Senarai Penerbitan
Terdapat sebilangan besar penyelidikan berkaitan autisme yang boleh dijumpai di Malaysia yang umumnya menumpukan pada ASD, gangguan pembelajaran, alat bantu komunikasi, terapi dan banyak lagi. Senarai penerbitan disediakan di bawah:
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2020 |
de Vries, M; Cader, S; Rakan sekerja, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 50 (4), hlm. 1281-1294, 2020, ISSN: 01623257, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda @artikel{deVries20201281, tajuk = {Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya}, pengarang = {M de Vries dan S Cader dan L Colleer dan E Batteux dan M B Yasdiman dan Y J Tan dan E Sheppard}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85077543652&doi = 10.1007% 2fs10803-019-04343-z&rakan kongsi = 40&md5 = 53dc04b76c29629e875adaf44a9831b6}, doi = {10.1007/s10803-019-04343-z}, terbitan = {01623257}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {50}, nombor = {4}, halaman = {1281-1294}, penerbit = {Pemecut}, abstrak = {Latar belakang budaya mungkin mempengaruhi pengetahuan dan sikap mengenai autisme, mempengaruhi kesediaan untuk berinteraksi. Kami mengkaji sama ada kepercayaan, pengetahuan, kenalan, dan sikap berbeza antara Inggeris dan Malaysia. Dengan analisis mediasi, kami mengkaji bagaimana faktor-faktor ini mempengaruhi kesediaan untuk berinteraksi. Autisme lebih kerap dikaitkan dengan makanan di UK, dan asuhan di Malaysia. Pengetahuan, kenalan, dan penerimaan lebih besar di UK. Semasa tidak termasuk pelajar psikologi, Pelajar Malaysia kurang bersedia untuk berinteraksi dengan orang autistik. Pengetahuan dan hubungan muncul untuk meningkatkan penerimaan, tetapi penerimaan tidak menjadi perantara hubungan antara negara, kepercayaan, pengetahuan, dan pengalaman; dan kesediaan untuk berinteraksi. Pengetahuan dan hubungan mengenai autisme dapat meningkatkan penerimaan dalam budaya yang berbeza, tetapi bagaimana penerimaan dapat meningkatkan interaksi tidak jelas. © 2020, Pengarang(s).}, nota = {dipetik oleh 0}, kata kunci = {Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang budaya mungkin mempengaruhi pengetahuan dan sikap mengenai autisme, mempengaruhi kesediaan untuk berinteraksi. Kami mengkaji sama ada kepercayaan, pengetahuan, kenalan, dan sikap berbeza antara Inggeris dan Malaysia. Dengan analisis mediasi, kami mengkaji bagaimana faktor-faktor ini mempengaruhi kesediaan untuk berinteraksi. Autisme lebih kerap dikaitkan dengan makanan di UK, dan asuhan di Malaysia. Pengetahuan, kenalan, dan penerimaan lebih besar di UK. Semasa tidak termasuk pelajar psikologi, Pelajar Malaysia kurang bersedia untuk berinteraksi dengan orang autistik. Pengetahuan dan hubungan muncul untuk meningkatkan penerimaan, tetapi penerimaan tidak menjadi perantara hubungan antara negara, kepercayaan, pengetahuan, dan pengalaman; dan kesediaan untuk berinteraksi. Pengetahuan dan hubungan mengenai autisme dapat meningkatkan penerimaan dalam budaya yang berbeza, tetapi bagaimana penerimaan dapat meningkatkan interaksi tidak jelas. © 2020, Pengarang(s). |
Leong, D; Hedley, D; Uljarevic, M Poh-tay-toe, Poh-tah-toe: Diagnosis dan Konseptualisasi Autisme Artikel Jurnal Jurnal Neurologi Kanak-kanak, 35 (3), hlm. 247-248, 2020, ISSN: 08830738, (dipetik oleh 0). Pautan | BibTeX | Tag: Keresahan, Gangguan Defisit Perhatian, Autisme, Pengasuh, Anak-anak, Artikel Klinikal, Amalan Klinikal, Kelakuan Mengganggu, DSM-5, Susulan, Manusia, Gangguan Pembelajaran, Surat, Kesihatan mental, Gangguan Mood, Pasukan Pelbagai Disiplin, Neuropsychiatry, Jurnal Keutamaan, Pengangguran, Tenaga kerja @artikel{Leong2020247, tajuk = {Poh-tay-toe, Poh-tah-toe: Diagnosis dan Konseptualisasi Autisme}, pengarang = {D Leong dan D Hedley dan M Uljarević}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85078570091&doi = 10.1177% 2f0883073819887587&rakan kongsi = 40&md5 = f40e68dc7723d94e6c9dfeb9820558a4}, doi = {10.1177/0883073819887587}, terbitan = {08830738}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Jurnal Neurologi Kanak-kanak}, isi padu = {35}, nombor = {3}, halaman = {247-248}, penerbit = {SAGE Publications Inc.}, nota = {dipetik oleh 0}, kata kunci = {Keresahan, Gangguan Defisit Perhatian, Autisme, Pengasuh, Anak-anak, Artikel Klinikal, Amalan Klinikal, Kelakuan Mengganggu, DSM-5, Susulan, Manusia, Gangguan Pembelajaran, Surat, Kesihatan mental, Gangguan Mood, Pasukan Pelbagai Disiplin, Neuropsychiatry, Jurnal Keutamaan, Pengangguran, Tenaga kerja}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Djatmika, ; Wibowo, A H; Sugini, ; Halim, H; Mohamad, B Strategi multimodal dalam mengajar kanak-kanak dengan autisme: Analisis wacana Artikel Jurnal Ulasan Sistematik di Farmasi, 11 (2), hlm. 219-229, 2020, ISSN: 09758453, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Pergerakan Badan, Anak-anak, Analisis Wacana, Gerak isyarat, Manusia, Bahasa, Kesunyian, Perhubungan tanpa percakapan, Paralanguage, Jurnal Keutamaan, Berdiri, Perancangan strategik, Pelajar, Cikgu, Mengajar, Tingkah laku Lisan, Komunikasi Lisan @artikel{Djatmika2020219, tajuk = {Strategi multimodal dalam mengajar kanak-kanak dengan autisme: Analisis wacana}, pengarang = {Djatmika dan A H Wibowo dan Sugini dan H Halim dan B Mohamad}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85081273665&dua = 10.5530% 2fsrp.2020.2.34&rakan kongsi = 40&md5 = 598f159688f9329625ae19d12e489ff9}, doi = {10.5530/Jul.2020.2.34}, terbitan = {09758453}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Ulasan Sistematik di Farmasi}, isi padu = {11}, nombor = {2}, halaman = {219-229}, penerbit = {Teknologi EManuscript}, abstrak = {Proses pengajaran dan pembelajaran yang melibatkan kanak-kanak autisme memerlukan guru untuk kreatif dalam merancang strategi khas dan berkesan untuk memastikan pemahaman pelajar. Ini disebabkan oleh fakta bahawa kanak-kanak ini mempunyai masalah dalam berkomunikasi dengan orang lain, oleh itu memerlukan perhatian khusus dari para guru. Penyelidikan ini bertujuan untuk lebih memahami keperluan anak-anak ini dengan meneliti strategi yang dilakukan oleh guru-guru di Sekolah-sekolah untuk Kanak-kanak Luar Biasa dan Pusat Autisme di bandar Solo yang membantu kanak-kanak dengan autisme. Lima kelas diperhatikan dan dirakam secara audio-visual. Data yang mewakili aspek tingkah laku verbal, tingkah laku bukan lisan, dan eksploitasi alat bantu mengajar dikumpulkan. Hasil kajian menunjukkan bahawa keadaan kanak-kanak autisme adalah pengaruh utama strategi dalam mengeksploitasi aspek multimodal. Oleh itu, guru mesti merancang pendekatan yang berbeza dalam memindahkan pengetahuan kepada kanak-kanak ini. Secara umum, guru selalu melakukan eksploitasi secara lisan bekerjasama dengan aspek bukan lisan seperti gerak tubuh, pergerakan badan, kedudukan berdiri, dan sumber daya paralinguistik seperti intonasi dan kelantangan. Kajian ini juga mendapati bahawa dari lima kelas yang sedang dikaji, dua kelas disokong oleh penggunaan alat bantu mengajar yang berkesan. Penemuan ini menyumbang kepada pemahaman yang lebih baik bagi guru dan ibu bapa mengenai keperluan kanak-kanak autisme semasa proses pengajaran dan pembelajaran. © Penyelidikan Ilmiah Lanjutan. Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {Artikel, Autisme, Pergerakan Badan, Anak-anak, Analisis Wacana, Gerak isyarat, Manusia, Bahasa, Kesunyian, Perhubungan tanpa percakapan, Paralanguage, Jurnal Keutamaan, Berdiri, Perancangan strategik, Pelajar, Cikgu, Mengajar, Tingkah laku Lisan, Komunikasi Lisan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Proses pengajaran dan pembelajaran yang melibatkan kanak-kanak autisme memerlukan guru untuk kreatif dalam merancang strategi khas dan berkesan untuk memastikan pemahaman pelajar. Ini disebabkan oleh fakta bahawa kanak-kanak ini mempunyai masalah dalam berkomunikasi dengan orang lain, oleh itu memerlukan perhatian khusus dari para guru. Penyelidikan ini bertujuan untuk lebih memahami keperluan anak-anak ini dengan meneliti strategi yang dilakukan oleh guru-guru di Sekolah-sekolah untuk Kanak-kanak Luar Biasa dan Pusat Autisme di bandar Solo yang membantu kanak-kanak dengan autisme. Lima kelas diperhatikan dan dirakam secara audio-visual. Data yang mewakili aspek tingkah laku verbal, tingkah laku bukan lisan, dan eksploitasi alat bantu mengajar dikumpulkan. Hasil kajian menunjukkan bahawa keadaan kanak-kanak autisme adalah pengaruh utama strategi dalam mengeksploitasi aspek multimodal. Oleh itu, guru mesti merancang pendekatan yang berbeza dalam memindahkan pengetahuan kepada kanak-kanak ini. Secara umum, guru selalu melakukan eksploitasi secara lisan bekerjasama dengan aspek bukan lisan seperti gerak tubuh, pergerakan badan, kedudukan berdiri, dan sumber daya paralinguistik seperti intonasi dan kelantangan. Kajian ini juga mendapati bahawa dari lima kelas yang sedang dikaji, dua kelas disokong oleh penggunaan alat bantu mengajar yang berkesan. Penemuan ini menyumbang kepada pemahaman yang lebih baik bagi guru dan ibu bapa mengenai keperluan kanak-kanak autisme semasa proses pengajaran dan pembelajaran. © Penyelidikan Ilmiah Lanjutan. Hak cipta terpelihara. |
2019 |
Prabhakar, S; Cheah, P S; Zhang, X; Zinter, M; Gianatasio, M; Hudry, E; Bronson, R T; Kwiatkowski, D J; Stemmer-Rachamimov, A; Maguire, C A; Sena-Esteves, M; Tannous, B A; Breakefield, X O Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1 Artikel Jurnal Molecular Therapy - Methods and Clinical Development, 15 , hlm. 18-26, 2019, ISSN: 23290501, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Adeno Associated Virus, Adeno Associated Virus Vector, Animal Experiment, Animal Model, Artikel, Beta Actin, Blood Brain Barrier, Berat badan, Body Weight Gain, Brain Nerve Cell, Brain Ventricle, Percambahan Sel, Complementary DNA, Kajian Terkawal, Cre Recombinase, Drug Efficacy, Perempuan, Gen, Gene Replacement Therapy, Hamartin, HEK293 Cell Line, Hydrocephalus, Immunohistochemistry, Inverted Terminal Repeat, Long Term Care, Lelaki, Motor Activity, Motor Performance, Tetikus, Bukan Manusia, Jurnal Keutamaan, Promoter Region, Fungsi Protein, Protein Phosphorylation, Quantitative Analysis, Subventricular Zone, Survival Time, Tuberous Sclerosis, Tuberous Sclerosis Type 1, Vascularization, Viral Gene Delivery System @artikel{Prabhakar201918, tajuk = {Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1}, pengarang = {S Prabhakar and P S Cheah and X Zhang and M Zinter and M Gianatasio and E Hudry and R T Bronson and D J Kwiatkowski and A Stemmer-Rachamimov and C A Maguire and M Sena-Esteves and B A Tannous and X O Breakefield}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070908794&doi=10.1016%2fj.omtm.2019.08.003&rakan kongsi = 40&md5=b169187dde0d3b05f8a9d5295a4ad8c4}, doi = {10.1016/j.omtm.2019.08.003}, terbitan = {23290501}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Molecular Therapy - Methods and Clinical Development}, isi padu = {15}, halaman = {18-26}, penerbit = {Akhbar Sel}, abstrak = {Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, masing-masing. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth and proliferation. Loss of either protein leads to overgrowth in many organs, including subependymal nodules, subependymal giant cell astrocytomas, and cortical tubers in the human brain. Neurological manifestations in TSC include intellectual disability, autisme, hydrocephalus, and epilepsy. In a stochastic mouse model of TSC1 brain lesions, complete loss of Tsc1 is achieved in homozygous Tsc1-floxed mice in a subpopulation of neural cells in the brain by intracerebroventricular (i.c.v.) injection at birth of an adeno-associated virus (AAV) vector encoding Cre recombinase. This results in median survival of 38 days and brain pathology, including subependymal lesions and enlargement of neuronal cells. Remarkably, when these mice were injected intravenously on day 21 with an AAV9 vector encoding hamartin, most survived at least up to 429 days in apparently healthy condition with marked reduction in brain pathology. Oleh itu, a single intravenous administration of an AAV vector encoding hamartin restored protein function in enough cells in the brain to extend lifespan in this TSC1 mouse model. © 2019}, nota = {dipetik oleh 2}, kata kunci = {Adeno Associated Virus, Adeno Associated Virus Vector, Animal Experiment, Animal Model, Artikel, Beta Actin, Blood Brain Barrier, Berat badan, Body Weight Gain, Brain Nerve Cell, Brain Ventricle, Percambahan Sel, Complementary DNA, Kajian Terkawal, Cre Recombinase, Drug Efficacy, Perempuan, Gen, Gene Replacement Therapy, Hamartin, HEK293 Cell Line, Hydrocephalus, Immunohistochemistry, Inverted Terminal Repeat, Long Term Care, Lelaki, Motor Activity, Motor Performance, Tetikus, Bukan Manusia, Jurnal Keutamaan, Promoter Region, Fungsi Protein, Protein Phosphorylation, Quantitative Analysis, Subventricular Zone, Survival Time, Tuberous Sclerosis, Tuberous Sclerosis Type 1, Vascularization, Viral Gene Delivery System}, pubstate = {diterbitkan}, tppubtype = {artikel} } Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, masing-masing. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth and proliferation. Loss of either protein leads to overgrowth in many organs, including subependymal nodules, subependymal giant cell astrocytomas, and cortical tubers in the human brain. Neurological manifestations in TSC include intellectual disability, autisme, hydrocephalus, and epilepsy. In a stochastic mouse model of TSC1 brain lesions, complete loss of Tsc1 is achieved in homozygous Tsc1-floxed mice in a subpopulation of neural cells in the brain by intracerebroventricular (i.c.v.) injection at birth of an adeno-associated virus (AAV) vector encoding Cre recombinase. This results in median survival of 38 days and brain pathology, including subependymal lesions and enlargement of neuronal cells. Remarkably, when these mice were injected intravenously on day 21 with an AAV9 vector encoding hamartin, most survived at least up to 429 days in apparently healthy condition with marked reduction in brain pathology. Oleh itu, a single intravenous administration of an AAV vector encoding hamartin restored protein function in enough cells in the brain to extend lifespan in this TSC1 mouse model. © 2019 |
Jaafar, N H; Othman, A; Majid, N A; Harith, S; Zabidi-Hussin, DENGAN Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review Artikel Jurnal Developmental Medicine and Child Neurology, 61 (2), hlm. 135-144, 2019, ISSN: 00121622, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability @artikel{Jaafar2019135, tajuk = {Parent-report instruments for assessing feeding difficulties in children with neurological impairments: a systematic review}, pengarang = {N H Jaafar and A Othman and N A Majid and S Harith and Z Zabidi-Hussin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052789833&doi=10.1111%2fdmcn.13986&rakan kongsi = 40&md5=d02a2bfcd15a25988b9c23855cd87444}, doi = {10.1111/dmcn.13986}, terbitan = {00121622}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Developmental Medicine and Child Neurology}, isi padu = {61}, nombor = {2}, halaman = {135-144}, penerbit = {Blackwell Publishing Ltd}, abstrak = {Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press}, nota = {dipetik oleh 1}, kata kunci = {Assessment of Humans, Autisme, Behavioural Paediatric Feeding Assessment Scale, Caloric Intake, Tingkah Laku Kanak-kanak, Hubungan Ibu Bapa Anak, Childhood Disease, Anak-anak, Children's Eating Behaviour Inventory, Komplikasi, Construct Validity, Content Validity, Criterion Related Validity, Cystic Fibrosis, Gangguan Makan, Enalapril Maleate, Eosinophilic Gastrointestinal Disorder, Esophagus Atresia, Feeding, Feeding and Eating Disorders, Tingkah Laku Makan, Kesukaran Memberi Makan, Pengambilan makanan, Manusia, Nervous System Diseases, Neurologic Disease, Penilaian Pemakanan, Ibu bapa, Pediatric Assessment Scale for Severe Feeding Problem, Pediatric Eating Assessment Tool, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Psikometrik, Psikometri, Kualiti hidup, Receiver Operating Characteristic, Kaji semula, Sistem Pemarkahan, Self Disclosure, Kepekaan dan Kekhususan, Syndrome CHARGE, Kajian Sistematik, Test Retest Reliability}, pubstate = {diterbitkan}, tppubtype = {artikel} } Aim: This study aimed to review the psychometric properties and clinical application of parent-report instruments that assess feeding difficulties in children with neurological impairments. Kaedah: Papers were identified through five electronic databases based on 15 keywords and were included if they met the following criteria: published in English, described the implementation of parent-report instruments, and included children with neurological impairments (either in the report or a related study population). Keputusan: In total, 1220 relevant abstracts were screened and 22 full-text articles were evaluated. The following six parent-report instruments met the inclusion criteria: (1) Screening Tool of Feeding Problems applied to children, (2) Paediatric Eating Assessment Tool, (3) Paediatric Assessment Scale for Severe Feeding Problems, (4) Montreal Children's Hospital Feeding Scale, (5) Children's Eating Behaviour Inventory, dan (6) Behavioural Paediatric Feeding Assessment Scale (BPFAS). Based on comprehensive psychometric testing and consistently good results, the BPFAS was considered the most valid and reliable instrument. The BPFAS also showed good clinical applicability because it was readily available, required a short administration time, and used a simple scoring system. Interpretation: We reviewed the available parent-report instruments for assessing feeding difficulties in children with neurological impairments. The BPFAS had the best psychometric properties and clinical applicability. What this paper adds: Six parent-report instruments were suitable for assessing feeding in children with neurological impairments. The Behavioural Paediatric Feeding Assessment Scale (BPFAS) has the strongest psychometric properties. The BPFAS also has good clinical applicability. © 2018 Mac Keith Press |
2018 |
Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N GRIN2D variants in three cases of developmental and epileptic encephalopathy Artikel Jurnal Clinical Genetics, 94 (6), hlm. 538-547, 2018, ISSN: 00099163, (dipetik oleh 4). Abstrak | Pautan | BibTeX | Tag: Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing @artikel{Tsuchida2018538, tajuk = {GRIN2D variants in three cases of developmental and epileptic encephalopathy}, pengarang = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&rakan kongsi = 40&md5=f0d32670db57261820bc244943cffd62}, doi = {10.1111/cge.13454}, terbitan = {00099163}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Clinical Genetics}, isi padu = {94}, nombor = {6}, halaman = {538-547}, penerbit = {Blackwell Publishing Ltd}, abstrak = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Baru-baru ini, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. Dalam kajian ini, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd}, nota = {dipetik oleh 4}, kata kunci = {Remaja, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Artikel, Atonic Seizure, Gangguan Defisit Perhatian, Autisme, Binding Affinity, Otak, Brain Atrophy, Carbamazepine, Laporan kes, Channel Gating, Kimia, Anak-anak, Artikel Klinikal, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Kelewatan Perkembangan, Gangguan Perkembangan, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Perempuan, Frontal Lobe Epilepsy, Gen, Gene Frequency, Genetic Variation, Genetik, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Manusia, Sel Manusia, Hydrogen Bond, Kemerosotan Intelektual, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Lelaki, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, Budak sekolah, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing}, pubstate = {diterbitkan}, tppubtype = {artikel} } N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Baru-baru ini, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. Dalam kajian ini, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
Paudel, Y N; Syeikh, M F; Shah, S; Kumari, Y; Othman, Saya Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi Artikel Jurnal Jurnal Farmakologi Eropah, 837 , hlm. 145-155, 2018, ISSN: 00142999, (dipetik oleh 14). Abstrak | Pautan | BibTeX | Tag: 3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan @artikel{Paudel2018145, tajuk = {Peranan keradangan dalam epilepsi dan komorbiditi neurobehavioral: Implikasi untuk terapi}, pengarang = {Y N Paudel dan MF Shaikh dan S Shah dan Y Kumari dan I Othman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053082063&doi = 10.1016% 2fj.ejphar.2018.08.020&rakan kongsi = 40&md5=27ff0199bae72f156425637a7ad02228}, doi = {10.1016/j.ejphar.2018.08.020}, terbitan = {00142999}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Farmakologi Eropah}, isi padu = {837}, halaman = {145-155}, penerbit = {Elsevier B.V.}, abstrak = {Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V.}, nota = {dipetik oleh 14}, kata kunci = {3 Dioksigenase, Asid Acetylsalicylic, Adalimumab, Anakinra, Haiwan, Agen Anti-Radang, Keresahan, Autacoid, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Belnacasan, Celecoxib, Kognisi, komorbiditi, Komplikasi, Cyclooxygenase 2, Cyclooxygenase 2 Perencat, Sitokin, Sitokin, Kemurungan, Dexmedetomidine, Persatuan Penyakit, Penghantaran Dopaminergik, Elektroencephalogram, Elektroensefalografi, Epilepsi, Epileptogenesis, Esculetin, Protein Kumpulan B1 Mobiliti Tinggi, Manusia, Ibuprofen, Icariin, IImmunoglobulin Enhancer Mengikat Protein, Imunologi, Indoleamine 2, Keradangan, Pengantara Inflamasi, Infliximab, Interleukin 1beta, Interleukin 6, Minocycline, Keplastikan Sel Saraf, Pembangunan Sistem Saraf, Keradangan Sistem Saraf, Peraturan Neuroendokrin, Pelepasan Neurotransmitter, Bukan Manusia, Palmidrol, Paracetamol, Fisiologi, Jurnal Keutamaan, Prostaglandin E2, Psikologi, Kaji semula, SC 51089, Skizofrenia, Reseptor Seperti Tol 4, Mengubah Faktor Pertumbuhan Beta, Tryptophan Hydroxylase, Faktor Nekrosis Tumor, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Epilepsi adalah keadaan yang dahsyat yang menjejaskan sekeliling 70 juta orang di seluruh dunia. Lebih-lebih lagi, kualiti hidup penghidap epilepsi (PWE) diburukkan oleh beberapa siri komorbiditi. Komorbiditi neurobehavioral yang dibincangkan di sini berkongsi hubungan timbal balik dan kompleks dengan epilepsi, yang akhirnya merumitkan proses rawatan di PWE. Memahami laluan mekanistik yang mana komorbiditi ini dikaitkan dengan epilepsi mungkin memainkan peranan penting dalam membangunkan campur tangan terapeutik. Isyarat sitokin radang dalam otak mengawal fungsi otak yang penting termasuk metabolisme neurotransmitter, fungsi neuroendokrin, keplastikan sinaptik, penghantaran dopaminergik, laluan kynurenine, dan menjejaskan neurogenesis serta litar saraf mood. Dalam ulasan ini, kami membuat hipotesis bahawa hubungan kompleks antara epilepsi dan komorbiditi yang berkaitan (kecacatan kognitif, kemurungan, kegelisahan, autisme, dan skizofrenia) boleh dirungkai melalui mekanisme keradangan yang memainkan peranan penting dalam semua keadaan individu ini. Sebilangan besar bukti tersedia melaporkan peranan keradangan dalam epilepsi dan semua keadaan komorbid individu tetapi hubungan kompleks mereka dengan epilepsi masih belum diterokai melalui prospek laluan keradangan.. Kajian kami menunjukkan bahawa epilepsi dan komorbiditi neurobehavioralnya dikaitkan dengan peningkatan tahap beberapa penanda keradangan utama. Kajian ini juga memberi penerangan tentang persatuan mekanistik antara epilepsi dan komorbiditi neurobehavioralnya. Lebih-lebih lagi, kami menganalisis beberapa terapi anti-radang yang tersedia untuk epilepsi dan komorbiditi neurobehavioralnya. Kami mencadangkan, terapi anti-radang ini mungkin merupakan campur tangan yang mungkin dan boleh menjadi strategi yang menjanjikan untuk mencegah epileptogenesis dan komorbiditi neurobehavioral yang berkaitan.. © 2018 Elsevier B.V. |
Diurut, R Tingkah laku merangsang dalam kanak-kanak perempuan berusia 4 tahun dengan gangguan spektrum autisme Artikel Jurnal Laporan Kes BMJ, 2018 , 2018, ISSN: 1757790X, (dipetik oleh 0). Pautan | BibTeX | Tag: Autisme, Gangguan Spektrum Autisme, biskut, Menggigit Objek Keras, Laporan kes, Mainan Kunyah, Keselamatan Kanak-kanak, Anak-anak, Artikel Klinikal, Perempuan, Makanan, Tekstur Makanan, Makanan panas, Manusia, Ketidakupayaan Bahasa, Nota, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psikologi, Rangsangan Diri, Makanan pedas, Kelakuan Stereotaip, Stereotaip, Tingkah Laku Merangsang, Biskut Tumbuh Gigi, sayur @artikel{Masiran2018, tajuk = {Tingkah laku merangsang dalam kanak-kanak perempuan berusia 4 tahun dengan gangguan spektrum autisme}, pengarang = {R Diurut}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042604824&doi = 10.1136% 2fbcr-2017-223671&rakan kongsi = 40&md5=c7b6514a4758257be1360250bf120de3}, doi = {10.1136/bcr-2017-223671}, terbitan = {1757790X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Laporan Kes BMJ}, isi padu = {2018}, penerbit = {Kumpulan Penerbitan BMJ}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Gangguan Spektrum Autisme, biskut, Menggigit Objek Keras, Laporan kes, Mainan Kunyah, Keselamatan Kanak-kanak, Anak-anak, Artikel Klinikal, Perempuan, Makanan, Tekstur Makanan, Makanan panas, Manusia, Ketidakupayaan Bahasa, Nota, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psikologi, Rangsangan Diri, Makanan pedas, Kelakuan Stereotaip, Stereotaip, Tingkah Laku Merangsang, Biskut Tumbuh Gigi, sayur}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Toh, T -H; Tan, V W -Y; Lau, PST; Kiyu, A Jurnal Autisme dan Gangguan Perkembangan, 48 (1), hlm. 28-35, 2018, ISSN: 01623257, (dipetik oleh 9). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil @artikel{Toh201828, tajuk = {Ketepatan Senarai Semak Perubahan untuk Autisme pada Kanak-kanak (M-CHAT) dalam Mengesan Autisme dan Gangguan Perkembangan Lain di Klinik Komuniti}, pengarang = {T -H Toh dan V W -Y Tan dan P S -T Lau dan A Kiyu}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85028764085&doi=10.1007/s10803-017-3287-x&rakan kongsi = 40&md5 = 21bce2407197b8b1e43b4420d274861b}, doi = {10.1007/s10803-017-3287-x}, terbitan = {01623257}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {48}, nombor = {1}, halaman = {28-35}, penerbit = {Springer New York LLC}, abstrak = {Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC.}, nota = {dipetik oleh 9}, kata kunci = {Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil}, pubstate = {diterbitkan}, tppubtype = {artikel} } Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 bulan dan kohort umur 27–36 bulan (54.5–64.3%). Walaupun nilai ramalan positif (PPV) miskin untuk ASD, terutamanya kohort yang lebih muda, positif M-CHAT membantu dalam mengesan semua DD (PPV = 81.6%). Ini mencadangkan M-CHAT untuk pemeriksaan ASD adalah tepat untuk kohort yang lebih tua (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC. |
Diurut, R Autisme dan trikotilomania dalam remaja lelaki Artikel Jurnal Laporan Kes BMJ, 2018 , 2018, ISSN: 1757790X, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Alopecia, Keresahan, Artikel, Gangguan Defisit Perhatian, Gangguan Hiperaktifan Kekurangan Perhatian, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Berat badan, Laporan kes, Perangsang Sistem Saraf Pusat, Senarai Semak Tingkah Laku Kanak-kanak, Artikel Klinikal, komorbiditi, Komplikasi, Diagnosis, Berbeza, Diagnosis pembezaan, Pentitratan Dos Ubat, Toleransi Dadah, DSM-5, Echolalia, Fluvoxamine, Susulan, Manusia, Hiperaktif, Kemerosotan Intelektual, Lelaki, Metilfenidat, Obesiti, Terapi pekerjaan, Indeks Penaakulan Persepsi, Jurnal Keutamaan, Indeks Kelajuan Pemprosesan, Skala Penarafan Status Psikiatri, Skala Penarafan Psikologi, Skala penilaian, Kegelisahan, Ganjaran, Perencat Serapan Serotonin, Perencat Serapan Serotonin, Pendidikan Khas, Kelewatan Pertuturan, Gangguan Pertuturan, Terapi ucapan, Trikotilomania, Indeks Kefahaman Lisan, Skala Kepintaran Wechsler, Indeks Memori Bekerja @artikel{Masiran2018b, tajuk = {Autisme dan trikotilomania dalam remaja lelaki}, pengarang = {R Diurut}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053164449&doi = 10.1136% 2fbcr-2018-226270&rakan kongsi = 40&md5=7eed3f6af717df527dce73838feab571}, doi = {10.1136/bcr-2018-226270}, terbitan = {1757790X}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Laporan Kes BMJ}, isi padu = {2018}, penerbit = {Kumpulan Penerbitan BMJ}, abstrak = {Remaja yang mengalami gangguan spektrum autisme dan gangguan hiperaktif kekurangan perhatian yang tidak dirawat dengan betul ditunjukkan dengan tarikan rambut berulang. Rawatan dengan perencat pengambilan semula serotonin terpilih dan perangsang memperbaiki keadaan ini. © © BMJ Publishing Group Limited 2018.}, nota = {dipetik oleh 0}, kata kunci = {Remaja, Alopecia, Keresahan, Artikel, Gangguan Defisit Perhatian, Gangguan Hiperaktifan Kekurangan Perhatian, Autisme, Gangguan Spektrum Autisme, Gangguan Tingkah Laku, Berat badan, Laporan kes, Perangsang Sistem Saraf Pusat, Senarai Semak Tingkah Laku Kanak-kanak, Artikel Klinikal, komorbiditi, Komplikasi, Diagnosis, Berbeza, Diagnosis pembezaan, Pentitratan Dos Ubat, Toleransi Dadah, DSM-5, Echolalia, Fluvoxamine, Susulan, Manusia, Hiperaktif, Kemerosotan Intelektual, Lelaki, Metilfenidat, Obesiti, Terapi pekerjaan, Indeks Penaakulan Persepsi, Jurnal Keutamaan, Indeks Kelajuan Pemprosesan, Skala Penarafan Status Psikiatri, Skala Penarafan Psikologi, Skala penilaian, Kegelisahan, Ganjaran, Perencat Serapan Serotonin, Perencat Serapan Serotonin, Pendidikan Khas, Kelewatan Pertuturan, Gangguan Pertuturan, Terapi ucapan, Trikotilomania, Indeks Kefahaman Lisan, Skala Kepintaran Wechsler, Indeks Memori Bekerja}, pubstate = {diterbitkan}, tppubtype = {artikel} } Remaja yang mengalami gangguan spektrum autisme dan gangguan hiperaktif kekurangan perhatian yang tidak dirawat dengan betul ditunjukkan dengan tarikan rambut berulang. Rawatan dengan perencat pengambilan semula serotonin terpilih dan perangsang memperbaiki keadaan ini. © © BMJ Publishing Group Limited 2018. |
2017 |
Di mana, S W; Ong, L C; Rendah, W Y; Lai, P S M Epilepsy Research, 136 , hlm. 35-45, 2017, ISSN: 09201211, (dipetik oleh 8). Abstrak | Pautan | BibTeX | Tag: Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement @artikel{Wo201735, tajuk = {The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: Kajian semula yang sistematik}, pengarang = {S W Wo and L C Ong and W Y Low and P S M Lai}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025636897&doi=10.1016%2fj.eplepsyres.2017.07.009&rakan kongsi = 40&md5=f34a0aada2cc5dc6e4d6beab18ac779c}, doi = {10.1016/j.eplepsyres.2017.07.009}, terbitan = {09201211}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {Epilepsy Research}, isi padu = {136}, halaman = {35-45}, penerbit = {Elsevier B.V.}, abstrak = {Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V.}, nota = {dipetik oleh 8}, kata kunci = {Academic Achievement, Academic Success, Achievement, Sikap Terhadap Kesihatan, Autisme, Benign Childhood Epilepsy, Anak-anak, Children with Epilepsy, Analisis Kohort, komorbiditi, Kajian Lintas Bahagian, Bahasa Inggeris (Bahasa), Epilepsi, Manusia, Kemerosotan Intelektual, Intelligence, Intelligence Quotient, Gangguan Pembelajaran, Observational Study, Parenting Education, Jurnal Keutamaan, Psikologi, Recurrent Disease, Recurrent Epilepsy, Kaji semula, Sistem Pemarkahan, Kajian Sistematik, Underachievement}, pubstate = {diterbitkan}, tppubtype = {artikel} } Purpose To systematically examine published literature which assessed the prevalence of academic difficulties in children with epilepsy (CWE) kecerdasan normal, and its associating factors. Methods A search was conducted on five databases for articles published in English from 1980 till March 2015. Included were studies who recruited children (aged 5–18 years), with a diagnosis or newly/recurrent epilepsy, an intelligent quotient (IQ) of ≥70 or attending regular school, with or without a control group, which measured academic achievement using a standardised objective measure, and published in English. Excluded were children with learning difficulties, kecacatan intelektual (IQ < 70) and other comorbidities such as attention deficits hyperactive disorder or autism. Two pairs of reviewers extracted the data, and met to resolve any differences from the data extraction process. Results Twenty studies were included. The majority of the studies assessed “low achievement” whist only two studies used the IQ-achievement discrepancy definition of “underachievement”. Fourteen studies (70%) reported that CWE had significantly lower academic achievement scores compared to healthy controls, children with asthma or reported norms. The remaining six studies (30%) did not report any differences. CWE had stable academic achievement scores over time (2–4 years), even among those whose seizure frequency improved. Higher parental education and children with higher IQ, and had better attention or had a positive attitude towards epilepsy, were associated with higher academic achievement score. Older children were found to have lower academic achievement score. Conclusions In CWE of normal intelligence, the majority of published literature found that academic achievement was lower than controls or reported norms. The high percentages of low achievement in CWE, especially in the older age group, and the stability of scores even as seizure frequency improved, highlights the need for early screening of learning problems, and continued surveillance. © 2017 Elsevier B.V. |
2016 |
Tan, M L; Ho, BUKAN PERKATAAN; Teh, K H Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders Artikel Jurnal Pangkalan Data Cochrane dari Ulasan Sistematik, 2016 (9), 2016, ISSN: 1469493X, (dipetik oleh 6). Abstrak | Pautan | BibTeX | Tag: Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik @artikel{Tan2016, tajuk = {Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders}, pengarang = {M L Tan and J J Ho and K H Teh}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988922340&doi=10.1002%2f14651858.CD009398.pub3&rakan kongsi = 40&md5=3460f403b8829b4692a0b6f795f4a2a3}, doi = {10.1002/14651858.CD009398.pub3}, terbitan = {1469493X}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Pangkalan Data Cochrane dari Ulasan Sistematik}, isi padu = {2016}, nombor = {9}, penerbit = {John Wiley and Sons Ltd}, abstrak = {Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration.}, nota = {dipetik oleh 6}, kata kunci = {Gangguan Defisit Perhatian, Autisme, Carnosine, Anak-anak, Diet Supplementation, Drug Effect, Gastrointestinal Symptom, Manusia, Gangguan Pembelajaran, Meta Analysis, Penilaian Hasil, Placebo, Polyunsaturated Fatty Acid, Jurnal Keutamaan, Percubaan Terkawal Rawak, Kaji semula, Kajian Sistematik}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega-3 and omega-6 fatty acids, which normally are abundant in the brain and in the retina, are important for learning. Some children with specific learning disorders have been found to be deficient in these PUFAs, and it is argued that supplementation of PUFAs may help these children improve their learning abilities. Objektif: 1. To assess effects on learning outcomes of supplementation of polyunsaturated fatty acids (PUFAs) for children with specific learning disorders.2. To determine whether adverse effects of supplementation of PUFAs are reported in these children. Search methods: In November 2015, we searched CENTRAL, Ovid MEDLINE, Embase, PsycINFO, 10 other databases and two trials registers. We also searched the reference lists of relevant articles. Selection criteria: Randomised controlled trials (RCTs) or quasi-RCTs comparing PUFAs with placebo or no treatment in children younger than 18 years with specific learning disabilities, as diagnosed in accordance with the fifth (or earlier) edition of theDiagnostic and Statistical Manual of Mental Disorders (DSM-5), or the 10th (or earlier) revision of the International Classification of Diseases (ICD-10) or equivalent criteria. We included children with coexisting developmental disorders such as attention deficit hyperactivity disorder (ADHD) or autism. Data collection and analysis: Two review authors (MLT and KHT) independently screened the titles and abstracts of articles identified by the search and eliminated all studies that did not meet the inclusion criteria. We contacted study authors to ask for missing information and clarification, when needed. We used the GRADE approach to assess the quality of evidence. Main results: Two small studies involving 116 kanak-kanak, mainly boys between 10 dan 18 years of age, met the inclusion criteria. One study was conducted in a school setting, the other at a specialised clinic. Both studies used three months of a combination of omega-3 and omega-6 supplements as the intervention compared with placebo. Although both studies had generally low risk of bias, we judged the risk of reporting bias as unclear in one study, and as high in the other study. Sebagai tambahan, one of the studies was funded by industry and reported active company involvement in the study. None of the studies reported data on the primary outcomes of reading, menulis, spelling and mathematics scores, as assessed by standardised tests. Evidence of low quality indicates that supplementation of PUFAs did not increase the risk of gastrointestinal disturbances (risk ratio 1.43, 95% confidence interval 0.25 ke 8.15; two studies, 116 kanak-kanak). Investigators reported no other adverse effects. Both studies reported attention deficit hyperactivity disorder (ADHD)-related behaviour outcomes. We were unable to combine the results in a meta-analysis because one study reported findings as a continuous outcome, and the other as a dichotomous outcome. No other secondary outcomes were reported. We excluded one study because it used a cointervention (carnosine), and five other studies because they did not provide a robust diagnosis of a specific learning disorder. We identified one ongoing study and found three studies awaiting classification. Authors' conclusions: Evidence is insufficient to permit any conclusions about the effect of PUFAs on the learning abilities of children with specific learning disorders. Well-designed RCTs with clearly defined populations of children with specific learning disorders who have been diagnosed by standardised diagnostic criteria are needed. © 2016 The Cochrane Collaboration. |
Sheppard, E; Pillai, D; Wong, G T -L; Panggil, D; Mitchell, P How Easy is it to Read the Minds of People with Autism Spectrum Disorder? Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 46 (4), hlm. 1247-1254, 2016, ISSN: 01623257, (dipetik oleh 37). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Membuat keputusan, Emosi, Ekspresi wajah, Perempuan, Manusia, Lelaki, Kesihatan mental, Perhubungan tanpa percakapan, Patofisiologi, Jurnal Keutamaan, Psikologi, Video Recording, Dewasa Muda @artikel{Sheppard20161247, tajuk = {How Easy is it to Read the Minds of People with Autism Spectrum Disorder?}, pengarang = {E Sheppard and D Pillai and G T -L Wong and D Ropar and P Mitchell}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961215349&doi=10.1007%2fs10803-015-2662-8&rakan kongsi = 40&md5=d39b6bdebe3c2f33e304eb4d4c09b6fd}, doi = {10.1007/s10803-015-2662-8}, terbitan = {01623257}, tahun = {2016}, tarikh = {2016-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {46}, nombor = {4}, halaman = {1247-1254}, penerbit = {Springer New York LLC}, abstrak = {How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science + Business Media New York.}, nota = {dipetik oleh 37}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Membuat keputusan, Emosi, Ekspresi wajah, Perempuan, Manusia, Lelaki, Kesihatan mental, Perhubungan tanpa percakapan, Patofisiologi, Jurnal Keutamaan, Psikologi, Video Recording, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } How well can neurotypical adults’ interpret mental states in people with ASD? ‘Targets’ (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD. © 2015, Springer Science + Business Media New York. |
2015 |
Pelik, B; Jomhari, N; Ahmad, R Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 45 (10), hlm. 3069-3084, 2015, ISSN: 01623257, (dipetik oleh 7). Abstrak | Pautan | BibTeX | Tag: Artikel, Perhatian, Autisme, Gangguan Spektrum Autisme, Anak-anak, Computer Interface, Pendidikan, Education of Intellectually Disabled, Educational Model, Feedback System, Perempuan, Manusia, Belajar, Lelaki, Models, Occupational Therapist, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kualiti hidup, Treatment Duration, Antara Muka Pengguna, Visual Hybrid Development Learning System, Visual Stimulation @artikel{Banire20153069, tajuk = {Visual Hybrid Development Learning System (VHDLS) Framework for Children with Autism}, pengarang = {B Banire and N Jomhari and R Ahmad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941942795&doi=10.1007%2fs10803-015-2469-7&rakan kongsi = 40&md5=3c5ecc776725aea4e585e17a1ae805c7}, doi = {10.1007/s10803-015-2469-7}, terbitan = {01623257}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {45}, nombor = {10}, halaman = {3069-3084}, penerbit = {Springer New York LLC}, abstrak = {The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. Dalam kajian ini, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science + Business Media New York.}, nota = {dipetik oleh 7}, kata kunci = {Artikel, Perhatian, Autisme, Gangguan Spektrum Autisme, Anak-anak, Computer Interface, Pendidikan, Education of Intellectually Disabled, Educational Model, Feedback System, Perempuan, Manusia, Belajar, Lelaki, Models, Occupational Therapist, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kualiti hidup, Treatment Duration, Antara Muka Pengguna, Visual Hybrid Development Learning System, Visual Stimulation}, pubstate = {diterbitkan}, tppubtype = {artikel} } The effect of education on children with autism serves as a relative cure for their deficits. As a result of this, they require special techniques to gain their attention and interest in learning as compared to typical children. Several studies have shown that these children are visual learners. Dalam kajian ini, we proposed a Visual Hybrid Development Learning System (VHDLS) framework that is based on an instructional design model, multimedia cognitive learning theory, and learning style in order to guide software developers in developing learning systems for children with autism. The results from this study showed that the attention of children with autism increased more with the proposed VHDLS framework. © 2015, Springer Science + Business Media New York. |
Bhagat, V; Simbak, Bin N; Haque, M Journal of Young Pharmacists, 7 (4), hlm. 403-414, 2015, ISSN: 09751483, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik @artikel{Bhagat2015403, tajuk = {The peripheral focus on the psychological parameters of parents of autistic children in the intervention methods: A review and recommending the strategy, focusing psychological parameters of parents of autistic children in intervention methods}, pengarang = {V Bhagat and N Bin Simbak and M Haque}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959853109&doi=10.5530%2fjyp.2015.4s.1&rakan kongsi = 40&md5=ed5b5faede6650d1249a902d7201ed43}, doi = {10.5530/jyp.2015.4s.1}, terbitan = {09751483}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Journal of Young Pharmacists}, isi padu = {7}, nombor = {4}, halaman = {403-414}, penerbit = {EManuscript Services}, abstrak = {The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them.}, nota = {dipetik oleh 0}, kata kunci = {Autisme, Tingkah Laku Menghadapi, Membuat keputusan, Keterukan Penyakit, Economic Aspect, Emosi, Emotionality, Experience, Manusia, Perhubungan Manusia, Intervention Study, Sikap Ibu Bapa, Tekanan Ibu Bapa, Jurnal Keutamaan, Psychological Well Being, Kaji semula, Kepuasan hati, Kelakuan Sosial, Perancangan strategik}, pubstate = {diterbitkan}, tppubtype = {artikel} } The experience of parents with an Autism Spectrum Disorders (ASD) can be devastating. Parents and families have to cope with the compound, demanding situation in their life. The presence of pervasive and severe deficits in children with ASD increases the adjusting demands of parent's in their life situations. Those coping with life complexity with the parents of ASD nudge them into stress later into distress slowly incapacitates them that of their efficiency to deal with this situation. These parents are found with disturbances in their psychological parameters such as social, sexual, economic, and emotional. Perhaps this shatters them from their interpersonal relationship and family life. Sesungguhnya, these aspects of parental distress stand lower in position, and the focus goes with the treatment of ASD. Oleh itu, the management of ASD by these parents to their deficit child capacitating to reach their fullest abilities remains questionable. Oleh itu, there is a need for intervention of autistic children with a peripheral focus on psychological parameters of parents of ASD. This review study focuses on division of attention required for the treatment of ASD towards the child with autism and the parents who manage them. |
Roffeei, Mohd S H; Abdullah, N; bazar, S K R Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs) Artikel Jurnal International Journal of Medical Informatics, 84 (5), hlm. 375-385, 2015, ISSN: 13865056, (dipetik oleh 43). Abstrak | Pautan | BibTeX | Tag: Artikel, ASD, Autisme, Gangguan Spektrum Autisme, Pengasuh, Anak-anak, Consumer Health Information, Content Analysis, Penyakit, E-mail, Facebook, Keluarga, Friendship, Manusia, Internet, Ibu bapa, Patient Referral, Jurnal Keutamaan, Psikologi, Analisis Kualitatif, Self Esteem, Media sosial, Rangkaian sosial, Sokongan Sosial, Statistik, Support Group, Telemedicine, Utilization @artikel{MohdRoffeei2015375, tajuk = {Seeking social support on Facebook for children with Autism Spectrum Disorders (ASDs)}, pengarang = {S H Mohd Roffeei and N Abdullah and S K R Basar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924517643&doi=10.1016%2fj.ijmedinf.2015.01.015&rakan kongsi = 40&md5=7296825093cbf87388b5b65023e59371}, doi = {10.1016/j.ijmedinf.2015.01.015}, terbitan = {13865056}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {International Journal of Medical Informatics}, isi padu = {84}, nombor = {5}, halaman = {375-385}, penerbit = {Elsevier Ireland Ltd}, abstrak = {Tujuan: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (PAGI) and Autism Children Club (ACA). Kaedah: Sejumlah 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% dan 20.2%, masing-masing. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Kesimpulannya: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd.}, nota = {dipetik oleh 43}, kata kunci = {Artikel, ASD, Autisme, Gangguan Spektrum Autisme, Pengasuh, Anak-anak, Consumer Health Information, Content Analysis, Penyakit, E-mail, Facebook, Keluarga, Friendship, Manusia, Internet, Ibu bapa, Patient Referral, Jurnal Keutamaan, Psikologi, Analisis Kualitatif, Self Esteem, Media sosial, Rangkaian sosial, Sokongan Sosial, Statistik, Support Group, Telemedicine, Utilization}, pubstate = {diterbitkan}, tppubtype = {artikel} } Tujuan: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (PAGI) and Autism Children Club (ACA). Kaedah: Sejumlah 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members. Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% dan 20.2%, masing-masing. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines. Kesimpulannya: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. © 2015 Elsevier Ireland Ltd. |
Haerian, B S; Shaári, H M; Tan, H J; Fong, C Y; Wong, S W; Ong, L C; Raymond, A A; Tan, C T; Mohamed, DENGAN Genomics, 105 (4), hlm. 229-236, 2015, ISSN: 08887543, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda @artikel{Haerian2015229, tajuk = {RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia}, pengarang = {B S Haerian and H M Shaári and H J Tan and C Y Fong and S W Wong and L C Ong and A A Raymond and C T Tan and Z Mohamed}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924135981&doi=10.1016%2fj.ygeno.2015.02.001&rakan kongsi = 40&md5=209a1720cddfd76bfa515ee8940749d5}, doi = {10.1016/j.ygeno.2015.02.001}, terbitan = {08887543}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Genomics}, isi padu = {105}, nombor = {4}, halaman = {229-236}, penerbit = {Academic Press Inc.}, abstrak = {RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Oleh itu, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.}, nota = {dipetik oleh 5}, kata kunci = {Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Oleh itu, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.. |
Gallagher, D; Voronova, A; Zander, M A; Cancun, G I; Bramall, A; Krause, M P; Abad, C; Tekin, M; Neilsen, P M; Callen, D F; Scherer, S W; Pembunuh, G M; Kaplan, D R; Walz, K; Miller, F D Ankrd11 adalah pengatur kromatin yang terlibat dalam autisme yang penting untuk perkembangan saraf Artikel Jurnal Sel Perkembangan, 32 (1), hlm. 31-42, 2015, ISSN: 15345807, (dipetik oleh 52). Abstrak | Pautan | BibTeX | Tag: Asetilasi, Tingkah Laku Haiwan, Sel Haiwan, Haiwan, Protein Ankrd11, Ankyrin, Domain Ulangan Ankyrin yang Mengandungi Protein 11, Artikel, Autisme, Gangguan Spektrum Autisme, Kelakuan, Penanda Biologi, Meletup, Budaya Sel Otak, Kultur sel, Pembezaan Sel, Percambahan Sel, Sel, Kimia, Kromatin, Immunoprecipitation Chromatin, Berbudaya, Protein Mengikat DNA, Microarray DNA, Protein Pengikat DNA, Aktiviti Enzim, Perempuan, Gen, Profil Ekspresi Gen, Penyasaran Gen, Genetik, Histone, Asetilasi Histone, Histone Acetyltransferase, Histone Deacetylase, Histone Deacetylase 3, Deacetylases Histone, Histones, Manusia, Sel Manusia, Imunoprecipitasi, Utusan, Messenger RNA, Metabolisme, Tikus, Tetikus, Murinae, Mus, Pembezaan Sel Saraf, Pembangunan Sistem Saraf, Neurogenesis, Bukan Manusia, Analisis Urutan Array Oligonukleotida, Patologi, Fenotip, Fisiologi, Titik Mutasi, Pasca Terjemahan, Jurnal Keutamaan, Ekspresi Protein, Pemprosesan Protein, Tindak balas Rantai Polimerase Masa Nyata, Tindak balas Rantai Polimerase Transkrip terbalik, Reaksi Rantai Polimerase Transkripsi Berbalik, RNA, Kecil Mengganggu, RNA Mengganggu Kecil, Dadah yang tidak dikelaskan, Barat, Blotting Barat @artikel{Gallagher201531, tajuk = {Ankrd11 adalah pengatur kromatin yang terlibat dalam autisme yang penting untuk perkembangan saraf}, pengarang = {D Gallagher dan A Voronova dan M A Zander dan G I Cancino dan A Bramall dan M P Krause dan C Abad dan M Tekin dan P M Neilsen dan D F Callen dan S W Scherer dan G M Keller dan D R Kaplan dan K Walz dan F D Miller}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84922343890&doi = 10.1016% 2fj.devcel.2014.11.031&rakan kongsi = 40&md5 = ad7b8bd3ead790f092e1d8a276d4f25c}, doi = {10.1016/j.devcel.2014.11.031}, terbitan = {15345807}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Sel Perkembangan}, isi padu = {32}, nombor = {1}, halaman = {31-42}, penerbit = {Akhbar Sel}, abstrak = {Ankrd11 adalah pengatur kromatin yang berpotensi terlibat dalam perkembangan saraf dan gangguan spektrum autisme (ASD) tanpa fungsi yang diketahui di otak. Di sini, kami menunjukkan bahawa pengurangan Ankrd11 dalam mengembangkan prekursor saraf kortikal manusia atau manusia menyebabkan penurunan percambahan, neurogenesis berkurang, dan kedudukan neuron yang tidak betul. Fenotip selular yang serupa dan tingkah laku seperti ASD yang menyimpang diperhatikan pada tikus Yoda yang membawa mutasi titik dalam domain pengikat HDAC Ankrd11. Selaras dengan peranan untuk Ankrd11 dalam asetilasi histon, Ankrd11 dikaitkan dengan kromatin dan colocalized dengan HDAC3, dan ungkapan dan asetilasi histon gen sasaran Ankrd11 diubah pada pendahulu saraf Yoda. Lebih-lebih lagi, penurunan proliferasi prekursor yang dimediasi oleh Ankrd11 berjaya diselamatkan dengan menghalang aktiviti histon asetiltransferase atau menyatakan HDAC3. Oleh itu, Ankrd11 adalah pengatur kromatin penting yang mengawal asetilasi histon dan ekspresi gen semasa perkembangan saraf, sehingga memberikan penjelasan yang mungkin untuk kaitannya dengan disfungsi kognitif dan ASD. © 2015 Elsevier Inc.}, nota = {dipetik oleh 52}, kata kunci = {Asetilasi, Tingkah Laku Haiwan, Sel Haiwan, Haiwan, Protein Ankrd11, Ankyrin, Domain Ulangan Ankyrin yang Mengandungi Protein 11, Artikel, Autisme, Gangguan Spektrum Autisme, Kelakuan, Penanda Biologi, Meletup, Budaya Sel Otak, Kultur sel, Pembezaan Sel, Percambahan Sel, Sel, Kimia, Kromatin, Immunoprecipitation Chromatin, Berbudaya, Protein Mengikat DNA, Microarray DNA, Protein Pengikat DNA, Aktiviti Enzim, Perempuan, Gen, Profil Ekspresi Gen, Penyasaran Gen, Genetik, Histone, Asetilasi Histone, Histone Acetyltransferase, Histone Deacetylase, Histone Deacetylase 3, Deacetylases Histone, Histones, Manusia, Sel Manusia, Imunoprecipitasi, Utusan, Messenger RNA, Metabolisme, Tikus, Tetikus, Murinae, Mus, Pembezaan Sel Saraf, Pembangunan Sistem Saraf, Neurogenesis, Bukan Manusia, Analisis Urutan Array Oligonukleotida, Patologi, Fenotip, Fisiologi, Titik Mutasi, Pasca Terjemahan, Jurnal Keutamaan, Ekspresi Protein, Pemprosesan Protein, Tindak balas Rantai Polimerase Masa Nyata, Tindak balas Rantai Polimerase Transkrip terbalik, Reaksi Rantai Polimerase Transkripsi Berbalik, RNA, Kecil Mengganggu, RNA Mengganggu Kecil, Dadah yang tidak dikelaskan, Barat, Blotting Barat}, pubstate = {diterbitkan}, tppubtype = {artikel} } Ankrd11 adalah pengatur kromatin yang berpotensi terlibat dalam perkembangan saraf dan gangguan spektrum autisme (ASD) tanpa fungsi yang diketahui di otak. Di sini, kami menunjukkan bahawa pengurangan Ankrd11 dalam mengembangkan prekursor saraf kortikal manusia atau manusia menyebabkan penurunan percambahan, neurogenesis berkurang, dan kedudukan neuron yang tidak betul. Fenotip selular yang serupa dan tingkah laku seperti ASD yang menyimpang diperhatikan pada tikus Yoda yang membawa mutasi titik dalam domain pengikat HDAC Ankrd11. Selaras dengan peranan untuk Ankrd11 dalam asetilasi histon, Ankrd11 dikaitkan dengan kromatin dan colocalized dengan HDAC3, dan ungkapan dan asetilasi histon gen sasaran Ankrd11 diubah pada pendahulu saraf Yoda. Lebih-lebih lagi, penurunan proliferasi prekursor yang dimediasi oleh Ankrd11 berjaya diselamatkan dengan menghalang aktiviti histon asetiltransferase atau menyatakan HDAC3. Oleh itu, Ankrd11 adalah pengatur kromatin penting yang mengawal asetilasi histon dan ekspresi gen semasa perkembangan saraf, sehingga memberikan penjelasan yang mungkin untuk kaitannya dengan disfungsi kognitif dan ASD. © 2015 Elsevier Inc.. |
2014 |
Alwi, N; Harun, D; Henry, L J Psychological distress among parents having offspring with autism spectrum disorder (ASD) - A clinical view point Artikel Jurnal Disability and Health Journal, 7 (4), hlm. 369-370, 2014, ISSN: 19366574, (dipetik oleh 1). Pautan | BibTeX | Tag: Autisme, Gangguan Spektrum Autisme, Pengasuh, Hubungan Ibu Bapa Anak, Tingkah Laku Menghadapi, Counseling, Kemurungan, Disabled Person, Disabled Persons, Distress Syndrome, Keluarga, Manusia, Surat, Marriage, Tekanan Mental, Tekanan Ibu Bapa, Ibu bapa, Jurnal Keutamaan, Progeny, Psikologi, Psychological Well Being, Psikologi, Single Parent, Status sosial, Tekanan, Kesejahteraan @artikel{Alwi2014369, tajuk = {Psychological distress among parents having offspring with autism spectrum disorder (ASD) - A clinical view point}, pengarang = {N Alwi and D Harun and L J Henry}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927968335&doi=10.1016%2fj.dhjo.2014.04.008&rakan kongsi = 40&md5=a07c401e41bcac2ae5884cd4e8b8db30}, doi = {10.1016/j.dhjo.2014.04.008}, terbitan = {19366574}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {Disability and Health Journal}, isi padu = {7}, nombor = {4}, halaman = {369-370}, penerbit = {Elsevier Inc.}, nota = {dipetik oleh 1}, kata kunci = {Autisme, Gangguan Spektrum Autisme, Pengasuh, Hubungan Ibu Bapa Anak, Tingkah Laku Menghadapi, Counseling, Kemurungan, Disabled Person, Disabled Persons, Distress Syndrome, Keluarga, Manusia, Surat, Marriage, Tekanan Mental, Tekanan Ibu Bapa, Ibu bapa, Jurnal Keutamaan, Progeny, Psikologi, Psychological Well Being, Psikologi, Single Parent, Status sosial, Tekanan, Kesejahteraan}, pubstate = {diterbitkan}, tppubtype = {artikel} } |
Cassidy, S; Panggil, D; Mitchell, P; Kapten, P Can adults with autism spectrum disorders infer what happened to someone from their emotional response? Artikel Jurnal Penyelidikan Autisme, 7 (1), hlm. 112-123, 2014, ISSN: 19393792, (dipetik oleh 21). Abstrak | Pautan | BibTeX | Tag: Ketepatan, Dewasa, Aged, Artikel, Sindrom Asperger, Perhatian, Autisme, Kelakuan, Cacao, Gangguan Perkembangan Kanak-kanak, Artikel Klinikal, Concept Formation, Kajian Terkawal, Deception, Discrimination (Psikologi), Emosi, Pergerakan Mata, Eye Tracking, Face Processing, Ekspresi wajah, Perempuan, Manusia, Interpersonal Relations, Lelaki, Pertengahan umur, Money, Meresap, Jurnal Keutamaan, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Dewasa Muda @artikel{Cassidy2014112, tajuk = {Can adults with autism spectrum disorders infer what happened to someone from their emotional response?}, pengarang = {S Cassidy and D Ropar and P Mitchell and P Chapman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894307909&doi=10.1002%2faur.1351&rakan kongsi = 40&md5=8c6736bc006e9eebde29427879d023c3}, doi = {10.1002/aur.1351}, terbitan = {19393792}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {Penyelidikan Autisme}, isi padu = {7}, nombor = {1}, halaman = {112-123}, penerbit = {John Wiley and Sons Inc.}, abstrak = {Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. © 2013 International Society for Autism Research, Berkala Wiley, Inc.}, nota = {dipetik oleh 21}, kata kunci = {Ketepatan, Dewasa, Aged, Artikel, Sindrom Asperger, Perhatian, Autisme, Kelakuan, Cacao, Gangguan Perkembangan Kanak-kanak, Artikel Klinikal, Concept Formation, Kajian Terkawal, Deception, Discrimination (Psikologi), Emosi, Pergerakan Mata, Eye Tracking, Face Processing, Ekspresi wajah, Perempuan, Manusia, Interpersonal Relations, Lelaki, Pertengahan umur, Money, Meresap, Jurnal Keutamaan, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. © 2013 International Society for Autism Research, Berkala Wiley, Syarikat. |
Batt, S; Acharya, U R; Adeli, H; Tenusu, G M; Adeli, A Automated diagnosis of autism: In search of a mathematical marker Artikel Jurnal Reviews in the Neurosciences, 25 (6), hlm. 851-861, 2014, ISSN: 03341763, (dipetik oleh 34). Abstrak | Pautan | BibTeX | Tag: Algoritma, Artikel, Autisme, Gangguan Spektrum Autisme, Automasi, Biological Model, Otak, Chaos Theory, Correlation Analysis, Detrended Fluctuation Analysis, Disease Marker, Electrode, Elektroencephalogram, Elektroensefalografi, Entropy, Fourier Transformation, Fractal Analysis, Frequency Domain Analysis, Manusia, Mathematical Analysis, Mathematical Marker, Mathematical Parameters, Models, Neurologic Disease, Neurological, Nonlinear Dynamics, Nonlinear System, Patofisiologi, Jurnal Keutamaan, Prosedur, Pemprosesan isyarat, Model Statistik, Masa, Time Frequency Analysis, Wavelet Analysis @artikel{Bhat2014851, tajuk = {Automated diagnosis of autism: In search of a mathematical marker}, pengarang = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925286949&doi=10.1515%2frevneuro-2014-0036&rakan kongsi = 40&md5=04858a5c9860e9027e3113835ca2e11f}, doi = {10.1515/revneuro-2014-0036}, terbitan = {03341763}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {Reviews in the Neurosciences}, isi padu = {25}, nombor = {6}, halaman = {851-861}, penerbit = {Walter de Gruyter GmbH}, abstrak = {Autism is a type of neurodevelopmental disorder affecting the memory, behavior, emotion, learning ability, and communication of an individual. An early detection of the abnormality, due to irregular processing in the brain, can be achieved using electroencephalograms (LIHAT). The variations in the EEG signals cannot be deciphered by mere visual inspection. Computer-aided diagnostic tools can be used to recognize the subtle and invisible information present in the irregular EEG pattern and diagnose autism. This paper presents a state-of-theart review of automated EEG-based diagnosis of autism. Various time domain, frequency domain, time-frequency domain, and nonlinear dynamics for the analysis of autistic EEG signals are described briefly. A focus of the review is the use of nonlinear dynamics and chaos theory to discover the mathematical biomarkers for the diagnosis of the autism analogous to biological markers. A combination of the time-frequency and nonlinear dynamic analysis is the most effective approach to characterize the nonstationary and chaotic physiological signals for the automated EEGbased diagnosis of autism spectrum disorder (ASD). The features extracted using these nonlinear methods can be used as mathematical markers to detect the early stage of autism and aid the clinicians in their diagnosis. This will expedite the administration of appropriate therapies to treat the disorder. © 2014 Walter de Gruyter GmbH.}, nota = {dipetik oleh 34}, kata kunci = {Algoritma, Artikel, Autisme, Gangguan Spektrum Autisme, Automasi, Biological Model, Otak, Chaos Theory, Correlation Analysis, Detrended Fluctuation Analysis, Disease Marker, Electrode, Elektroencephalogram, Elektroensefalografi, Entropy, Fourier Transformation, Fractal Analysis, Frequency Domain Analysis, Manusia, Mathematical Analysis, Mathematical Marker, Mathematical Parameters, Models, Neurologic Disease, Neurological, Nonlinear Dynamics, Nonlinear System, Patofisiologi, Jurnal Keutamaan, Prosedur, Pemprosesan isyarat, Model Statistik, Masa, Time Frequency Analysis, Wavelet Analysis}, pubstate = {diterbitkan}, tppubtype = {artikel} } Autism is a type of neurodevelopmental disorder affecting the memory, behavior, emotion, learning ability, and communication of an individual. An early detection of the abnormality, due to irregular processing in the brain, can be achieved using electroencephalograms (LIHAT). The variations in the EEG signals cannot be deciphered by mere visual inspection. Computer-aided diagnostic tools can be used to recognize the subtle and invisible information present in the irregular EEG pattern and diagnose autism. This paper presents a state-of-theart review of automated EEG-based diagnosis of autism. Various time domain, frequency domain, time-frequency domain, and nonlinear dynamics for the analysis of autistic EEG signals are described briefly. A focus of the review is the use of nonlinear dynamics and chaos theory to discover the mathematical biomarkers for the diagnosis of the autism analogous to biological markers. A combination of the time-frequency and nonlinear dynamic analysis is the most effective approach to characterize the nonstationary and chaotic physiological signals for the automated EEGbased diagnosis of autism spectrum disorder (ASD). The features extracted using these nonlinear methods can be used as mathematical markers to detect the early stage of autism and aid the clinicians in their diagnosis. This will expedite the administration of appropriate therapies to treat the disorder. © 2014 Walter de Gruyter GmbH. |
Batt, S; Acharya, U R; Adeli, H; Tenusu, G M; Adeli, A Autisme: Cause factors, early diagnosis and therapies Artikel Jurnal Reviews in the Neurosciences, 25 (6), hlm. 841-850, 2014, ISSN: 03341763, (dipetik oleh 52). Abstrak | Pautan | BibTeX | Tag: 4 Aminobutyric Acid, Remaja, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Artikel, Teknologi Bantuan, Perhatian, Autisme, Gangguan Spektrum Autisme, Behaviour Therapy, Penanda Biologi, Otak, Gangguan Perkembangan Kanak-kanak, Anak-anak, Kognisi, Cystine, Gangguan Perkembangan, Penyakit, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emosi, Ekspresi wajah, Pengimejan Resonans Magnetik Berfungsi, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Manusia, Bayi, Komunikasi Interpersonal, Methionine, Keradangan Sistem Saraf, Neurobiology, Neurofeedback, Oxidative Stress, Meresap, Fisiologi, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psychoeducation, Budak sekolah, Interaksi Sosial, Terapi ucapan, Realiti maya, Zonisamide @artikel{Bhat2014841, tajuk = {Autisme: Cause factors, early diagnosis and therapies}, pengarang = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925284617&doi=10.1515%2frevneuro-2014-0056&rakan kongsi = 40&md5=caaa32e66af70e70ec325241d01564c9}, doi = {10.1515/revneuro-2014-0056}, terbitan = {03341763}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {Reviews in the Neurosciences}, isi padu = {25}, nombor = {6}, halaman = {841-850}, penerbit = {Walter de Gruyter GmbH}, abstrak = {Gangguan spektrum autisme (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 dalam 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH.}, nota = {dipetik oleh 52}, kata kunci = {4 Aminobutyric Acid, Remaja, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Artikel, Teknologi Bantuan, Perhatian, Autisme, Gangguan Spektrum Autisme, Behaviour Therapy, Penanda Biologi, Otak, Gangguan Perkembangan Kanak-kanak, Anak-anak, Kognisi, Cystine, Gangguan Perkembangan, Penyakit, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emosi, Ekspresi wajah, Pengimejan Resonans Magnetik Berfungsi, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Manusia, Bayi, Komunikasi Interpersonal, Methionine, Keradangan Sistem Saraf, Neurobiology, Neurofeedback, Oxidative Stress, Meresap, Fisiologi, Kanak-kanak Prasekolah, Jurnal Keutamaan, Psychoeducation, Budak sekolah, Interaksi Sosial, Terapi ucapan, Realiti maya, Zonisamide}, pubstate = {diterbitkan}, tppubtype = {artikel} } Gangguan spektrum autisme (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 dalam 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH. |
2013 |
Freeth, M; Sheppard, E; Ramachandran, R; Milne, E Perbandingan silang budaya ciri autistik di UK, India and Malaysia Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 43 (11), hlm. 2569-2583, 2013, ISSN: 01623257, (dipetik oleh 39). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Kumpulan Leluhur Benua Asia, Perhatian, Autisme, Gangguan Spektrum Autisme, Kuantiti Spektrum Autisme, Kemahiran komunikasi, Kajian Perbandingan, Perbandingan Merentas Budaya, Faktor Budaya, Etnik, Perempuan, Great Britain, Manusia, Eksperimen Manusia, Khayalan, India, Orang India, Malaysia, Lelaki, Keperibadian, Fenotip, Pelajar Pascasiswazah, Jurnal Keutamaan, Psikometri, Soal selidik, Faktor Seks, Penyesuaian Sosial, Spektrum, Pelajar, Pelajar Prasiswazah, United Kingdom, Dewasa Muda @artikel{Freeth20132569, tajuk = {Perbandingan silang budaya ciri autistik di UK, India and Malaysia}, pengarang = {M Freeth dan E Sheppard dan R Ramachandran dan E Milne}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84886802970&doi = 10.1007% 2fs10803-013-1808-9&rakan kongsi = 40&md5 = d8acde51c0626be3862facc1d6bc493c}, doi = {10.1007/s10803-013-1808-9}, terbitan = {01623257}, tahun = {2013}, tarikh = {2013-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {43}, nombor = {11}, halaman = {2569-2583}, abstrak = {Gangguan autisme dikenali secara meluas di seluruh dunia. Walau bagaimanapun, kriteria diagnostik dan teori autisme didasarkan pada penyelidikan yang kebanyakannya dilakukan dalam budaya Barat. Di sini kita membandingkan ekspresi sifat autistik dalam sampel individu neurotipikal dari satu budaya Barat (UK) dan dua budaya Timur (India and Malaysia), menggunakan Autisme-spektrum Quotient (AQ) untuk mengenal pasti kemungkinan perbezaan budaya dalam penyataan sifat autistik. Tingkah laku yang berkaitan dengan sifat autistik dilaporkan pada tahap yang lebih besar dalam budaya Timur daripada budaya Barat. Lelaki mendapat markah lebih tinggi daripada pelajar perempuan dan pelajar sains mendapat markah lebih tinggi daripada pelajar bukan sains dalam setiap budaya. Pelajar India mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub-skala Imaginasi, Pelajar Malaysia mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub skala Attention Switching. Struktur faktor asas AQ untuk setiap populasi diperoleh dan dibincangkan. © 2013 Springer Science + Business Media New York.}, nota = {dipetik oleh 39}, kata kunci = {Remaja, Dewasa, Artikel, Kumpulan Leluhur Benua Asia, Perhatian, Autisme, Gangguan Spektrum Autisme, Kuantiti Spektrum Autisme, Kemahiran komunikasi, Kajian Perbandingan, Perbandingan Merentas Budaya, Faktor Budaya, Etnik, Perempuan, Great Britain, Manusia, Eksperimen Manusia, Khayalan, India, Orang India, Malaysia, Lelaki, Keperibadian, Fenotip, Pelajar Pascasiswazah, Jurnal Keutamaan, Psikometri, Soal selidik, Faktor Seks, Penyesuaian Sosial, Spektrum, Pelajar, Pelajar Prasiswazah, United Kingdom, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } Gangguan autisme dikenali secara meluas di seluruh dunia. Walau bagaimanapun, kriteria diagnostik dan teori autisme didasarkan pada penyelidikan yang kebanyakannya dilakukan dalam budaya Barat. Di sini kita membandingkan ekspresi sifat autistik dalam sampel individu neurotipikal dari satu budaya Barat (UK) dan dua budaya Timur (India and Malaysia), menggunakan Autisme-spektrum Quotient (AQ) untuk mengenal pasti kemungkinan perbezaan budaya dalam penyataan sifat autistik. Tingkah laku yang berkaitan dengan sifat autistik dilaporkan pada tahap yang lebih besar dalam budaya Timur daripada budaya Barat. Lelaki mendapat markah lebih tinggi daripada pelajar perempuan dan pelajar sains mendapat markah lebih tinggi daripada pelajar bukan sains dalam setiap budaya. Pelajar India mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub-skala Imaginasi, Pelajar Malaysia mendapat markah lebih tinggi daripada kedua-dua kumpulan lain pada sub skala Attention Switching. Struktur faktor asas AQ untuk setiap populasi diperoleh dan dibincangkan. © 2013 Springer Science + Business Media New York. |
Assaf, M; Hyatt, C J; Wong, C G; Johnson, ENCIK; Schultz, R T; Hendler, T; Pearlson, G D Mentalizing and motivation neural function during social interactions in autism spectrum disorders Artikel Jurnal NeuroImage: klinikal, 3 , hlm. 321-331, 2013, ISSN: 22131582, (dipetik oleh 28). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan @artikel{Assaf2013321, tajuk = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders}, pengarang = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&rakan kongsi = 40&md5=b63630c997b658167792266e40e855b6}, doi = {10.1016/j.nicl.2013.09.005}, terbitan = {22131582}, tahun = {2013}, tarikh = {2013-01-01}, jurnal = {NeuroImage: klinikal}, isi padu = {3}, halaman = {321-331}, abstrak = {Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis.}, nota = {dipetik oleh 28}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis. |
Khowaja, K; Salim, S S Kajian sistematik mengenai strategi dan intervensi berasaskan komputer (CBI) untuk membaca pemahaman kanak-kanak dengan autisme Artikel Jurnal Penyelidikan dalam Gangguan Spektrum Autisme, 7 (9), hlm. 1111-1121, 2013, ISSN: 17509467, (dipetik oleh 28). Abstrak | Pautan | BibTeX | Tag: Perhatian, Autisme, Pangkalan Data Bibliografi, Anak-anak, Keberkesanan Klinikal, Pemerhatian Klinikal, Kognisi, Kefahaman, Terapi Berbantukan Komputer, Intervensi Berasaskan Komputer, Ingatan Eksplisit, Manusia, Belajar, Linguistik, Motivasi, Multimedia, Reka Bentuk Posttest Pretest, Jurnal Keutamaan, Membaca, Pemahaman bacaan, Kaji semula, Kajian Sistematik, Hasil Rawatan @artikel{Khowaja20131111, tajuk = {Kajian sistematik mengenai strategi dan intervensi berasaskan komputer (CBI) untuk membaca pemahaman kanak-kanak dengan autisme}, pengarang = {K Khowaja dan S S Salim}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-84879609907&doi=10.1016/j.rasd.2013.05.009&rakan kongsi = 40&md5 = 6ba3e9315ee8b3cecb6248b97198313d}, doi = {10.1016/j.rasd.2013.05.009}, terbitan = {17509467}, tahun = {2013}, tarikh = {2013-01-01}, jurnal = {Penyelidikan dalam Gangguan Spektrum Autisme}, isi padu = {7}, nombor = {9}, halaman = {1111-1121}, abstrak = {Makalah ini membentangkan tinjauan sistematik mengenai kajian yang diterbitkan yang berkaitan mengenai pemahaman membaca untuk kanak-kanak dengan autisme, memberi tumpuan kepada arahan perbendaharaan kata dan pengajaran pemahaman teks dari tahun 2000 ke 2011. Kajian sistematik ini cuba menangani tiga persoalan kajian khusus: strategi pengajaran kosa kata dan arahan pemahaman teks yang digunakan, campur tangan berasaskan komputer (CBI) digunakan atau dikembangkan semasa belajar, dan keberkesanan penggunaan CBI untuk mengajar kanak-kanak dengan autisme. Terdapat lima strategi pengajaran kosa kata dan tujuh strategi pengajaran pemahaman teks. Hasil menunjukkan bahawa dua strategi pengajaran kosa kata, kaedah multimedia dan arahan eksplisit didapati lebih biasa digunakan daripada tiga kaedah lain. Pada nota yang sama, strategi menjawab soalan pengajaran pemahaman teks didapati digunakan lebih kerap daripada enam yang lain. Hasilnya juga menunjukkan bahawa kanak-kanak dengan autisme dapat memanfaatkan strategi pemahaman membaca dan penggunaan CBI sebagai kaedah pengajaran untuk pemahaman membaca meningkatkan pembelajaran anak-anak. Ini jelas dilihat dari prestasi kanak-kanak antara ujian pra dan ujian pasca kajian di mana CBI digunakan. Walau bagaimanapun, kerana heterogenitas peserta, ini tidak selalu berlaku; beberapa kajian melaporkan tiada peningkatan dalam pembelajaran kanak-kanak dengan autisme. © 2013 Elsevier Ltd.. Hak cipta terpelihara.}, nota = {dipetik oleh 28}, kata kunci = {Perhatian, Autisme, Pangkalan Data Bibliografi, Anak-anak, Keberkesanan Klinikal, Pemerhatian Klinikal, Kognisi, Kefahaman, Terapi Berbantukan Komputer, Intervensi Berasaskan Komputer, Ingatan Eksplisit, Manusia, Belajar, Linguistik, Motivasi, Multimedia, Reka Bentuk Posttest Pretest, Jurnal Keutamaan, Membaca, Pemahaman bacaan, Kaji semula, Kajian Sistematik, Hasil Rawatan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Makalah ini membentangkan tinjauan sistematik mengenai kajian yang diterbitkan yang berkaitan mengenai pemahaman membaca untuk kanak-kanak dengan autisme, memberi tumpuan kepada arahan perbendaharaan kata dan pengajaran pemahaman teks dari tahun 2000 ke 2011. Kajian sistematik ini cuba menangani tiga persoalan kajian khusus: strategi pengajaran kosa kata dan arahan pemahaman teks yang digunakan, campur tangan berasaskan komputer (CBI) digunakan atau dikembangkan semasa belajar, dan keberkesanan penggunaan CBI untuk mengajar kanak-kanak dengan autisme. Terdapat lima strategi pengajaran kosa kata dan tujuh strategi pengajaran pemahaman teks. Hasil menunjukkan bahawa dua strategi pengajaran kosa kata, kaedah multimedia dan arahan eksplisit didapati lebih biasa digunakan daripada tiga kaedah lain. Pada nota yang sama, strategi menjawab soalan pengajaran pemahaman teks didapati digunakan lebih kerap daripada enam yang lain. Hasilnya juga menunjukkan bahawa kanak-kanak dengan autisme dapat memanfaatkan strategi pemahaman membaca dan penggunaan CBI sebagai kaedah pengajaran untuk pemahaman membaca meningkatkan pembelajaran anak-anak. Ini jelas dilihat dari prestasi kanak-kanak antara ujian pra dan ujian pasca kajian di mana CBI digunakan. Walau bagaimanapun, kerana heterogenitas peserta, ini tidak selalu berlaku; beberapa kajian melaporkan tiada peningkatan dalam pembelajaran kanak-kanak dengan autisme. © 2013 Elsevier Ltd.. Hak cipta terpelihara. |
2012 |
Tan, E H; Razak, S A; Abdullah, J M; Yusoff, Mohamed A A Epilepsy Research, 102 (3), hlm. 210-215, 2012, ISSN: 09201211, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Alanine, Amino Acid Substitution, Arginine, Artikel, Asparagine, Aspartic Acid, Anak-anak, Artikel Klinikal, Clinical Feature, Kajian Terkawal, Persatuan Penyakit, DNA Mutational Analysis, DNA Sequence, Elektroensefalografi, Epilepsi, Febrile, Febrile Convulsion, Perempuan, Gen, Gene Frequency, Pengenalan Gen, Generalized, Generalized Epilepsy, Persatuan Genetik, Kecenderungan Genetik, Genetic Screening, Genetic Variability, Glycine, Histidine, Manusia, Bayi, Malaysia, Lelaki, Missense Mutation, Molecular Pathology, Mutation, Mutational Analysis, Mutator Gene, Nav1.1 Voltage-Gated Sodium Channel, Onset Age, Patient Assessment, Polimorfisme, Kanak-kanak Prasekolah, Jurnal Keutamaan, Promoter Region, Budak sekolah, Seizure, Sequence Analysis, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Voltage Gated Sodium Channel Alpha1 Subunit Gene @artikel{Tan2012210, tajuk = {De-novo mutations and genetic variation in the SCN1A gene in Malaysian patients with generalized epilepsy with febrile seizures plus (GEFS+)}, pengarang = {E H Tan and S A Razak and J M Abdullah and A A Mohamed Yusoff}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870296042&doi=10.1016%2fj.eplepsyres.2012.08.004&rakan kongsi = 40&md5=25cc4eeb07db2492a7c04c6b3b3b2167}, doi = {10.1016/j.eplepsyres.2012.08.004}, terbitan = {09201211}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Epilepsy Research}, isi padu = {102}, nombor = {3}, halaman = {210-215}, abstrak = {Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Di sini, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty seven sequence variants (missense mutation and silent polymorphism also intronic polymorphism), as well as 2 novel de-novo mutations were found in our patients at coding regions, c.5197A>G (N1733D) and c.4748A>G (H1583R). Our findings provide potential genetic insights into the pathogenesis of GEFS+ in Malaysian populations concerning the SCN1A gene mutations. © 2012 Elsevier B.V.}, nota = {dipetik oleh 2}, kata kunci = {Alanine, Amino Acid Substitution, Arginine, Artikel, Asparagine, Aspartic Acid, Anak-anak, Artikel Klinikal, Clinical Feature, Kajian Terkawal, Persatuan Penyakit, DNA Mutational Analysis, DNA Sequence, Elektroensefalografi, Epilepsi, Febrile, Febrile Convulsion, Perempuan, Gen, Gene Frequency, Pengenalan Gen, Generalized, Generalized Epilepsy, Persatuan Genetik, Kecenderungan Genetik, Genetic Screening, Genetic Variability, Glycine, Histidine, Manusia, Bayi, Malaysia, Lelaki, Missense Mutation, Molecular Pathology, Mutation, Mutational Analysis, Mutator Gene, Nav1.1 Voltage-Gated Sodium Channel, Onset Age, Patient Assessment, Polimorfisme, Kanak-kanak Prasekolah, Jurnal Keutamaan, Promoter Region, Budak sekolah, Seizure, Sequence Analysis, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Voltage Gated Sodium Channel Alpha1 Subunit Gene}, pubstate = {diterbitkan}, tppubtype = {artikel} } Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Di sini, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty seven sequence variants (missense mutation and silent polymorphism also intronic polymorphism), as well as 2 novel de-novo mutations were found in our patients at coding regions, c.5197A>G (N1733D) and c.4748A>G (H1583R). Our findings provide potential genetic insights into the pathogenesis of GEFS+ in Malaysian populations concerning the SCN1A gene mutations. © 2012 Elsevier B.V. |
Salih, M R M; Laut, M B; Hassali, M A A; Shafie, A A; Al-Lela, Wahai Q B; Abd, Ke dan; Ganesan, V M Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Artikel Jurnal Journal of Neurosciences in Rural Practice, 3 (3), hlm. 244-250, 2012, ISSN: 09763147, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease @artikel{Salih2012244, tajuk = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy}, pengarang = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&rakan kongsi = 40&md5=039bd22d6c38366ebfdd00a4254c20f0}, doi = {10.4103/0976-3147.102596}, terbitan = {09763147}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Journal of Neurosciences in Rural Practice}, isi padu = {3}, nombor = {3}, halaman = {244-250}, abstrak = {Pengenalan: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 bulan, the required data were extracted from the medical records using a pre-designed data collection form. Keputusan: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. Walau bagaimanapun, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.}, nota = {dipetik oleh 1}, kata kunci = {Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 bulan, the required data were extracted from the medical records using a pre-designed data collection form. Keputusan: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. Walau bagaimanapun, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, masing-masing) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Kesimpulannya: Among children with structural-metabolic epilepsy, Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients. |
Cheah, P -S; Ramshaw, H S; Thomas, P; Toyo-Oka, K; Syiling, X; Martin, S; Coyle, P; Guthridge, M A; Stomski, F; Tetapi, Van Den M; Wynshaw-Boris, A; Lopez, A F; Schwarz, Q Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency Artikel Jurnal Molecular Psychiatry, 17 (4), hlm. 451-466, 2012, ISSN: 13594184, (dipetik oleh 58). Abstrak | Pautan | BibTeX | Tag: 14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan @artikel{Cheah2012451, tajuk = {Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency}, pengarang = {P -S Cheah and H S Ramshaw and P Q Thomas and K Toyo-Oka and X Xu and S Martin and P Coyle and M A Guthridge and F Stomski and M Van Den Buuse and A Wynshaw-Boris and A F Lopez and Q P Schwarz}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859007028&doi=10.1038%2fmp.2011.158&rakan kongsi = 40&md5=7f507fef31a192a10b3cde7bf69b5442}, doi = {10.1038/mp.2011.158}, terbitan = {13594184}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Molecular Psychiatry}, isi padu = {17}, nombor = {4}, halaman = {451-466}, abstrak = {Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Di sini, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved.}, nota = {dipetik oleh 58}, kata kunci = {14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Di sini, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved. |
2011 |
Freeth, M; Panggil, D; Mitchell, P; Kapten, P; Loher, S Jurnal Autisme dan Gangguan Perkembangan, 41 (3), hlm. 364-371, 2011, ISSN: 01623257, (dipetik oleh 21). Abstrak | Pautan | BibTeX | Tag: Remaja, Artikel, Association, Perhatian, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kajian Terkawal, Cues, Emosi, Eye Fixation, Pergerakan Mata, Eye Tracking, Perempuan, Gaze, Manusia, Intelligence Quotient, Lelaki, Mental Function, Kesihatan mental, Persepsi, Meresap, Photic Stimulation, Photostimulation, Jurnal Keutamaan, Aspek Psikologi, Budak sekolah, Aspek Sosial, Social Perception, Stimulus Response, Komunikasi Lisan, Penglihatan, Persepsi Visual, Visual Stimulation @artikel{Freeth2011364, tajuk = {Brief report: How adolescents with ASD process social information in complex scenes. Combining evidence from eye movements and verbal descriptions}, pengarang = {M Freeth and D Ropar and P Mitchell and P Chapman and S Loher}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79956006659&doi=10.1007%2fs10803-010-1053-4&rakan kongsi = 40&md5=35b5c8dd813f7eab2963b27081f11e78}, doi = {10.1007/s10803-010-1053-4}, terbitan = {01623257}, tahun = {2011}, tarikh = {2011-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {41}, nombor = {3}, halaman = {364-371}, abstrak = {We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (berumur 11-16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Namun begitu, the verbal descriptions revealed that participants with ASD frequently processed the observed person's emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed. © Springer Science+Business Media, LLC 2010.}, nota = {dipetik oleh 21}, kata kunci = {Remaja, Artikel, Association, Perhatian, Autisme, Gangguan Perkembangan Kanak-kanak, Anak-anak, Artikel Klinikal, Kajian Terkawal, Cues, Emosi, Eye Fixation, Pergerakan Mata, Eye Tracking, Perempuan, Gaze, Manusia, Intelligence Quotient, Lelaki, Mental Function, Kesihatan mental, Persepsi, Meresap, Photic Stimulation, Photostimulation, Jurnal Keutamaan, Aspek Psikologi, Budak sekolah, Aspek Sosial, Social Perception, Stimulus Response, Komunikasi Lisan, Penglihatan, Persepsi Visual, Visual Stimulation}, pubstate = {diterbitkan}, tppubtype = {artikel} } We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (berumur 11-16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Namun begitu, the verbal descriptions revealed that participants with ASD frequently processed the observed person's emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed. © Springer Science+Business Media, LLC 2010. |
2010 |
Sheppard, E; Panggil, D; Di bawah kayu, G; Loon, Dari E Brief report: Driving hazard perception in autism Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 40 (4), hlm. 504-508, 2010, ISSN: 01623257, (dipetik oleh 42). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Association, Autisme, Gangguan Spektrum Autisme, Automobile Driving, Car Driving, Case-Control Studies, Artikel Klinikal, Kajian Terkawal, Hazard Assessment, Manusia, Information Processing, Intelligence Quotient, Lelaki, Kesihatan mental, Motor Dysfunction, Neuropsychological Tests, Persepsi, Photic Stimulation, Jurnal Keutamaan, Reaction Time, Social Perception, Traffic Accident, Traffic Safety, Visual Impairment, Persepsi Visual, Visual Stimulation, Dewasa Muda @artikel{Sheppard2010504, tajuk = {Brief report: Driving hazard perception in autism}, pengarang = {E Sheppard and D Ropar and G Underwood and E Van Loon}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954458984&doi=10.1007%2fs10803-009-0890-5&rakan kongsi = 40&md5=f0036a737ebb461359baf1bd8b388b23}, doi = {10.1007/s10803-009-0890-5}, terbitan = {01623257}, tahun = {2010}, tarikh = {2010-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {40}, nombor = {4}, halaman = {504-508}, abstrak = {This study investigated whether individuals with ASD (autistic spectrum disorders) are able to identify driving hazards, given their difficulties processing social information, Klin et al. (Archives of General Psychiatry 59: 809-816, 2002). Twenty-three adult males with ASD and 21 comparison participants viewed 10 video clips containing driving hazards. In half of the clips the source of the hazard was a visible person (sosial); in the other half the source was a car (non-social). Participants with ASD identified fewer social hazards than the comparison participants (U = 163.00}, nota = {dipetik oleh 42}, kata kunci = {Remaja, Dewasa, Artikel, Association, Autisme, Gangguan Spektrum Autisme, Automobile Driving, Car Driving, Case-Control Studies, Artikel Klinikal, Kajian Terkawal, Hazard Assessment, Manusia, Information Processing, Intelligence Quotient, Lelaki, Kesihatan mental, Motor Dysfunction, Neuropsychological Tests, Persepsi, Photic Stimulation, Jurnal Keutamaan, Reaction Time, Social Perception, Traffic Accident, Traffic Safety, Visual Impairment, Persepsi Visual, Visual Stimulation, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } This study investigated whether individuals with ASD (autistic spectrum disorders) are able to identify driving hazards, given their difficulties processing social information, Klin et al. (Archives of General Psychiatry 59: 809-816, 2002). Twenty-three adult males with ASD and 21 comparison participants viewed 10 video clips containing driving hazards. In half of the clips the source of the hazard was a visible person (sosial); in the other half the source was a car (non-social). Participants with ASD identified fewer social hazards than the comparison participants (U = 163.00 |
Patel, V; Mungkin, M; Flisher, A J; Silva, Dari M J; Koschorke, M; Putera, M; Tempier, R; Ikan, M B; Sanchez, M; Campodonico, F D; Risiko, L; Gask, L; Wahlberg, H; Roca, M; Lecic-Tosevski, D; Soghoyan, A; Moussaoui, D; Baddoura, C; Adeyemi, J; Rataemane, S; Jalili, S A; Mohandas, E; Shinfuku, N; Freidin, J; Stagnaro, J C; Puig, Saya J; Kirkby, K; Musalek, M; Ismayilov, N; Rabbani, G; Harvey, S; Sabbe, B; Noya-Tapia, N; Burgic-Radmanovic, M; Hetem, L A; Vasconcellos, F; Maass, J; Miranda, C; Papaneophytou, N; Raboch, J; Fink-Jensen, A; Okasha, A; Korkeila, J; Guelphs, J D; Schneider, F; Ohene, S; Christodoulou, G; Askar, C R; Barrera, S K E Q; Mendoza, M; Kallivayalil, R A; Gudarzi, S S; Lafta, ENCIK; Bass, M; Kerani, M; Gibson, R; Yang mana, T; Nurmagambetova, S; Untuk, S -C; Kadyrova, T; Mikati, N; Bajraktarov, S; Yen, T H; Ayushjav, B; Stevovic, L Saya; Molina, J S S; Gureje, THE; Johannessen, J O; Hakim, H R; Al-Ashhab, B; Araszkiewicz, A; Prelipceanu, D; Krasnov, V; Bogdanov, A; Jasovic-Gasic, M; Ваврусова, L; Pregelj, P; Kebebasan, A F; Abdelrahman, A; Udomratn, P; Kaji semula, H; Gokaip, P; Kigozi, F N; Richardson, G Reducing the treatment gap for mental disorders: A WPA survey Artikel Jurnal World Psychiatry, 9 (3), hlm. 169-176, 2010, ISSN: 17238617, (dipetik oleh 127). Abstrak | Pautan | BibTeX | Tag: Anxiety Disorder, Artikel, Atomoxetine, Atypical Antipsychotic Agent, Autisme, Benzodiazepine, Bipolar Disorder, Perangsang Sistem Saraf Pusat, Cholinesterase Inhibitor, Cognitive Therapy, Community Mental Health Center, Conduct Disorder, Cost Effectiveness Analysis, Dementia, Kemurungan, Amalan Berasaskan Bukti, Keluarga, Family Therapy, Haloperidol, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Kakitangan Penjagaan Kesihatan, Health Practitioner, Tinjauan Kesihatan, Help Seeking Behavior, Home Mental Health Care, Manusia, Hyperkinesia, Long Term Care, Lowest Income Group, Mental Deficiency, Mental Disease, Kesihatan mental, Mental Health Care, Perkhidmatan Kesihatan Mental, Nootropic Agent, Open Ended Questionnaire, Penilaian Hasil, Patient Compliance, Personality Disorder, Garis Panduan Amalan, Jurnal Keutamaan, Psychiatry, Psychoeducation, Psychotherapy, Skizofrenia, Serotonin Noradrenalin Reuptake Inhibitor, Perencat Serapan Serotonin, Substance Abuse, Terapi, Therapy Delay, Tricyclic Antidepressant Agent, World Health Organization @artikel{Patel2010169, tajuk = {Reducing the treatment gap for mental disorders: A WPA survey}, pengarang = {V Patel and M Maj and A J Flisher and M J De Silva and M Koschorke and M Prince and R Tempier and M B Riba and M Sanchez and F D Campodonico and L Risco and L Gask and H Wahlberg and M Roca and D Lecic-Tosevski and A Soghoyan and D Moussaoui and C Baddoura and J Adeyemi and S Rataemane and S A Jalili and E Mohandas and N Shinfuku and J Freidin and J C Stagnaro and I J Puig and K Kirkby and M Musalek and N Ismayilov and G Rabbani and S Harvey and B Sabbe and N Noya-Tapia and M Burgic-Radmanovic and L A Hetem and F Vasconcellos and J Maass and C Miranda and N Papaneophytou and J Raboch and A Fink-Jensen and A Okasha and J Korkeila and J D Guelfi and F Schneider and S Ohene and G Christodoulou and C R Soldatos and S K E Q Barrera and M Mendoza and R A Kallivayalil and S S Gudarzi and M R Lafta and M Bassi and M Clerici and R Gibson and T Kojima and S Nurmagambetova and S -C Cho and T Kadyrova and N Mikati and S Bajraktarov and T H Yen and B Ayushjav and L I Stevovic and J S S Molina and O Gureje and J O Johannessen and H R Chaudhry and B Al-Ashhab and A Araszkiewicz and D Prelipceanu and V Krasnov and A Bogdanov and M Jasovic-Gasic and L Vavrusova and P Pregelj and A F Liria and A Abdelrahman and P Udomratn and H Ulas and P Gokaip and F N Kigozi and G Richardson}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79851492757&doi=10.1002%2fj.2051-5545.2010.tb00305.x&rakan kongsi = 40&md5=ebf47e1e84f22271aea10a73c93e9892}, doi = {10.1002/j.2051-5545.2010.tb00305.x}, terbitan = {17238617}, tahun = {2010}, tarikh = {2010-01-01}, jurnal = {World Psychiatry}, isi padu = {9}, nombor = {3}, halaman = {169-176}, penerbit = {Blackwell Publishing Ltd}, abstrak = {The treatment gap for people with mental disorders exceeds 50% in all countries of the world, approaching astonishingly high rates of 90% in the least resourced countries. We report the findings of the first systematic survey of leaders of psychiatry in nearly 60 countries on the strategies for reducing the treatment gap. We sought to elicit the views of these representatives on the roles of different human resources and health care settings in delivering care and on the importance of a range of strategies to increase the coverage of evidence-based treatments for priority mental disorders for each demographic stage (childhood, adolescence, adulthood and old age). Our findings clearly indicate three strategies for reducing the treatment gap: increasing the numbers of psychiatrists and other mental health professionals; increasing the involvement of a range of appropriately trained non-specialist providers; and the active involvement of people affected by mental disorders. This is true for both high income and low/middle income countries, though relatively of more importance in the latter. We view this survey as a critically important first step in ascertaining the position of psychiatrists, one of the most influential stakeholder communities in global mental health, in addressing the global challenge of scaling up mental health services to reduce the treatment gap.}, nota = {dipetik oleh 127}, kata kunci = {Anxiety Disorder, Artikel, Atomoxetine, Atypical Antipsychotic Agent, Autisme, Benzodiazepine, Bipolar Disorder, Perangsang Sistem Saraf Pusat, Cholinesterase Inhibitor, Cognitive Therapy, Community Mental Health Center, Conduct Disorder, Cost Effectiveness Analysis, Dementia, Kemurungan, Amalan Berasaskan Bukti, Keluarga, Family Therapy, Haloperidol, Penjagaan Kesihatan, Akses Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Kakitangan Penjagaan Kesihatan, Health Practitioner, Tinjauan Kesihatan, Help Seeking Behavior, Home Mental Health Care, Manusia, Hyperkinesia, Long Term Care, Lowest Income Group, Mental Deficiency, Mental Disease, Kesihatan mental, Mental Health Care, Perkhidmatan Kesihatan Mental, Nootropic Agent, Open Ended Questionnaire, Penilaian Hasil, Patient Compliance, Personality Disorder, Garis Panduan Amalan, Jurnal Keutamaan, Psychiatry, Psychoeducation, Psychotherapy, Skizofrenia, Serotonin Noradrenalin Reuptake Inhibitor, Perencat Serapan Serotonin, Substance Abuse, Terapi, Therapy Delay, Tricyclic Antidepressant Agent, World Health Organization}, pubstate = {diterbitkan}, tppubtype = {artikel} } The treatment gap for people with mental disorders exceeds 50% in all countries of the world, approaching astonishingly high rates of 90% in the least resourced countries. We report the findings of the first systematic survey of leaders of psychiatry in nearly 60 countries on the strategies for reducing the treatment gap. We sought to elicit the views of these representatives on the roles of different human resources and health care settings in delivering care and on the importance of a range of strategies to increase the coverage of evidence-based treatments for priority mental disorders for each demographic stage (childhood, adolescence, adulthood and old age). Our findings clearly indicate three strategies for reducing the treatment gap: increasing the numbers of psychiatrists and other mental health professionals; increasing the involvement of a range of appropriately trained non-specialist providers; and the active involvement of people affected by mental disorders. This is true for both high income and low/middle income countries, though relatively of more importance in the latter. We view this survey as a critically important first step in ascertaining the position of psychiatrists, one of the most influential stakeholder communities in global mental health, in addressing the global challenge of scaling up mental health services to reduce the treatment gap. |
2007 |
Pandi-Perumal, S R; Srinivasan, V; Spence, D W; Kardinal, D P Role of the melatonin system in the control of sleep: Therapeutic implications Artikel Jurnal CNS Drugs, 21 (12), hlm. 995-1018, 2007, ISSN: 11727047, (dipetik oleh 90). Abstrak | Pautan | BibTeX | Tag: Absence of Side Effects, Acetylserotonin Methyltransferase, Advanced Sleep Phase Syndrome, Agomelatine, Alpha Tocopherol, Alzheimer Disease, Haiwan, Ascorbic Acid, Beta Adrenergic Receptor Blocking Agent, Biosynthesis, Circadian Rhythm, Circadian Rhythm Sleep Disorder, Clinical Trial, Confusion, Delayed Sleep Phase Syndrome, Drowsiness, Drug Dose Comparison, Drug Efficacy, Drug Half Life, Drug Mechanism, Fatigue, Fluvoxamine, Headache, Hormone Metabolism, Manusia, Hypnosis, Hypothalamus, Insomnia, Jet Lag, Macaca, Melatonin, Melatonin Receptor, Muscle Cramp, Nausea, Non-24-Hour Sleep-Wake Syndrome, Bukan Manusia, Noradrenalin, Pineal Body, Jurnal Keutamaan, Ekspresi Protein, Ramelteon, Rat Strain, Receptor Density, Receptors, REM Sleep, Retina Ganglion Cell, Kaji semula, Serotonin, Shift Worker, Sleep, Gangguan Tidur, Sleep Waking Cycle, Smith Magenis Syndrome, Suprachiasmatic Nucleus, Sustained Drug Release, Vomiting @artikel{Pandi-Perumal2007995, tajuk = {Role of the melatonin system in the control of sleep: Therapeutic implications}, pengarang = {S R Pandi-Perumal and V Srinivasan and D W Spence and D P Cardinali}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-36248949004&doi=10.2165%2f00023210-200721120-00004&rakan kongsi = 40&md5=489ee976fa444beb95b26cdb77b722c2}, doi = {10.2165/00023210-200721120-00004}, terbitan = {11727047}, tahun = {2007}, tarikh = {2007-01-01}, jurnal = {CNS Drugs}, isi padu = {21}, nombor = {12}, halaman = {995-1018}, abstrak = {The circadian rhythm of pineal melatonin secretion, which is controlled by the suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control of the sleep/wake cycle. Melatonin can influence sleep-promoting and sleep/wake rhythm-regulating actions through the specific activation of MT1 (melatonin 1a) and MT2 (melatonin 1b) receptors, the two major melatonin receptor subtypes found in mammals. Both receptors are highly concentrated in the SCN. In diurnal animals, exogenous melatonin induces sleep over a wide range of doses. In healthy humans, melatonin also induces sleep, although its maximum hypnotic effectiveness, as shown by studies of the timing of dose administration, is influenced by the circadian phase. In both young and elderly individuals with primary insomnia, nocturnal plasma melatonin levels tend to be lower than those in healthy controls. There are data indicating that, in affected individuals, melatonin therapy may be beneficial for ameliorating insomnia symptoms. Melatonin has been successfully used to treat insomnia in children with attention-deficit hyperactivity disorder or autism, as well as in other neurodevelopmental disorders in which sleep disturbance is commonly reported. In circadian rhythm sleep disorders, such as delayed sleep-phase syndrome, melatonin can significantly advance the phase of the sleep/wake rhythm. Begitu juga, among shift workers or individuals experiencing jet lag, melatonin is beneficial for promoting adjustment to work schedules and improving sleep quality. The hypnotic and rhythm-regulating properties of melatonin and its agonists (ramelteon, agomelatine) make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders. © 2007 Adis Data Information BV. Hak cipta terpelihara.}, nota = {dipetik oleh 90}, kata kunci = {Absence of Side Effects, Acetylserotonin Methyltransferase, Advanced Sleep Phase Syndrome, Agomelatine, Alpha Tocopherol, Alzheimer Disease, Haiwan, Ascorbic Acid, Beta Adrenergic Receptor Blocking Agent, Biosynthesis, Circadian Rhythm, Circadian Rhythm Sleep Disorder, Clinical Trial, Confusion, Delayed Sleep Phase Syndrome, Drowsiness, Drug Dose Comparison, Drug Efficacy, Drug Half Life, Drug Mechanism, Fatigue, Fluvoxamine, Headache, Hormone Metabolism, Manusia, Hypnosis, Hypothalamus, Insomnia, Jet Lag, Macaca, Melatonin, Melatonin Receptor, Muscle Cramp, Nausea, Non-24-Hour Sleep-Wake Syndrome, Bukan Manusia, Noradrenalin, Pineal Body, Jurnal Keutamaan, Ekspresi Protein, Ramelteon, Rat Strain, Receptor Density, Receptors, REM Sleep, Retina Ganglion Cell, Kaji semula, Serotonin, Shift Worker, Sleep, Gangguan Tidur, Sleep Waking Cycle, Smith Magenis Syndrome, Suprachiasmatic Nucleus, Sustained Drug Release, Vomiting}, pubstate = {diterbitkan}, tppubtype = {artikel} } The circadian rhythm of pineal melatonin secretion, which is controlled by the suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control of the sleep/wake cycle. Melatonin can influence sleep-promoting and sleep/wake rhythm-regulating actions through the specific activation of MT1 (melatonin 1a) and MT2 (melatonin 1b) receptors, the two major melatonin receptor subtypes found in mammals. Both receptors are highly concentrated in the SCN. In diurnal animals, exogenous melatonin induces sleep over a wide range of doses. In healthy humans, melatonin also induces sleep, although its maximum hypnotic effectiveness, as shown by studies of the timing of dose administration, is influenced by the circadian phase. In both young and elderly individuals with primary insomnia, nocturnal plasma melatonin levels tend to be lower than those in healthy controls. There are data indicating that, in affected individuals, melatonin therapy may be beneficial for ameliorating insomnia symptoms. Melatonin has been successfully used to treat insomnia in children with attention-deficit hyperactivity disorder or autism, as well as in other neurodevelopmental disorders in which sleep disturbance is commonly reported. In circadian rhythm sleep disorders, such as delayed sleep-phase syndrome, melatonin can significantly advance the phase of the sleep/wake rhythm. Begitu juga, among shift workers or individuals experiencing jet lag, melatonin is beneficial for promoting adjustment to work schedules and improving sleep quality. The hypnotic and rhythm-regulating properties of melatonin and its agonists (ramelteon, agomelatine) make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders. © 2007 Adis Data Information BV. Hak cipta terpelihara. |
2005 |
Jayachandra, S Need for internet based scoring system for autism treatment evaluation [2] Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 35 (5), hlm. 685, 2005, ISSN: 01623257, (dipetik oleh 1). Pautan | BibTeX | Tag: Sindrom Asperger, Autisme, Gangguan Spektrum Autisme, Diagnostic and Statistical Manual of Mental Disorders, Evaluation, Perkhidmatan kesihatan, Health Services Needs and Demand, Manusia, Bayi, Infantile Autism, Instrumentation, Internet, Surat, Jurnal Keutamaan, Psychoeducation, Psychotherapy, Reliability, Sistem Pemarkahan, Hasil Rawatan @artikel{Jayachandra2005685, tajuk = {Need for internet based scoring system for autism treatment evaluation [2]}, pengarang = {S Jayachandra}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644946467&doi=10.1007%2fs10803-005-0016-7&rakan kongsi = 40&md5=6d3e95280dce87a6ec735d67e27fe5bc}, doi = {10.1007/s10803-005-0016-7}, terbitan = {01623257}, tahun = {2005}, tarikh = {2005-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {35}, nombor = {5}, halaman = {685}, penerbit = {Springer Science and Business Media Deutschland GmbH}, nota = {dipetik oleh 1}, kata kunci = {Sindrom Asperger, Autisme, Gangguan Spektrum Autisme, Diagnostic and Statistical Manual of Mental Disorders, Evaluation, Perkhidmatan kesihatan, Health Services Needs and Demand, Manusia, Bayi, Infantile Autism, Instrumentation, Internet, Surat, Jurnal Keutamaan, Psychoeducation, Psychotherapy, Reliability, Sistem Pemarkahan, Hasil Rawatan}, pubstate = {diterbitkan}, tppubtype = {artikel} } |