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Terdapat sebilangan besar penyelidikan berkaitan autisme yang boleh dijumpai di Malaysia yang umumnya menumpukan pada ASD, gangguan pembelajaran, alat bantu komunikasi, terapi dan banyak lagi. Senarai penerbitan disediakan di bawah:
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2019 |
Tidak juga, N K; Ghozali, A H; Ismail, J Sempadan dalam Pediatrik, 7 (FEB), 2019, ISSN: 22962360, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang @artikel{Nor2019, tajuk = {Kelebihan berat badan berlebihan dan obesiti di kalangan kanak-kanak dan remaja dengan gangguan spektrum autisme dan faktor risiko yang berkaitan}, pengarang = {N K Nor dan A H Ghozali dan J Ismail}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85064414280&dua = 10.3389% 2kurang.2019.00038&rakan kongsi = 40&md5 = 4bb61b1df043a4adf79618e223d77f26}, doi = {10.3389/fped.2019.00038}, terbitan = {22962360}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Sempadan dalam Pediatrik}, isi padu = {7}, nombor = {FEB}, penerbit = {Frontiers Media S.A.}, abstrak = {Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.}, nota = {dipetik oleh 5}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95persentil ke-) adalah 11.3% dan berlakunya kegemukan (BMI persentil ke-95) adalah 21.9%. Umur rata-rata kanak-kanak ASD yang berlebihan berat badan / gemuk lebih tinggi pada 8.5 tahun (IQR 5.81-10.13) berbanding dengan kumpulan normal / kurang berat badan 6.33 tahun (IQR 4.75-7.7) dengan nilai p 0.001. Kedua-dua kumpulan juga berbeza secara signifikan untuk BMI ibu dan usia bapa. BMI ibu rata-rata dalam kumpulan berat badan berlebihan / gemuk adalah 26.05 (IQR 23.35-32.25), secara statistik lebih tinggi secara signifikan (p = 0.003) berbanding kumpulan yang tidak berlebihan berat badan / gemuk, 24.7 (IQR 21-27.9). Umur bapa median pada 40 tahun (IQR 37-44) secara statistik lebih tinggi secara signifikan (p = 0.039) dalam kumpulan berlebihan berat badan / gemuk, berbanding dengan usia bapa rata-rata pada kumpulan bukan berat badan berlebihan / obes 38 (IQR 35-42). Kanak-kanak lelaki yang berlebihan berat badan / gemuk mempunyai skor PAQ-C median 2.44 (IQR 2.00-3.00) lwn. 2.89 (IQR 2.35-3.53) dalam kumpulan rakan niaga dengan nilai p 0.01. Menggunakan kaedah regresi linear berganda, tiga peramal yang berkaitan dengan persentil BMI mencapai tahap kepentingan statistik; Skor PAQ-C pada lelaki (hlm < 0.001), domain BAMBI dari Penolakan Makanan (p = 0.001) dan Pelbagai Jenis Makanan yang Terhad (p = 0.001). Kesimpulannya: Kelaziman obesiti dan berat badan berlebihan adalah tinggi di kalangan kanak-kanak dan remaja ASD Malaysia. Umur kanak-kanak yang lebih tua, BMI ibu yang tinggi, usia bapa yang lebih tua, aktiviti fizikal yang rendah, kemungkinan rendahnya penolakan makanan dan kemungkinan tinggi pemilihan makanan didapati menjadi faktor risiko BMI tinggi pada kanak-kanak ini. © 2019 Kamal Nor, Ghozali and Ismail. |
2012 |
Cheah, P -S; Ramshaw, H S; Thomas, P; Toyo-Oka, K; Syiling, X; Martin, S; Coyle, P; Guthridge, M A; Stomski, F; Tetapi, Van Den M; Wynshaw-Boris, A; Lopez, A F; Schwarz, Q Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency Artikel Jurnal Molecular Psychiatry, 17 (4), hlm. 451-466, 2012, ISSN: 13594184, (dipetik oleh 58). Abstrak | Pautan | BibTeX | Tag: 14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan @artikel{Cheah2012451, tajuk = {Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency}, pengarang = {P -S Cheah and H S Ramshaw and P Q Thomas and K Toyo-Oka and X Xu and S Martin and P Coyle and M A Guthridge and F Stomski and M Van Den Buuse and A Wynshaw-Boris and A F Lopez and Q P Schwarz}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859007028&doi=10.1038%2fmp.2011.158&rakan kongsi = 40&md5=7f507fef31a192a10b3cde7bf69b5442}, doi = {10.1038/mp.2011.158}, terbitan = {13594184}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Molecular Psychiatry}, isi padu = {17}, nombor = {4}, halaman = {451-466}, abstrak = {Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Di sini, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved.}, nota = {dipetik oleh 58}, kata kunci = {14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Haiwan, Artikel, Autisme, Gangguan Tingkah Laku, Bipolar Disorder, Otak, Cell Movement, Sel, Cognitive Defect, Kajian Terkawal, Berbudaya, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Perempuan, Gen, Gene Deletion, Kecenderungan Genetik kepada Penyakit, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Manusia, Hiperaktif, Inbred C57BL, Isoprotein, Knockout, Belajar, Lelaki, Maze Learning, Memory, Tikus, Motor Activity, Tetikus, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Bukan Manusia, Jurnal Keutamaan, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Faktor risiko, Skizofrenia, Sensory Gating, Synapse, Dadah yang tidak dikelaskan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Di sini, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved. |
Abdullah, M N; Mohamad, W M Z W; Abdullah, ENCIK; Yaacob, M J; Baharuddin, CIK Perinatal, maternal and antenatal associated factors for autism: A case control study Persidangan 2012, ISBN: 9781467316668, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Antenatal, ASD, Autisme, Autistik, Kejuruteraan Bioperubatan, Case-Control Studies, Delivery, Penyakit, Hospital, Logistics, Maternal, Obstetrics, Ibu bapa, Perinatal, Pregnancy, pranatal, Retrospective, Faktor risiko @ persidangan{Abdullah2012144, tajuk = {Perinatal, maternal and antenatal associated factors for autism: A case control study}, pengarang = {M N Abdullah and W M Z W Mohamad and M R Abdullah and M J Yaacob and M S Baharuddin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876762294&doi=10.1109%2fIECBES.2012.6498121&rakan kongsi = 40&md5=b14466b2341cc29599332d94d866ea9a}, doi = {10.1109/IECBES.2012.6498121}, isbn = {9781467316668}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {2012 Persidangan IEEE-EMBS mengenai Kejuruteraan dan Sains Bioperubatan, IECBES 2012}, halaman = {144-148}, abstrak = {Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 ke 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the perinatal, maternal and antenatal associated factors associated with autistic disorder children. There were seven associated factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted Odds Ratio (OR): 1.41; 95% Confidence Interval (CI): (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 dan 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics. © 2012 IEEE.}, nota = {dipetik oleh 0}, kata kunci = {Antenatal, ASD, Autisme, Autistik, Kejuruteraan Bioperubatan, Case-Control Studies, Delivery, Penyakit, Hospital, Logistics, Maternal, Obstetrics, Ibu bapa, Perinatal, Pregnancy, pranatal, Retrospective, Faktor risiko}, pubstate = {diterbitkan}, tppubtype = {persidangan} } Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 ke 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the perinatal, maternal and antenatal associated factors associated with autistic disorder children. There were seven associated factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted Odds Ratio (OR): 1.41; 95% Confidence Interval (CI): (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 dan 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics. © 2012 IEEE. |