Senarai Penerbitan
Terdapat sebilangan besar penyelidikan berkaitan autisme yang boleh dijumpai di Malaysia yang umumnya menumpukan pada ASD, gangguan pembelajaran, alat bantu komunikasi, terapi dan banyak lagi. Senarai penerbitan disediakan di bawah:
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2020 |
Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z Faktor-faktor yang berkaitan dengan keparahan autisme di kalangan kanak-kanak Malaysia dengan Autism Spectrum Disorder Artikel Jurnal Penyelidikan Ketidakupayaan Pembangunan, 100 , 2020, ISSN: 08914222, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Berat badan, Anak-anak, Kajian Lintas Bahagian, Demografi, Persatuan Penyakit, Keterukan Penyakit, Pekerjaan, Perempuan, Manusia, Gaya hidup, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Ibu bapa, Kanak-kanak Prasekolah, Budak sekolah, Status sosial @artikel{Eow2020, tajuk = {Faktor-faktor yang berkaitan dengan keparahan autisme di kalangan kanak-kanak Malaysia dengan Autism Spectrum Disorder}, pengarang = {S Y Eow dan W Y Gan dan P Y Lim dan H Awang dan Z Mohd Shariff}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85081212440&doi = 10.1016% 2fj.ridd.2020.103632&rakan kongsi = 40&md5 = a2814a66b9d649278ea7f764ed7e4125}, doi = {10.1016/j.ridd.2020.103632}, terbitan = {08914222}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Penyelidikan Ketidakupayaan Pembangunan}, isi padu = {100}, penerbit = {Elsevier Inc.}, abstrak = {Latar belakang: Kanak-kanak dengan Gangguan Spektrum Autisme (ASD) tahap keparahan gejala yang berlainan boleh menunjukkan pelbagai tingkah laku dan ciri. Terdapat kajian berkaitan pemakanan terhad pada kanak-kanak dengan ASD dengan tahap keparahan yang berbeza di Malaysia. Matlamat: Kajian keratan rentas ini bertujuan untuk mengetahui perkaitan antara faktor sosiodemografi, faktor ibu bapa, dan faktor gaya hidup dengan keparahan autisme pada kanak-kanak dengan ASD. Kaedah dan prosedur: Sejumlah 224 kanak-kanak dengan ASD dimasukkan dalam kajian ini. Ibu mereka melengkapkan borang soal selidik mengenai ciri sosiodemografi, keterukan autisme, gaya keibubapaan, amalan memberi makan ibu bapa, tekanan keibubapaan, tabiat tidur anak dan tingkah laku makan. Hasil dan hasil: Setinggi 78.1 % kanak-kanak dengan ASD menunjukkan tahap keparahan autisme yang tinggi. Regresi linear berganda menunjukkan bahawa status pekerjaan bapa (B = 6.970, 95 % CI = 3.172, 10.768, hlm < 0.001) and perceived child weight (B = 3.338, 95 % CI = 1.350, 5.327}, nota = {dipetik oleh 0}, kata kunci = {Artikel, Autisme, Berat badan, Anak-anak, Kajian Lintas Bahagian, Demografi, Persatuan Penyakit, Keterukan Penyakit, Pekerjaan, Perempuan, Manusia, Gaya hidup, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Ibu bapa, Kanak-kanak Prasekolah, Budak sekolah, Status sosial}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: Kanak-kanak dengan Gangguan Spektrum Autisme (ASD) tahap keparahan gejala yang berlainan boleh menunjukkan pelbagai tingkah laku dan ciri. Terdapat kajian berkaitan pemakanan terhad pada kanak-kanak dengan ASD dengan tahap keparahan yang berbeza di Malaysia. Matlamat: Kajian keratan rentas ini bertujuan untuk mengetahui perkaitan antara faktor sosiodemografi, faktor ibu bapa, dan faktor gaya hidup dengan keparahan autisme pada kanak-kanak dengan ASD. Kaedah dan prosedur: Sejumlah 224 kanak-kanak dengan ASD dimasukkan dalam kajian ini. Ibu mereka melengkapkan borang soal selidik mengenai ciri sosiodemografi, keterukan autisme, gaya keibubapaan, amalan memberi makan ibu bapa, tekanan keibubapaan, tabiat tidur anak dan tingkah laku makan. Hasil dan hasil: Setinggi 78.1 % kanak-kanak dengan ASD menunjukkan tahap keparahan autisme yang tinggi. Regresi linear berganda menunjukkan bahawa status pekerjaan bapa (B = 6.970, 95 % CI = 3.172, 10.768, hlm < 0.001) dan berat badan anak yang dirasakan (B = 3.338, 95 % CI = 1.350, 5.327 |
de Vries, M; Cader, S; Rakan sekerja, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya Artikel Jurnal Jurnal Autisme dan Gangguan Perkembangan, 50 (4), hlm. 1281-1294, 2020, ISSN: 01623257, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda @artikel{deVries20201281, tajuk = {Pengertian Pelajar Universiti mengenai Keadaan Spektrum Autisme: Kajian Merentas Budaya}, pengarang = {M de Vries dan S Cader dan L Colleer dan E Batteux dan M B Yasdiman dan Y J Tan dan E Sheppard}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85077543652&doi = 10.1007% 2fs10803-019-04343-z&rakan kongsi = 40&md5 = 53dc04b76c29629e875adaf44a9831b6}, doi = {10.1007/s10803-019-04343-z}, terbitan = {01623257}, tahun = {2020}, tarikh = {2020-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {50}, nombor = {4}, halaman = {1281-1294}, penerbit = {Pemecut}, abstrak = {Latar belakang budaya mungkin mempengaruhi pengetahuan dan sikap mengenai autisme, mempengaruhi kesediaan untuk berinteraksi. Kami mengkaji sama ada kepercayaan, pengetahuan, kenalan, dan sikap berbeza antara Inggeris dan Malaysia. Dengan analisis mediasi, kami mengkaji bagaimana faktor-faktor ini mempengaruhi kesediaan untuk berinteraksi. Autisme lebih kerap dikaitkan dengan makanan di UK, dan asuhan di Malaysia. Pengetahuan, kenalan, dan penerimaan lebih besar di UK. Semasa tidak termasuk pelajar psikologi, Pelajar Malaysia kurang bersedia untuk berinteraksi dengan orang autistik. Pengetahuan dan hubungan muncul untuk meningkatkan penerimaan, tetapi penerimaan tidak menjadi perantara hubungan antara negara, kepercayaan, pengetahuan, dan pengalaman; dan kesediaan untuk berinteraksi. Pengetahuan dan hubungan mengenai autisme dapat meningkatkan penerimaan dalam budaya yang berbeza, tetapi bagaimana penerimaan dapat meningkatkan interaksi tidak jelas. © 2020, Pengarang(s).}, nota = {dipetik oleh 0}, kata kunci = {Dewasa, Artikel, Sikap Terhadap Kesihatan, Autisme, Perempuan, Kepercayaan Kesihatan, Manusia, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Orang Malaysia, Lelaki, Jurnal Keutamaan, Penerimaan Sosial, Interaksi Sosial, Sosiologi, Sikap Pelajar, Pelajar, United Kingdom, Pelajar universiti, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang budaya mungkin mempengaruhi pengetahuan dan sikap mengenai autisme, mempengaruhi kesediaan untuk berinteraksi. Kami mengkaji sama ada kepercayaan, pengetahuan, kenalan, dan sikap berbeza antara Inggeris dan Malaysia. Dengan analisis mediasi, kami mengkaji bagaimana faktor-faktor ini mempengaruhi kesediaan untuk berinteraksi. Autisme lebih kerap dikaitkan dengan makanan di UK, dan asuhan di Malaysia. Pengetahuan, kenalan, dan penerimaan lebih besar di UK. Semasa tidak termasuk pelajar psikologi, Pelajar Malaysia kurang bersedia untuk berinteraksi dengan orang autistik. Pengetahuan dan hubungan muncul untuk meningkatkan penerimaan, tetapi penerimaan tidak menjadi perantara hubungan antara negara, kepercayaan, pengetahuan, dan pengalaman; dan kesediaan untuk berinteraksi. Pengetahuan dan hubungan mengenai autisme dapat meningkatkan penerimaan dalam budaya yang berbeza, tetapi bagaimana penerimaan dapat meningkatkan interaksi tidak jelas. © 2020, Pengarang(s). |
2019 |
Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Bersendirian, F M; Badgujar, S; Govindan, S N; Ansari, M T Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Artikel Jurnal Human Vaccines and Immunotherapeutics, 15 (11), hlm. 2544-2551, 2019, ISSN: 21645515, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Attitude, Sikap Terhadap Kesihatan, Autisme, Child Health, Childhood Vaccination, Anak-anak, Kajian Lintas Bahagian, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Pendidikan, Pekerjaan, Etnik, Perempuan, Health Knowledge, Manusia, Immunization Programs, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Ibu, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Kanak-kanak Prasekolah, Preventive Health Service, Psikologi, Soal selidik, Seasonal Influenza, Tinjauan, Vaccination, Dewasa Muda @artikel{BalbirSingh20192544, tajuk = {Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia}, pengarang = {H K Balbir Singh and V B Badgujar and R S Yahaya and S Abd Rahman and F M Sami and S Badgujar and S N Govindan and M T Ansari}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067899547&doi=10.1080%2f21645515.2019.1612666&rakan kongsi = 40&md5=2da8ecc4fd4df251566a2f8b2454e763}, doi = {10.1080/21645515.2019.1612666}, terbitan = {21645515}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Human Vaccines and Immunotherapeutics}, isi padu = {15}, nombor = {11}, halaman = {2544-2551}, penerbit = {Taylor dan Francis Inc.}, abstrak = {Aim: Mothers knowledge and attitude toward childhood vaccination influence uptake is the most adequate tool and preventive aspects to infectious disease epidemics. The present study assesses and measures knowledge and attitude of postnatal mothers toward vaccination. Methods and results: The present study adopted a cross-sectional study design, whereby 200 postnatal mothers were identified during their postnatal visit to clinics. The subjects were accessed using questionnaire to assess the level of knowledge and attitude of mothers regarding vaccination. The objectives were to study the level of knowledge, the attitude, and to find the association between knowledge and attitude of the study subjects. The data were analyzed using SPSS version 16. The results was analyzed through chi-square test. The association between age (p =.031), pendidikan (p =.021), occupation (p =.013), and knowledge score toward vaccination was found to be statistically significant. Walau bagaimanapun, ethnicity (p =.127), employment (p =.197), and mode of delivery (p =.750) toward mothers vaccination knowledge were not significant for the study. Mothers education, age, and occupation were found to be associated with attitude toward childhood vaccination. No association was found between ethnicity, employment, and mode of delivery with attitude of childhood vaccination. Kesimpulannya: More than half of the studied mothers had good knowledge scores on vaccination, more than two-thirds of the studied mothers had good attitude scores on vaccination. Walau bagaimanapun, the religious misconception and fear of autism was the main cause of vaccine resistance in Malaysia. © 2019, © 2019 Kumpulan Taylor & Francis, LLC.}, nota = {dipetik oleh 0}, kata kunci = {Remaja, Dewasa, Artikel, Attitude, Sikap Terhadap Kesihatan, Autisme, Child Health, Childhood Vaccination, Anak-anak, Kajian Lintas Bahagian, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Pendidikan, Pekerjaan, Etnik, Perempuan, Health Knowledge, Manusia, Immunization Programs, Pengetahuan, Skala Likert, Kajian Klinikal Utama, Malaysia, Ibu, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Kanak-kanak Prasekolah, Preventive Health Service, Psikologi, Soal selidik, Seasonal Influenza, Tinjauan, Vaccination, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } Aim: Mothers knowledge and attitude toward childhood vaccination influence uptake is the most adequate tool and preventive aspects to infectious disease epidemics. The present study assesses and measures knowledge and attitude of postnatal mothers toward vaccination. Methods and results: The present study adopted a cross-sectional study design, whereby 200 postnatal mothers were identified during their postnatal visit to clinics. The subjects were accessed using questionnaire to assess the level of knowledge and attitude of mothers regarding vaccination. The objectives were to study the level of knowledge, the attitude, and to find the association between knowledge and attitude of the study subjects. The data were analyzed using SPSS version 16. The results was analyzed through chi-square test. The association between age (p =.031), pendidikan (p =.021), occupation (p =.013), and knowledge score toward vaccination was found to be statistically significant. Walau bagaimanapun, ethnicity (p =.127), employment (p =.197), and mode of delivery (p =.750) toward mothers vaccination knowledge were not significant for the study. Mothers education, age, and occupation were found to be associated with attitude toward childhood vaccination. No association was found between ethnicity, employment, and mode of delivery with attitude of childhood vaccination. Kesimpulannya: More than half of the studied mothers had good knowledge scores on vaccination, more than two-thirds of the studied mothers had good attitude scores on vaccination. Walau bagaimanapun, the religious misconception and fear of autism was the main cause of vaccine resistance in Malaysia. © 2019, © 2019 Taylor & Kumpulan Francis, LLC. |
Ramachandram, S Medical Journal of Malaysia, 74 (5), hlm. 372-376, 2019, ISSN: 03005283, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Remaja, Artikel, Asthma, Autisme, Birth Weight, Pembangunan kanak-kanak, Anak-anak, Chinese, Conception, Demografi, Diet Restriction, DSM-5, Eczema, Pendidikan, Educational Status, Epilepsi, Perempuan, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Manusia, Orang India, Kajian Klinikal Utama, Malay, Lelaki, Medical Record Review, Pulau Pinang, Prematurity, Gangguan Pertuturan, Upper Respiratory Tract Congestion, Wakefulness @artikel{Ramachandram2019372, tajuk = {Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia}, pengarang = {S Ramachandram}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073688991&rakan kongsi = 40&md5=3ed147d56181ccd44321c47629a4aa54}, terbitan = {03005283}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Medical Journal of Malaysia}, isi padu = {74}, nombor = {5}, halaman = {372-376}, penerbit = {Malaysian Medical Association}, abstrak = {Objektif: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Keputusan: Daripada 331 children with ASD, 82.5% were males, 17.5% perempuan, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 bulan (SD 31.68 bulan) with age range from 19 months to 18 years and 4 bulan. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% dan 5.7% masing-masing. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 dan 31.6 years respectively. Kesimpulannya: Dalam kajian ini, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. Hak cipta terpelihara.}, nota = {dipetik oleh 0}, kata kunci = {Remaja, Artikel, Asthma, Autisme, Birth Weight, Pembangunan kanak-kanak, Anak-anak, Chinese, Conception, Demografi, Diet Restriction, DSM-5, Eczema, Pendidikan, Educational Status, Epilepsi, Perempuan, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Manusia, Orang India, Kajian Klinikal Utama, Malay, Lelaki, Medical Record Review, Pulau Pinang, Prematurity, Gangguan Pertuturan, Upper Respiratory Tract Congestion, Wakefulness}, pubstate = {diterbitkan}, tppubtype = {artikel} } Objektif: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Keputusan: Daripada 331 children with ASD, 82.5% were males, 17.5% perempuan, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 bulan (SD 31.68 bulan) with age range from 19 months to 18 years and 4 bulan. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% dan 5.7% masing-masing. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 dan 31.6 years respectively. Kesimpulannya: Dalam kajian ini, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. Hak cipta terpelihara. |
Cth, N A N; Ibrahim, M Saya; Rahman, A A; Bakar ia, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam, 16 (10), 2019, ISSN: 16617827, (dipetik oleh 0). Abstrak | Pautan | BibTeX | Tag: Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Anak-anak, komorbiditi, Perundingan, Kajian Terkawal, Kajian Lintas Bahagian, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Sistem penjagaan kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kepuasan kerja, Kelantan, Kajian Klinikal Utama, Malaysia, Lelaki, Pengurusan, Kesihatan mental, Pertengahan umur, Terapi pekerjaan, Soal Selidik Skala Kepuasan Ibu Bapa, Persepsi, Kepuasan Peribadi, Penjagaan Kesihatan Utama, Penjagaan Perubatan Utama, Psikologi, Soal selidik, Kepuasan hati, Penjagaan Kesihatan Sekunder, Terapi ucapan, Tinjauan, Penjagaan Kesihatan Tertiari, West Malaysia @artikel{Adib2019, tajuk = {Peramal kepuasan penjaga terhadap pengurusan kanak-kanak dengan gangguan spektrum autisme: Kajian di pelbagai peringkat penjagaan kesihatan}, pengarang = {N A N Adib dan M I Ibrahim dan A A Rahman dan R S Bakar dan N A Yahaya dan S Hussin dan W N A Wan Mansor}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066861959&doi=10.3390/ijerph16101684&rakan kongsi = 40&md5=7f7b4ccd7484a6dcc6e2f03375b1ffb7}, doi = {10.3390/ijerph16101684}, terbitan = {16617827}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Jurnal Antarabangsa Penyelidikan Alam Sekitar dan Kesihatan Awam}, isi padu = {16}, nombor = {10}, penerbit = {MDPI AG}, abstrak = {Latar belakang: Pengasuh adalah penjaga pintu awal dalam pengurusan penjagaan kesihatan kanak-kanak dengan gangguan spektrum autisme (ASD). Kaedah: Kajian keratan rentas ini bertujuan untuk menentukan faktor-faktor yang berkaitan dengan kepuasan penjaga terhadap tahap perkhidmatan penjagaan kesihatan yang berbeza dalam menguruskan kanak-kanak ASD di Kelantan.. Markah kepuasan daripada 227 penjaga utama kanak-kanak ASD yang disahkan telah dinilai dengan Skala Kepuasan Ibu Bapa yang diubah suai (PSS) soal selidik. Keputusan: Analisis menunjukkan bahawa penjaga yang menunggu lebih lama untuk perundingan doktor dalam penjagaan primer mempunyai skor PSS yang berkurangan, manakala penjaga yang berpuas hati dengan masa menunggu di jagaan primer mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan menengah, penjaga yang memiliki sekurang-kurangnya diploma telah mengurangkan markah PSS, manakala penjaga yang berpuas hati dengan masa konsultasi doktor dan pelantikan terapi pekerjaan mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan tertiari, penjaga yang mempunyai masalah perubatan yang mendasari dan yang mempunyai anak yang menjalani terapi pekerjaan selama dua bulan atau lebih telah mengurangkan markah PSS. Namun begitu, analisis menunjukkan bahawa penjaga yang prihatin dengan masalah tidur anak-anak mereka, yang telah dimaklumkan tentang sokongan ibu bapa, yang berpuas hati dengan pelantikan terapi pertuturan dan pekerjaan, yang berpuas hati dengan masa menunggu di klinik penjagaan tertiari, dan yang berpuas hati dengan pengetahuan dan pengalaman doktor mereka mempunyai markah PSS yang lebih tinggi. Kesimpulannya: Kajian ini menjelaskan kepentingan memahami kepuasan penjaga dalam mendapatkan penjagaan untuk anak ASD mereka dan menekankan keperluan untuk mempromosikan faktor yang akan meningkatkan kepuasan penjaga terhadap perkhidmatan ASD semasa.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland.}, nota = {dipetik oleh 0}, kata kunci = {Dewasa, Artikel, Autisme, Gangguan Spektrum Autisme, Pengasuh, Penjagaan Kanak-kanak, Anak-anak, komorbiditi, Perundingan, Kajian Terkawal, Kajian Lintas Bahagian, Perempuan, Penjagaan Kesihatan, Penyampaian Penjagaan Kesihatan, Sistem penjagaan kesihatan, Perkhidmatan kesihatan, Pekerja kesihatan, Manusia, Kepuasan kerja, Kelantan, Kajian Klinikal Utama, Malaysia, Lelaki, Pengurusan, Kesihatan mental, Pertengahan umur, Terapi pekerjaan, Soal Selidik Skala Kepuasan Ibu Bapa, Persepsi, Kepuasan Peribadi, Penjagaan Kesihatan Utama, Penjagaan Perubatan Utama, Psikologi, Soal selidik, Kepuasan hati, Penjagaan Kesihatan Sekunder, Terapi ucapan, Tinjauan, Penjagaan Kesihatan Tertiari, West Malaysia}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar belakang: Pengasuh adalah penjaga pintu awal dalam pengurusan penjagaan kesihatan kanak-kanak dengan gangguan spektrum autisme (ASD). Kaedah: Kajian keratan rentas ini bertujuan untuk menentukan faktor-faktor yang berkaitan dengan kepuasan penjaga terhadap tahap perkhidmatan penjagaan kesihatan yang berbeza dalam menguruskan kanak-kanak ASD di Kelantan.. Markah kepuasan daripada 227 penjaga utama kanak-kanak ASD yang disahkan telah dinilai dengan Skala Kepuasan Ibu Bapa yang diubah suai (PSS) soal selidik. Keputusan: Analisis menunjukkan bahawa penjaga yang menunggu lebih lama untuk perundingan doktor dalam penjagaan primer mempunyai skor PSS yang berkurangan, manakala penjaga yang berpuas hati dengan masa menunggu di jagaan primer mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan menengah, penjaga yang memiliki sekurang-kurangnya diploma telah mengurangkan markah PSS, manakala penjaga yang berpuas hati dengan masa konsultasi doktor dan pelantikan terapi pekerjaan mempunyai markah PSS yang lebih tinggi. Di peringkat penjagaan tertiari, penjaga yang mempunyai masalah perubatan yang mendasari dan yang mempunyai anak yang menjalani terapi pekerjaan selama dua bulan atau lebih telah mengurangkan markah PSS. Namun begitu, analisis menunjukkan bahawa penjaga yang prihatin dengan masalah tidur anak-anak mereka, yang telah dimaklumkan tentang sokongan ibu bapa, yang berpuas hati dengan pelantikan terapi pertuturan dan pekerjaan, yang berpuas hati dengan masa menunggu di klinik penjagaan tertiari, dan yang berpuas hati dengan pengetahuan dan pengalaman doktor mereka mempunyai markah PSS yang lebih tinggi. Kesimpulannya: Kajian ini menjelaskan kepentingan memahami kepuasan penjaga dalam mendapatkan penjagaan untuk anak ASD mereka dan menekankan keperluan untuk mempromosikan faktor yang akan meningkatkan kepuasan penjaga terhadap perkhidmatan ASD semasa.. © 2019 oleh pengarang. MDPI pemegang lesen, Basel, Switzerland. |
Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T PLoS SATU, 14 (3), 2019, ISSN: 19326203, (dipetik oleh 4). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat @artikel{Pichitpunpong2019, tajuk = {Analisis subkumpulan fenotip dan multi-omik mendedahkan perencat pengikat diazepam yang berkurangan (DBI) tahap protein dalam gangguan spektrum autisme dengan gangguan bahasa yang teruk}, pengarang = {C Pichitpunpong dan S Thongkorn dan S Kanlayaprasit dan W Yuwattana dan W Plaingam dan S Sangsuthum dan W M Aizat dan SN Baharum dan T Tencomnao dan V W Hu dan T Sarachana}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371/journal.pone.0214198&rakan kongsi = 40&md5=0a4c25481edee56984a59de94fedc414}, doi = {10.1371/jurnal.pone.0214198}, terbitan = {19326203}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {PLoS SATU}, isi padu = {14}, nombor = {3}, penerbit = {Perpustakaan Awam Sains}, abstrak = {Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.}, nota = {dipetik oleh 4}, kata kunci = {Artikel, Autisme, Gangguan Spektrum Autisme, Mengikat Protein, Penanda Biologi, Penanda bio, Talian Sel, Kajian Terkawal, Gangguan Perkembangan, Gangguan Bahasa Perkembangan, Perencat Pengikat Diazepam, Protein Perencat Pengikat Diazepam, Keterukan Penyakit, Perempuan, Analisis Genetik, Manusia, Sel Manusia, Keradangan, Gangguan Perkembangan Bahasa, Ketidakupayaan Bahasa, Kromatografi Cecair-Spektrometri Jisim, Sel Limfoblastoid, Kajian Klinikal Utama, Lelaki, Metabolisme, Fenotip, Analisis Protein, Ekspresi Protein, Fungsi Protein, Proteome, Proteomik, Peraturan Transkripsi, Transkriptom, Dadah yang tidak dikelaskan, Blotting Barat}, pubstate = {diterbitkan}, tppubtype = {artikel} } Latar Belakang Mekanisme yang mendasari gangguan spektrum autisme (ASD) tetap tidak jelas, dan biomarker klinikal belum tersedia untuk ASD. Perbezaan dalam protein disregulasi dalam ASD telah menunjukkan sedikit kebolehulangan, yang sebahagiannya disebabkan oleh heterogeniti ASD. Kajian terkini telah menunjukkan bahawa subkumpulan kes ASD berdasarkan fenotip klinikal berguna untuk mengenal pasti gen calon yang didisregulasi dalam subkumpulan ASD. Walau bagaimanapun, strategi ini tidak digunakan dalam analisis pemprofilan protein untuk mengenal pasti protein biomarker ASD untuk subkumpulan tertentu. Kaedah Oleh itu, kami menjalankan analisis kelompok Temuduga Diagnostik Autisme-Disemak (ADI-R) markah daripada 85 individu yang mempunyai ASD untuk meramalkan subkumpulan dan kemudiannya mengenal pasti gen disregulasi dengan menganalisis semula profil transkrip individu yang mempunyai ASD dan individu yang tidak terjejas. Profil protein garisan sel limfoblastoid daripada individu ini dilakukan melalui elektroforesis 2D-gel, dan kemudian spektrometri jisim. Protein yang terganggu telah dikenal pasti dan dibandingkan dengan transkrip yang tidak dikawal dan melaporkan protein yang tidak dikawal daripada kajian protein sebelumnya. Fungsi biologi telah diramalkan menggunakan Analisis Laluan Kecerdikan (IPA) program. Protein terpilih juga dianalisis oleh Western blotting. Keputusan Analisis kelompok data ADI-R mendedahkan empat subkumpulan ASD, termasuk ASD dengan kecacatan bahasa yang teruk, dan pemprofilan transkriptom mengenal pasti gen tidak terkawal dalam setiap subkumpulan. Pemeriksaan melalui analisis proteome didedahkan 82 protein yang diubah dalam subkumpulan ASD dengan gangguan bahasa yang teruk. Lapan belas daripada protein ini dikenal pasti lagi oleh nano-LC-MS/MS. Antara protein ini, empat belas telah diramalkan oleh IPA dikaitkan dengan fungsi neurologi dan keradangan. Antara protein ini, perencat pengikat diazepam (DBI) protein telah disahkan oleh analisis Western blot untuk dinyatakan pada tahap penurunan yang ketara dalam subkumpulan ASD dengan gangguan bahasa yang teruk, dan tahap ekspresi DBI dikaitkan dengan markah beberapa item ADI-R. Kesimpulan Dengan subkumpulan individu dengan ASD berdasarkan fenotip klinikal, dan kemudian melakukan analisis transkriptom-proteome bersepadu, kami mengenal pasti DBI sebagai protein calon baru untuk ASD dengan gangguan bahasa yang teruk. Mekanisme protein ini dan potensi penggunaannya sebagai biomarker ASD memerlukan kajian lanjut. © 2019 Pihitpunpong et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan. |
Tidak juga, N K; Ghozali, A H; Ismail, J Sempadan dalam Pediatrik, 7 (FEB), 2019, ISSN: 22962360, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang @artikel{Nor2019, tajuk = {Kelebihan berat badan berlebihan dan obesiti di kalangan kanak-kanak dan remaja dengan gangguan spektrum autisme dan faktor risiko yang berkaitan}, pengarang = {N K Nor dan A H Ghozali dan J Ismail}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85064414280&dua = 10.3389% 2kurang.2019.00038&rakan kongsi = 40&md5 = 4bb61b1df043a4adf79618e223d77f26}, doi = {10.3389/fped.2019.00038}, terbitan = {22962360}, tahun = {2019}, tarikh = {2019-01-01}, jurnal = {Sempadan dalam Pediatrik}, isi padu = {7}, nombor = {FEB}, penerbit = {Frontiers Media S.A.}, abstrak = {Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.}, nota = {dipetik oleh 5}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Berat badan, Soal Selidik Bingkah Lakuan Autisme Ringkas, Pembangunan kanak-kanak, Obesiti Kanak-kanak, Anak-anak, Soal Selidik Tabiat Tidur Kanak-kanak, Kajian Terkawal, Kajian Lintas Bahagian, Kesukaran Memberi Makan, Perempuan, Penolakan Makanan, Manusia, Kajian Klinikal Utama, Orang Malaysia, Lelaki, Ibu, Zaman Bapa, Aktiviti fizikal, Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua, Kelaziman, Soal selidik, Faktor risiko, Gangguan Tidur, Berat badan kurang}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Prevalensi obesiti dalam Autism Spectrum Disorder (ASD) telah dilaporkan lebih tinggi daripada pada populasi umum. Menentukan prevalensi dapat membantu meningkatkan kesedaran mengenai kegemukan pada ASD dan berpotensi membawa kepada inisiatif untuk mengurangkan kegemukan. Untuk memahami kegemukan pada kanak-kanak ASD, faktor risiko biasa dinilai termasuk aktiviti fizikal, masalah makan dan gangguan tidur. Kaedah: Ini adalah kajian keratan rentas yang dilakukan di Pusat Perkembangan Kanak-kanak di Pusat Perubatan Universiti Kebangsaan Malaysia pada 151 Kanak-kanak ASD berumur 2-18 tahun. Maklumat antropometrik dan demografi diperoleh dan ibu bapa melengkapkan tiga soal selidik; Soal Selidik Tabiat Tidur Kanak-kanak (CSHQ), Soal Selidik Aktiviti Fizikal untuk Kanak-kanak Tua (PAQ-C) dan Soal Selidik Tingkah Laku Waktu Makan Autisme Ringkas (BAMBI). Keputusan: Untuk kanak-kanak ASD dalam sampel kami, kelaziman berat badan berlebihan (BMI ≥85 hingga < 95persentil ke-) adalah 11.3% dan berlakunya kegemukan (BMI persentil ke-95) adalah 21.9%. Umur rata-rata kanak-kanak ASD yang berlebihan berat badan / gemuk lebih tinggi pada 8.5 tahun (IQR 5.81-10.13) berbanding dengan kumpulan normal / kurang berat badan 6.33 tahun (IQR 4.75-7.7) dengan nilai p 0.001. Kedua-dua kumpulan juga berbeza secara signifikan untuk BMI ibu dan usia bapa. BMI ibu rata-rata dalam kumpulan berat badan berlebihan / gemuk adalah 26.05 (IQR 23.35-32.25), secara statistik lebih tinggi secara signifikan (p = 0.003) berbanding kumpulan yang tidak berlebihan berat badan / gemuk, 24.7 (IQR 21-27.9). Umur bapa median pada 40 tahun (IQR 37-44) secara statistik lebih tinggi secara signifikan (p = 0.039) dalam kumpulan berlebihan berat badan / gemuk, berbanding dengan usia bapa rata-rata pada kumpulan bukan berat badan berlebihan / obes 38 (IQR 35-42). Kanak-kanak lelaki yang berlebihan berat badan / gemuk mempunyai skor PAQ-C median 2.44 (IQR 2.00-3.00) lwn. 2.89 (IQR 2.35-3.53) dalam kumpulan rakan niaga dengan nilai p 0.01. Menggunakan kaedah regresi linear berganda, tiga peramal yang berkaitan dengan persentil BMI mencapai tahap kepentingan statistik; Skor PAQ-C pada lelaki (hlm < 0.001), domain BAMBI dari Penolakan Makanan (p = 0.001) dan Pelbagai Jenis Makanan yang Terhad (p = 0.001). Kesimpulannya: Kelaziman obesiti dan berat badan berlebihan adalah tinggi di kalangan kanak-kanak dan remaja ASD Malaysia. Umur kanak-kanak yang lebih tua, BMI ibu yang tinggi, usia bapa yang lebih tua, aktiviti fizikal yang rendah, kemungkinan rendahnya penolakan makanan dan kemungkinan tinggi pemilihan makanan didapati menjadi faktor risiko BMI tinggi pada kanak-kanak ini. © 2019 Kamal Nor, Ghozali and Ismail. |
2018 |
Toh, T -H; Tan, V W -Y; Lau, PST; Kiyu, A Jurnal Autisme dan Gangguan Perkembangan, 48 (1), hlm. 28-35, 2018, ISSN: 01623257, (dipetik oleh 9). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil @artikel{Toh201828, tajuk = {Ketepatan Senarai Semak Perubahan untuk Autisme pada Kanak-kanak (M-CHAT) dalam Mengesan Autisme dan Gangguan Perkembangan Lain di Klinik Komuniti}, pengarang = {T -H Toh dan V W -Y Tan dan P S -T Lau dan A Kiyu}, url = {https://www.scopus.com/inward/record.uri?eid = 2-s2.0-85028764085&doi=10.1007/s10803-017-3287-x&rakan kongsi = 40&md5 = 21bce2407197b8b1e43b4420d274861b}, doi = {10.1007/s10803-017-3287-x}, terbitan = {01623257}, tahun = {2018}, tarikh = {2018-01-01}, jurnal = {Jurnal Autisme dan Gangguan Perkembangan}, isi padu = {48}, nombor = {1}, halaman = {28-35}, penerbit = {Springer New York LLC}, abstrak = {Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC.}, nota = {dipetik oleh 9}, kata kunci = {Artikel, Autisme, Penilaian Autisme, Gangguan Spektrum Autisme, Senarai semak, Anak-anak, Analisis Kohort, Kajian Kohort, Pusat Kesihatan Komuniti, Gangguan Perkembangan, Ketepatan Diagnostik, Perempuan, Pusat kesihatan, Manusia, Bayi, Kajian Klinikal Utama, Malaysia, Lelaki, Pemeriksaan Massa, Senarai Semak yang Diubahsuai untuk Autisme pada Kanak-kanak, Hospital Pediatrik, Nilai Ramalan, Prasekolah, Kanak-kanak Prasekolah, Jurnal Keutamaan, Prosedur, Psikologi, Kajian Retrospektif, Kajian Retrospektif, Kepekaan dan Kekhususan, Piawaian, Kanak-kanak kecil}, pubstate = {diterbitkan}, tppubtype = {artikel} } Kajian ini menentukan ketepatan Senarai Semak Modifikasi untuk Autisme pada Balita (M-CHAT) dalam mengesan balita dengan gangguan spektrum autisme (ASD) dan gangguan perkembangan lain (DD) di klinik kesihatan ibu dan anak. Kami menganalisis 19,297 kanak-kanak yang layak (15–36 bulan) yang telah melakukan M-CHAT pada tahun 2006-2011. Sensitiviti keseluruhan untuk mengesan ASD dan semua DD adalah lemah tetapi lebih baik pada 21 ke <27 bulan dan kohort umur 27–36 bulan (54.5–64.3%). Walaupun nilai ramalan positif (PPV) miskin untuk ASD, terutamanya kohort yang lebih muda, positif M-CHAT membantu dalam mengesan semua DD (PPV = 81.6%). Ini mencadangkan M-CHAT untuk pemeriksaan ASD adalah tepat untuk kohort yang lebih tua (>21 bulan) dan alat saringan yang berguna untuk semua DD. © 2017, Springer Science + Media Perniagaan, LLC. |
2017 |
Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Anda, T; Daoud, F; Wang, H; Bcheraoui, TERDAPAT; Khalil, Saya; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Tetapi, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Tetapi, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, Saya A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Lalai, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, Wahai A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, Seorang K; Mitchell, P B; Patton, G; Sagar, R; Satpati, M; Savuon, K; Seedat, S; Shiue, Saya; Hutan, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H The burden of mental disorders in the eastern mediterranean region, 1990-2013 Artikel Jurnal PLoS SATU, 12 (1), 2017, ISSN: 19326203, (dipetik oleh 30). Abstrak | Pautan | BibTeX | Tag: 80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda @artikel{Charara2017, tajuk = {The burden of mental disorders in the eastern mediterranean region, 1990-2013}, pengarang = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371/journal.pone.0169575&rakan kongsi = 40&md5=471830ec1239e37c6fc4681bed5698f6}, doi = {10.1371/jurnal.pone.0169575}, terbitan = {19326203}, tahun = {2017}, tarikh = {2017-01-01}, jurnal = {PLoS SATU}, isi padu = {12}, nombor = {1}, penerbit = {Perpustakaan Awam Sains}, abstrak = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan.}, nota = {dipetik oleh 30}, kata kunci = {80 and Over, Remaja, Dewasa, umur, Faktor Umur, Aged, Anxiety Disorder, Artikel, Gangguan Defisit Perhatian, Autisme, Bipolar Disorder, Anak-anak, Conduct Disorder, Kemurungan, Elderly People, Perempuan, Global Health, Groups by Age, Status kesihatan, Highest Income Group, Manusia, Bayi, Kemerosotan Intelektual, Kuwait, Life Expectancy, Kajian Klinikal Utama, Lelaki, Mediterranean Region, Mental Disease, Gangguan Mental, Kesihatan mental, Perkhidmatan Kesihatan Mental, Pertengahan umur, Middle Income Group, Mortality, Baru lahir, Palestine, Premature Mortality, Prasekolah, Kanak-kanak Prasekolah, Kelaziman, Qatar, Quality Adjusted Life Year, Skizofrenia, Sex Difference, Faktor Seks, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. Dalam 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 jantan, 2426/100,000 perempuan) in high-income countries, 1884 DALYS/100,000 (1618/100,000 jantan, 2157/100,000 perempuan) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 jantan, 1717/100,000 perempuan) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 ke 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Lebih-lebih lagi, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Sesungguhnya, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. Ini ialah artikel akses terbuka yang diedarkan di bawah syarat Lesen Atribusi Creative Commons, yang membenarkan penggunaan tanpa had, pengedaran, dan pembiakan dalam mana-mana medium, dengan syarat penulis dan sumber asal dikreditkan. |
2015 |
Siah, P -C; Tan, S -H Sense of coherence and WHOQoL among parents of children with ASD in Malaysia Artikel Jurnal International Journal on Disability and Human Development, 14 (1), hlm. 59-66, 2015, ISSN: 21911231, (dipetik oleh 2). Abstrak | Pautan | BibTeX | Tag: Dewasa, umur, Artikel, Autisme, Anak-anak, Kefahaman, Pendidikan, Pekerjaan, Faktor Persekitaran, Perempuan, Jantina, Han Chinese, Health, Housewife, Manusia, Income, Orang India, Kajian Klinikal Utama, Malay, Malaysia, Lelaki, Marriage, Kesihatan mental, Sikap Ibu Bapa, Pensioner, Aspek Psikologi, Kualiti hidup, Religion, Sampling, Sense of Coherence, Interaksi Sosial @artikel{Siah201559, tajuk = {Sense of coherence and WHOQoL among parents of children with ASD in Malaysia}, pengarang = {P -C Siah and S -H Tan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922567900&doi=10.1515%2fijdhd-2013-0039&rakan kongsi = 40&md5=a909c24c26550aebe2c8922063d70001}, doi = {10.1515/ijdhd-2013-0039}, terbitan = {21911231}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {International Journal on Disability and Human Development}, isi padu = {14}, nombor = {1}, halaman = {59-66}, penerbit = {Walter de Gruyter GmbH}, abstrak = {Studies have shown that most parents of children with autism spectrum disorder (ASD) face more stress and have a poorer quality of life (QoL) than other parents. Walaupun begitu, there are still some parents of children with ASD who are able to maintain or even improve their QoL. This study is aimed to explore the relationship between SoC and WHOQoL among parents of children with ASD. Kaedah: Sejumlah 96 parents of children with ASD were invited to participate using a purposive sampling method. Keputusan: The results suggested that participants in the high SoC group had better QoL in the four domains than those in the low SoC group. More importantly, not all types of SoC were relevant to QoL. Comprehensibility was relevant to all the four QoL domains and manageability was relevant to physical and psychological health, while meaningfulness was not relevant to any of the QoL domains. Kesimpulannya: NGOs may improve the QoL of these parents by providing trainings to improve their SOC, especially in comprehensibility and manageability. © 2015 by De Gruyter.}, nota = {dipetik oleh 2}, kata kunci = {Dewasa, umur, Artikel, Autisme, Anak-anak, Kefahaman, Pendidikan, Pekerjaan, Faktor Persekitaran, Perempuan, Jantina, Han Chinese, Health, Housewife, Manusia, Income, Orang India, Kajian Klinikal Utama, Malay, Malaysia, Lelaki, Marriage, Kesihatan mental, Sikap Ibu Bapa, Pensioner, Aspek Psikologi, Kualiti hidup, Religion, Sampling, Sense of Coherence, Interaksi Sosial}, pubstate = {diterbitkan}, tppubtype = {artikel} } Studies have shown that most parents of children with autism spectrum disorder (ASD) face more stress and have a poorer quality of life (QoL) than other parents. Walaupun begitu, there are still some parents of children with ASD who are able to maintain or even improve their QoL. This study is aimed to explore the relationship between SoC and WHOQoL among parents of children with ASD. Kaedah: Sejumlah 96 parents of children with ASD were invited to participate using a purposive sampling method. Keputusan: The results suggested that participants in the high SoC group had better QoL in the four domains than those in the low SoC group. More importantly, not all types of SoC were relevant to QoL. Comprehensibility was relevant to all the four QoL domains and manageability was relevant to physical and psychological health, while meaningfulness was not relevant to any of the QoL domains. Kesimpulannya: NGOs may improve the QoL of these parents by providing trainings to improve their SOC, especially in comprehensibility and manageability. © 2015 by De Gruyter. |
Haerian, B S; Shaári, H M; Tan, H J; Fong, C Y; Wong, S W; Ong, L C; Raymond, A A; Tan, C T; Mohamed, DENGAN Genomics, 105 (4), hlm. 229-236, 2015, ISSN: 08887543, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda @artikel{Haerian2015229, tajuk = {RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia}, pengarang = {B S Haerian and H M Shaári and H J Tan and C Y Fong and S W Wong and L C Ong and A A Raymond and C T Tan and Z Mohamed}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924135981&doi=10.1016%2fj.ygeno.2015.02.001&rakan kongsi = 40&md5=209a1720cddfd76bfa515ee8940749d5}, doi = {10.1016/j.ygeno.2015.02.001}, terbitan = {08887543}, tahun = {2015}, tarikh = {2015-01-01}, jurnal = {Genomics}, isi padu = {105}, nombor = {4}, halaman = {229-236}, penerbit = {Academic Press Inc.}, abstrak = {RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Oleh itu, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.}, nota = {dipetik oleh 5}, kata kunci = {Remaja, Dewasa, Artikel, Case-Control Studies, Kajian Terkawal, DNA, Epilepsi, Epistasis, Perempuan, Gen, Gene Interaction, Genetic Polymorphism, Kecenderungan Genetik, Kecenderungan Genetik kepada Penyakit, Risiko Genetik, Genetic Variability, Genetik, Genotype, Group F, Manusia, Kajian Klinikal Utama, Malaysia, Lelaki, Member 1, Member 2, Pertengahan umur, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polimorfisme, Jurnal Keutamaan, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Nukleotida Tunggal, Polimorfisme Nukleotida Tunggal, Sodium Channel Nav1.1, Dewasa Muda}, pubstate = {diterbitkan}, tppubtype = {artikel} } RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Oleh itu, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.. |
2014 |
Shobana, M; Saravanan, C Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Artikel Jurnal East Asian Archives of Psychiatry, 24 (1), hlm. 16-22, 2014, ISSN: 20789947, (dipetik oleh 6). Abstrak | Pautan | BibTeX | Tag: Dewasa, Keresahan, Artikel, Attitude, Autisme, Gangguan Spektrum Autisme, Anak-anak, Kajian Perbandingan, Kemurungan, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Sindrom Down, Pendidikan, Perempuan, General Health Questionnaire 28, Home Care, Hostility, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kajian Klinikal Utama, Malaysia, Lelaki, Gangguan Mental, Mother Child Relation, Mothers, Named Inventories, Sikap Ibu Bapa, Parental Attitude Scale, Kelaziman, Psychological Well Being, Soal selidik, Skala penilaian, Budak sekolah, Social Disability @artikel{Shobana201416, tajuk = {Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability}, pengarang = {M Shobana and C Saravanan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898619897&rakan kongsi = 40&md5=e877e03b868d1a11ed8f859a33057d5d}, terbitan = {20789947}, tahun = {2014}, tarikh = {2014-01-01}, jurnal = {East Asian Archives of Psychiatry}, isi padu = {24}, nombor = {1}, halaman = {16-22}, penerbit = {Hong Kong Academy of Medicine Press}, abstrak = {Objektif: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Kaedah: Dalam kajian ini, 112 mothers of children having mild and moderate levels of autism disorder, Sindrom Down, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Keputusan: Secara keseluruhan, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, kegelisahan, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Kesimpulannya: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists.}, nota = {dipetik oleh 6}, kata kunci = {Dewasa, Keresahan, Artikel, Attitude, Autisme, Gangguan Spektrum Autisme, Anak-anak, Kajian Perbandingan, Kemurungan, Ketidakupayaan Perkembangan, Gangguan Perkembangan, Sindrom Down, Pendidikan, Perempuan, General Health Questionnaire 28, Home Care, Hostility, Manusia, Kecacatan Intelektual, Kemerosotan Intelektual, Kajian Klinikal Utama, Malaysia, Lelaki, Gangguan Mental, Mother Child Relation, Mothers, Named Inventories, Sikap Ibu Bapa, Parental Attitude Scale, Kelaziman, Psychological Well Being, Soal selidik, Skala penilaian, Budak sekolah, Social Disability}, pubstate = {diterbitkan}, tppubtype = {artikel} } Objektif: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Kaedah: Dalam kajian ini, 112 mothers of children having mild and moderate levels of autism disorder, Sindrom Down, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Keputusan: Secara keseluruhan, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, kegelisahan, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Kesimpulannya: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists. |
2013 |
Assaf, M; Hyatt, C J; Wong, C G; Johnson, ENCIK; Schultz, R T; Hendler, T; Pearlson, G D Mentalizing and motivation neural function during social interactions in autism spectrum disorders Artikel Jurnal NeuroImage: klinikal, 3 , hlm. 321-331, 2013, ISSN: 22131582, (dipetik oleh 28). Abstrak | Pautan | BibTeX | Tag: Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan @artikel{Assaf2013321, tajuk = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders}, pengarang = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&rakan kongsi = 40&md5=b63630c997b658167792266e40e855b6}, doi = {10.1016/j.nicl.2013.09.005}, terbitan = {22131582}, tahun = {2013}, tarikh = {2013-01-01}, jurnal = {NeuroImage: klinikal}, isi padu = {3}, halaman = {321-331}, abstrak = {Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis.}, nota = {dipetik oleh 28}, kata kunci = {Remaja, Dewasa, Artikel, Autisme, Brain Function, Anak-anak, Komputer, Kajian Terkawal, Perempuan, Pengimejan Resonans Magnetik Berfungsi, Permainan, Groups by Age, Manusia, Kajian Klinikal Utama, Lelaki, Mental Capacity, Middle Temporal Gyrus, Motivasi, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Jurnal Keutamaan, Punishment, Ganjaran, Budak sekolah, Kognisi Sosial, Social Environment, Interaksi Sosial, Task Performance, Theory of Mind, Penglihatan}, pubstate = {diterbitkan}, tppubtype = {artikel} } Gangguan Spektrum Autisme (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e.. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. Walau bagaimanapun, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e.. motivation) and concurrently process information about their opponent's potential next actions (i.e.. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, dan 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e.. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, masing-masing, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 Penulis. |
2012 |
Salih, M R M; Laut, M B; Hassali, M A A; Shafie, A A; Al-Lela, Wahai Q B; Abd, Ke dan; Ganesan, V M Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Artikel Jurnal Journal of Neurosciences in Rural Practice, 3 (3), hlm. 244-250, 2012, ISSN: 09763147, (dipetik oleh 1). Abstrak | Pautan | BibTeX | Tag: Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease @artikel{Salih2012244, tajuk = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy}, pengarang = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&rakan kongsi = 40&md5=039bd22d6c38366ebfdd00a4254c20f0}, doi = {10.4103/0976-3147.102596}, terbitan = {09763147}, tahun = {2012}, tarikh = {2012-01-01}, jurnal = {Journal of Neurosciences in Rural Practice}, isi padu = {3}, nombor = {3}, halaman = {244-250}, abstrak = {Pengenalan: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 bulan, the required data were extracted from the medical records using a pre-designed data collection form. Keputusan: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. Walau bagaimanapun, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.}, nota = {dipetik oleh 1}, kata kunci = {Remaja, Anticonvulsive Agent, Artikel, Autisme, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Anak-anak, Chinese, Clonazepam, Analisis Kohort, Congenital Toxoplasmosis, Kajian Terkawal, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Gangguan Perkembangan, Disorders of Mitochondrial Functions, Sindrom Down, Epilepsi, Etnik, Etiracetam, Perempuan, Focal Epilepsy, Happy Puppet Syndrome, Manusia, Hydrocephalus, Orang India, Kemerosotan Intelektual, Lamotrigine, Kajian Klinikal Utama, Malay, Lelaki, Medical Record, Microcephaly, Monotherapy, Kanak-kanak Prasekolah, Jurnal Keutamaan, Kajian Retrospektif, Budak sekolah, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease}, pubstate = {diterbitkan}, tppubtype = {artikel} } Pengenalan: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 bulan, the required data were extracted from the medical records using a pre-designed data collection form. Keputusan: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. Walau bagaimanapun, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, masing-masing) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Kesimpulannya: Among children with structural-metabolic epilepsy, Malays, perempuan, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients. |
2008 |
Tan, K L; Yadav, H Reassessment on the development of children with disability in Malaysia Artikel Jurnal Medical Journal of Malaysia, 63 (1), hlm. 17-20, 2008, ISSN: 03005283, (dipetik oleh 5). Abstrak | Pautan | BibTeX | Tag: Artikel, Autisme, Pembangunan kanak-kanak, Anak-anak, Clinical Assessment Tool, Analisis Kohort, Kajian Terkawal, Gangguan Perkembangan, Developmental Screening, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Perempuan, Susulan, Manusia, Bayi, Gangguan Pembelajaran, Kajian Klinikal Utama, Malaysia, Lelaki, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Prasekolah, Penjagaan Kesihatan Utama, Register, Gangguan Pertuturan, Statistical Significance @artikel{Tan200817, tajuk = {Reassessment on the development of children with disability in Malaysia}, pengarang = {K L Tan and H Yadav}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649115291&rakan kongsi = 40&md5=8838ddaa3d9906d8b696be13e88f1baa}, terbitan = {03005283}, tahun = {2008}, tarikh = {2008-01-01}, jurnal = {Medical Journal of Malaysia}, isi padu = {63}, nombor = {1}, halaman = {17-20}, abstrak = {This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. Sejumlah 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autisme, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment.}, nota = {dipetik oleh 5}, kata kunci = {Artikel, Autisme, Pembangunan kanak-kanak, Anak-anak, Clinical Assessment Tool, Analisis Kohort, Kajian Terkawal, Gangguan Perkembangan, Developmental Screening, Kanak-kanak Kurang Upaya, Sindrom Down, Keluarga, Perempuan, Susulan, Manusia, Bayi, Gangguan Pembelajaran, Kajian Klinikal Utama, Malaysia, Lelaki, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Prasekolah, Penjagaan Kesihatan Utama, Register, Gangguan Pertuturan, Statistical Significance}, pubstate = {diterbitkan}, tppubtype = {artikel} } This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. Sejumlah 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autisme, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment. |