List of Publications
There are numbers of autism related research can be found in Malaysia that generally focus on the ASD, learning disorder, communication aids, therapy and many more. The list of publications is provided below:
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2014 |
Cassidy, S; Ropar, D; Mitchell, P; Chapman, P Can adults with autism spectrum disorders infer what happened to someone from their emotional response? Journal Article Autism Research, 7 (1), pp. 112-123, 2014, ISSN: 19393792, (cited By 21). Abstract | Links | BibTeX | Tags: Accuracy, Adult, Aged, Article, Asperger Syndrome, Attention, Autism, Behaviour, Cacao, Child Development Disorders, Clinical Article, Concept Formation, Controlled Study, Deception, Discrimination (Psychology), Emotion, Eye Movement, Eye Tracking, Face Processing, Facial Expression, Female, Human, Interpersonal Relations, Male, Middle Aged, Money, Pervasive, Priority Journal, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Young Adult @article{Cassidy2014112, title = {Can adults with autism spectrum disorders infer what happened to someone from their emotional response?}, author = {S Cassidy and D Ropar and P Mitchell and P Chapman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894307909&doi=10.1002%2faur.1351&partnerID=40&md5=8c6736bc006e9eebde29427879d023c3}, doi = {10.1002/aur.1351}, issn = {19393792}, year = {2014}, date = {2014-01-01}, journal = {Autism Research}, volume = {7}, number = {1}, pages = {112-123}, publisher = {John Wiley and Sons Inc.}, abstract = {Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.}, note = {cited By 21}, keywords = {Accuracy, Adult, Aged, Article, Asperger Syndrome, Attention, Autism, Behaviour, Cacao, Child Development Disorders, Clinical Article, Concept Formation, Controlled Study, Deception, Discrimination (Psychology), Emotion, Eye Movement, Eye Tracking, Face Processing, Facial Expression, Female, Human, Interpersonal Relations, Male, Middle Aged, Money, Pervasive, Priority Journal, Recipient, Recognition, Reference Values, Retrodictive Mindreading, Spontaneous Emotion Recognition, Theory of Mind, Video Recording, Young Adult}, pubstate = {published}, tppubtype = {article} } Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. |
Bhat, S; Acharya, U R; Adeli, H; Bairy, G M; Adeli, A Automated diagnosis of autism: In search of a mathematical marker Journal Article Reviews in the Neurosciences, 25 (6), pp. 851-861, 2014, ISSN: 03341763, (cited By 34). Abstract | Links | BibTeX | Tags: Algorithms, Article, Autism, Autism Spectrum Disorders, Automation, Biological Model, Brain, Chaos Theory, Correlation Analysis, Detrended Fluctuation Analysis, Disease Marker, Electrode, Electroencephalogram, Electroencephalography, Entropy, Fourier Transformation, Fractal Analysis, Frequency Domain Analysis, Human, Mathematical Analysis, Mathematical Marker, Mathematical Parameters, Models, Neurologic Disease, Neurological, Nonlinear Dynamics, Nonlinear System, Pathophysiology, Priority Journal, Procedures, Signal Processing, Statistical Model, Time, Time Frequency Analysis, Wavelet Analysis @article{Bhat2014851, title = {Automated diagnosis of autism: In search of a mathematical marker}, author = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925286949&doi=10.1515%2frevneuro-2014-0036&partnerID=40&md5=04858a5c9860e9027e3113835ca2e11f}, doi = {10.1515/revneuro-2014-0036}, issn = {03341763}, year = {2014}, date = {2014-01-01}, journal = {Reviews in the Neurosciences}, volume = {25}, number = {6}, pages = {851-861}, publisher = {Walter de Gruyter GmbH}, abstract = {Autism is a type of neurodevelopmental disorder affecting the memory, behavior, emotion, learning ability, and communication of an individual. An early detection of the abnormality, due to irregular processing in the brain, can be achieved using electroencephalograms (EEG). The variations in the EEG signals cannot be deciphered by mere visual inspection. Computer-aided diagnostic tools can be used to recognize the subtle and invisible information present in the irregular EEG pattern and diagnose autism. This paper presents a state-of-theart review of automated EEG-based diagnosis of autism. Various time domain, frequency domain, time-frequency domain, and nonlinear dynamics for the analysis of autistic EEG signals are described briefly. A focus of the review is the use of nonlinear dynamics and chaos theory to discover the mathematical biomarkers for the diagnosis of the autism analogous to biological markers. A combination of the time-frequency and nonlinear dynamic analysis is the most effective approach to characterize the nonstationary and chaotic physiological signals for the automated EEGbased diagnosis of autism spectrum disorder (ASD). The features extracted using these nonlinear methods can be used as mathematical markers to detect the early stage of autism and aid the clinicians in their diagnosis. This will expedite the administration of appropriate therapies to treat the disorder. © 2014 Walter de Gruyter GmbH.}, note = {cited By 34}, keywords = {Algorithms, Article, Autism, Autism Spectrum Disorders, Automation, Biological Model, Brain, Chaos Theory, Correlation Analysis, Detrended Fluctuation Analysis, Disease Marker, Electrode, Electroencephalogram, Electroencephalography, Entropy, Fourier Transformation, Fractal Analysis, Frequency Domain Analysis, Human, Mathematical Analysis, Mathematical Marker, Mathematical Parameters, Models, Neurologic Disease, Neurological, Nonlinear Dynamics, Nonlinear System, Pathophysiology, Priority Journal, Procedures, Signal Processing, Statistical Model, Time, Time Frequency Analysis, Wavelet Analysis}, pubstate = {published}, tppubtype = {article} } Autism is a type of neurodevelopmental disorder affecting the memory, behavior, emotion, learning ability, and communication of an individual. An early detection of the abnormality, due to irregular processing in the brain, can be achieved using electroencephalograms (EEG). The variations in the EEG signals cannot be deciphered by mere visual inspection. Computer-aided diagnostic tools can be used to recognize the subtle and invisible information present in the irregular EEG pattern and diagnose autism. This paper presents a state-of-theart review of automated EEG-based diagnosis of autism. Various time domain, frequency domain, time-frequency domain, and nonlinear dynamics for the analysis of autistic EEG signals are described briefly. A focus of the review is the use of nonlinear dynamics and chaos theory to discover the mathematical biomarkers for the diagnosis of the autism analogous to biological markers. A combination of the time-frequency and nonlinear dynamic analysis is the most effective approach to characterize the nonstationary and chaotic physiological signals for the automated EEGbased diagnosis of autism spectrum disorder (ASD). The features extracted using these nonlinear methods can be used as mathematical markers to detect the early stage of autism and aid the clinicians in their diagnosis. This will expedite the administration of appropriate therapies to treat the disorder. © 2014 Walter de Gruyter GmbH. |
Bhat, S; Acharya, U R; Adeli, H; Bairy, G M; Adeli, A Autism: Cause factors, early diagnosis and therapies Journal Article Reviews in the Neurosciences, 25 (6), pp. 841-850, 2014, ISSN: 03341763, (cited By 52). Abstract | Links | BibTeX | Tags: 4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide @article{Bhat2014841, title = {Autism: Cause factors, early diagnosis and therapies}, author = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925284617&doi=10.1515%2frevneuro-2014-0056&partnerID=40&md5=caaa32e66af70e70ec325241d01564c9}, doi = {10.1515/revneuro-2014-0056}, issn = {03341763}, year = {2014}, date = {2014-01-01}, journal = {Reviews in the Neurosciences}, volume = {25}, number = {6}, pages = {841-850}, publisher = {Walter de Gruyter GmbH}, abstract = {Autism spectrum disorder (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 in 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH.}, note = {cited By 52}, keywords = {4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide}, pubstate = {published}, tppubtype = {article} } Autism spectrum disorder (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 in 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH. |
Pillai, D; Sheppard, E; Ropar, D; Marsh, L; Pearson, A; Mitchell, P Using other minds as a window onto the world: Guessing what happened from clues in behaviour Journal Article Journal of Autism and Developmental Disorders, 44 (10), pp. 2430-2439, 2014, ISSN: 01623257, (cited By 17). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Child Development Disorders, Children, Clinical Article, Cognition, Controlled Study, Eye Movement, Eye Tracking, Facial Expression, Gaze, Human, Intelligence Quotient, Male, Measurement Accuracy, Mouth, Pathophysiology, Pervasive, Physiology, Psychological Aspect, Psychology, Retrodiction, Task Performance, Theory of Mind, Verbal Communication, Video Recording, Videotape Recording, Young Adult @article{Pillai20142430, title = {Using other minds as a window onto the world: Guessing what happened from clues in behaviour}, author = {D Pillai and E Sheppard and D Ropar and L Marsh and A Pearson and P Mitchell}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84912053354&doi=10.1007%2fs10803-014-2106-x&partnerID=40&md5=c3396f6f468e37e253c657f998993859}, doi = {10.1007/s10803-014-2106-x}, issn = {01623257}, year = {2014}, date = {2014-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {44}, number = {10}, pages = {2430-2439}, publisher = {Springer New York LLC}, abstract = {It has been proposed that mentalising involves retrodicting as well as predicting behaviour, by inferring previous mental states of a target. This study investigated whether retrodiction is impaired in individuals with autism spectrum disorders (ASD). Participants watched videos of real people reacting to the researcher behaving in one of four possible ways. Their task was to decide which of these four ‘‘scenarios’’ each person responded to. Participants’ eye movements were recorded. Participants with ASD were poorer than comparison participants at identifying the scenario to which people in the videos were responding. There were no group differences in time spent looking at the eyes or mouth. The findings imply those with ASD are impaired in using mentalising skills for retrodiction. © Springer Science+Business Media New York 2014.}, note = {cited By 17}, keywords = {Adolescent, Adult, Article, Autism, Child Development Disorders, Children, Clinical Article, Cognition, Controlled Study, Eye Movement, Eye Tracking, Facial Expression, Gaze, Human, Intelligence Quotient, Male, Measurement Accuracy, Mouth, Pathophysiology, Pervasive, Physiology, Psychological Aspect, Psychology, Retrodiction, Task Performance, Theory of Mind, Verbal Communication, Video Recording, Videotape Recording, Young Adult}, pubstate = {published}, tppubtype = {article} } It has been proposed that mentalising involves retrodicting as well as predicting behaviour, by inferring previous mental states of a target. This study investigated whether retrodiction is impaired in individuals with autism spectrum disorders (ASD). Participants watched videos of real people reacting to the researcher behaving in one of four possible ways. Their task was to decide which of these four ‘‘scenarios’’ each person responded to. Participants’ eye movements were recorded. Participants with ASD were poorer than comparison participants at identifying the scenario to which people in the videos were responding. There were no group differences in time spent looking at the eyes or mouth. The findings imply those with ASD are impaired in using mentalising skills for retrodiction. © Springer Science+Business Media New York 2014. |
Chen, B C; Rawi, Mohd R; Meinsma, R; Meijer, J; Hennekam, R C M; Kuilenburg, Van A B P Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings Journal Article Molecular Syndromology, 5 (6), pp. 299-303, 2014, ISSN: 16618769, (cited By 4). Abstract | Links | BibTeX | Tags: Alanine, Article, Asymptomatic Disease, Autism, Autosomal Recessive Disorder, Case Report, Cerebellum Atrophy, Children, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Disease Severity, DPYD Gene, Eye Malformation, Female, Gene, Gene Mutation, Homozygosity, Human, Intellectual Impairment, Malaysian, Male, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Preschool Child, Pyrimidine, Pyrimidine Metabolism, School Child, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil @article{Chen2014299, title = {Dihydropyrimidine dehydrogenase deficiency in two Malaysian siblings with abnormal MRI findings}, author = {B C Chen and R Mohd Rawi and R Meinsma and J Meijer and R C M Hennekam and A B P Van Kuilenburg}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919783242&doi=10.1159%2f000366074&partnerID=40&md5=1ebfb9aedb7cb64e3423811b41b6aa7c}, doi = {10.1159/000366074}, issn = {16618769}, year = {2014}, date = {2014-01-01}, journal = {Molecular Syndromology}, volume = {5}, number = {6}, pages = {299-303}, publisher = {S. Karger AG}, abstract = {Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine metabolism. Deficiency of this enzyme leads to an accumulation of thymine and uracil and a deficiency of metabolites distal to the catabolic enzyme. The disorder presents with a wide clinical spectrum, ranging from asymptomatic to severe neurological manifestations, including intellectual disability, seizures, microcephaly, autistic behavior, and eye abnormalities. Here, we report on an 11-year-old Malaysian girl and her 6-year-old brother with DPD deficiency who presented with intellectual disability, microcephaly, and hypotonia. Brain MRI scans showed generalized cerebral and cerebellar atrophy and callosal body dysgenesis in the boy. Urine analysis showed strongly elevated levels of uracil in the girl and boy (571 and 578 mmol/mol creatinine, respectively) and thymine (425 and 427 mmol/mol creatinine, respectively). Sequence analysis of the DPYD gene showed that both siblings were homozygous for the mutation c.1651G>A (pAla551Thr). © 2014 S. Karger AG, Basel.}, note = {cited By 4}, keywords = {Alanine, Article, Asymptomatic Disease, Autism, Autosomal Recessive Disorder, Case Report, Cerebellum Atrophy, Children, Creatinine, Dihydropyrimidine Dehydrogenase, Dihydropyrimidine Dehydrogenase Deficiency, Disease Severity, DPYD Gene, Eye Malformation, Female, Gene, Gene Mutation, Homozygosity, Human, Intellectual Impairment, Malaysian, Male, Microcephaly, Muscle Hypotonia, Nuclear Magnetic Resonance Imaging, Preschool Child, Pyrimidine, Pyrimidine Metabolism, School Child, Seizure, Sequence Analysis, Sibling, Threonine, Thymine, Uracil}, pubstate = {published}, tppubtype = {article} } Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine metabolism. Deficiency of this enzyme leads to an accumulation of thymine and uracil and a deficiency of metabolites distal to the catabolic enzyme. The disorder presents with a wide clinical spectrum, ranging from asymptomatic to severe neurological manifestations, including intellectual disability, seizures, microcephaly, autistic behavior, and eye abnormalities. Here, we report on an 11-year-old Malaysian girl and her 6-year-old brother with DPD deficiency who presented with intellectual disability, microcephaly, and hypotonia. Brain MRI scans showed generalized cerebral and cerebellar atrophy and callosal body dysgenesis in the boy. Urine analysis showed strongly elevated levels of uracil in the girl and boy (571 and 578 mmol/mol creatinine, respectively) and thymine (425 and 427 mmol/mol creatinine, respectively). Sequence analysis of the DPYD gene showed that both siblings were homozygous for the mutation c.1651G>A (pAla551Thr). © 2014 S. Karger AG, Basel. |
Fauzan, Norsiah; Mahayuddin, Nurul Aina Mohd Brain Training to Improve Sociability and Behavior of Autism Spectrum Disorder (ASD) Children and Young Adults Inproceedings Uzunboylu, H (Ed.): 3RD CYPRUS INTERNATIONAL CONFERENCE ON EDUCATIONAL RESEARCH (CY-ICER 2014), pp. 308-314, ELSEVIER SCIENCE BV, SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2014, ISSN: 1877-0428, (3rd Cyprus International Conference on Educational Research (CY-ICER), Near E Univ, Nicosia, CYPRUS, JAN 30-FEB 01, 2014). Abstract | Links | BibTeX | Tags: Autism, EEG Training, Neurofeedback Training, QEEG @inproceedings{ISI:000345440000061, title = {Brain Training to Improve Sociability and Behavior of Autism Spectrum Disorder (ASD) Children and Young Adults}, author = {Norsiah Fauzan and Nurul Aina Mohd Mahayuddin}, editor = {H Uzunboylu}, url = {https://ir.unimas.my/id/eprint/9758/1/Brain-Waves-and-Connectivity-of-Autism-Spectrum-Disorders_2015_Procedia-Social-and-Behavioral-Sciences(abstract).pdf}, doi = {10.1016/j.sbspro.2014.07.410}, issn = {1877-0428}, year = {2014}, date = {2014-01-01}, booktitle = {3RD CYPRUS INTERNATIONAL CONFERENCE ON EDUCATIONAL RESEARCH (CY-ICER 2014)}, volume = {143}, pages = {308-314}, publisher = {ELSEVIER SCIENCE BV}, address = {SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, series = {Procedia Social and Behavioral Sciences}, abstract = {This article details on the use of brain training device, Neuro feedback Training (NFT) device to improve the sociability and behaviour of ASD children and young adults. A quasi-experimental study using pre-test and post-test within subject design was used. The research involved thirty-four participants, purposively selected from Kuching Autistic Association (KAA). The Autism Treatment Evaluation Checklist (ATEC) was used to measure the effectiveness of NFT on ASD children and young adults in KAA. The observation emphasized on sociability and behavioral changes among the participants. The findings showed an overall improvement in total ATEC score. Sociability and behaviors are among ASD children and young adults. There is a difference between ATEC post-test score in behavior with the age of participants (C) 2014 Published by Elsevier Ltd.}, note = {3rd Cyprus International Conference on Educational Research (CY-ICER), Near E Univ, Nicosia, CYPRUS, JAN 30-FEB 01, 2014}, keywords = {Autism, EEG Training, Neurofeedback Training, QEEG}, pubstate = {published}, tppubtype = {inproceedings} } This article details on the use of brain training device, Neuro feedback Training (NFT) device to improve the sociability and behaviour of ASD children and young adults. A quasi-experimental study using pre-test and post-test within subject design was used. The research involved thirty-four participants, purposively selected from Kuching Autistic Association (KAA). The Autism Treatment Evaluation Checklist (ATEC) was used to measure the effectiveness of NFT on ASD children and young adults in KAA. The observation emphasized on sociability and behavioral changes among the participants. The findings showed an overall improvement in total ATEC score. Sociability and behaviors are among ASD children and young adults. There is a difference between ATEC post-test score in behavior with the age of participants (C) 2014 Published by Elsevier Ltd. |
2013 |
Ramachandram, Sathyabama; Lope, Raja Juanita Raja; Chandran, Vijayalakshmi; Nor, Norazlin Kamal; Ismail, Juriza Use of parent administered picture activity cards to teach toileting skills in children with autism Journal Article EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22 (2), pp. S213-S214, 2013, ISSN: 1018-8827. BibTeX | Tags: Autism, Children, Picture Activity Cards, Toileting @article{ISI:000209547900343, title = {Use of parent administered picture activity cards to teach toileting skills in children with autism}, author = {Sathyabama Ramachandram and Raja Juanita Raja Lope and Vijayalakshmi Chandran and Norazlin Kamal Nor and Juriza Ismail}, issn = {1018-8827}, year = {2013}, date = {2013-07-01}, journal = {EUROPEAN CHILD & ADOLESCENT PSYCHIATRY}, volume = {22}, number = {2}, pages = {S213-S214}, publisher = {SPRINGER}, address = {233 SPRING ST, NEW YORK, NY 10013 USA}, keywords = {Autism, Children, Picture Activity Cards, Toileting}, pubstate = {published}, tppubtype = {article} } |
Freeth, M; Sheppard, E; Ramachandran, R; Milne, E A cross-cultural comparison of autistic traits in the UK, India and Malaysia Journal Article Journal of Autism and Developmental Disorders, 43 (11), pp. 2569-2583, 2013, ISSN: 01623257, (cited By 39). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Asian Continental Ancestry Group, Attention, Autism, Autism Spectrum Disorders, Autism Spectrum Quotient, Communication Skills, Comparative Study, Cross-Cultural Comparison, Cultural Factor, Ethnicity, Female, Great Britain, Human, Human Experiment, Imagination, India, Indian, Malaysia, Male, Personality, Phenotype, Postgraduate Student, Priority Journal, Psychometry, Questionnaires, Sex Factors, Social Adaptation, Spectrum, Students, Undergraduate Student, United Kingdom, Young Adult @article{Freeth20132569, title = {A cross-cultural comparison of autistic traits in the UK, India and Malaysia}, author = {M Freeth and E Sheppard and R Ramachandran and E Milne}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886802970&doi=10.1007%2fs10803-013-1808-9&partnerID=40&md5=d8acde51c0626be3862facc1d6bc493c}, doi = {10.1007/s10803-013-1808-9}, issn = {01623257}, year = {2013}, date = {2013-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {43}, number = {11}, pages = {2569-2583}, abstract = {The disorder of autism is widely recognised throughout the world. However, the diagnostic criteria and theories of autism are based on research predominantly conducted in Western cultures. Here we compare the expression of autistic traits in a sample of neurotypical individuals from one Western culture (UK) and two Eastern cultures (India and Malaysia), using the Autism-spectrum Quotient (AQ) in order to identify possible cultural differences in the expression of autistic traits. Behaviours associated with autistic traits were reported to a greater extent in the Eastern cultures than the Western culture. Males scored higher than females and science students scored higher than non-science students in each culture. Indian students scored higher than both other groups on the Imagination sub-scale, Malaysian students scored higher than both other groups on the Attention Switching sub-scale. The underlying factor structures of the AQ for each population were derived and discussed. © 2013 Springer Science+Business Media New York.}, note = {cited By 39}, keywords = {Adolescent, Adult, Article, Asian Continental Ancestry Group, Attention, Autism, Autism Spectrum Disorders, Autism Spectrum Quotient, Communication Skills, Comparative Study, Cross-Cultural Comparison, Cultural Factor, Ethnicity, Female, Great Britain, Human, Human Experiment, Imagination, India, Indian, Malaysia, Male, Personality, Phenotype, Postgraduate Student, Priority Journal, Psychometry, Questionnaires, Sex Factors, Social Adaptation, Spectrum, Students, Undergraduate Student, United Kingdom, Young Adult}, pubstate = {published}, tppubtype = {article} } The disorder of autism is widely recognised throughout the world. However, the diagnostic criteria and theories of autism are based on research predominantly conducted in Western cultures. Here we compare the expression of autistic traits in a sample of neurotypical individuals from one Western culture (UK) and two Eastern cultures (India and Malaysia), using the Autism-spectrum Quotient (AQ) in order to identify possible cultural differences in the expression of autistic traits. Behaviours associated with autistic traits were reported to a greater extent in the Eastern cultures than the Western culture. Males scored higher than females and science students scored higher than non-science students in each culture. Indian students scored higher than both other groups on the Imagination sub-scale, Malaysian students scored higher than both other groups on the Attention Switching sub-scale. The underlying factor structures of the AQ for each population were derived and discussed. © 2013 Springer Science+Business Media New York. |
Hamid, A C; Miskam, M A; Yussof, H; Shamsuddin, S; Hashim, H; Ismail, L Human-robot interaction (HRI) for children with autism to augment communication skills Journal Article Applied Mechanics and Materials, 393 , pp. 598-603, 2013, ISSN: 16609336, (cited By 1). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism, Children with Autism, Communication, Communication Skills, Diseases, Education, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Intervention Programs, Learning, Man Machine Systems, Mechanical Engineering, Teaching, Two-Way Communications @article{Hamid2013598, title = {Human-robot interaction (HRI) for children with autism to augment communication skills}, author = {A C Hamid and M A Miskam and H Yussof and S Shamsuddin and H Hashim and L Ismail}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886245343&doi=10.4028%2fwww.scientific.net%2fAMM.393.598&partnerID=40&md5=a580bbcbd654ebb6c19b75fa27bdf75e}, doi = {10.4028/www.scientific.net/AMM.393.598}, issn = {16609336}, year = {2013}, date = {2013-01-01}, journal = {Applied Mechanics and Materials}, volume = {393}, pages = {598-603}, abstract = {This paper presents a case study of robot-based intervention program for children with autism. The study focuses on two-way communication between children with autism and a humanoid robot NAO. The aim of this study is to develop a set of teaching and learning modules on communication through question type conversation and song-based approach. Module developed in this study is programmed using NAO's choregraphe, being imbedded later on and perform action. Both children participating in this study can communicate verbally and have been diagnosed with mild autism. Response from this exposure shows that the human toddler-like robot can be used as a platform to augment and facilitate communication effectively with children with autism. © (2013) Trans Tech Publications, Switzerland.}, note = {cited By 1}, keywords = {Anthropomorphic Robots, Autism, Children with Autism, Communication, Communication Skills, Diseases, Education, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Intervention Programs, Learning, Man Machine Systems, Mechanical Engineering, Teaching, Two-Way Communications}, pubstate = {published}, tppubtype = {article} } This paper presents a case study of robot-based intervention program for children with autism. The study focuses on two-way communication between children with autism and a humanoid robot NAO. The aim of this study is to develop a set of teaching and learning modules on communication through question type conversation and song-based approach. Module developed in this study is programmed using NAO's choregraphe, being imbedded later on and perform action. Both children participating in this study can communicate verbally and have been diagnosed with mild autism. Response from this exposure shows that the human toddler-like robot can be used as a platform to augment and facilitate communication effectively with children with autism. © (2013) Trans Tech Publications, Switzerland. |
Miskam, M A; Hamid, M A C; Yussof, H; Shamsuddin, S; Malik, N A; Basir, S N Study on social interaction between children with autism and humanoid robot NAO Journal Article Applied Mechanics and Materials, 393 , pp. 573-578, 2013, ISSN: 16609336, (cited By 10). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism, Children with Autism, Communication, Developmental Disorders, Diseases, Education, Educational Intervention, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Mechanical Engineering, Patient Rehabilitation, Social Interactions, Social Sciences, Two-Way Communications @article{Miskam2013573, title = {Study on social interaction between children with autism and humanoid robot NAO}, author = {M A Miskam and M A C Hamid and H Yussof and S Shamsuddin and N A Malik and S N Basir}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886245367&doi=10.4028%2fwww.scientific.net%2fAMM.393.573&partnerID=40&md5=95d6cec2dc5888c99213397d5b94b003}, doi = {10.4028/www.scientific.net/AMM.393.573}, issn = {16609336}, year = {2013}, date = {2013-01-01}, journal = {Applied Mechanics and Materials}, volume = {393}, pages = {573-578}, abstract = {Autism cannot run away from their triangle deficits: social, communication and stereotyped behaviour. There is no cure for autism or any definitive treatment to treat the core symptoms of this developmental disorder. However, the deficits can be minimized by maximize their learning through behavioural therapy and educational intervention. Nowadays, the methods in the rehabilitation of autism have been upgraded by the innovation of humanoid robots, in particular the humanoid robot NAO. In this study, NAO has being programmed using Choregraphe as programming tool to develop lesson modules for children with autism to practice their social interaction skill. This paper focuses specifically on social interaction subscale to observe the behaviour of the autistic children during interaction with the humanoid robot NAO. The observation is based on six items referenced from the Gilliam Autism Rating Scale-second edition (GARS-2). The use of humanoid robot NAO in the rehabilitation of autistic children is expected to help them to interact and practice their social traits just like normal children. The results evidently showed that children with autism are positively affected by NAO by giving encouraging responses in social interaction when interacting with the robot. Two-way communication between the child and robot in real time significantly give positive impact in the responses towards the robot. © (2013) Trans Tech Publications, Switzerland.}, note = {cited By 10}, keywords = {Anthropomorphic Robots, Autism, Children with Autism, Communication, Developmental Disorders, Diseases, Education, Educational Intervention, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Mechanical Engineering, Patient Rehabilitation, Social Interactions, Social Sciences, Two-Way Communications}, pubstate = {published}, tppubtype = {article} } Autism cannot run away from their triangle deficits: social, communication and stereotyped behaviour. There is no cure for autism or any definitive treatment to treat the core symptoms of this developmental disorder. However, the deficits can be minimized by maximize their learning through behavioural therapy and educational intervention. Nowadays, the methods in the rehabilitation of autism have been upgraded by the innovation of humanoid robots, in particular the humanoid robot NAO. In this study, NAO has being programmed using Choregraphe as programming tool to develop lesson modules for children with autism to practice their social interaction skill. This paper focuses specifically on social interaction subscale to observe the behaviour of the autistic children during interaction with the humanoid robot NAO. The observation is based on six items referenced from the Gilliam Autism Rating Scale-second edition (GARS-2). The use of humanoid robot NAO in the rehabilitation of autistic children is expected to help them to interact and practice their social traits just like normal children. The results evidently showed that children with autism are positively affected by NAO by giving encouraging responses in social interaction when interacting with the robot. Two-way communication between the child and robot in real time significantly give positive impact in the responses towards the robot. © (2013) Trans Tech Publications, Switzerland. |
Assaf, M; Hyatt, C J; Wong, C G; Johnson, M R; Schultz, R T; Hendler, T; Pearlson, G D Mentalizing and motivation neural function during social interactions in autism spectrum disorders Journal Article NeuroImage: Clinical, 3 , pp. 321-331, 2013, ISSN: 22131582, (cited By 28). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision @article{Assaf2013321, title = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders}, author = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&partnerID=40&md5=b63630c997b658167792266e40e855b6}, doi = {10.1016/j.nicl.2013.09.005}, issn = {22131582}, year = {2013}, date = {2013-01-01}, journal = {NeuroImage: Clinical}, volume = {3}, pages = {321-331}, abstract = {Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors.}, note = {cited By 28}, keywords = {Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision}, pubstate = {published}, tppubtype = {article} } Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors. |
Khowaja, K; Salim, S S A systematic review of strategies and computer-based intervention (CBI) for reading comprehension of children with autism Journal Article Research in Autism Spectrum Disorders, 7 (9), pp. 1111-1121, 2013, ISSN: 17509467, (cited By 28). Abstract | Links | BibTeX | Tags: Attention, Autism, Bibliographic Database, Children, Clinical Effectiveness, Clinical Observation, Cognition, Comprehension, Computer Assisted Therapy, Computer Based Intervention, Explicit Memory, Human, Learning, Linguistics, Motivation, Multimedia, Pretest Posttest Design, Priority Journal, Reading, Reading Comprehension, Review, Systematic Review, Treatment Outcome @article{Khowaja20131111, title = {A systematic review of strategies and computer-based intervention (CBI) for reading comprehension of children with autism}, author = {K Khowaja and S S Salim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879609907&doi=10.1016%2fj.rasd.2013.05.009&partnerID=40&md5=6ba3e9315ee8b3cecb6248b97198313d}, doi = {10.1016/j.rasd.2013.05.009}, issn = {17509467}, year = {2013}, date = {2013-01-01}, journal = {Research in Autism Spectrum Disorders}, volume = {7}, number = {9}, pages = {1111-1121}, abstract = {This paper presents a systematic review of relevant published studies on reading comprehension for children with autism, focusing on vocabulary instruction and text comprehension instruction from years 2000 to 2011. This systematic review attempts to address three specific research questions: strategies of vocabulary instruction and text comprehension instruction used, computer-based intervention (CBI) used or developed during study, and the effectiveness of using CBI for teaching children with autism. There are five strategies of vocabulary instruction and seven strategies of text comprehension instruction. Results indicate that two strategies of vocabulary instruction, multimedia methods and explicit instruction were found to be more commonly used than the other three. On the same note, question answering strategy of text comprehension instruction was discovered to be used more often than the other six. Results also indicate that children with autism can benefit from the strategies of reading comprehension and that the use of CBI as a mode of instruction for reading comprehension improved learning of children. This is clearly evident judging from the performance of children between pre-tests and post-tests of studies in which CBI was used. However, due to heterogeneity of participants, this is not always the case; a few studies reported no improvement in the learning of children with autism. © 2013 Elsevier Ltd. Allrights reserved.}, note = {cited By 28}, keywords = {Attention, Autism, Bibliographic Database, Children, Clinical Effectiveness, Clinical Observation, Cognition, Comprehension, Computer Assisted Therapy, Computer Based Intervention, Explicit Memory, Human, Learning, Linguistics, Motivation, Multimedia, Pretest Posttest Design, Priority Journal, Reading, Reading Comprehension, Review, Systematic Review, Treatment Outcome}, pubstate = {published}, tppubtype = {article} } This paper presents a systematic review of relevant published studies on reading comprehension for children with autism, focusing on vocabulary instruction and text comprehension instruction from years 2000 to 2011. This systematic review attempts to address three specific research questions: strategies of vocabulary instruction and text comprehension instruction used, computer-based intervention (CBI) used or developed during study, and the effectiveness of using CBI for teaching children with autism. There are five strategies of vocabulary instruction and seven strategies of text comprehension instruction. Results indicate that two strategies of vocabulary instruction, multimedia methods and explicit instruction were found to be more commonly used than the other three. On the same note, question answering strategy of text comprehension instruction was discovered to be used more often than the other six. Results also indicate that children with autism can benefit from the strategies of reading comprehension and that the use of CBI as a mode of instruction for reading comprehension improved learning of children. This is clearly evident judging from the performance of children between pre-tests and post-tests of studies in which CBI was used. However, due to heterogeneity of participants, this is not always the case; a few studies reported no improvement in the learning of children with autism. © 2013 Elsevier Ltd. Allrights reserved. |
Modugumudi, Y R; Santhosh, J; Anand, S Efficacy of collaborative virtual environment intervention programs in emotion expression of children with autism Journal Article Journal of Medical Imaging and Health Informatics, 3 (2), pp. 321-325, 2013, ISSN: 21567018, (cited By 4). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Children, Clinical Article, Collaborative Virtual Environment, Controlled Study, DSM-IV, Electroencephalogram, Electroencephalography, Electrooculogram, Emotion, Environment, Event Related Potential, Facial Expression, Female, Human, Latent Period, Male, Recognition, School Child @article{Modugumudi2013321, title = {Efficacy of collaborative virtual environment intervention programs in emotion expression of children with autism}, author = {Y R Modugumudi and J Santhosh and S Anand}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84881262807&doi=10.1166%2fjmihi.2013.1167&partnerID=40&md5=c8e767c8eba2bbbec5ff36a43eb59af6}, doi = {10.1166/jmihi.2013.1167}, issn = {21567018}, year = {2013}, date = {2013-01-01}, journal = {Journal of Medical Imaging and Health Informatics}, volume = {3}, number = {2}, pages = {321-325}, abstract = {Exploratory empirical studies on Collaborative Virtual Environments (CVEs) were conducted to determine if children with autism could make basic emotional recognition effectively, with the use of CVEs as assistive technology. In this paper we report the results of electro-physiological study of two groups of autistic children after an intervention program with and without using Collaborative Virtual Environment. The group trained with CVE showed better results compared to the group trained without Collaborative virtual Environment. There is an emphasized early emotion expression positivity component at around 120 ms latency for CVE trained group which clearly distinguishes the CVE untrained group. Also there are differences observed in Event Related Potential component at about 170 ms latency after the stimulus. Results indicate that the Collaborative Virtual Environments are effective in training Autistic children. © 2013 American Scientific Publishers.}, note = {cited By 4}, keywords = {Adolescent, Adult, Article, Autism, Children, Clinical Article, Collaborative Virtual Environment, Controlled Study, DSM-IV, Electroencephalogram, Electroencephalography, Electrooculogram, Emotion, Environment, Event Related Potential, Facial Expression, Female, Human, Latent Period, Male, Recognition, School Child}, pubstate = {published}, tppubtype = {article} } Exploratory empirical studies on Collaborative Virtual Environments (CVEs) were conducted to determine if children with autism could make basic emotional recognition effectively, with the use of CVEs as assistive technology. In this paper we report the results of electro-physiological study of two groups of autistic children after an intervention program with and without using Collaborative Virtual Environment. The group trained with CVE showed better results compared to the group trained without Collaborative virtual Environment. There is an emphasized early emotion expression positivity component at around 120 ms latency for CVE trained group which clearly distinguishes the CVE untrained group. Also there are differences observed in Event Related Potential component at about 170 ms latency after the stimulus. Results indicate that the Collaborative Virtual Environments are effective in training Autistic children. © 2013 American Scientific Publishers. |
Mousavizadeh, K; Askari, M; Arian, H; Gorjipour, F; Nikpour, A R; Tavafjadid, M; Aryani, O; Kamalidehghan, B; Maroof, H R; Houshmand, M Association of human mtDNA mutations with autism in Iranian patients Journal Article Journal of Research in Medical Sciences, 18 (10), pp. 926, 2013, ISSN: 17351995, (cited By 2). Links | BibTeX | Tags: Autism, Clinical Article, Controlled Study, Gene, Gene Frequency, Gene Mutation, Gene Sequence, Genetic Association, Genetic Risk, Human, Letter, Mitochondrial DNA, Molecular Phylogeny, Pathophysiology, Point Mutation, Polymerase Chain Reaction @article{Mousavizadeh2013926, title = {Association of human mtDNA mutations with autism in Iranian patients}, author = {K Mousavizadeh and M Askari and H Arian and F Gorjipour and A R Nikpour and M Tavafjadid and O Aryani and B Kamalidehghan and H R Maroof and M Houshmand}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887270916&partnerID=40&md5=3922601b0364489a2b76d620316cc150}, issn = {17351995}, year = {2013}, date = {2013-01-01}, journal = {Journal of Research in Medical Sciences}, volume = {18}, number = {10}, pages = {926}, publisher = {Isfahan University of Medical Sciences(IUMS)}, note = {cited By 2}, keywords = {Autism, Clinical Article, Controlled Study, Gene, Gene Frequency, Gene Mutation, Gene Sequence, Genetic Association, Genetic Risk, Human, Letter, Mitochondrial DNA, Molecular Phylogeny, Pathophysiology, Point Mutation, Polymerase Chain Reaction}, pubstate = {published}, tppubtype = {article} } |
Mitchell, Peter Mentalizing in autism: Interpreting facial expressions, following gaze, reading body language and inferring traits Journal Article JOURNAL OF EDUCATIONAL SCIENCES & PSYCHOLOGY, 3 (1), pp. 111-120, 2013, ISSN: 2247-6377. Abstract | BibTeX | Tags: Autism, Developmental Disorders, Mentalizing, Social Functioning @article{ISI:000217241600014, title = {Mentalizing in autism: Interpreting facial expressions, following gaze, reading body language and inferring traits}, author = {Peter Mitchell}, issn = {2247-6377}, year = {2013}, date = {2013-01-01}, journal = {JOURNAL OF EDUCATIONAL SCIENCES & PSYCHOLOGY}, volume = {3}, number = {1}, pages = {111-120}, publisher = {PETROLEUM-GAS UNIV PLOIESTI}, address = {BD BUCURESTI 39, PLOIESTI, 100680, ROMANIA}, abstract = {Autism is a pervasive developmental disorder occurring at about the rate of one per hundred of the population. Past research has been interpreted to suggest that people with autism have profound deficits in understanding people's minds. The research summarized in this article suggests, however, that high functioning adults with autism differ in but a subtle way from comparison participants in the cognitive underpinnings of their social functioning. In particular, it seems participants with autism are fairly effective in interpreting psychological information from another person's eyes, are effective in following gaze and to some degree they are successful in guessing what happened to a person from their body language. In all of these skills, people with autism are not quite as skillful as people without autism. Speculations are offered on how developmental factors might contribute to lack of opportunity to refine cognitive skills associated with interpersonal activities in people with autism.}, keywords = {Autism, Developmental Disorders, Mentalizing, Social Functioning}, pubstate = {published}, tppubtype = {article} } Autism is a pervasive developmental disorder occurring at about the rate of one per hundred of the population. Past research has been interpreted to suggest that people with autism have profound deficits in understanding people's minds. The research summarized in this article suggests, however, that high functioning adults with autism differ in but a subtle way from comparison participants in the cognitive underpinnings of their social functioning. In particular, it seems participants with autism are fairly effective in interpreting psychological information from another person's eyes, are effective in following gaze and to some degree they are successful in guessing what happened to a person from their body language. In all of these skills, people with autism are not quite as skillful as people without autism. Speculations are offered on how developmental factors might contribute to lack of opportunity to refine cognitive skills associated with interpersonal activities in people with autism. |
2012 |
Abdullah, M N; Mohamad, W M Z W; Abdullah, M R; Yaacob, M J; Baharuddin, M S Perinatal, maternal and antenatal associated factors for autism: A case control study Conference 2012, ISBN: 9781467316668, (cited By 0). Abstract | Links | BibTeX | Tags: Antenatal, ASD, Autism, Autistic, Biomedical Engineering, Case-Control Studies, Delivery, Diseases, Hospitals, Logistics, Maternal, Obstetrics, Parents, Perinatal, Pregnancy, Prenatal, Retrospective, Risk Factor @conference{Abdullah2012144, title = {Perinatal, maternal and antenatal associated factors for autism: A case control study}, author = {M N Abdullah and W M Z W Mohamad and M R Abdullah and M J Yaacob and M S Baharuddin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876762294&doi=10.1109%2fIECBES.2012.6498121&partnerID=40&md5=b14466b2341cc29599332d94d866ea9a}, doi = {10.1109/IECBES.2012.6498121}, isbn = {9781467316668}, year = {2012}, date = {2012-01-01}, journal = {2012 IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2012}, pages = {144-148}, abstract = {Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 to 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the perinatal, maternal and antenatal associated factors associated with autistic disorder children. There were seven associated factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted Odds Ratio (OR): 1.41; 95% Confidence Interval (CI): (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 and 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics. © 2012 IEEE.}, note = {cited By 0}, keywords = {Antenatal, ASD, Autism, Autistic, Biomedical Engineering, Case-Control Studies, Delivery, Diseases, Hospitals, Logistics, Maternal, Obstetrics, Parents, Perinatal, Pregnancy, Prenatal, Retrospective, Risk Factor}, pubstate = {published}, tppubtype = {conference} } Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 to 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the perinatal, maternal and antenatal associated factors associated with autistic disorder children. There were seven associated factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted Odds Ratio (OR): 1.41; 95% Confidence Interval (CI): (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 and 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics. © 2012 IEEE. |
Yee, H S S Mobile technology for children with autism spectrum disorder: Major trends and issues Conference 2012, ISBN: 9781467323895, (cited By 17). Abstract | Links | BibTeX | Tags: Assistive Technology, Autism, Computer Technology, Diseases, E-learning, Mobile Devices, Mobile Technology, Mobile Telecommunication Systems, Research, Trends @conference{Yee20126, title = {Mobile technology for children with autism spectrum disorder: Major trends and issues}, author = {H S S Yee}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874045323&doi=10.1109%2fIS3e.2012.6414954&partnerID=40&md5=7ce6fc2bfa0651860ccbc3b48c67e1eb}, doi = {10.1109/IS3e.2012.6414954}, isbn = {9781467323895}, year = {2012}, date = {2012-01-01}, journal = {2012 IEEE Symposium on E-Learning, E-Management and E-Services, IS3e 2012}, pages = {6-10}, abstract = {Mobile devices had gained popularity among the special needs community. These mobile devices are the new and cool gadgets to be seen with, unlike the óld', complex and 'I-am-not-normal-looking' assistive devices. These mobile devices were said to serve as a communication device in the pocket, a learning device on the go and even a lifesaver for some. Among the features are its flexible multimedia content and storage, portability, mobility and affordability. The touch screen interface makes it appealing and simple to use, particularly for those who have weak fine motor skills. It offers practical communication solutions for autistic persons in relating to their families and others in the community. The flexibility and the advanced capabilities of mobile technology are opening new opportunities for further research in the area of computer-based intervention for children with ASD. Several anecdotal reports gave an early indication of the immense possibilities of how these devices could play a significant role in enhancing the quality of life of the children with ASD and their families. There is definitely lack of published research studies on the use of mobile technology with children with ASD. Due to the growing popularity of adopting mobile devices as assistive devices, more in depth research in warranted. © 2012 IEEE.}, note = {cited By 17}, keywords = {Assistive Technology, Autism, Computer Technology, Diseases, E-learning, Mobile Devices, Mobile Technology, Mobile Telecommunication Systems, Research, Trends}, pubstate = {published}, tppubtype = {conference} } Mobile devices had gained popularity among the special needs community. These mobile devices are the new and cool gadgets to be seen with, unlike the óld', complex and 'I-am-not-normal-looking' assistive devices. These mobile devices were said to serve as a communication device in the pocket, a learning device on the go and even a lifesaver for some. Among the features are its flexible multimedia content and storage, portability, mobility and affordability. The touch screen interface makes it appealing and simple to use, particularly for those who have weak fine motor skills. It offers practical communication solutions for autistic persons in relating to their families and others in the community. The flexibility and the advanced capabilities of mobile technology are opening new opportunities for further research in the area of computer-based intervention for children with ASD. Several anecdotal reports gave an early indication of the immense possibilities of how these devices could play a significant role in enhancing the quality of life of the children with ASD and their families. There is definitely lack of published research studies on the use of mobile technology with children with ASD. Due to the growing popularity of adopting mobile devices as assistive devices, more in depth research in warranted. © 2012 IEEE. |
Salih, M R M; Bahari, M B; Hassali, M A A; Shafie, A A; Al-Lela, O Q B; Abd, A Y; Ganesan, V M Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Journal Article Journal of Neurosciences in Rural Practice, 3 (3), pp. 244-250, 2012, ISSN: 09763147, (cited By 1). Abstract | Links | BibTeX | Tags: Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease @article{Salih2012244, title = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy}, author = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&partnerID=40&md5=039bd22d6c38366ebfdd00a4254c20f0}, doi = {10.4103/0976-3147.102596}, issn = {09763147}, year = {2012}, date = {2012-01-01}, journal = {Journal of Neurosciences in Rural Practice}, volume = {3}, number = {3}, pages = {244-250}, abstract = {Introduction: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form. Results: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.}, note = {cited By 1}, keywords = {Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease}, pubstate = {published}, tppubtype = {article} } Introduction: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form. Results: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients. |
Tan, E H; Yusoff, A A M; Abdullah, J M; Razak, S A Generalized epilepsy with febrile seizure plus (GEFS+) spectrum: Novel de novo mutation of SCN1A detected in a Malaysian patient Journal Article Journal of Pediatric Neurosciences, 7 (2), pp. 123-125, 2012, ISSN: 18171745, (cited By 3). Abstract | Links | BibTeX | Tags: Adolescent, Anxiety Disorder, Article, Autism, Carbamazepine, Case Report, Computer Assisted Tomography, Electroencephalogram, Electroencephalography, Febrile Convulsion, Gene, Generalized Epilepsy, Generalized Epilepsy with Febrile Seizure Plus, Human, Karyotype, Malaysia, Male, Medical History, Mental Deficiency, Missense Mutation, Nuclear Magnetic Resonance Imaging, Phenotype, SCN1A Gene, Tonic Clonic Seizure, Topiramate, Valproic Acid @article{Tan2012123, title = {Generalized epilepsy with febrile seizure plus (GEFS+) spectrum: Novel de novo mutation of SCN1A detected in a Malaysian patient}, author = {E H Tan and A A M Yusoff and J M Abdullah and S A Razak}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870194979&doi=10.4103%2f1817-1745.102575&partnerID=40&md5=b73f0bdb583e84404e0fff232faf30cb}, doi = {10.4103/1817-1745.102575}, issn = {18171745}, year = {2012}, date = {2012-01-01}, journal = {Journal of Pediatric Neurosciences}, volume = {7}, number = {2}, pages = {123-125}, abstract = {In this report, we describe a 15-year-old Malaysian male patient with a de novo SCN1A mutation who experienced prolonged febrile seizures after his first seizure at 6 months of age. This boy had generalized tonic clonic seizure (GTCS) which occurred with and without fever. Sequencing analysis of voltage-gated sodium channel a1-subunit gene, SCN1A, confirmed a homozygous A to G change at nucleotide 5197 (c.5197A > G) in exon 26 resulting in amino acid substitution of asparagines to aspartate at codon 1733 of sodium channel. The mutation identified in this patient is located in the pore-forming loop of SCN1A and this case report suggests missense mutation in pore-forming loop causes generalized epilepsy with febrile seizure plus (GEFS+) with clinically more severe neurologic phenotype including intellectual disabilities (mental retardation and autism features) and neuropsychiatric disease (anxiety disorder).}, note = {cited By 3}, keywords = {Adolescent, Anxiety Disorder, Article, Autism, Carbamazepine, Case Report, Computer Assisted Tomography, Electroencephalogram, Electroencephalography, Febrile Convulsion, Gene, Generalized Epilepsy, Generalized Epilepsy with Febrile Seizure Plus, Human, Karyotype, Malaysia, Male, Medical History, Mental Deficiency, Missense Mutation, Nuclear Magnetic Resonance Imaging, Phenotype, SCN1A Gene, Tonic Clonic Seizure, Topiramate, Valproic Acid}, pubstate = {published}, tppubtype = {article} } In this report, we describe a 15-year-old Malaysian male patient with a de novo SCN1A mutation who experienced prolonged febrile seizures after his first seizure at 6 months of age. This boy had generalized tonic clonic seizure (GTCS) which occurred with and without fever. Sequencing analysis of voltage-gated sodium channel a1-subunit gene, SCN1A, confirmed a homozygous A to G change at nucleotide 5197 (c.5197A > G) in exon 26 resulting in amino acid substitution of asparagines to aspartate at codon 1733 of sodium channel. The mutation identified in this patient is located in the pore-forming loop of SCN1A and this case report suggests missense mutation in pore-forming loop causes generalized epilepsy with febrile seizure plus (GEFS+) with clinically more severe neurologic phenotype including intellectual disabilities (mental retardation and autism features) and neuropsychiatric disease (anxiety disorder). |
Cheah, P -S; Ramshaw, H S; Thomas, P Q; Toyo-Oka, K; Xu, X; Martin, S; Coyle, P; Guthridge, M A; Stomski, F; Buuse, Van Den M; Wynshaw-Boris, A; Lopez, A F; Schwarz, Q P Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency Journal Article Molecular Psychiatry, 17 (4), pp. 451-466, 2012, ISSN: 13594184, (cited By 58). Abstract | Links | BibTeX | Tags: 14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Animals, Article, Autism, Behaviour Disorder, Bipolar Disorder, Brain, Cell Movement, Cells, Cognitive Defect, Controlled Study, Cultured, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Female, Gene, Gene Deletion, Genetic Predisposition to Disease, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Human, Hyperactivity, Inbred C57BL, Isoprotein, Knockout, Learning, Male, Maze Learning, Memory, Mice, Motor Activity, Mouse, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Nonhuman, Priority Journal, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Risk Factor, Schizophrenia, Sensory Gating, Synapse, Unclassified Drug @article{Cheah2012451, title = {Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency}, author = {P -S Cheah and H S Ramshaw and P Q Thomas and K Toyo-Oka and X Xu and S Martin and P Coyle and M A Guthridge and F Stomski and M Van Den Buuse and A Wynshaw-Boris and A F Lopez and Q P Schwarz}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859007028&doi=10.1038%2fmp.2011.158&partnerID=40&md5=7f507fef31a192a10b3cde7bf69b5442}, doi = {10.1038/mp.2011.158}, issn = {13594184}, year = {2012}, date = {2012-01-01}, journal = {Molecular Psychiatry}, volume = {17}, number = {4}, pages = {451-466}, abstract = {Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved.}, note = {cited By 58}, keywords = {14-3-3 Proteins, Animal Experiment, Animal Model, Animal Tissue, Animals, Article, Autism, Behaviour Disorder, Bipolar Disorder, Brain, Cell Movement, Cells, Cognitive Defect, Controlled Study, Cultured, Disease Models, Disrupted in Schizophrenia 1 Protein, Embryo, Female, Gene, Gene Deletion, Genetic Predisposition to Disease, Glutamic Acid, Hippocampal Mossy Fiber, Hippocampus, Human, Hyperactivity, Inbred C57BL, Isoprotein, Knockout, Learning, Male, Maze Learning, Memory, Mice, Motor Activity, Mouse, Neurogenesis, Neuronal Migration Disorder, Neurons, Neuropsychiatry, Nonhuman, Priority Journal, Protein 14-3-3, Protein 14-3-3 Zeta, Protein Deficiency, Protein Interaction, Recognition, Risk Factor, Schizophrenia, Sensory Gating, Synapse, Unclassified Drug}, pubstate = {published}, tppubtype = {article} } Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network. © 2012 Macmillan Publishers Limited All rights reserved. |
Clark, M; Brown, R; Karrapaya, R An initial look at the quality of life of Malaysian families that include children with disabilities Journal Article Journal of Intellectual Disability Research, 56 (1), pp. 45-60, 2012, ISSN: 09642633, (cited By 16). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Caregiver, Cerebral Palsy, Children, Cost of Illness, Cross-Cultural Comparison, Developmental Disabilities, Developmental Disorders, Disabled Children, Down Syndrome, Family, Family Health, Female, Health Care, Health Care Delivery, Health Survey, Human, Intellectual Disability, Intellectual Impairment, Life Satisfaction, Malaysia, Male, Parents, Policy, Preschool, Preschool Child, Psychometrics, Quality of Life, Questionnaires, School Child, Social Support, Socioeconomic Factors @article{Clark201245, title = {An initial look at the quality of life of Malaysian families that include children with disabilities}, author = {M Clark and R Brown and R Karrapaya}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-83855165819&doi=10.1111%2fj.1365-2788.2011.01408.x&partnerID=40&md5=4822406179501d1b0b93c5374e383637}, doi = {10.1111/j.1365-2788.2011.01408.x}, issn = {09642633}, year = {2012}, date = {2012-01-01}, journal = {Journal of Intellectual Disability Research}, volume = {56}, number = {1}, pages = {45-60}, abstract = {Background While there is a growing body of literature in the quality of life of families that include children with disabilities, the majority of research has been conducted in western countries. The present study provides an initial exploration of the quality of life of Malaysian families that include children with developmental/intellectual disabilities. Dynamics characterising Malaysian society are described as developments in social policy and service delivery that support persons with disabilities and their families. Method Questionnaire data were collected using the Family Quality of Life Survey - Short Version. Members of 52 families that included one or two children with disabilities were interviewed. Their responses provided their perceptions within six dimensions of family quality of life across the nine life domains assessed. Results Findings showed a consistent pattern of relatively strong perceived ímportance' ratings in each of life domains as compared to mean ratings for other family quality of life dimensions. Some dimensions of family quality of life, in particular ópportunities', ínitiative' and áttainment', demonstrated particularly strong associations with each other. Overall means of satisfaction with and attainment of family quality of life as well as global evaluations of quality of life and satisfaction all demonstrated significant associations, although each of these correlations accounted for less than 50% of the common variance. Conclusions The importance rating can be viewed as a determining factor in terms of quality of life, and it played a critical role in supporting attainment of, and satisfaction with, family quality of life, assuming opportunities, initiative and stability are adequate. The need for a broader sample including families that were not receiving services was noted. Future research questions based on the results of the current study and some of the dynamics impacting Malaysian society are also suggested. © 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd.}, note = {cited By 16}, keywords = {Adolescent, Adult, Article, Autism, Caregiver, Cerebral Palsy, Children, Cost of Illness, Cross-Cultural Comparison, Developmental Disabilities, Developmental Disorders, Disabled Children, Down Syndrome, Family, Family Health, Female, Health Care, Health Care Delivery, Health Survey, Human, Intellectual Disability, Intellectual Impairment, Life Satisfaction, Malaysia, Male, Parents, Policy, Preschool, Preschool Child, Psychometrics, Quality of Life, Questionnaires, School Child, Social Support, Socioeconomic Factors}, pubstate = {published}, tppubtype = {article} } Background While there is a growing body of literature in the quality of life of families that include children with disabilities, the majority of research has been conducted in western countries. The present study provides an initial exploration of the quality of life of Malaysian families that include children with developmental/intellectual disabilities. Dynamics characterising Malaysian society are described as developments in social policy and service delivery that support persons with disabilities and their families. Method Questionnaire data were collected using the Family Quality of Life Survey - Short Version. Members of 52 families that included one or two children with disabilities were interviewed. Their responses provided their perceptions within six dimensions of family quality of life across the nine life domains assessed. Results Findings showed a consistent pattern of relatively strong perceived ímportance' ratings in each of life domains as compared to mean ratings for other family quality of life dimensions. Some dimensions of family quality of life, in particular ópportunities', ínitiative' and áttainment', demonstrated particularly strong associations with each other. Overall means of satisfaction with and attainment of family quality of life as well as global evaluations of quality of life and satisfaction all demonstrated significant associations, although each of these correlations accounted for less than 50% of the common variance. Conclusions The importance rating can be viewed as a determining factor in terms of quality of life, and it played a critical role in supporting attainment of, and satisfaction with, family quality of life, assuming opportunities, initiative and stability are adequate. The need for a broader sample including families that were not receiving services was noted. Future research questions based on the results of the current study and some of the dynamics impacting Malaysian society are also suggested. © 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd. |
Dolah, Jasni; Yahaya, Wan Ahmad Jaafar Wan; Chong, Toh Seong; Mohamed, Rahman A Identifying Autism Symptoms using Autism Spectrum Quotient (ASQ) A survey amongst Universiti Sains Malaysia Students Inproceedings Isman, A; Liu, EZF; Kiyici, M (Ed.): 12TH INTERNATIONAL EDUCATIONAL TECHNOLOGY CONFERENCE - IETC 2012, pp. 618-625, ELSEVIER SCIENCE BV, SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2012, ISSN: 1877-0428, (12th International Educational Technology Conference (IETC), Taoyuan, TAIWAN, JUL 11-13, 2012). Abstract | Links | BibTeX | Tags: Autism, Quotient, Spectrum, Surveys, Symptom @inproceedings{ISI:000317142200072, title = {Identifying Autism Symptoms using Autism Spectrum Quotient (ASQ) A survey amongst Universiti Sains Malaysia Students}, author = {Jasni Dolah and Wan Ahmad Jaafar Wan Yahaya and Toh Seong Chong and Rahman A Mohamed}, editor = {A Isman and EZF Liu and M Kiyici}, doi = {10.1016/j.sbspro.2012.11.072}, issn = {1877-0428}, year = {2012}, date = {2012-01-01}, booktitle = {12TH INTERNATIONAL EDUCATIONAL TECHNOLOGY CONFERENCE - IETC 2012}, volume = {64}, pages = {618-625}, publisher = {ELSEVIER SCIENCE BV}, address = {SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, series = {Procedia Social and Behavioral Sciences}, abstract = {The advancement of ICT technology especially in detecting rare diseases has becomingly common in today's technology. One of the issues that arise is how this technology could help human to identify Autism characters? Little research has being made to educate society how to recognize this symptom and most of the past research was concentrated only for autistic child and none of the outcomes are dedicated for the society to understand. This study investigates the levels of autism symptoms amongst target respondents in Universiti Sains Malaysia by using Autism Spectrum Quotient (ASQ). This instruments is a questionnaire published in 2001 by Simon Baron-Cohen and it consists of fifty questions and it aims is to investigate whether adults of average intelligence have symptoms of autism or one of the other autism spectrum conditions. A quantitative survey method through the distribution of questionnaire and online survey form has being applied. The finding shows that significance levels of autism symptoms amongst respondents are rising and become silently increased. The findings from this study will help researcher to analyze and propose suitable method in identifying Autistic behavioral symptoms through engaging multimedia learning environment. (C) 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of The Association Science Education and Technology}, note = {12th International Educational Technology Conference (IETC), Taoyuan, TAIWAN, JUL 11-13, 2012}, keywords = {Autism, Quotient, Spectrum, Surveys, Symptom}, pubstate = {published}, tppubtype = {inproceedings} } The advancement of ICT technology especially in detecting rare diseases has becomingly common in today's technology. One of the issues that arise is how this technology could help human to identify Autism characters? Little research has being made to educate society how to recognize this symptom and most of the past research was concentrated only for autistic child and none of the outcomes are dedicated for the society to understand. This study investigates the levels of autism symptoms amongst target respondents in Universiti Sains Malaysia by using Autism Spectrum Quotient (ASQ). This instruments is a questionnaire published in 2001 by Simon Baron-Cohen and it consists of fifty questions and it aims is to investigate whether adults of average intelligence have symptoms of autism or one of the other autism spectrum conditions. A quantitative survey method through the distribution of questionnaire and online survey form has being applied. The finding shows that significance levels of autism symptoms amongst respondents are rising and become silently increased. The findings from this study will help researcher to analyze and propose suitable method in identifying Autistic behavioral symptoms through engaging multimedia learning environment. (C) 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of The Association Science Education and Technology |
2011 |
Shams, Khazaal W; Rahman, Abdul A W Characterizing autistic disorder based on principle component analysis Conference 2011, ISBN: 9781457714184, (cited By 6). Abstract | Links | BibTeX | Tags: Autism, Brain Function, Brain Signals, Classification Process, Data Dimensions, Diseases, Electroencephalogram Signals, Electroencephalography, Frequency Domain Analysis, Industrial Electronics, Motor Movements, Motor Tasks, PCA, Principal Component Analysis, Signal Detection, Time Frequency Domain @conference{KhazaalShams2011653, title = {Characterizing autistic disorder based on principle component analysis}, author = {W Khazaal Shams and A W Abdul Rahman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855644760&doi=10.1109%2fISIEA.2011.6108797&partnerID=40&md5=c486566e2d7ff404d830704c0b404067}, doi = {10.1109/ISIEA.2011.6108797}, isbn = {9781457714184}, year = {2011}, date = {2011-01-01}, journal = {2011 IEEE Symposium on Industrial Electronics and Applications, ISIEA 2011}, pages = {653-657}, abstract = {Autism is often diagnosed during preschool or toddled age. This diagnosis often depends on behavioral test. It is known that individuals with autism have abnormal brain signals different from typical persons yet this difference in signals is slight that it is often difficult to distinguish from the normal. However, Electroencephalogram (EEG) signals have a lot of information which reflect the behavior of brain functions which therefore captures the marker for autism, help to early diagnose and speed the treatment. This work investigates and compares classification process for autism in open-eyed tasks and motor movement by using Principle Component Analysis (PCA) for feature extracted in Time-frequency domain to reduce data dimension. The results show that the proposed method gives accuracy in the range 90-100% for autism and normal children in motor task and around 90% to detect normal in open-eyed tasks though difficult to detect autism in this task. © 2011 IEEE.}, note = {cited By 6}, keywords = {Autism, Brain Function, Brain Signals, Classification Process, Data Dimensions, Diseases, Electroencephalogram Signals, Electroencephalography, Frequency Domain Analysis, Industrial Electronics, Motor Movements, Motor Tasks, PCA, Principal Component Analysis, Signal Detection, Time Frequency Domain}, pubstate = {published}, tppubtype = {conference} } Autism is often diagnosed during preschool or toddled age. This diagnosis often depends on behavioral test. It is known that individuals with autism have abnormal brain signals different from typical persons yet this difference in signals is slight that it is often difficult to distinguish from the normal. However, Electroencephalogram (EEG) signals have a lot of information which reflect the behavior of brain functions which therefore captures the marker for autism, help to early diagnose and speed the treatment. This work investigates and compares classification process for autism in open-eyed tasks and motor movement by using Principle Component Analysis (PCA) for feature extracted in Time-frequency domain to reduce data dimension. The results show that the proposed method gives accuracy in the range 90-100% for autism and normal children in motor task and around 90% to detect normal in open-eyed tasks though difficult to detect autism in this task. © 2011 IEEE. |
Masuri, M G; Musa, N S; Isa, K A M The effects of animal assisted therapy in improving attention among autistic children Conference 2011, ISBN: 9781467300193, (cited By 0). Abstract | Links | BibTeX | Tags: Animals, Autism, Autistic Children, Behavioral Research, Children with Autism, Errors, Performance Tests, Sensory Integration, Student Performance, Students, Three Phasis @conference{Masuri2011813, title = {The effects of animal assisted therapy in improving attention among autistic children}, author = {M G Masuri and N S Musa and K A M Isa}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858995499&doi=10.1109%2fCHUSER.2011.6163849&partnerID=40&md5=1f29b24b9c2f78766401528f4e40a41d}, doi = {10.1109/CHUSER.2011.6163849}, isbn = {9781467300193}, year = {2011}, date = {2011-01-01}, journal = {2011 IEEE Colloquium on Humanities, Science and Engineering, CHUSER 2011}, pages = {813-818}, abstract = {Objective. This study examines the effect of Animal Assisted Therapy (AAT) towards improving attention among Autistic children. Method. A single case study using ABA design was used to measure duration of attention and errors omitted using Mesulam Continuous Performance Test (CPT) across three phases among 4 participants. Task Behavior/ Completion section in School Function Assessment (SFA) was given to teachers to rate student performance before and after intervention phase. Results. Results from this study showed that AAT did not improve attention and task behavior among 4 participants. However there is noted slight increase in attention among participants during the intervention phase. All participants also had slight decrease in attention during withdrawal phase. Decreases in numbers of errors omitted in CPM were noted in all participants during intervention phase. Conversely, all participants except participant 4 had increase in numbers of errors omitted during withdrawal phase. Result from Task behavior also showed no improvement. Conclusions. The findings from this study demonstrate that AAT did not improve attention and task behavior among Autistic children. However, the findings suggest that AAT can be one of treatment approach among Autistics children. Further study with longer timelines is needed to demonstrate a much better outcome as well as to ensure that the impact of the interventions really give an effect to the sample. © 2011 IEEE.}, note = {cited By 0}, keywords = {Animals, Autism, Autistic Children, Behavioral Research, Children with Autism, Errors, Performance Tests, Sensory Integration, Student Performance, Students, Three Phasis}, pubstate = {published}, tppubtype = {conference} } Objective. This study examines the effect of Animal Assisted Therapy (AAT) towards improving attention among Autistic children. Method. A single case study using ABA design was used to measure duration of attention and errors omitted using Mesulam Continuous Performance Test (CPT) across three phases among 4 participants. Task Behavior/ Completion section in School Function Assessment (SFA) was given to teachers to rate student performance before and after intervention phase. Results. Results from this study showed that AAT did not improve attention and task behavior among 4 participants. However there is noted slight increase in attention among participants during the intervention phase. All participants also had slight decrease in attention during withdrawal phase. Decreases in numbers of errors omitted in CPM were noted in all participants during intervention phase. Conversely, all participants except participant 4 had increase in numbers of errors omitted during withdrawal phase. Result from Task behavior also showed no improvement. Conclusions. The findings from this study demonstrate that AAT did not improve attention and task behavior among Autistic children. However, the findings suggest that AAT can be one of treatment approach among Autistics children. Further study with longer timelines is needed to demonstrate a much better outcome as well as to ensure that the impact of the interventions really give an effect to the sample. © 2011 IEEE. |
Valeria, N; Lau, B T Learn with me: Collaborative virtual learning for the special children Journal Article Communications in Computer and Information Science, 179 CCIS (PART 1), pp. 486-505, 2011, ISSN: 18650929, (cited By 0). Abstract | Links | BibTeX | Tags: Autism, Cerebral Palsy, Collaborative Learning, Collaborative Virtual Learning, Computer Supported Cooperative Work, Diseases, E-learning, Emotion, Face Recognition, Facial Expression, Gesture Recognition, Handicapped Persons, Software Engineering @article{Valeria2011486, title = {Learn with me: Collaborative virtual learning for the special children}, author = {N Valeria and B T Lau}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960383135&doi=10.1007%2f978-3-642-22170-5_42&partnerID=40&md5=89b9176492a888e25b3dc5711a8a9f97}, doi = {10.1007/978-3-642-22170-5_42}, issn = {18650929}, year = {2011}, date = {2011-01-01}, journal = {Communications in Computer and Information Science}, volume = {179 CCIS}, number = {PART 1}, pages = {486-505}, abstract = {Collaborative learning environment is regarded as stimulating and engaging for normal learners. The main aim of our research is to investigate its effectiveness in assisting the learning of children with disabilities. We developed a prototype, Learn with Me and conducted a testing on 6 children who have been diagnosed with cerebral palsy and 7 children who have been diagnosed with autism spectrum disorders. Participants were invited to take part in two tests. Result showed participants learn better with responsive virtual tutor as compared to non-responsive virtual learning. © 2011 Springer-Verlag.}, note = {cited By 0}, keywords = {Autism, Cerebral Palsy, Collaborative Learning, Collaborative Virtual Learning, Computer Supported Cooperative Work, Diseases, E-learning, Emotion, Face Recognition, Facial Expression, Gesture Recognition, Handicapped Persons, Software Engineering}, pubstate = {published}, tppubtype = {article} } Collaborative learning environment is regarded as stimulating and engaging for normal learners. The main aim of our research is to investigate its effectiveness in assisting the learning of children with disabilities. We developed a prototype, Learn with Me and conducted a testing on 6 children who have been diagnosed with cerebral palsy and 7 children who have been diagnosed with autism spectrum disorders. Participants were invited to take part in two tests. Result showed participants learn better with responsive virtual tutor as compared to non-responsive virtual learning. © 2011 Springer-Verlag. |
Freeth, M; Ropar, D; Mitchell, P; Chapman, P; Loher, S Journal of Autism and Developmental Disorders, 41 (3), pp. 364-371, 2011, ISSN: 01623257, (cited By 21). Abstract | Links | BibTeX | Tags: Adolescent, Article, Association, Attention, Autism, Child Development Disorders, Children, Clinical Article, Controlled Study, Cues, Emotion, Eye Fixation, Eye Movement, Eye Tracking, Female, Gaze, Human, Intelligence Quotient, Male, Mental Function, Mental Health, Perception, Pervasive, Photic Stimulation, Photostimulation, Priority Journal, Psychological Aspect, School Child, Social Aspect, Social Perception, Stimulus Response, Verbal Communication, Vision, Visual Perception, Visual Stimulation @article{Freeth2011364, title = {Brief report: How adolescents with ASD process social information in complex scenes. Combining evidence from eye movements and verbal descriptions}, author = {M Freeth and D Ropar and P Mitchell and P Chapman and S Loher}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79956006659&doi=10.1007%2fs10803-010-1053-4&partnerID=40&md5=35b5c8dd813f7eab2963b27081f11e78}, doi = {10.1007/s10803-010-1053-4}, issn = {01623257}, year = {2011}, date = {2011-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {41}, number = {3}, pages = {364-371}, abstract = {We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (aged 11-16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Nevertheless, the verbal descriptions revealed that participants with ASD frequently processed the observed person's emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed. © Springer Science+Business Media, LLC 2010.}, note = {cited By 21}, keywords = {Adolescent, Article, Association, Attention, Autism, Child Development Disorders, Children, Clinical Article, Controlled Study, Cues, Emotion, Eye Fixation, Eye Movement, Eye Tracking, Female, Gaze, Human, Intelligence Quotient, Male, Mental Function, Mental Health, Perception, Pervasive, Photic Stimulation, Photostimulation, Priority Journal, Psychological Aspect, School Child, Social Aspect, Social Perception, Stimulus Response, Verbal Communication, Vision, Visual Perception, Visual Stimulation}, pubstate = {published}, tppubtype = {article} } We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (aged 11-16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Nevertheless, the verbal descriptions revealed that participants with ASD frequently processed the observed person's emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed. © Springer Science+Business Media, LLC 2010. |
2010 |
Sudirman, ; Saidin, S; Safri, Mat N Study of electroencephalography signal of autism and down syndrome children using FFT Conference 2010, ISBN: 9781424476473, (cited By 15). Abstract | Links | BibTeX | Tags: Alpha Value, Autism, Down Syndrome, EEG Signals, Electroencephalography, Electrophysiology, Fast Fourier Transforms, Industrial Electronics, Metadata, User Interfaces, Visual Evoked Potential, Visualization @conference{Sudirman2010401, title = {Study of electroencephalography signal of autism and down syndrome children using FFT}, author = {Sudirman and S Saidin and N Mat Safri}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251542066&doi=10.1109%2fISIEA.2010.5679434&partnerID=40&md5=17fce4f69b27a3cc644f36c118b6ec6e}, doi = {10.1109/ISIEA.2010.5679434}, isbn = {9781424476473}, year = {2010}, date = {2010-01-01}, journal = {ISIEA 2010 - 2010 IEEE Symposium on Industrial Electronics and Applications}, pages = {401-406}, abstract = {Electroencephalography (EEG) signal between normal and special children is slightly different. Different types of special children will generate different shape of EEG patterns depend on their neurological function. This paper demonstrates the classification of EEG signal for special children: to determine and to classify level and pattern of EEG signal for autism and Down syndrome children. EEG signal was recorded and captured from normal and special children based on their visual response using Visual Evoked Potential (VEP) method. The data is analyzed using Fast Fourier Transform (FFT), so that, normal and special children can be distinguished based on alpha (α) value. As a result, alpha value for normal children at 10 Hz is higher than autism and Down syndrome children. A friendly user interface was built for easy storage and visualization. ©2010 IEEE.}, note = {cited By 15}, keywords = {Alpha Value, Autism, Down Syndrome, EEG Signals, Electroencephalography, Electrophysiology, Fast Fourier Transforms, Industrial Electronics, Metadata, User Interfaces, Visual Evoked Potential, Visualization}, pubstate = {published}, tppubtype = {conference} } Electroencephalography (EEG) signal between normal and special children is slightly different. Different types of special children will generate different shape of EEG patterns depend on their neurological function. This paper demonstrates the classification of EEG signal for special children: to determine and to classify level and pattern of EEG signal for autism and Down syndrome children. EEG signal was recorded and captured from normal and special children based on their visual response using Visual Evoked Potential (VEP) method. The data is analyzed using Fast Fourier Transform (FFT), so that, normal and special children can be distinguished based on alpha (α) value. As a result, alpha value for normal children at 10 Hz is higher than autism and Down syndrome children. A friendly user interface was built for easy storage and visualization. ©2010 IEEE. |
Razali, N; Rahman, A W A Motor movement for autism spectrum disorder (ASD) detection Conference 2010, ISBN: 9789791948913, (cited By 3). Abstract | Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Autistic Children, Children with Autism, Data Collection, Diseases, Early Detection, Early Intervention, Finger Tapping, Gaussian Mixture Model, Information Technology, Motor Movements, Multi Layer Perceptron, Multilayer Perceptron (MLP), Multilayers @conference{Razali2010, title = {Motor movement for autism spectrum disorder (ASD) detection}, author = {N Razali and A W A Rahman}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052346152&doi=10.1109%2fICT4M.2010.5971921&partnerID=40&md5=234cdd8f3906ad980ed163a1036215ee}, doi = {10.1109/ICT4M.2010.5971921}, isbn = {9789791948913}, year = {2010}, date = {2010-01-01}, journal = {Proceeding of the 3rd International Conference on Information and Communication Technology for the Moslem World: ICT Connecting Cultures, ICT4M 2010}, pages = {E90-E95}, abstract = {In this paper, we are looking at the differences between autistic and normal children in term of fine motor movement. Previous findings have shown that there are differences between autistic children and normal children when performing a simple motor movement tasks. Imitating a finger tapping and clinching a hand are two examples of a simple motor movement tasks. Our study had adopted one of the video stimuli for clinching the hand from Brainmarkers. 6 selected autistic children and 6 selected normal children were involved in this study. The data collection is using EEG device and will be analyzed using Gaussian mixture model (GMM) and Multilayer perceptron (MLP) as classifier to discriminate between autistic and normal children. Experimental result shows the potential of verifying between autistic and normal children with accuracy of 92%. The potential of using these techniques to identify autistic children can help early detection for the purpose of early intervention. Moreover, the spectrums of the signals also present big differences between the two groups. © 2010 IEEE.}, note = {cited By 3}, keywords = {Autism, Autism Spectrum Disorders, Autistic Children, Children with Autism, Data Collection, Diseases, Early Detection, Early Intervention, Finger Tapping, Gaussian Mixture Model, Information Technology, Motor Movements, Multi Layer Perceptron, Multilayer Perceptron (MLP), Multilayers}, pubstate = {published}, tppubtype = {conference} } In this paper, we are looking at the differences between autistic and normal children in term of fine motor movement. Previous findings have shown that there are differences between autistic children and normal children when performing a simple motor movement tasks. Imitating a finger tapping and clinching a hand are two examples of a simple motor movement tasks. Our study had adopted one of the video stimuli for clinching the hand from Brainmarkers. 6 selected autistic children and 6 selected normal children were involved in this study. The data collection is using EEG device and will be analyzed using Gaussian mixture model (GMM) and Multilayer perceptron (MLP) as classifier to discriminate between autistic and normal children. Experimental result shows the potential of verifying between autistic and normal children with accuracy of 92%. The potential of using these techniques to identify autistic children can help early detection for the purpose of early intervention. Moreover, the spectrums of the signals also present big differences between the two groups. © 2010 IEEE. |
Sheppard, E; Ropar, D; Underwood, G; Loon, Van E Brief report: Driving hazard perception in autism Journal Article Journal of Autism and Developmental Disorders, 40 (4), pp. 504-508, 2010, ISSN: 01623257, (cited By 42). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Association, Autism, Autism Spectrum Disorders, Automobile Driving, Car Driving, Case-Control Studies, Clinical Article, Controlled Study, Hazard Assessment, Human, Information Processing, Intelligence Quotient, Male, Mental Health, Motor Dysfunction, Neuropsychological Tests, Perception, Photic Stimulation, Priority Journal, Reaction Time, Social Perception, Traffic Accident, Traffic Safety, Visual Impairment, Visual Perception, Visual Stimulation, Young Adult @article{Sheppard2010504, title = {Brief report: Driving hazard perception in autism}, author = {E Sheppard and D Ropar and G Underwood and E Van Loon}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954458984&doi=10.1007%2fs10803-009-0890-5&partnerID=40&md5=f0036a737ebb461359baf1bd8b388b23}, doi = {10.1007/s10803-009-0890-5}, issn = {01623257}, year = {2010}, date = {2010-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {40}, number = {4}, pages = {504-508}, abstract = {This study investigated whether individuals with ASD (autistic spectrum disorders) are able to identify driving hazards, given their difficulties processing social information, Klin et al. (Archives of General Psychiatry 59: 809-816, 2002). Twenty-three adult males with ASD and 21 comparison participants viewed 10 video clips containing driving hazards. In half of the clips the source of the hazard was a visible person (social); in the other half the source was a car (non-social). Participants with ASD identified fewer social hazards than the comparison participants (U = 163.00}, note = {cited By 42}, keywords = {Adolescent, Adult, Article, Association, Autism, Autism Spectrum Disorders, Automobile Driving, Car Driving, Case-Control Studies, Clinical Article, Controlled Study, Hazard Assessment, Human, Information Processing, Intelligence Quotient, Male, Mental Health, Motor Dysfunction, Neuropsychological Tests, Perception, Photic Stimulation, Priority Journal, Reaction Time, Social Perception, Traffic Accident, Traffic Safety, Visual Impairment, Visual Perception, Visual Stimulation, Young Adult}, pubstate = {published}, tppubtype = {article} } This study investigated whether individuals with ASD (autistic spectrum disorders) are able to identify driving hazards, given their difficulties processing social information, Klin et al. (Archives of General Psychiatry 59: 809-816, 2002). Twenty-three adult males with ASD and 21 comparison participants viewed 10 video clips containing driving hazards. In half of the clips the source of the hazard was a visible person (social); in the other half the source was a car (non-social). Participants with ASD identified fewer social hazards than the comparison participants (U = 163.00 |
Patel, V; Maj, M; Flisher, A J; Silva, De M J; Koschorke, M; Prince, M; Tempier, R; Riba, M B; Sanchez, M; Campodonico, F D; Risco, L; Gask, L; Wahlberg, H; Roca, M; Lecic-Tosevski, D; Soghoyan, A; Moussaoui, D; Baddoura, C; Adeyemi, J; Rataemane, S; Jalili, S A; Mohandas, E; Shinfuku, N; Freidin, J; Stagnaro, J C; Puig, I J; Kirkby, K; Musalek, M; Ismayilov, N; Rabbani, G; Harvey, S; Sabbe, B; Noya-Tapia, N; Burgic-Radmanovic, M; Hetem, L A; Vasconcellos, F; Maass, J; Miranda, C; Papaneophytou, N; Raboch, J; Fink-Jensen, A; Okasha, A; Korkeila, J; Guelfi, J D; Schneider, F; Ohene, S; Christodoulou, G; Soldatos, C R; Barrera, S K E Q; Mendoza, M; Kallivayalil, R A; Gudarzi, S S; Lafta, M R; Bassi, M; Clerici, M; Gibson, R; Kojima, T; Nurmagambetova, S; Cho, S -C; Kadyrova, T; Mikati, N; Bajraktarov, S; Yen, T H; Ayushjav, B; Stevovic, L I; Molina, J S S; Gureje, O; Johannessen, J O; Chaudhry, H R; Al-Ashhab, B; Araszkiewicz, A; Prelipceanu, D; Krasnov, V; Bogdanov, A; Jasovic-Gasic, M; Vavrusova, L; Pregelj, P; Liria, A F; Abdelrahman, A; Udomratn, P; Ulas, H; Gokaip, P; Kigozi, F N; Richardson, G Reducing the treatment gap for mental disorders: A WPA survey Journal Article World Psychiatry, 9 (3), pp. 169-176, 2010, ISSN: 17238617, (cited By 127). Abstract | Links | BibTeX | Tags: Anxiety Disorder, Article, Atomoxetine, Atypical Antipsychotic Agent, Autism, Benzodiazepine, Bipolar Disorder, Central Nervous System Stimulants, Cholinesterase Inhibitor, Cognitive Therapy, Community Mental Health Center, Conduct Disorder, Cost Effectiveness Analysis, Dementia, Depression, Evidence-based Practice, Family, Family Therapy, Haloperidol, Health Care, Health Care Access, Health Care Delivery, Health Care Personnel, Health Practitioner, Health Survey, Help Seeking Behavior, Home Mental Health Care, Human, Hyperkinesia, Long Term Care, Lowest Income Group, Mental Deficiency, Mental Disease, Mental Health, Mental Health Care, Mental Health Service, Nootropic Agent, Open Ended Questionnaire, Outcome Assessment, Patient Compliance, Personality Disorder, Practice Guideline, Priority Journal, Psychiatry, Psychoeducation, Psychotherapy, Schizophrenia, Serotonin Noradrenalin Reuptake Inhibitor, Serotonin Uptake Inhibitor, Substance Abuse, Therapy, Therapy Delay, Tricyclic Antidepressant Agent, World Health Organization @article{Patel2010169, title = {Reducing the treatment gap for mental disorders: A WPA survey}, author = {V Patel and M Maj and A J Flisher and M J De Silva and M Koschorke and M Prince and R Tempier and M B Riba and M Sanchez and F D Campodonico and L Risco and L Gask and H Wahlberg and M Roca and D Lecic-Tosevski and A Soghoyan and D Moussaoui and C Baddoura and J Adeyemi and S Rataemane and S A Jalili and E Mohandas and N Shinfuku and J Freidin and J C Stagnaro and I J Puig and K Kirkby and M Musalek and N Ismayilov and G Rabbani and S Harvey and B Sabbe and N Noya-Tapia and M Burgic-Radmanovic and L A Hetem and F Vasconcellos and J Maass and C Miranda and N Papaneophytou and J Raboch and A Fink-Jensen and A Okasha and J Korkeila and J D Guelfi and F Schneider and S Ohene and G Christodoulou and C R Soldatos and S K E Q Barrera and M Mendoza and R A Kallivayalil and S S Gudarzi and M R Lafta and M Bassi and M Clerici and R Gibson and T Kojima and S Nurmagambetova and S -C Cho and T Kadyrova and N Mikati and S Bajraktarov and T H Yen and B Ayushjav and L I Stevovic and J S S Molina and O Gureje and J O Johannessen and H R Chaudhry and B Al-Ashhab and A Araszkiewicz and D Prelipceanu and V Krasnov and A Bogdanov and M Jasovic-Gasic and L Vavrusova and P Pregelj and A F Liria and A Abdelrahman and P Udomratn and H Ulas and P Gokaip and F N Kigozi and G Richardson}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79851492757&doi=10.1002%2fj.2051-5545.2010.tb00305.x&partnerID=40&md5=ebf47e1e84f22271aea10a73c93e9892}, doi = {10.1002/j.2051-5545.2010.tb00305.x}, issn = {17238617}, year = {2010}, date = {2010-01-01}, journal = {World Psychiatry}, volume = {9}, number = {3}, pages = {169-176}, publisher = {Blackwell Publishing Ltd}, abstract = {The treatment gap for people with mental disorders exceeds 50% in all countries of the world, approaching astonishingly high rates of 90% in the least resourced countries. We report the findings of the first systematic survey of leaders of psychiatry in nearly 60 countries on the strategies for reducing the treatment gap. We sought to elicit the views of these representatives on the roles of different human resources and health care settings in delivering care and on the importance of a range of strategies to increase the coverage of evidence-based treatments for priority mental disorders for each demographic stage (childhood, adolescence, adulthood and old age). Our findings clearly indicate three strategies for reducing the treatment gap: increasing the numbers of psychiatrists and other mental health professionals; increasing the involvement of a range of appropriately trained non-specialist providers; and the active involvement of people affected by mental disorders. This is true for both high income and low/middle income countries, though relatively of more importance in the latter. We view this survey as a critically important first step in ascertaining the position of psychiatrists, one of the most influential stakeholder communities in global mental health, in addressing the global challenge of scaling up mental health services to reduce the treatment gap.}, note = {cited By 127}, keywords = {Anxiety Disorder, Article, Atomoxetine, Atypical Antipsychotic Agent, Autism, Benzodiazepine, Bipolar Disorder, Central Nervous System Stimulants, Cholinesterase Inhibitor, Cognitive Therapy, Community Mental Health Center, Conduct Disorder, Cost Effectiveness Analysis, Dementia, Depression, Evidence-based Practice, Family, Family Therapy, Haloperidol, Health Care, Health Care Access, Health Care Delivery, Health Care Personnel, Health Practitioner, Health Survey, Help Seeking Behavior, Home Mental Health Care, Human, Hyperkinesia, Long Term Care, Lowest Income Group, Mental Deficiency, Mental Disease, Mental Health, Mental Health Care, Mental Health Service, Nootropic Agent, Open Ended Questionnaire, Outcome Assessment, Patient Compliance, Personality Disorder, Practice Guideline, Priority Journal, Psychiatry, Psychoeducation, Psychotherapy, Schizophrenia, Serotonin Noradrenalin Reuptake Inhibitor, Serotonin Uptake Inhibitor, Substance Abuse, Therapy, Therapy Delay, Tricyclic Antidepressant Agent, World Health Organization}, pubstate = {published}, tppubtype = {article} } The treatment gap for people with mental disorders exceeds 50% in all countries of the world, approaching astonishingly high rates of 90% in the least resourced countries. We report the findings of the first systematic survey of leaders of psychiatry in nearly 60 countries on the strategies for reducing the treatment gap. We sought to elicit the views of these representatives on the roles of different human resources and health care settings in delivering care and on the importance of a range of strategies to increase the coverage of evidence-based treatments for priority mental disorders for each demographic stage (childhood, adolescence, adulthood and old age). Our findings clearly indicate three strategies for reducing the treatment gap: increasing the numbers of psychiatrists and other mental health professionals; increasing the involvement of a range of appropriately trained non-specialist providers; and the active involvement of people affected by mental disorders. This is true for both high income and low/middle income countries, though relatively of more importance in the latter. We view this survey as a critically important first step in ascertaining the position of psychiatrists, one of the most influential stakeholder communities in global mental health, in addressing the global challenge of scaling up mental health services to reduce the treatment gap. |
2009 |
Yusoff, Mohd N; Wahab, Abdul M H; Aziz, M A; AshaÁri, Jalil F ESSE: Learning disability classification system for autism and dyslexia Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 5614 LNCS (PART 1), pp. 395-402, 2009, ISSN: 03029743, (cited By 2). Abstract | Links | BibTeX | Tags: Autism, Centralized Decision Making, Classification System, Decision Making, Errors, Expert Systems, Human Computer Interaction, Human Errors, Knowledge Engineering, Knowledge Management, Knowledge-Based Classification, Learning Disorder, Malaysia, Special Education, Teaching @article{MohdYusoff2009395, title = {ESSE: Learning disability classification system for autism and dyslexia}, author = {N Mohd Yusoff and M H Abdul Wahab and M A Aziz and F Jalil AshaÁri}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-76249116153&doi=10.1007%2f978-3-642-02707-9_45&partnerID=40&md5=f51c6dd35a86b7eef7ee117d1daa41dd}, doi = {10.1007/978-3-642-02707-9_45}, issn = {03029743}, year = {2009}, date = {2009-01-01}, journal = {Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)}, volume = {5614 LNCS}, number = {PART 1}, pages = {395-402}, abstract = {This paper presents an Expert System for Special Education (ESSE) based on scenario in Malaysia. This system is developed through the process of knowledge-gaining which is gathered from various expertise in chosen domain. Realizing the limitation of traditional classification system that teachers adopted, we developed ESSE to automate a centralized decision making system. ESSE is also able to provide consistent answers for repetitive decisions, processes and tasks. Besides, teachers using this system hold and maintain significant level of information pertaining both learning disabilities, thus reduce amount of human errors. ESSE knowledge-based resulted from the knowledge engineering called Qualifiers and Choice. Both are gathered from the analysis of symptoms that are experienced by Autism and Dyslexia patients. Every type of disability is divided to several categories and sub-category to facilitate question's arrangement. This paper presents a review of Expert System for Special Education (ESSE), problems arises and the knowledge-based classification systems. © 2009 Springer Berlin Heidelberg.}, note = {cited By 2}, keywords = {Autism, Centralized Decision Making, Classification System, Decision Making, Errors, Expert Systems, Human Computer Interaction, Human Errors, Knowledge Engineering, Knowledge Management, Knowledge-Based Classification, Learning Disorder, Malaysia, Special Education, Teaching}, pubstate = {published}, tppubtype = {article} } This paper presents an Expert System for Special Education (ESSE) based on scenario in Malaysia. This system is developed through the process of knowledge-gaining which is gathered from various expertise in chosen domain. Realizing the limitation of traditional classification system that teachers adopted, we developed ESSE to automate a centralized decision making system. ESSE is also able to provide consistent answers for repetitive decisions, processes and tasks. Besides, teachers using this system hold and maintain significant level of information pertaining both learning disabilities, thus reduce amount of human errors. ESSE knowledge-based resulted from the knowledge engineering called Qualifiers and Choice. Both are gathered from the analysis of symptoms that are experienced by Autism and Dyslexia patients. Every type of disability is divided to several categories and sub-category to facilitate question's arrangement. This paper presents a review of Expert System for Special Education (ESSE), problems arises and the knowledge-based classification systems. © 2009 Springer Berlin Heidelberg. |
2008 |
Amar, H S S Meeting the needs of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 1-3, 2008, ISSN: 03005283, (cited By 20). Links | BibTeX | Tags: Autism, Behaviour Modification, Child Development, Child Health Care, Children, Clinical Assessment, Clinical Decision Making, Developmental Disorders, Developmental Screening, Disabled Children, Editorial, Health Care, Health Care Delivery, Health Practitioner, Health Program, Health Survey, Human, Intellectual Impairment, Learning Disorder, Malaysia, Pediatric Physiotherapy, Pediatric Rehabilitation, Physical Disability, Preschool, Public Health Service, Register, Sensitivity and Specificity, Sensory Dysfunction, Social Adaptation, Social Welfare, Speech Therapy, Support Group, United Kingdom, United States @article{Amar20081, title = {Meeting the needs of children with disability in Malaysia}, author = {H S S Amar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49749107033&partnerID=40&md5=968c527b940374a37322a599d3ccc812}, issn = {03005283}, year = {2008}, date = {2008-01-01}, journal = {Medical Journal of Malaysia}, volume = {63}, number = {1}, pages = {1-3}, note = {cited By 20}, keywords = {Autism, Behaviour Modification, Child Development, Child Health Care, Children, Clinical Assessment, Clinical Decision Making, Developmental Disorders, Developmental Screening, Disabled Children, Editorial, Health Care, Health Care Delivery, Health Practitioner, Health Program, Health Survey, Human, Intellectual Impairment, Learning Disorder, Malaysia, Pediatric Physiotherapy, Pediatric Rehabilitation, Physical Disability, Preschool, Public Health Service, Register, Sensitivity and Specificity, Sensory Dysfunction, Social Adaptation, Social Welfare, Speech Therapy, Support Group, United Kingdom, United States}, pubstate = {published}, tppubtype = {article} } |
Tan, K L; Yadav, H Reassessment on the development of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 17-20, 2008, ISSN: 03005283, (cited By 5). Abstract | Links | BibTeX | Tags: Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance @article{Tan200817, title = {Reassessment on the development of children with disability in Malaysia}, author = {K L Tan and H Yadav}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649115291&partnerID=40&md5=8838ddaa3d9906d8b696be13e88f1baa}, issn = {03005283}, year = {2008}, date = {2008-01-01}, journal = {Medical Journal of Malaysia}, volume = {63}, number = {1}, pages = {17-20}, abstract = {This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. A total of 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autism, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment.}, note = {cited By 5}, keywords = {Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance}, pubstate = {published}, tppubtype = {article} } This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. A total of 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autism, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment. |
2006 |
Blum, J D; Talib, N Balancing individual rights versus collective good in public health enforcement Journal Article Medicine and Law, 25 (2), pp. 273-281, 2006, ISSN: 07231393, (cited By 6). Abstract | Links | BibTeX | Tags: Article, Autism, Childhood, Court, Freedom, Government, Harm Reduction, Human, Human Rights, Immunization, Infection Control, Infection Prevention, Jurisprudence, Mercury, Parental Behavior, Public Health Service, Severe Acute Respiratory Syndrome, Severe Acute Respiratory Syndrome Vaccine, Social Isolation, Treatment Refusal, United States, Vaccination @article{Blum2006273, title = {Balancing individual rights versus collective good in public health enforcement}, author = {J D Blum and N Talib}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746936600&partnerID=40&md5=a2c4c6236febc643356d94b27241a893}, issn = {07231393}, year = {2006}, date = {2006-01-01}, journal = {Medicine and Law}, volume = {25}, number = {2}, pages = {273-281}, publisher = {Yozmot Heiliger Ltd}, abstract = {This paper explores the balance between common good and individual liberty in the context of public health regulation. The issues are explored in reference to two areas of regulation, isolation and quarantine in the case of SARS, and the rights of parents to refuse mandatory childhood immunizations. In the case of SARS, the analysis explores the age old practice of isolation and quarantine, an important preventive measure with clear civil liberty implications. In reference to childhood immunization the paper considers the American controversy involving the refusal of parents to have their children vaccinated, fearing that mercury in vaccines will lead to autism. The analysis explores the US Supreme Court case of Jacobson v. Massachusetts which 100 years ago established a four part test for evaluating claims of individuals that government public health authorities were infringing on their liberty interests. The paper endorses the four elements of necessity, reasonableness, proportionality, and harm avoidance identified in Jacobson, but calls for a more rigorous scientific evaluation to accompany this traditional test. © YOZMOT 2006.}, note = {cited By 6}, keywords = {Article, Autism, Childhood, Court, Freedom, Government, Harm Reduction, Human, Human Rights, Immunization, Infection Control, Infection Prevention, Jurisprudence, Mercury, Parental Behavior, Public Health Service, Severe Acute Respiratory Syndrome, Severe Acute Respiratory Syndrome Vaccine, Social Isolation, Treatment Refusal, United States, Vaccination}, pubstate = {published}, tppubtype = {article} } This paper explores the balance between common good and individual liberty in the context of public health regulation. The issues are explored in reference to two areas of regulation, isolation and quarantine in the case of SARS, and the rights of parents to refuse mandatory childhood immunizations. In the case of SARS, the analysis explores the age old practice of isolation and quarantine, an important preventive measure with clear civil liberty implications. In reference to childhood immunization the paper considers the American controversy involving the refusal of parents to have their children vaccinated, fearing that mercury in vaccines will lead to autism. The analysis explores the US Supreme Court case of Jacobson v. Massachusetts which 100 years ago established a four part test for evaluating claims of individuals that government public health authorities were infringing on their liberty interests. The paper endorses the four elements of necessity, reasonableness, proportionality, and harm avoidance identified in Jacobson, but calls for a more rigorous scientific evaluation to accompany this traditional test. © YOZMOT 2006. |
2005 |
Jayachandra, S Is secretin effective in treatment for Autism Spectrum Disorders (ASD)? Journal Article International Journal of Psychiatry in Medicine, 35 (1), pp. 99-101, 2005, ISSN: 00912174, (cited By 2). Links | BibTeX | Tags: Autism, Autism Spectrum Disorders, Children, Clinical Trial, Drug Effect, Drug Efficacy, Drug Mechanism, Gastrointestinal Symptom, Human, Hypersensitivity, Injections, Intravenous, Letter, Secretin, Treatment Outcome @article{Jayachandra200599, title = {Is secretin effective in treatment for Autism Spectrum Disorders (ASD)?}, author = {S Jayachandra}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-23044481281&doi=10.2190%2fQ1D2-5DNB-V4FJ-J9M5&partnerID=40&md5=791bd90c9cdaa7b82bc5d7e8b8c5a7de}, doi = {10.2190/Q1D2-5DNB-V4FJ-J9M5}, issn = {00912174}, year = {2005}, date = {2005-01-01}, journal = {International Journal of Psychiatry in Medicine}, volume = {35}, number = {1}, pages = {99-101}, note = {cited By 2}, keywords = {Autism, Autism Spectrum Disorders, Children, Clinical Trial, Drug Effect, Drug Efficacy, Drug Mechanism, Gastrointestinal Symptom, Human, Hypersensitivity, Injections, Intravenous, Letter, Secretin, Treatment Outcome}, pubstate = {published}, tppubtype = {article} } |
Jayachandra, S Need for internet based scoring system for autism treatment evaluation [2] Journal Article Journal of Autism and Developmental Disorders, 35 (5), pp. 685, 2005, ISSN: 01623257, (cited By 1). Links | BibTeX | Tags: Asperger Syndrome, Autism, Autism Spectrum Disorders, Diagnostic and Statistical Manual of Mental Disorders, Evaluation, Health Service, Health Services Needs and Demand, Human, Infant, Infantile Autism, Instrumentation, Internet, Letter, Priority Journal, Psychoeducation, Psychotherapy, Reliability, Scoring System, Treatment Outcome @article{Jayachandra2005685, title = {Need for internet based scoring system for autism treatment evaluation [2]}, author = {S Jayachandra}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644946467&doi=10.1007%2fs10803-005-0016-7&partnerID=40&md5=6d3e95280dce87a6ec735d67e27fe5bc}, doi = {10.1007/s10803-005-0016-7}, issn = {01623257}, year = {2005}, date = {2005-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {35}, number = {5}, pages = {685}, publisher = {Springer Science and Business Media Deutschland GmbH}, note = {cited By 1}, keywords = {Asperger Syndrome, Autism, Autism Spectrum Disorders, Diagnostic and Statistical Manual of Mental Disorders, Evaluation, Health Service, Health Services Needs and Demand, Human, Infant, Infantile Autism, Instrumentation, Internet, Letter, Priority Journal, Psychoeducation, Psychotherapy, Reliability, Scoring System, Treatment Outcome}, pubstate = {published}, tppubtype = {article} } |
1995 |
Kasmini, K; Zasmani, S Asperger's syndrome: a report of two cases from Malaysia. Journal Article Singapore medical journal, 36 (6), pp. 641-643, 1995, ISSN: 00375675, (cited By 2). Abstract | Links | BibTeX | Tags: Article, Autism, Autism Spectrum Disorders, Case Report, Child Development Disorders, Children, Classification (of information), Human, Language Development Disorders, Language Disability, Malaysia, Male, Pervasive, Psychiatric Status Rating Scales, Psychological Aspect, Psychological Rating Scale, Social Behaviour, Stereotyped Behaviour, Stereotypy, Syndrome @article{Kasmini1995641, title = {Asperger's syndrome: a report of two cases from Malaysia.}, author = {K Kasmini and S Zasmani}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029445569&partnerID=40&md5=6280382e5c679f84eea178a916b2e19f}, issn = {00375675}, year = {1995}, date = {1995-01-01}, journal = {Singapore medical journal}, volume = {36}, number = {6}, pages = {641-643}, abstract = {Asperger's Syndrome is a distinct variant of autism, with a prevalence rate of 10 to 26 per 10,000 of normal intelligence, and 0.4 per 10,000 in those with mild mental retardation. The syndrome now has its own clinical entity and diagnostic criteria. It is being officially listed in the ICD-10 under pervasive developmental disorder. Two such cases are described in this article. Case One lacked the ability to relate to others, was excessively preoccupied with the late actor P. Ramlee and demonstrated a peculiar behaviour of holding on to toothbrushes in his early childhood. Cognitively, he was unable to synthesise words into meaningful sentences. Similarly, Case Two was unable to relate well to others and was preoccupied with the planets and its constellations. Though he appeared intelligent with an IQ score of 101, he was unable to follow instructions at school. Both children had motor clumsiness and fulfilled the criteria for the diagnosis of Asperger's Syndrome.}, note = {cited By 2}, keywords = {Article, Autism, Autism Spectrum Disorders, Case Report, Child Development Disorders, Children, Classification (of information), Human, Language Development Disorders, Language Disability, Malaysia, Male, Pervasive, Psychiatric Status Rating Scales, Psychological Aspect, Psychological Rating Scale, Social Behaviour, Stereotyped Behaviour, Stereotypy, Syndrome}, pubstate = {published}, tppubtype = {article} } Asperger's Syndrome is a distinct variant of autism, with a prevalence rate of 10 to 26 per 10,000 of normal intelligence, and 0.4 per 10,000 in those with mild mental retardation. The syndrome now has its own clinical entity and diagnostic criteria. It is being officially listed in the ICD-10 under pervasive developmental disorder. Two such cases are described in this article. Case One lacked the ability to relate to others, was excessively preoccupied with the late actor P. Ramlee and demonstrated a peculiar behaviour of holding on to toothbrushes in his early childhood. Cognitively, he was unable to synthesise words into meaningful sentences. Similarly, Case Two was unable to relate well to others and was preoccupied with the planets and its constellations. Though he appeared intelligent with an IQ score of 101, he was unable to follow instructions at school. Both children had motor clumsiness and fulfilled the criteria for the diagnosis of Asperger's Syndrome. |