@artikel{EiThu2018865,
tajuk = {New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects},
pengarang = {H Ei Thu and Z Hussain and A N Shuid},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048981535&doi=10.2174%2f1389450117666161125174625&rakan kongsi = 40&md5=d32e5bc9766ff9d68dd79f082b9ca4bc},
doi = {10.2174/1389450117666161125174625},
terbitan = {13894501},
tahun = {2018},
tarikh = {2018-01-01},
jurnal = {Current Drug Targets},
isi padu = {19},
nombor = {8},
halaman = {865-876},
penerbit = {Bentham Science Publishers B.V.},
abstrak = {Psychotic disorders are recognized as severe mental disorders that rigorously affect pa-tient’s personality, critical thinking, and perceptional ability. High prevalence, global dissemination and limitations of conventional pharmacological approaches compel a significant burden to the patient, medical professionals and the healthcare system. Sehingga kini, numerous orally administered therapies are available for the management of depressive disorders, schizophrenia, kegelisahan, bipolar disorders and autism spectrum problems. Walau bagaimanapun, poor water solubility, erratic oral absorption, extensive first-pass metabolism, low oral bioavailability and short half-lives are the major factors which limit the pharmaceutical significance and therapeutic feasibility of these agents. In recent decades, nanotechnology-based delivery systems have gained remarkable attention of the researchers to mitigate the pharmaceutical issues related to the antipsychotic therapies and to optimize their oral drug delivery, therapeutic outcomes, and patient compliance. Oleh itu, the present review was aimed to summarize the available in vitro and in vivo evidences signifying the pharmaceutical importance of the advanced delivery systems in improving the aqueous solubility, transmembrane permeability, oral bioavailability and therapeutic outcome of the antipsychotic agents. © 2018 Bentham Science Publishers.},
nota = {dipetik oleh 2},
kata kunci = {Amisulpride, Amitriptyline, Haiwan, Antipsychotic Agents, Keresahan, Aripiprazole, Autisme, Bioavailability, Biological Availability, Bipolar Disorder, Buspirone, Kimia, Clonazepam, Clozapine, Kemurungan, Diazepam, Drug Delivery System, Drug Delivery Systems, Duloxetine, Half Life Time, Half-Life, Penjagaan Kesihatan, Manusia, Iloperidone, In Vitro Study, In Vivo Study, Mental Disease, Gangguan Mental, Midazolam, Nanotechnology, Neuroleptic Agent, Olanzapine, Patofisiologi, Kebolehtelapan, Physical Chemistry, Psychosis, Kaji semula, Risperidone, Skizofrenia, Solubility, Sulpiride, Hasil Rawatan, Venlafaxine, Ziprasidone},
pubstate = {diterbitkan},
tppubtype = {artikel}
}