 2) dengan penggunaan CMA sebagai ujian peringkat pertama. Kami mengenal pasti 7 (6.1%) CNV patogenik dan 22 (19.3%) varian kepentingan klinikal yang tidak pasti (ANDA). Sejumlah 29 pesakit dengan CNV patogen dan VOUS ditemui di 22% (15/68) dan 30.4% (14/46) daripada pesakit dalam kumpulan 1 dan 2, masing-masing. Perbezaan frekuensi CNV yang dikesan antara 2 kumpulan tidak signifikan secara statistik (Chi kuasa dua = 1.02}, nota = {dipetik oleh 6}, kata kunci = {Remaja, Autisme, Gangguan Spektrum Autisme, Anak-anak, Pemetaan Kromosom, Pemetaan Kromosom, Analisis Kohort, Kajian Kohort, Variasi Nombor Salin, Variasi Nombor Salinan DNA, Perempuan, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Genetik, Manusia, Bayi, Lelaki, Protein Membran, Protein Membran, Analisis Mikroarray, Polimorfisme, Prasekolah, Kanak-kanak Prasekolah, Prosedur, SERINC2 Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal}, pubstate = {diterbitkan}, tppubtype = {artikel} } Mikroarray kromosom (CMA) kini diiktiraf sebagai ujian genetik peringkat pertama untuk pengesanan variasi nombor salinan (CNV) pada pesakit dengan gangguan spektrum autisme (ASD). Matlamat kajian ini adalah untuk mengenal pasti ASD-CNV yang diketahui dan baru yang berkaitan dan untuk menilai hasil diagnostik CMA dalam pesakit Thai dengan ASD. Infinium CytoSNP-850K BeadChip telah digunakan untuk mengesan CNV dalam 114 Pesakit Thai terdiri daripada 68 pesakit ASD retrospektif (kumpulan 1) dengan penggunaan CMA sebagai ujian baris kedua dan 46 bakal pesakit ASD dan kelewatan perkembangan (kumpulan 2) dengan penggunaan CMA sebagai ujian peringkat pertama. Kami mengenal pasti 7 (6.1%) CNV patogenik dan 22 (19.3%) varian kepentingan klinikal yang tidak pasti (ANDA). Sejumlah 29 pesakit dengan CNV patogen dan VOUS ditemui di 22% (15/68) dan 30.4% (14/46) daripada pesakit dalam kumpulan 1 dan 2, masing-masing. Perbezaan frekuensi CNV yang dikesan antara 2 kumpulan tidak signifikan secara statistik (Chi kuasa dua = 1.02 |
Hameed, S S; Hassan, R; Muhammad, F F Pemilihan dan klasifikasi ekspresi gen dalam gangguan autisme: Penggunaan gabungan penapis statistik dan algoritma GBPSO-SVM Artikel Jurnal PLoS SATU, 12 (11), 2017, ISSN: 19326203, (dipetik oleh 11). Abstrak | Pautan | BibTeX | Tag: Ketepatan, Algoritma, Artikel, Autisme, Gangguan Spektrum Autisme, Gen CAPS2, Pengelasan (maklumat), Pengelas, Kajian Eksperimen, Gen, Ekspresi Gen, Pengenalan Gen, Persatuan Genetik, Prosedur Genetik, Risiko Genetik, Genetik, Algoritma Mesin Vektor Sokongan Pengoptimuman Zarah Perduaan Perduaan Geometri, Manusia, Penilaian risiko, Penyeragaman, Penapis Statistik, Parameter Statistik, Statistik, Mesin Vektor Sokongan @artikel{Hameed2017, tajuk = {Pemilihan dan klasifikasi ekspresi gen dalam gangguan autisme: Penggunaan gabungan penapis statistik dan algoritma GBPSO-SVM}, pengarang = {S S Hameed dan R Hassan dan F F Muhammad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033361187&doi=10.1371/journal.pone.0187371&rakan kongsi = 40&md5=f9260d41165145f229a3cf157699635e}, doi = {10.1371/jurnal.pone.0187371}, terbitan = {19326203}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {PLoS SATU}, isi padu = {12}, nombor = {11}, penerbit = {Perpustakaan Awam Sains}, abstrak = {Dalam kerja ini, ekspresi gen dalam gangguan spektrum autisme (ASD) dianalisis dengan matlamat untuk memilih gen yang paling dikaitkan dan melaksanakan pengelasan. Objektif ini dicapai dengan menggunakan gabungan pelbagai penapis statistik dan mesin vektor sokongan pengoptimuman zarah binari geometri berasaskan pembalut (GBPSO-SVM) algoritma. Penggunaan penapis yang berbeza telah diserlahkan dengan memasukkan kriteria nisbah min dan median untuk membuang gen yang sangat serupa. Keputusan menunjukkan bahawa gen yang paling diskriminatif yang dikenal pasti dalam langkah pemilihan pertama dan terakhir termasuk kehadiran gen berulang. (CAPS2), yang ditugaskan sebagai gen yang paling berkaitan dengan risiko ASD. Subset gen gabungan yang dipilih oleh algoritma GBPSO-SVM dapat meningkatkan ketepatan klasifikasi. © 2017 Hameed et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.}, nota = {dipetik oleh 11}, kata kunci = {Ketepatan, Algoritma, Artikel, Autisme, Gangguan Spektrum Autisme, Gen CAPS2, Pengelasan (maklumat), Pengelas, Kajian Eksperimen, Gen, Ekspresi Gen, Pengenalan Gen, Persatuan Genetik, Prosedur Genetik, Risiko Genetik, Genetik, Algoritma Mesin Vektor Sokongan Pengoptimuman Zarah Perduaan Perduaan Geometri, Manusia, Penilaian risiko, Penyeragaman, Penapis Statistik, Parameter Statistik, Statistik, Mesin Vektor Sokongan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Dalam kerja ini, ekspresi gen dalam gangguan spektrum autisme (ASD) dianalisis dengan matlamat untuk memilih gen yang paling dikaitkan dan melaksanakan pengelasan. Objektif ini dicapai dengan menggunakan gabungan pelbagai penapis statistik dan mesin vektor sokongan pengoptimuman zarah binari geometri berasaskan pembalut (GBPSO-SVM) algoritma. Penggunaan penapis yang berbeza telah diserlahkan dengan memasukkan kriteria nisbah min dan median untuk membuang gen yang sangat serupa. Keputusan menunjukkan bahawa gen yang paling diskriminatif yang dikenal pasti dalam langkah pemilihan pertama dan terakhir termasuk kehadiran gen berulang. (CAPS2), yang ditugaskan sebagai gen yang paling berkaitan dengan risiko ASD. Subset gen gabungan yang dipilih oleh algoritma GBPSO-SVM dapat meningkatkan ketepatan klasifikasi. © 2017 Hameed et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan. |
Di mana, S W; Ong, L C; Rendah, W Y; Lai, P S M Epilepsy Research, 136 , hlm. 35-45, 2017, ISSN: 09201211, (dipetik oleh 8). Abstrak | Pautan | BibTeX | Tag: Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement @artikel{Wo201735, tajuk = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: Kajian semula yang sistematik}, pengarang = {S W Wo and L C Ong and W Y Low and P S M Lai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&rakan kongsi = 40&md5=f34a0aada2cc5dc6e4d6beab18ac779c}, doi = {10.1016/j.eplepsyres.2017.07.009}, terbitan = {09201211}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Epilepsy Research}, isi padu = {136}, halaman = {35-45}, penerbit = {Elsevier B.V.}, abstrak = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.}, nota = {dipetik oleh 8}, kata kunci = {Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement}, pubstate = {diterbitkan}, tppubtype = {artikel} } Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V. |
Hasan, C Z C; Jailani, R; Tahir, Md N; Ilias, S Analisis daya tindak balas tanah tiga dimensi semasa berjalan pada kanak-kanak dengan gangguan spektrum autisme Artikel Jurnal Penyelidikan Ketidakupayaan Pembangunan, 66 , hlm. 55-63, 2017, ISSN: 08914222, (dipetik oleh 8). Abstrak | Pautan | BibTeX | Tag: Taburan Umur, Artikel, Autisme, Gangguan Spektrum Autisme, Fenomena Biomekanikal, Biomekanik, Keseimbangan Badan, Tinggi Badan, Berat badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Penilaian Penyakit, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Angkatan Tindak Balas Tanah, Manusia, Pengimejan, Panjang Kaki, Malaysia, Lelaki, Pemeriksaan Neurologi, Patofisiologi, Fisiologi, Keseimbangan Postur, Prosedur, Psikologi, Statistik, Tiga Dimensi, Pengimejan Tiga Dimensi, Daya Tindak Balas Tanah Tiga Dimensi, berjalan @artikel{Hasan201755, tajuk = {Analisis daya tindak balas tanah tiga dimensi semasa berjalan pada kanak-kanak dengan gangguan spektrum autisme}, pengarang = {C Z C Hasan and R Jailani and N Md Tahir and S Ilias}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015640386&doi = 10.1016% 2fj.ridd.2017.02.015&rakan kongsi = 40&md5=d6a9839cda7f62bcce9bdcca33d3d33b}, doi = {10.1016/j.ridd.2017.02.015}, terbitan = {08914222}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Penyelidikan Ketidakupayaan Pembangunan}, isi padu = {66}, halaman = {55-63}, penerbit = {Elsevier Inc.}, abstrak = {Maklumat minimum diketahui tentang tiga dimensi (3D) daya tindak balas tanah (GRF) mengenai corak gaya berjalan individu yang mengalami gangguan spektrum autisme (ASD). Tujuan kajian ini adalah untuk menyiasat sama ada komponen GRF 3D berbeza secara signifikan antara kanak-kanak dengan ASD dan kawalan rakan sebaya.. 15 kanak-kanak dengan ASD dan 25 biasanya berkembang (TD) kanak-kanak telah mengambil bahagian dalam kajian ini. Dua plat daya digunakan untuk mengukur data GRF 3D semasa berjalan. Teknik parameterisasi siri masa telah digunakan untuk mengekstrak 17 ciri diskret daripada bentuk gelombang GRF 3D. Dengan menggunakan ujian-t bebas dan ujian Mann-Whitney U, perbezaan yang ketara (hlm < 0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. © 2017 Elsevier Ltd}, nota = {dipetik oleh 8}, kata kunci = {Taburan Umur, Artikel, Autisme, Gangguan Spektrum Autisme, Fenomena Biomekanikal, Biomekanik, Keseimbangan Badan, Tinggi Badan, Berat badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Penilaian Penyakit, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Angkatan Tindak Balas Tanah, Manusia, Pengimejan, Panjang Kaki, Malaysia, Lelaki, Pemeriksaan Neurologi, Patofisiologi, Fisiologi, Keseimbangan Postur, Prosedur, Psikologi, Statistik, Tiga Dimensi, Pengimejan Tiga Dimensi, Daya Tindak Balas Tanah Tiga Dimensi, berjalan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Maklumat minimum diketahui tentang tiga dimensi (3D) daya tindak balas tanah (GRF) mengenai corak gaya berjalan individu yang mengalami gangguan spektrum autisme (ASD). Tujuan kajian ini adalah untuk menyiasat sama ada komponen GRF 3D berbeza secara signifikan antara kanak-kanak dengan ASD dan kawalan rakan sebaya.. 15 kanak-kanak dengan ASD dan 25 biasanya berkembang (TD) kanak-kanak telah mengambil bahagian dalam kajian ini. Dua plat daya digunakan untuk mengukur data GRF 3D semasa berjalan. Teknik parameterisasi siri masa telah digunakan untuk mengekstrak 17 ciri diskret daripada bentuk gelombang GRF 3D. Dengan menggunakan ujian-t bebas dan ujian Mann-Whitney U, perbezaan yang ketara (hlm < 0.05) antara kumpulan ASD dan TD didapati untuk empat ciri GRF. Kanak-kanak dengan ASD menunjukkan daya brek maksimum yang lebih tinggi, masa relatif lebih rendah kepada daya brek maksimum, dan masa relatif lebih rendah kepada daya sifar semasa berdiri pertengahan. Kanak-kanak dengan ASD juga didapati telah mengurangkan puncak kedua GRF menegak dalam pendirian terminal. Penemuan utama ini mencadangkan bahawa kanak-kanak dengan ASD mengalami kesukaran yang ketara dalam menyokong berat badan mereka dan menanggung ketidakstabilan gaya berjalan semasa fasa berdiri.. Penemuan penyelidikan ini berguna kepada kedua-dua doktor dan ibu bapa yang ingin menyediakan kanak-kanak ini dengan rawatan dan program pemulihan yang sesuai. © 2017 Elsevier Ltd. |
Singh, Joginder S; Hussein, N H; Kamal, Mustaffa R; Hassan, F H Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Artikel Jurnal AAC: Augmentative and Alternative Communication, 33 (2), hlm. 110-120, 2017, ISSN: 07434618, (dipetik oleh 10). Abstrak | Pautan | BibTeX | Tag: Dewasa, Sikap Terhadap Kesihatan, Augmentative and Alternative Communication, Anak-anak, Communication Aid, Communication Aids for Disabled, Gangguan Komunikasi, Communication Disorders, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Disabilities, Penyakit, Keluarga, Perempuan, Manusia, Human Rehabilitation Engineering, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Prasekolah, Kanak-kanak Prasekolah, Qualitative Research @artikel{JoginderSingh2017110, tajuk = {Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC}, pengarang = {S Joginder Singh and N H Hussein and R Mustaffa Kamal and F H Hassan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131769&doi=10.1080%2f07434618.2017.1309457&rakan kongsi = 40&md5=067c39e0c318e76caff96b29bb4dbb21}, doi = {10.1080/07434618.2017.1309457}, terbitan = {07434618}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {AAC: Augmentative and Alternative Communication}, isi padu = {33}, nombor = {2}, halaman = {110-120}, penerbit = {Taylor and Francis Ltd}, abstrak = {Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. Sehingga kini, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. Untuk kajian ini, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, dan (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication.}, nota = {dipetik oleh 10}, kata kunci = {Dewasa, Sikap Terhadap Kesihatan, Augmentative and Alternative Communication, Anak-anak, Communication Aid, Communication Aids for Disabled, Gangguan Komunikasi, Communication Disorders, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Disabilities, Penyakit, Keluarga, Perempuan, Manusia, Human Rehabilitation Engineering, Malaysia, Lelaki, Pertengahan umur, Ibu bapa, Prasekolah, Kanak-kanak Prasekolah, Qualitative Research}, pubstate = {diterbitkan}, tppubtype = {artikel} } Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. Sehingga kini, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. Untuk kajian ini, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, dan (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication. |
Shuib, S; Saaid, N N; Zakaria, DENGAN; Ismail, J; Latiff, Abdul Z Penduaan 17p11.2 (Sindrom Potocki-Lupski) pada kanak-kanak yang mengalami kelewatan perkembangan Artikel Jurnal Jurnal Patologi Malaysia, 39 (1), hlm. 77-81, 2017, ISSN: 01268635, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Keabnormalan, Agarose, Artikel, Autisme, Gangguan Spektrum Autisme, Budaya Darah, Laporan kes, Anak-anak, Kromosom 17, Analisis Kromosom, Gangguan Kromosom, Penduaan Kromosom, Kromosom, Artikel Klinikal, Hibridisasi Genomik Perbandingan, Kelewatan Perkembangan, Elektroforesis, Perempuan, Pendarfluor, Pendarfluor dalam Hibridisasi Situ, Gen, Pengenalan Gen, Genetik, DNA genomik, Manusia, Hibridisasi In Situ, Kultur Limfosit, Analisis Mikroarray, Pelbagai, Sindrom Malformasi Pelbagai, berpasangan 17, Fenotip, Sindrom Potocki Lupski, Prasekolah, Kanak-kanak Prasekolah, Prosedur, Gen RAI1, Spektrofotometri ultraungu @artikel{Shuib201777, tajuk = {Penduaan 17p11.2 (Sindrom Potocki-Lupski) pada kanak-kanak yang mengalami kelewatan perkembangan}, pengarang = {S Shuib and N N Saaid and Z Zakaria and J Ismail and Z Abdul Latiff}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037028880&rakan kongsi = 40&md5=624b87d1e9ebac2d1bf66b4d30c0f6e9}, terbitan = {01268635}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Jurnal Patologi Malaysia}, isi padu = {39}, nombor = {1}, halaman = {77-81}, penerbit = {Persatuan Pakar Patologi Malaysia}, abstrak = {Sindrom Potocki-Lupski (PTLS), juga dikenali sebagai sindrom duplikasi 17p11.2, trisomi 17p11.2 atau dup(17)(p11.2p11.2) sindrom, adalah gangguan perkembangan dan sindrom gen bersebelahan yang jarang menjejaskan 1 dalam 20,000 kelahiran hidup. Antara ciri utama pesakit tersebut ialah gangguan spektrum autisme, ketidakupayaan pembelajaran, kelewatan perkembangan, gangguan kurang perhatian, hipotonia bayi dan keabnormalan kardiovaskular. Kajian terdahulu menggunakan microarray mengenal pasti variasi dalam saiz dan takat kawasan pendua kromosom 17p11.2. Walau bagaimanapun, terdapat beberapa gen yang dianggap sebagai calon PTLS termasuk RAI1, SREBF1, DRG2, LLGL1, SHMT1 dan ZFP179. Dalam laporan ini, kami menyiasat kes seorang kanak-kanak perempuan berumur 3 tahun yang mengalami kelewatan perkembangan. Analisis kromosomnya menunjukkan karyotype normal (46,XX). Analisis menggunakan tatasusunan CGH (4X44 K, Agilent USA) mengenal pasti pertindihan ~4.2 Mb de novo dalam kromosom 17p11.2. Hasilnya disahkan oleh hibridisasi in situ pendarfluor (IKAN) menggunakan probe di kawasan PTLS kritikal. Laporan ini menunjukkan kepentingan microarray dan FISH dalam diagnosis PTLS. © 2017, Persatuan Pakar Patologi Malaysia. Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {Keabnormalan, Agarose, Artikel, Autisme, Gangguan Spektrum Autisme, Budaya Darah, Laporan kes, Anak-anak, Kromosom 17, Analisis Kromosom, Gangguan Kromosom, Penduaan Kromosom, Kromosom, Artikel Klinikal, Hibridisasi Genomik Perbandingan, Kelewatan Perkembangan, Elektroforesis, Perempuan, Pendarfluor, Pendarfluor dalam Hibridisasi Situ, Gen, Pengenalan Gen, Genetik, DNA genomik, Manusia, Hibridisasi In Situ, Kultur Limfosit, Analisis Mikroarray, Pelbagai, Sindrom Malformasi Pelbagai, berpasangan 17, Fenotip, Sindrom Potocki Lupski, Prasekolah, Kanak-kanak Prasekolah, Prosedur, Gen RAI1, Spektrofotometri ultraungu}, pubstate = {diterbitkan}, tppubtype = {artikel} } Sindrom Potocki-Lupski (PTLS), juga dikenali sebagai sindrom duplikasi 17p11.2, trisomi 17p11.2 atau dup(17)(p11.2p11.2) sindrom, adalah gangguan perkembangan dan sindrom gen bersebelahan yang jarang menjejaskan 1 dalam 20,000 kelahiran hidup. Antara ciri utama pesakit tersebut ialah gangguan spektrum autisme, ketidakupayaan pembelajaran, kelewatan perkembangan, gangguan kurang perhatian, hipotonia bayi dan keabnormalan kardiovaskular. Kajian terdahulu menggunakan microarray mengenal pasti variasi dalam saiz dan takat kawasan pendua kromosom 17p11.2. Walau bagaimanapun, terdapat beberapa gen yang dianggap sebagai calon PTLS termasuk RAI1, SREBF1, DRG2, LLGL1, SHMT1 dan ZFP179. Dalam laporan ini, kami menyiasat kes seorang kanak-kanak perempuan berumur 3 tahun yang mengalami kelewatan perkembangan. Analisis kromosomnya menunjukkan karyotype normal (46,XX). Analisis menggunakan tatasusunan CGH (4X44 K, Agilent USA) mengenal pasti pertindihan ~4.2 Mb de novo dalam kromosom 17p11.2. Hasilnya disahkan oleh hibridisasi in situ pendarfluor (IKAN) menggunakan probe di kawasan PTLS kritikal. Laporan ini menunjukkan kepentingan microarray dan FISH dalam diagnosis PTLS. © 2017, Persatuan Pakar Patologi Malaysia. Hak cipta terpelihara. |
Bhagat, V; Haque, M; Simbak, N B; Husain, R Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education Artikel Jurnal Journal of Global Pharma Technology, 9 (7), hlm. 32-43, 2017, ISSN: 09758542, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Adaptive Behavior, Amygdala, Autisme, Awareness, Kognisi, komorbiditi, Kerangka Konseptual, Cost Benefit Analysis, Pendidikan, Emosi, Emotional Disorder, Emotionality, Penjagaan Kesihatan, Health Promotion, Manusia, Impulsif, Belajar, Motivasi, Parent Education, Persepsi, Garis Panduan Amalan, Prefrontal Cortex, Kelaziman, Problem Behavior, Psychoeducation, Psychological Well Being, Kaji semula, Sex Difference, Kelakuan Sosial, Kognisi Sosial, Kecekapan Sosial, Social Learning @artikel{Bhagat201732, tajuk = {Emotional regulation in autism spectrum disorders: A new proposed model for regulating emotions through parent education}, pengarang = {V Bhagat and M Haque and N B Simbak and R Husain}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021786235&rakan kongsi = 40&md5=ece2d7c28018f0c4526810e08e314461}, terbitan = {09758542}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Journal of Global Pharma Technology}, isi padu = {9}, nombor = {7}, halaman = {32-43}, penerbit = {Journal of Global Pharma Technology}, abstrak = {Autism spectrum disorders (ASD) boleh menjejaskan semua bidang kehidupan kanak-kanak. One of the areas of the behavioral spectrum need to be focused is affected. Oleh itu, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Oleh itu, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT.}, nota = {dipetik oleh 0}, kata kunci = {Adaptive Behavior, Amygdala, Autisme, Awareness, Kognisi, komorbiditi, Kerangka Konseptual, Cost Benefit Analysis, Pendidikan, Emosi, Emotional Disorder, Emotionality, Penjagaan Kesihatan, Health Promotion, Manusia, Impulsif, Belajar, Motivasi, Parent Education, Persepsi, Garis Panduan Amalan, Prefrontal Cortex, Kelaziman, Problem Behavior, Psychoeducation, Psychological Well Being, Kaji semula, Sex Difference, Kelakuan Sosial, Kognisi Sosial, Kecekapan Sosial, Social Learning}, pubstate = {diterbitkan}, tppubtype = {artikel} } Autism spectrum disorders (ASD) boleh menjejaskan semua bidang kehidupan kanak-kanak. One of the areas of the behavioral spectrum need to be focused is affected. Oleh itu, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Oleh itu, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on the psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard. © 2009-2017, JGPT. |
Hasan, C Z C; Jailani, R; Tahir, Md N Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder Artikel Jurnal International Journal of Biology and Biomedical Engineering, 11 , hlm. 74-79, 2017, ISSN: 19984510, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Artikel, Artificial Neural Network, Autisme, Tinggi Badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Analisis Diskriminan, Early Diagnosis, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Manusia, Belajar, Lelaki, Pediatrics, Budak sekolah, Statistical Analysis, Statistik, Time Series Analysis @artikel{Hasan201774, tajuk = {Use of statistical approaches and artificial neural networks to identify gait deviations in children with autism spectrum disorder}, pengarang = {C Z C Hasan and R Jailani and N Md Tahir}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043500605&rakan kongsi = 40&md5=6f2ffe7c2f5daf9fd02d4456acb94438}, terbitan = {19984510}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {International Journal of Biology and Biomedical Engineering}, isi padu = {11}, halaman = {74-79}, penerbit = {North Atlantic University Union NAUN}, abstrak = {Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% ketepatan, 93.3% kepekaan, dan 90.0% kekhususan. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. Hak cipta terpelihara.}, nota = {dipetik oleh 1}, kata kunci = {Artikel, Artificial Neural Network, Autisme, Tinggi Badan, Berat badan, Anak-anak, Artikel Klinikal, Kajian Terkawal, Analisis Diskriminan, Early Diagnosis, Perempuan, Langkah, Analisis Gait, Gangguan Gaya Berjalan, Manusia, Belajar, Lelaki, Pediatrics, Budak sekolah, Statistical Analysis, Statistik, Time Series Analysis}, pubstate = {diterbitkan}, tppubtype = {artikel} } Automated differentiation of ASD gait from normal gait patterns is important for early diagnosis as well as ensuring rapid quantitative clinical decision and appropriate treatment planning. This study explores the use of statistical feature selection approaches and artificial neural networks (ANN) for automated identification of gait deviations in children with ASD, on the basis of dominant gait features derived from the three-dimensional (3D) joint kinematic data. The gait data from 30 ASD children and 30 normal healthy children were measured using a state-of-the-art 3D motion analysis system during self-selected speed barefoot walking. Kinematic gait features from the sagittal, frontal and transverse joint angles waveforms at the pelvis, hip, knee, and ankle were extracted using time-series parameterization. Two statistical feature selection techniques, namely the between-group tests (independent samples t-test and Mann-Whitney U test) and the stepwise discriminant analysis (SWDA) were adopted as feature selector to select the meaningful gait features that were then used to train the ANN. The 10-fold cross-validation test results indicate that the selected gait features using SWDA technique are more reliable for ASD gait classification with 91.7% ketepatan, 93.3% kepekaan, dan 90.0% kekhususan. The findings of the current study demonstrate that kinematic gait features with the combination of SWDA feature selector and ANN classifier would serve as a potential tool for early diagnosis of gait deviations in children with ASD as well as provide support to clinicians and therapists for making objective, accurate, and rapid clinical decisions that lead to the appropriate targeted treatments. © 2017 North Atlantic University Union NAUN. Hak cipta terpelihara. |
Hakim, N H A; Majlis, B Y; Suzuki, H; Tsukahara, T Neuron-specific splicing Artikel Jurnal BioScience Trends, 11 (1), hlm. 16-22, 2017, ISSN: 18817815, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Alternative RNA Splicing, Alternative Splicing, Haiwan, Antibody Specificity, Biological, Biological Model, Penyakit, Genetik, Manusia, Metabolisme, Models, Nerve Cell, Neurons, Organ Specificity, RNA Splicing @artikel{Hakim201716, tajuk = {Neuron-specific splicing}, pengarang = {N H A Hakim and B Y Majlis and H Suzuki and T Tsukahara}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014435502&doi=10.5582%2fbst.2016.01169&rakan kongsi = 40&md5=8a5044dbf3b905fc2553520a048bcd59}, doi = {10.5582/bst.2016.01169}, terbitan = {18817815}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {BioScience Trends}, isi padu = {11}, nombor = {1}, halaman = {16-22}, penerbit = {International Advancement Center for Medicine and Health Research Co., Ltd.}, abstrak = {During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. Dalam ulasan ini, we focus on neuronal splicing regulators and discuss several notable regulators in depth. Sebagai tambahan, we have also included an example of splicing regulation mediated by the RBFox protein family. Akhir kata, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.}, nota = {dipetik oleh 0}, kata kunci = {Alternative RNA Splicing, Alternative Splicing, Haiwan, Antibody Specificity, Biological, Biological Model, Penyakit, Genetik, Manusia, Metabolisme, Models, Nerve Cell, Neurons, Organ Specificity, RNA Splicing}, pubstate = {diterbitkan}, tppubtype = {artikel} } During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. Dalam ulasan ini, we focus on neuronal splicing regulators and discuss several notable regulators in depth. Sebagai tambahan, we have also included an example of splicing regulation mediated by the RBFox protein family. Akhir kata, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated. |
Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Anda, T; Daoud, F; Wang, H; Bcheraoui, TERDAPAT; Khalil, Saya; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Tetapi, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Tetapi, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, Saya A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Lalai, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, Wahai A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, Seorang K; Mitchell, P B; Patton, G; Sagar, R; Satpati, M; Savuon, K; Seedat, S; Shiue, Saya; Hutan, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H The burden of mental disorders in the eastern mediterranean region, 1990-2013 Artikel Jurnal PLoS SATU, 12 (1), 2017, ISSN: 19326203, (dipetik oleh 30). Abstrak | Pautan | BibTeX | Tag: 80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda @artikel{Charara2017, tajuk = {The burden of mental disorders in the eastern mediterranean region, 1990-2013}, pengarang = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371/journal.pone.0169575&rakan kongsi = 40&md5=471830ec1239e37c6fc4681bed5698f6}, doi = {10.1371/jurnal.pone.0169575}, terbitan = {19326203}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {PLoS SATU}, isi padu = {12}, nombor = {1}, penerbit = {Perpustakaan Awam Sains}, abstrak = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.}, nota = {dipetik oleh 30}, kata kunci = {80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan. |
2016 |
Tan, M L; Ho, BUKAN PERKATAAN; Teh, K H Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders Artikel Jurnal Pangkalan Data Cochrane dari Ulasan Sistematik, 2016 (9), 2016, ISSN: 1469493X, (dipetik oleh 6). Abstrak | Pautan | BibTeX | Tag: Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik @artikel{Tan2016, tajuk = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders}, pengarang = {M L Tan and J J Ho and K H Teh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988922340&doi=10.1002%2f14651858.CD009398.pub3&rakan kongsi = 40&md5=3460f403b8829b4692a0b6f795f4a2a3}, doi = {10.1002/14651858.CD009398.pub3}, terbitan = {1469493X}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Pangkalan Data Cochrane dari Ulasan Sistematik}, isi padu = {2016}, nombor = {9}, penerbit = {John Wiley and Sons Ltd}, abstrak = {Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.}, nota = {dipetik oleh 6}, kata kunci = {Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration. |
Ooi, K L; Ong, Y S; Yakub, S A; Khan, T M Meta-sintesis untuk mengasuh anak dengan autisme Artikel Jurnal Penyakit dan Rawatan Neuropsychiatrik, 12 , hlm. 745-762, 2016, ISSN: 11766328, (dipetik oleh 44). Abstrak | Pautan | BibTeX | Tag: Adaptasi, Artikel, Sikap Terhadap Kesihatan, Sikap Penyakit Mental, Autisme, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Zaman kanak-kanak, Keluarga, Penjagaan Berpusatkan Keluarga, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Pendidikan Kesihatan, Manusia, Sikap Ibu Bapa, Tekanan Ibu Bapa, Kualiti hidup, Aspek Sosial, Kajian Sistematik, Kesejahteraan @artikel{Ooi2016745, tajuk = {Meta-sintesis untuk mengasuh anak dengan autisme}, pengarang = {K L Ooi dan Y S Ong dan S A Jacob dan T M Khan}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84962625349&doi=10.2147/NDT.S100634&rakan kongsi = 40&md5 = 48b432dc361f8f3c373ed3b481e01e4c}, doi = {10.2147/NDT.S100634}, terbitan = {11766328}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Penyakit dan Rawatan Neuropsychiatrik}, isi padu = {12}, halaman = {745-762}, penerbit = {Dove Medical Press Ltd.}, abstrak = {Latar belakang: Sifat autisme seumur hidup pada seorang anak mempunyai implikasi yang mendalam terhadap ibu bapa kerana mereka menghadapi pelbagai cabaran dan akibat emosi dalam membesarkan anak. Tujuan meta-sintesis ini adalah untuk meneroka perspektif ibu bapa dalam membesarkan anak dengan autisme pada zaman kanak-kanak untuk mendapatkan gambaran mengenai penyesuaian dan kepercayaan ibu bapa terhadap autisme, pengalaman keluarga dan sosial mereka, serta persepsi mereka terhadap perkhidmatan kesihatan dan pendidikan. Kaedah: Pencarian sistematik enam pangkalan data (PubMed, ASAS, PsikInfo, Daftar Pusat Percubaan Terkawal Cochrane, Pangkalan Data Cochrane dari Ulasan Sistematik, dan Pangkalan Data Abstrak Ulasan Kesan [BERANI]) dijalankan dari awal hingga September 30, 2014. Artikel Inggeris penuh teks kajian kualitatif yang menggambarkan persepsi ibu bapa berkaitan dengan penjagaan anak-anak yang lebih muda dari 12 berumur tahun dan didiagnosis dengan gangguan autisme sahaja. Keputusan: Sejumlah 50 artikel yang layak dinilai dan dianalisis, mengenal pasti empat tema teras merangkumi semua pemikiran, emosi, dan pengalaman yang biasa dinyatakan oleh ibu bapa: 1) Ibu Bapa, 2) Kesan kepada Keluarga, 3) Impak sosial, dan 4) Perkhidmatan Kesihatan dan Pendidikan. Hasil kajian mendapati ibu bapa yang mempunyai anak dengan autisme mengalami pelbagai cabaran dalam aspek penjagaan yang berbeza, memberi kesan kepada tekanan dan penyesuaian ibu bapa. Kesimpulannya: Penyediaan penjagaan kesihatan harus berpusatkan keluarga, menangani dan menyokong keperluan seisi keluarga dan bukan hanya anak yang terkena, untuk memastikan kesejahteraan dan kualiti hidup keluarga dalam menghadapi diagnosis autisme. © 2016 Ooi et al.}, nota = {dipetik oleh 44}, kata kunci = {Adaptasi, Artikel, Sikap Terhadap Kesihatan, Sikap Penyakit Mental, Autisme, Penjagaan Kanak-kanak, Hubungan Ibu Bapa Anak, Zaman kanak-kanak, Keluarga, Penjagaan Berpusatkan Keluarga, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Pendidikan Kesihatan, Manusia, Sikap Ibu Bapa, Tekanan Ibu Bapa, Kualiti hidup, Aspek Sosial, Kajian Sistematik, Kesejahteraan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: Sifat autisme seumur hidup pada seorang anak mempunyai implikasi yang mendalam terhadap ibu bapa kerana mereka menghadapi pelbagai cabaran dan akibat emosi dalam membesarkan anak. Tujuan meta-sintesis ini adalah untuk meneroka perspektif ibu bapa dalam membesarkan anak dengan autisme pada zaman kanak-kanak untuk mendapatkan gambaran mengenai penyesuaian dan kepercayaan ibu bapa terhadap autisme, pengalaman keluarga dan sosial mereka, serta persepsi mereka terhadap perkhidmatan kesihatan dan pendidikan. Kaedah: Pencarian sistematik enam pangkalan data (PubMed, ASAS, PsikInfo, Daftar Pusat Percubaan Terkawal Cochrane, Pangkalan Data Cochrane dari Ulasan Sistematik, dan Pangkalan Data Abstrak Ulasan Kesan [BERANI]) dijalankan dari awal hingga September 30, 2014. Artikel Inggeris penuh teks kajian kualitatif yang menggambarkan persepsi ibu bapa berkaitan dengan penjagaan anak-anak yang lebih muda dari 12 berumur tahun dan didiagnosis dengan gangguan autisme sahaja. Keputusan: Sejumlah 50 artikel yang layak dinilai dan dianalisis, mengenal pasti empat tema teras merangkumi semua pemikiran, emosi, dan pengalaman yang biasa dinyatakan oleh ibu bapa: 1) Ibu Bapa, 2) Kesan kepada Keluarga, 3) Impak sosial, dan 4) Perkhidmatan Kesihatan dan Pendidikan. Hasil kajian mendapati ibu bapa yang mempunyai anak dengan autisme mengalami pelbagai cabaran dalam aspek penjagaan yang berbeza, memberi kesan kepada tekanan dan penyesuaian ibu bapa. Kesimpulannya: Penyediaan penjagaan kesihatan harus berpusatkan keluarga, menangani dan menyokong keperluan seisi keluarga dan bukan hanya anak yang terkena, untuk memastikan kesejahteraan dan kualiti hidup keluarga dalam menghadapi diagnosis autisme. © 2016 Ooi et al. |
Sheppard, E; Pillai, D; Wong, G T -L; Panggil, D; Mitchell, P How Easy is it to Read the Minds of People with Autism Spectrum Disorder? Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 46 (4), hlm. 1247-1254, 2016, ISSN: 01623257, (dipetik oleh 37). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Membuat keputusan, Emosi, Ekspresi wajah, Perempuan, Manusia, Lelaki, Kesihatan mental, Perhubungan tanpa percakapan, Patofisiologi, Jurnal Keutamaan, Psikologi, Video Recording, Dewasa Muda @artikel{Sheppard20161247, tajuk = {How Easy is it to Read the Minds of People with Autism Spectrum Disorder?}, pengarang = {E Sheppard and D Pillai and G T -L Wong and D Ropar and P Mitchell}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961215349&doi=10.1007%2fs10803-015-2662-8&rakan kongsi = 40&md5=d39b6bdebe3c2f33e304eb4d4c09b6fd}, doi = {10.1007/s10803-015-2662-8}, terbitan = {01623257}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {46}, nombor = {4}, halaman = {1247-1254}, penerbit = {Springer New York LLC}, abstrak = {How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science + Business Media New York.}, nota = {dipetik oleh 37}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Membuat keputusan, Emosi, Ekspresi wajah, Perempuan, Manusia, Lelaki, Kesihatan mental, Perhubungan tanpa percakapan, Patofisiologi, Jurnal Keutamaan, Psikologi, Video Recording, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science + Business Media New York. |
Bhagat, V; Mat, Khairi Che H J; Husain, R; Haque, M International Journal of Pharmaceutical Sciences Review and Research, 36 (1), hlm. 54-62, 2016, ISSN: 0976044X, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Autisme, Anak-anak, Keterukan Penyakit, Emosi, Emotionality, Amalan Berasaskan Bukti, Manusia, Perhubungan Manusia, Intervention Study, Negative Emotionality, Parent Counseling, Sikap Ibu Bapa, Parenting Education, Personality Assessment, Kaji semula, Status sosial, Tekanan @artikel{Bhagat201654, tajuk = {Parent’s negative emotionality impacting parenting and involvement in the intervention of their child with autism spectrum disorder: A review proposed the new model for intervention}, pengarang = {V Bhagat and H J Khairi Che Mat and R Husain and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957597820&rakan kongsi = 40&md5=40212e84a1b6be6ade2617d5c9df29a9}, terbitan = {0976044X}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {International Journal of Pharmaceutical Sciences Review and Research}, isi padu = {36}, nombor = {1}, halaman = {54-62}, penerbit = {Global Research Online}, abstrak = {Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Sesungguhnya, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, their negative emotions disturb their focus on the treatment of their ASD child. Oleh itu, the management of ASD child incapacitates their parents to bring out the best. Oleh itu, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. Walau bagaimanapun, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Anak-anak, Keterukan Penyakit, Emosi, Emotionality, Amalan Berasaskan Bukti, Manusia, Perhubungan Manusia, Intervention Study, Negative Emotionality, Parent Counseling, Sikap Ibu Bapa, Parenting Education, Personality Assessment, Kaji semula, Status sosial, Tekanan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Raising a child with an autism spectrum disorder (ASD) is a challenging for their parents. Child’s life with this disease is severely affected. Sesungguhnya, it impacts not only the child, but also parents and siblings, causing disturbances in the family. The experience of parents with an autism spectrum disorder can be distressing; they have a critical need to cope with complex situations in their lives. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parents in their life situations, this in turn distress them deliberately and further restrict them in the ways of child rearing and to give the best of themselves. These parents are found with negative emotionality in their personality component. They end up being shattered in their interpersonal relationship and family life. Sesungguhnya, their negative emotions disturb their focus on the treatment of their ASD child. Oleh itu, the management of ASD child incapacitates their parents to bring out the best. Oleh itu, there is a need for intervention of ASD with emphasis on negative emotions of these parents and affecting the parental efficacy. Walau bagaimanapun, it must also be kept in mind that the improvement in the diagnosed ASD child, especially as the time and expense spent on intervention can be even more detrimental to the parents, especially with their emotional component of their personality. This proposed a new model of intervention incorporating assessment and management of parental emotionality as a part of the intervention. Further aiming at integrating this model into the current regulated system of intervention and can be a source for directing the alternative platform for further research in this regard. © 2016, Global Research Online. Hak cipta terpelihara. |
2015 |
Pelik, B; Jomhari, N; Ahmad, R Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 45 (10), hlm. 3069-3084, 2015, ISSN: 01623257, (dipetik oleh 7). Abstrak | Pautan | BibTeX | Tag: Artikel, Perhatian, Autisme, Gangguan Spektrum Autisme, Anak-anak, Computer Interface, Pendidikan, Education of Intellectually Disabled, Educational Model, Feedback System, Perempuan, Manusia, Belajar, Lelaki, Models, Occupational Therapist, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kualiti hidup, Treatment Duration, Antara Muka Pengguna, Visual Hybrid Development Learning System, Visual Stimulation @artikel{Banire20153069, tajuk = {Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism}, pengarang = {B Banire and N Jomhari and R Ahmad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941942795&doi=10.1007%2fs10803-015-2469-7&rakan kongsi = 40&md5=3c5ecc776725aea4e585e17a1ae805c7}, doi = {10.1007/s10803-015-2469-7}, terbitan = {01623257}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {45}, nombor = {10}, halaman = {3069-3084}, penerbit = {Springer New York LLC}, abstrak = {The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. Dalam kajian ini, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science + Business Media New York.}, nota = {dipetik oleh 7}, kata kunci = {Artikel, Perhatian, Autisme, Gangguan Spektrum Autisme, Anak-anak, Computer Interface, Pendidikan, Education of Intellectually Disabled, Educational Model, Feedback System, Perempuan, Manusia, Belajar, Lelaki, Models, Occupational Therapist, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kualiti hidup, Treatment Duration, Antara Muka Pengguna, Visual Hybrid Development Learning System, Visual Stimulation}, pubstate = {diterbitkan}, tppubtype = {artikel} } The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. Dalam kajian ini, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science + Business Media New York. |
Bhagat, V; Simbak, Bin N; Haque, M Journal of Young Pharmacists, 7 (4), hlm. 403-414, 2015, ISSN: 09751483, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik @artikel{Bhagat2015403, tajuk = {The peripheral focus on the psychological parameters of parents of autistic children in the intervention methods: A review and recommending the strategy, focusing psychological parameters of parents of autistic children in intervention methods}, pengarang = {V Bhagat and N Bin Simbak and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959853109&doi=10.5530%2fjyp.2015.4s.1&rakan kongsi = 40&md5=ed5b5faede6650d1249a902d7201ed43}, doi = {10.5530/jyp.2015.4s.1}, terbitan = {09751483}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Journal of Young Pharmacists}, isi padu = {7}, nombor = {4}, halaman = {403-414}, penerbit = {EManuscript Services}, abstrak = {The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them.}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik}, pubstate = {diterbitkan}, tppubtype = {artikel} } The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them. |
Khowaja, K; Salim, S S Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD) Artikel Jurnal PLoS SATU, 10 (7), 2015, ISSN: 19326203, (dipetik oleh 12). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pangkalan Data Bibliografi, Anak-anak, Computer Interface, Program komputer, Kajian Terkawal, Evaluation Study, Perempuan, Heuristics, Manusia, Information System, Interactive System, Interrater Reliability, Lelaki, Garis Panduan Amalan, Soal selidik, Software, Tinjauan @artikel{Khowaja2015, tajuk = {Heuristics to evaluate interactive systems for children with Autism Spectrum Disorder (ASD)}, pengarang = {K Khowaja dan S S Salim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941313427&doi=10.1371/journal.pone.0132187&rakan kongsi = 40&md5=60f3ee4a32fd71be4b842755a58527cf}, doi = {10.1371/jurnal.pone.0132187}, terbitan = {19326203}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {PLoS SATU}, isi padu = {10}, nombor = {7}, penerbit = {Perpustakaan Awam Sains}, abstrak = {Dalam kertas ini, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim.}, nota = {dipetik oleh 12}, kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pangkalan Data Bibliografi, Anak-anak, Computer Interface, Program komputer, Kajian Terkawal, Evaluation Study, Perempuan, Heuristics, Manusia, Information System, Interactive System, Interrater Reliability, Lelaki, Garis Panduan Amalan, Soal selidik, Software, Tinjauan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Dalam kertas ini, we adapted and expanded a set of guidelines, also known as heuristics, to evaluate the usability of software to now be appropriate for software aimed at children with autism spectrum disorder (ASD). We started from the heuristics developed by Nielsen in 1990 and developed a modified set of 15 heuristics. The first 5 heuristics of this set are the same as those of the original Nielsen set, the next 5 heuristics are improved versions of Nielsen's, whereas the last 5 heuristics are new. We present two evaluation studies of our new heuristics. In the first, two groups compared Nielsen's set with the modified set of heuristics, with each group evaluating two interactive systems. The Nielsen's heuristics were assigned to the control group while the experimental group was given the modified set of heuristics, and a statistical analysis was conducted to determine the effectiveness of the modified set, the contribution of 5 new heuristics and the impact of 5 improved heuristics. The results show that the modified set is significantly more effective than the original, and we found a significant difference between the five improved heuristics and their corresponding heuristics in the original set. The five new heuristics are effective in problem identification using the modified set. The second study was conducted using a system which was developed to ascertain if the modified set was effective at identifying usability problems that could be fixed before the release of software. The post-study analysis revealed that the majority of the usability problems identified by the experts were fixed in the updated version of the system. © 2015 Khowaja, Salim. |
Roffeei, Mohd S H; Abdullah, N; bazar, S K R Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs) Artikel Jurnal International Journal of Medical Informatics, 84 (5), hlm. 375-385, 2015, ISSN: 13865056, (dipetik oleh 43). Abstrak | Pautan | BibTeX | Tag: Artikel, ASD, Autisme, Gangguan Spektrum Autisme, Pengasuh, Anak-anak, Consumer Health Information, Content Analysis, Penyakit, E-mail, Facebook, Keluarga, Friendship, Manusia, Internet, Ibu bapa, Patient Referral, Jurnal Keutamaan, Psikologi, Analisis Kualitatif, Self Esteem, Media sosial, Rangkaian sosial, Sokongan Sosial, Statistik, Support Group, Telemedicine, Utilization @artikel{MohdRoffeei2015375, tajuk = {Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs)}, pengarang = {S H Mohd Roffeei and N Abdullah and S K R Basar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924517643&doi=10.1016%2fj.ijmedinf.2015.01.015&rakan kongsi = 40&md5=7296825093cbf87388b5b65023e59371}, doi = {10.1016/j.ijmedinf.2015.01.015}, terbitan = {13865056}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {International Journal of Medical Informatics}, isi padu = {84}, nombor = {5}, halaman = {375-385}, penerbit = {Elsevier Ireland Ltd}, abstrak = {Tujuan: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (PAGI) and Autism Children Club (ACA). Kaedah: Sejumlah 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% dan 20.2%, masing-masing. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Kesimpulannya: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd.}, nota = {dipetik oleh 43}, kata kunci = {Artikel, ASD, Autisme, Gangguan Spektrum Autisme, Pengasuh, Anak-anak, Consumer Health Information, Content Analysis, Penyakit, E-mail, Facebook, Keluarga, Friendship, Manusia, Internet, Ibu bapa, Patient Referral, Jurnal Keutamaan, Psikologi, Analisis Kualitatif, Self Esteem, Media sosial, Rangkaian sosial, Sokongan Sosial, Statistik, Support Group, Telemedicine, Utilization}, pubstate = {diterbitkan}, tppubtype = {artikel} } Tujuan: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (PAGI) and Autism Children Club (ACA). Kaedah: Sejumlah 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% dan 20.2%, masing-masing. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Kesimpulannya: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd. |
Alwi, N; Harun, D; Abad, L Multidisciplinary Parent Education for Caregivers of Children With Autism Spectrum Disorders (ASD): Implications for Clinical Practice Artikel Jurnal Archives of Psychiatric Nursing, 29 (1), hlm. 5, 2015, ISSN: 08839417, (dipetik oleh 0). Pautan | BibTeX | Tag: Autisme, Gangguan Spektrum Autisme, Pengasuh, Gangguan Perkembangan Kanak-kanak, Anak-anak, Manusia, Ibu bapa, Meresap @artikel{Alwi20155, tajuk = {Multidisciplinary Parent Education for Caregivers of Children With Autism Spectrum Disorders (ASD): Implications for Clinical Practice}, pengarang = {N Alwi and D Harun and L Jh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921463937&doi=10.1016%2fj.apnu.2014.09.010&rakan kongsi = 40&md5=afc618a09a89f9461c587ab56a96559a}, doi = {10.1016/j.apnu.2014.09.010}, terbitan = {08839417}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Archives of Psychiatric Nursing}, isi padu = {29}, nombor = {1}, halaman = {5}, penerbit = {W.B. Saunders}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Gangguan Spektrum Autisme, Pengasuh, Gangguan Perkembangan Kanak-kanak, Anak-anak, Manusia, Ibu bapa, Meresap}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Alwi, N; Harun, D; Leonard, J H Clinical application of sensory integration therapy for children with autism Artikel Jurnal Egyptian Journal of Medical Human Genetics, 16 (4), hlm. 393-394, 2015, ISSN: 11108630, (dipetik oleh 1). Pautan | BibTeX | Tag: Autisme, Keterukan Penyakit, Groups by Age, Manusia, Surat, Motor Performance, Penilaian Hasil, Sensorimotor Integration, Terapi, Therapy Effect, Treatment Indication, Treatment Response @artikel{Alwi2015393, tajuk = {Clinical application of sensory integration therapy for children with autism}, pengarang = {N Alwi and D Harun and J H Leonard}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940898525&doi=10.1016%2fj.ejmhg.2015.05.009&rakan kongsi = 40&md5=5548f0db22520a480f09da9aaf4c872e}, doi = {10.1016/j.ejmhg.2015.05.009}, terbitan = {11108630}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Egyptian Journal of Medical Human Genetics}, isi padu = {16}, nombor = {4}, halaman = {393-394}, penerbit = {Egyptian Society of Human Genetics}, nota = {dipetik oleh 1}, kata kunci = {Autisme, Keterukan Penyakit, Groups by Age, Manusia, Surat, Motor Performance, Penilaian Hasil, Sensorimotor Integration, Terapi, Therapy Effect, Treatment Indication, Treatment Response}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Haque, S; Haque, M Terapi seni dan autisme Artikel Jurnal Asian Journal of Pharmaceutical and Clinical Research, 8 (6), hlm. 202-203, 2015, ISSN: 09742441, (dipetik oleh 0). Pautan | BibTeX | Tag: Terapi Seni, Artikel, Autisme, Tingkah Laku Kanak-kanak, Manusia, Perhubungan Manusia, Komunikasi Interpersonal, Perhubungan tanpa percakapan, Interaksi Sosial @artikel{Haque2015202, tajuk = {Terapi seni dan autisme}, pengarang = {S Haque dan M Haque}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84947426821&rakan kongsi = 40&md5 = 735d495bc1b2ce0c6370c265bb1a4802}, terbitan = {09742441}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Asian Journal of Pharmaceutical and Clinical Research}, isi padu = {8}, nombor = {6}, halaman = {202-203}, penerbit = {Asian Journal of Pharmaceutical and Clinical Research}, nota = {dipetik oleh 0}, kata kunci = {Terapi Seni, Artikel, Autisme, Tingkah Laku Kanak-kanak, Manusia, Perhubungan Manusia, Komunikasi Interpersonal, Perhubungan tanpa percakapan, Interaksi Sosial}, pubstate = {diterbitkan}, tppubtype = {artikel} } |