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Eow, S Y; Gan, W Y; Lim, P Y; Awang, H; Shariff, Mohd Z

Factors associated with autism severity among Malaysian children with Autism Spectrum Disorder Journal Article

Research in Developmental Disabilities, 100 , 2020, ISSN: 08914222, (cited By 0).

Abstract | Links | BibTeX | Tags: Article, Autism, Body Weight, Children, Cross-Sectional Study, Demography, Disease Association, Disease Severity, Employment, Female, Human, Lifestyle, Major Clinical Study, Malaysia, Malaysian, Male, Parents, Preschool Child, School Child, Social Status

de Vries, M; Cader, S; Colleer, L; Batteux, E; Yasdiman, M B; Tan, Y J; Sheppard, E

University Students’ Notion of Autism Spectrum Conditions: A Cross-Cultural Study Journal Article

Journal of Autism and Developmental Disorders, 50 (4), pp. 1281-1294, 2020, ISSN: 01623257, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Attitude to Health, Autism, Female, Health Belief, Human, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Malaysian, Male, Priority Journal, Social Acceptance, Social Interactions, Sociology, Student Attitude, Students, United Kingdom, University Student, Young Adult

Singh, Balbir H K; Badgujar, V B; Yahaya, R S; Rahman, Abd S; Sami, F M; Badgujar, S; Govindan, S N; Ansari, M T

Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia Journal Article

Human Vaccines and Immunotherapeutics, 15 (11), pp. 2544-2551, 2019, ISSN: 21645515, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Attitude, Attitude to Health, Autism, Child Health, Childhood Vaccination, Children, Cross-Sectional Study, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Education, Employment, Ethnicity, Female, Health Knowledge, Human, Immunization Programs, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Mother, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Preschool Child, Preventive Health Service, Psychology, Questionnaires, Seasonal Influenza, Surveys, Vaccination, Young Adult

@article{BalbirSingh20192544,
title = {Assessment of knowledge and attitude among postnatal mothers towards childhood vaccination in Malaysia},
author = {H K Balbir Singh and V B Badgujar and R S Yahaya and S Abd Rahman and F M Sami and S Badgujar and S N Govindan and M T Ansari},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067899547&doi=10.1080%2f21645515.2019.1612666&partnerID=40&md5=2da8ecc4fd4df251566a2f8b2454e763},
doi = {10.1080/21645515.2019.1612666},
issn = {21645515},
year = {2019},
date = {2019-01-01},
journal = {Human Vaccines and Immunotherapeutics},
volume = {15},
number = {11},
pages = {2544-2551},
publisher = {Taylor and Francis Inc.},
abstract = {Aim: Mothers knowledge and attitude toward childhood vaccination influence uptake is the most adequate tool and preventive aspects to infectious disease epidemics. The present study assesses and measures knowledge and attitude of postnatal mothers toward vaccination. Methods and results: The present study adopted a cross-sectional study design, whereby 200 postnatal mothers were identified during their postnatal visit to clinics. The subjects were accessed using questionnaire to assess the level of knowledge and attitude of mothers regarding vaccination. The objectives were to study the level of knowledge, the attitude, and to find the association between knowledge and attitude of the study subjects. The data were analyzed using SPSS version 16. The results was analyzed through chi-square test. The association between age (p =.031), education (p =.021), occupation (p =.013), and knowledge score toward vaccination was found to be statistically significant. However, ethnicity (p =.127), employment (p =.197), and mode of delivery (p =.750) toward mothers vaccination knowledge were not significant for the study. Mothers education, age, and occupation were found to be associated with attitude toward childhood vaccination. No association was found between ethnicity, employment, and mode of delivery with attitude of childhood vaccination. Conclusion: More than half of the studied mothers had good knowledge scores on vaccination, more than two-thirds of the studied mothers had good attitude scores on vaccination. However, the religious misconception and fear of autism was the main cause of vaccine resistance in Malaysia. © 2019, © 2019 Taylor & Francis Group, LLC.},
note = {cited By 0},
keywords = {Adolescent, Adult, Article, Attitude, Attitude to Health, Autism, Child Health, Childhood Vaccination, Children, Cross-Sectional Study, Diphtheria Pertussis Poliomyelitis Tetanus Haemophilus Influenzae Type B Hepatitis B Vaccine, Education, Employment, Ethnicity, Female, Health Knowledge, Human, Immunization Programs, Knowledge, Likert Scale, Major Clinical Study, Malaysia, Mother, Mothers, Needs Assessment, Occupation, Postnatal Care, Practice, Preschool Child, Preventive Health Service, Psychology, Questionnaires, Seasonal Influenza, Surveys, Vaccination, Young Adult},
pubstate = {published},
tppubtype = {article}
}

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Ramachandram, S

Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia Journal Article

Medical Journal of Malaysia, 74 (5), pp. 372-376, 2019, ISSN: 03005283, (cited By 0).

Abstract | Links | BibTeX | Tags: Adolescent, Article, Asthma, Autism, Birth Weight, Child Development, Children, Chinese, Conception, Demography, Diet Restriction, DSM-5, Eczema, Education, Educational Status, Epilepsy, Female, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Human, Indian, Major Clinical Study, Malay, Male, Medical Record Review, Penang, Prematurity, Speech Disorder, Upper Respiratory Tract Congestion, Wakefulness

@article{Ramachandram2019372,
title = {Clinical characteristics and demographic profile of children with autism spectrum disorder (Asd) at child development clinic (cdc), penang hospital, malaysia},
author = {S Ramachandram},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073688991&partnerID=40&md5=3ed147d56181ccd44321c47629a4aa54},
issn = {03005283},
year = {2019},
date = {2019-01-01},
journal = {Medical Journal of Malaysia},
volume = {74},
number = {5},
pages = {372-376},
publisher = {Malaysian Medical Association},
abstract = {Objective: To explore socio-demographics and clinical characteristics of children with Autism Spectrum Disorder (ASD) at Child Development Clinic (CDC), Penang Hospital. Study design: A record review study of 331 children with ASD attending CDC, Penang Hospital from September 2013 to April 2017. Results: Out of 331 children with ASD, 82.5% were males, 17.5% females, with male to female ratio of 4.7:1. Mean age at consultation was 5 years and 6 months (SD 31.68 months) with age range from 19 months to 18 years and 4 months. 85.8% were term infants with normal birth weight. History of speech regression was noted in 14.8%, epilepsy and genetic disorders in 9.4% and 5.7% respectively. Sleep problems was reported in 29.3%, dietary issues 22.1%, challenging behaviour 24.2% and ADHD 14.2%. Mean age of the father and mother at birth was 33.6 and 31.6 years respectively. Conclusion: In this study, we report a higher male to female ratio and mean age at referral with some similar rates of neurodevelopmental and medical comorbidities and relatively younger parental age with higher parental education levels. © 2019, Malaysian Medical Association. All rights reserved.},
note = {cited By 0},
keywords = {Adolescent, Article, Asthma, Autism, Birth Weight, Child Development, Children, Chinese, Conception, Demography, Diet Restriction, DSM-5, Eczema, Education, Educational Status, Epilepsy, Female, Genetic Disorder, Heart Atrium Septum Defect, Heart Ventricle Septum Defect, Human, Indian, Major Clinical Study, Malay, Male, Medical Record Review, Penang, Prematurity, Speech Disorder, Upper Respiratory Tract Congestion, Wakefulness},
pubstate = {published},
tppubtype = {article}
}

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Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T

Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment Journal Article

PLoS ONE, 14 (3), 2019, ISSN: 19326203, (cited By 4).

Abstract | Links | BibTeX | Tags: Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting

@article{Pichitpunpong2019,
title = {Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment},
author = {C Pichitpunpong and S Thongkorn and S Kanlayaprasit and W Yuwattana and W Plaingam and S Sangsuthum and W M Aizat and S N Baharum and T Tencomnao and V W Hu and T Sarachana},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371%2fjournal.pone.0214198&partnerID=40&md5=0a4c25481edee56984a59de94fedc414},
doi = {10.1371/journal.pone.0214198},
issn = {19326203},
year = {2019},
date = {2019-01-01},
journal = {PLoS ONE},
volume = {14},
number = {3},
publisher = {Public Library of Science},
abstract = {Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the
Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
note = {cited By 4},
keywords = {Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting},
pubstate = {published},
tppubtype = {article}
}

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Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the
Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Adib, N A N; Ibrahim, M I; Rahman, A A; Bakar, R S; Yahaya, N A; Hussin, S; Mansor, Wan W N A

Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care Journal Article

International Journal of Environmental Research and Public Health, 16 (10), 2019, ISSN: 16617827, (cited By 0).

Abstract | Links | BibTeX | Tags: Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia

@article{Adib2019,
title = {Predictors of caregivers’ satisfaction with the management of children with autism spectrum disorder: A study at multiple levels of health care},
author = {N A N Adib and M I Ibrahim and A A Rahman and R S Bakar and N A Yahaya and S Hussin and W N A Wan Mansor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066861959&doi=10.3390%2fijerph16101684&partnerID=40&md5=7f7b4ccd7484a6dcc6e2f03375b1ffb7},
doi = {10.3390/ijerph16101684},
issn = {16617827},
year = {2019},
date = {2019-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {16},
number = {10},
publisher = {MDPI AG},
abstract = {Background: Caregivers are the initial gatekeepers in the health care management of children with autism spectrum disorder (ASD). Methods: This cross-sectional study aimed to determine the factors associated with caregivers’ satisfaction with different levels of health care services in managing children with ASD in Kelantan. The satisfaction scores of 227 main caregivers of confirmed ASD children were assessed with a modified Parent Satisfaction Scale (PSS) questionnaire. Results: The analysis showed that caregivers who waited longer for a doctor’s consultation in primary care had a reduced PSS score, whereas caregivers who were satisfied with the waiting time in primary care had higher PSS scores. At the secondary care level, caregivers who possessed at least a diploma had reduced PSS scores, whereas caregivers who were satisfied with both doctors’ consultation times and occupational therapy appointments had higher PSS scores. At the tertiary care level, caregivers with an underlying medical problem and who had children undergoing occupational therapy for two months or more had reduced PSS scores. Nevertheless, the analysis showed that caregivers who were concerned with their children’s sleeping problems, who had been informed about parental support, who were satisfied with speech and occupational therapy appointments, who were satisfied with waiting times at tertiary care clinics, and who were satisfied with their doctor’s knowledge and experience had higher PSS scores. Conclusions: This study elucidated the importance of understanding caregivers’ satisfaction in attaining care for their ASD children and highlighted the need to promote factors that would increase caregivers’ satisfaction with current ASD services. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.},
note = {cited By 0},
keywords = {Adult, Article, Autism, Autism Spectrum Disorders, Caregiver, Child Care, Children, Comorbidity, Consultation, Controlled Study, Cross-Sectional Study, Female, Health Care, Health Care Delivery, Health Care System, Health Service, Health Worker, Human, Job Satisfaction, Kelantan, Major Clinical Study, Malaysia, Male, Management, Mental Health, Middle Aged, Occupational Therapy, Parent Satisfaction Scale Questionnaire, Perception, Personal Satisfaction, Primary Health Care, Primary Medical Care, Psychology, Questionnaires, Satisfaction, Secondary Health Care, Speech Therapy, Surveys, Tertiary Health Care, West Malaysia},
pubstate = {published},
tppubtype = {article}
}

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Nor, N K; Ghozali, A H; Ismail, J

Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors Journal Article

Frontiers in Pediatrics, 7 (FEB), 2019, ISSN: 22962360, (cited By 5).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight

@article{Nor2019,
title = {Prevalence of overweight and obesity among children and adolescents with autism spectrum disorder and associated risk factors},
author = {N K Nor and A H Ghozali and J Ismail},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064414280&doi=10.3389%2ffped.2019.00038&partnerID=40&md5=4bb61b1df043a4adf79618e223d77f26},
doi = {10.3389/fped.2019.00038},
issn = {22962360},
year = {2019},
date = {2019-01-01},
journal = {Frontiers in Pediatrics},
volume = {7},
number = {FEB},
publisher = {Frontiers Media S.A.},
abstract = {Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.},
note = {cited By 5},
keywords = {Adolescent, Adult, Article, Autism, Body Mass, Brief Autism Mealtime Beahavior Questionnaire, Child Development, Childhood Obesity, Children, Children Sleep Habits Questionnaire, Controlled Study, Cross-Sectional Study, Feeding Difficulty, Female, Food Refusal, Human, Major Clinical Study, Malaysian, Male, Mother, Paternal Age, Physical Activity, Physical Activity for Older Children Questionnaire, Prevalence, Questionnaires, Risk Factor, Sleep Disorder, Underweight},
pubstate = {published},
tppubtype = {article}
}

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Introduction: Prevalence of obesity in Autism Spectrum Disorder (ASD) has been reported to be higher than in the general population. Determining prevalence may help increase awareness of obesity in ASD and potentially lead to initiatives to reduce obesity. In order to understand obesity in ASD children, common risk factors were assessed including physical activity, feeding problems and sleep disturbances. Methods: This is a cross-sectional study performed at the Child Development Center at Universiti Kebangsaan Malaysia Medical Center on 151 ASD children aged 2-18 years. Anthropometric and demographic information were obtained and parents completed three questionnaires; Children Sleep Habits Questionnaire (CSHQ), Physical Activity for Older Children Questionnaire (PAQ-C) and Brief Autism Mealtime Behavior Questionnaire (BAMBI). Results: For ASD children in our sample, the prevalence of overweight (BMI ≥85th to < 95th percentiles) was 11.3% and the prevalence of obesity (BMI ≥95th percentile) was 21.9%. The overweight/obese ASD children's median age was higher at 8.5 years (IQR 5.81-10.13) compared to the normal/underweight group of 6.33 years (IQR 4.75-7.7) with a p-value of 0.001. The two groups also differed significantly for maternal BMI and paternal age. The median maternal BMI in the overweight/obese group was 26.05 (IQR 23.35-32.25), statistically significantly higher (p = 0.003) than in the non-overweight/obese group, 24.7 (IQR 21-27.9). The median paternal age of 40 years (IQR 37-44) was statistically significantly higher (p = 0.039) in the overweight/obese group, compared to the median paternal age in the non-overweight/obese group of 38 (IQR 35-42). The male overweight/obese children had median PAQ-C score of 2.44 (IQR 2.00-3.00) vs. 2.89 (IQR 2.35-3.53) in the counterpart group with a p-value of 0.01. Using the multiple linear regression stepwise method, three predictors associated with BMI percentiles reached a statistical level of significance; PAQ-C score in males (p < 0.001), the BAMBI domains of Food Refusal (p = 0.001) and Limited Variety of Food (p = 0.001). Conclusions: The prevalence of obesity and overweight is high among Malaysian ASD children and adolescents. Older child age, high maternal BMI, older paternal age, low physical activity, low likelihood of food refusal and high likelihood of food selectivity were found to be risk factors for high BMI in these children. © 2019 Kamal Nor, Ghozali and Ismail.

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Toh, T -H; Tan, V W -Y; Lau, P S -T; Kiyu, A

Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article

Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9).

Abstract | Links | BibTeX | Tags: Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler

@article{Toh201828,
title = {Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics},
author = {T -H Toh and V W -Y Tan and P S -T Lau and A Kiyu},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028764085&doi=10.1007%2fs10803-017-3287-x&partnerID=40&md5=21bce2407197b8b1e43b4420d274861b},
doi = {10.1007/s10803-017-3287-x},
issn = {01623257},
year = {2018},
date = {2018-01-01},
journal = {Journal of Autism and Developmental Disorders},
volume = {48},
number = {1},
pages = {28-35},
publisher = {Springer New York LLC},
abstract = {This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC.},
note = {cited By 9},
keywords = {Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler},
pubstate = {published},
tppubtype = {article}
}

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Charara, R; Forouzanfar, M; Naghavi, M; Moradi-Lakeh, M; Afshin, A; Vos, T; Daoud, F; Wang, H; Bcheraoui, C E; Khalil, I; Hamadeh, R R; Khosravi, A; Rahimi-Movaghar, V; Khader, Y; Al-Hamad, N; Obermeyer, C M; Rafay, A; Asghar, R; Rana, S M; Shaheen, A; Abu-Rmeileh, N M E; Husseini, A; Abu-Raddad, L J; Khoja, T; Rayess, Z A A; AlBuhairan, F S; Hsairi, M; Alomari, M A; Ali, R; Roshandel, G; Terkawi, A S; Hamidi, S; Refaat, A H; Westerman, R; Kiadaliri, A A; Akanda, A S; Ali, S D; Bacha, U; Badawi, A; Bazargan-Hejazi, S; Faghmous, I A D; Fereshtehnejad, S -M; Fischer, F; Jonas, J B; Defo, B K; Mehari, A; Omer, S B; Pourmalek, F; Uthman, O A; Mokdad, A A; Maalouf, F T; Abd-Allah, F; Akseer, N; Arya, D; Borschmann, R; Brazinova, A; Brugha, T S; Catala-Lopez, F; Degenhardt, L; Ferrari, A; Haro, J M; Horino, M; Hornberger, J C; Huang, H; Kieling, C; Kim, D; Kim, Y; Knudsen, A K; Mitchell, P B; Patton, G; Sagar, R; Satpathy, M; Savuon, K; Seedat, S; Shiue, I; Skogen, J C; Stein, D J; Tabb, K M; Whiteford, H A; Yip, P; Yonemoto, N; Murray, C J L; Mokdad, A H

The burden of mental disorders in the eastern mediterranean region, 1990-2013 Journal Article

PLoS ONE, 12 (1), 2017, ISSN: 19326203, (cited By 30).

Abstract | Links | BibTeX | Tags: 80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult

@article{Charara2017,
title = {The burden of mental disorders in the eastern mediterranean region, 1990-2013},
author = {R Charara and M Forouzanfar and M Naghavi and M Moradi-Lakeh and A Afshin and T Vos and F Daoud and H Wang and C E Bcheraoui and I Khalil and R R Hamadeh and A Khosravi and V Rahimi-Movaghar and Y Khader and N Al-Hamad and C M Obermeyer and A Rafay and R Asghar and S M Rana and A Shaheen and N M E Abu-Rmeileh and A Husseini and L J Abu-Raddad and T Khoja and Z A A Rayess and F S AlBuhairan and M Hsairi and M A Alomari and R Ali and G Roshandel and A S Terkawi and S Hamidi and A H Refaat and R Westerman and A A Kiadaliri and A S Akanda and S D Ali and U Bacha and A Badawi and S Bazargan-Hejazi and I A D Faghmous and S -M Fereshtehnejad and F Fischer and J B Jonas and B K Defo and A Mehari and S B Omer and F Pourmalek and O A Uthman and A A Mokdad and F T Maalouf and F Abd-Allah and N Akseer and D Arya and R Borschmann and A Brazinova and T S Brugha and F Catala-Lopez and L Degenhardt and A Ferrari and J M Haro and M Horino and J C Hornberger and H Huang and C Kieling and D Kim and Y Kim and A K Knudsen and P B Mitchell and G Patton and R Sagar and M Satpathy and K Savuon and S Seedat and I Shiue and J C Skogen and D J Stein and K M Tabb and H A Whiteford and P Yip and N Yonemoto and C J L Murray and A H Mokdad},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009892168&doi=10.1371%2fjournal.pone.0169575&partnerID=40&md5=471830ec1239e37c6fc4681bed5698f6},
doi = {10.1371/journal.pone.0169575},
issn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {1},
publisher = {Public Library of Science},
abstract = {The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
note = {cited By 30},
keywords = {80 and Over, Adolescent, Adult, Age, Age Factors, Aged, Anxiety Disorder, Article, Attention Deficit Disorder, Autism, Bipolar Disorder, Children, Conduct Disorder, Depression, Elderly People, Female, Global Health, Groups by Age, Health Status, Highest Income Group, Human, Infant, Intellectual Impairment, Kuwait, Life Expectancy, Major Clinical Study, Male, Mediterranean Region, Mental Disease, Mental Disorders, Mental Health, Mental Health Service, Middle Aged, Middle Income Group, Mortality, Newborn, Palestine, Premature Mortality, Preschool, Preschool Child, Prevalence, Qatar, Quality Adjusted Life Year, Schizophrenia, Sex Difference, Sex Factors, Southern Europe, Time Factor, Time Factors, United Arab Emirates, Young Adult},
pubstate = {published},
tppubtype = {article}
}

Close

The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income countries, 1884 DALYS/100,000 (1618/100,000 males, 2157/100,000 females) in middle-income countries, 1607 DALYS/100,000 (1500/100,000 males, 1717/100,000 females) in low-income countries. Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. The highest proportion of DALYs occurred in the 25-49 age group, with a peak in the 35-39 years age group (5344 DALYs/100,000). The burden of mental disorders Burden of Mental Disorders in EMR PLOS ONE in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). Within the mental disorders group in EMR, depressive disorders accounted for most DALYs, followed by anxiety disorders. Among EMR countries, Palestine had the largest burden of mental disorders. Nearly all EMR countries had a higher mental disorder burden compared to the global level. Our findings call for EMR ministries of health to increase provision of mental health services and to address the stigma of mental illness. Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. © 2017 Charara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Haerian, B S; Shaári, H M; Tan, H J; Fong, C Y; Wong, S W; Ong, L C; Raymond, A A; Tan, C T; Mohamed, Z

RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia Journal Article

Genomics, 105 (4), pp. 229-236, 2015, ISSN: 08887543, (cited By 5).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Case-Control Studies, Controlled Study, DNA, Epilepsy, Epistasis, Female, Gene, Gene Interaction, Genetic Polymorphism, Genetic Predisposition, Genetic Predisposition to Disease, Genetic Risk, Genetic Variability, Genetics, Genotype, Group F, Human, Major Clinical Study, Malaysia, Male, Member 1, Member 2, Middle Aged, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polymorphism, Priority Journal, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Single Nucleotide, Single Nucleotide Polymorphism, Sodium Channel Nav1.1, Young Adult

@article{Haerian2015229,
title = {RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia},
author = {B S Haerian and H M Shaári and H J Tan and C Y Fong and S W Wong and L C Ong and A A Raymond and C T Tan and Z Mohamed},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924135981&doi=10.1016%2fj.ygeno.2015.02.001&partnerID=40&md5=209a1720cddfd76bfa515ee8940749d5},
doi = {10.1016/j.ygeno.2015.02.001},
issn = {08887543},
year = {2015},
date = {2015-01-01},
journal = {Genomics},
volume = {105},
number = {4},
pages = {229-236},
publisher = {Academic Press Inc.},
abstract = {RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Hence, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. © 2015 Elsevier Inc.},
note = {cited By 5},
keywords = {Adolescent, Adult, Article, Case-Control Studies, Controlled Study, DNA, Epilepsy, Epistasis, Female, Gene, Gene Interaction, Genetic Polymorphism, Genetic Predisposition, Genetic Predisposition to Disease, Genetic Risk, Genetic Variability, Genetics, Genotype, Group F, Human, Major Clinical Study, Malaysia, Male, Member 1, Member 2, Middle Aged, Nav1.1 Voltage-Gated Sodium Channel, Nuclear Receptor Subfamily 1, Polymorphism, Priority Journal, Retinoid Related Orphan Receptor Alpha, Retinoid Related Orphan Receptor Beta, Risk, RORA Gene, RORA Protein, RORB Protein, SCN1A Gene, SCN1A Protein, Single Nucleotide, Single Nucleotide Polymorphism, Sodium Channel Nav1.1, Young Adult},
pubstate = {published},
tppubtype = {article}
}

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Siah, P -C; Tan, S -H

Sense of coherence and WHOQoL among parents of children with ASD in Malaysia Journal Article

International Journal on Disability and Human Development, 14 (1), pp. 59-66, 2015, ISSN: 21911231, (cited By 2).

Abstract | Links | BibTeX | Tags: Adult, Age, Article, Autism, Children, Comprehension, Education, Employment, Environmental Factor, Female, Gender, Han Chinese, Health, Housewife, Human, Income, Indian, Major Clinical Study, Malay, Malaysia, Male, Marriage, Mental Health, Parental Attitude, Pensioner, Psychological Aspect, Quality of Life, Religion, Sampling, Sense of Coherence, Social Interactions

@article{Siah201559,
title = {Sense of coherence and WHOQoL among parents of children with ASD in Malaysia},
author = {P -C Siah and S -H Tan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922567900&doi=10.1515%2fijdhd-2013-0039&partnerID=40&md5=a909c24c26550aebe2c8922063d70001},
doi = {10.1515/ijdhd-2013-0039},
issn = {21911231},
year = {2015},
date = {2015-01-01},
journal = {International Journal on Disability and Human Development},
volume = {14},
number = {1},
pages = {59-66},
publisher = {Walter de Gruyter GmbH},
abstract = {Studies have shown that most parents of children with autism spectrum disorder (ASD) face more stress and have a poorer quality of life (QoL) than other parents. Nonetheless, there are still some parents of children with ASD who are able to maintain or even improve their QoL. This study is aimed to explore the relationship between SoC and WHOQoL among parents of children with ASD. Method: A total of 96 parents of children with ASD were invited to participate using a purposive sampling method. Results: The results suggested that participants in the high SoC group had better QoL in the four domains than those in the low SoC group. More importantly, not all types of SoC were relevant to QoL. Comprehensibility was relevant to all the four QoL domains and manageability was relevant to physical and psychological health, while meaningfulness was not relevant to any of the QoL domains. Conclusions: NGOs may improve the QoL of these parents by providing trainings to improve their SOC, especially in comprehensibility and manageability. © 2015 by De Gruyter.},
note = {cited By 2},
keywords = {Adult, Age, Article, Autism, Children, Comprehension, Education, Employment, Environmental Factor, Female, Gender, Han Chinese, Health, Housewife, Human, Income, Indian, Major Clinical Study, Malay, Malaysia, Male, Marriage, Mental Health, Parental Attitude, Pensioner, Psychological Aspect, Quality of Life, Religion, Sampling, Sense of Coherence, Social Interactions},
pubstate = {published},
tppubtype = {article}
}

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Shobana, M; Saravanan, C

Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Journal Article

East Asian Archives of Psychiatry, 24 (1), pp. 16-22, 2014, ISSN: 20789947, (cited By 6).

Abstract | Links | BibTeX | Tags: Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability

@article{Shobana201416,
title = {Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability},
author = {M Shobana and C Saravanan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898619897&partnerID=40&md5=e877e03b868d1a11ed8f859a33057d5d},
issn = {20789947},
year = {2014},
date = {2014-01-01},
journal = {East Asian Archives of Psychiatry},
volume = {24},
number = {1},
pages = {16-22},
publisher = {Hong Kong Academy of Medicine Press},
abstract = {Objective: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Methods: In this study, 112 mothers of children having mild and moderate levels of autism disorder, Down syndrome, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Results: Overall, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, anxiety, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Conclusion: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists.},
note = {cited By 6},
keywords = {Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability},
pubstate = {published},
tppubtype = {article}
}

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Assaf, M; Hyatt, C J; Wong, C G; Johnson, M R; Schultz, R T; Hendler, T; Pearlson, G D

Mentalizing and motivation neural function during social interactions in autism spectrum disorders Journal Article

NeuroImage: Clinical, 3 , pp. 321-331, 2013, ISSN: 22131582, (cited By 28).

Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision

@article{Assaf2013321,
title = {Mentalizing and motivation neural function during social interactions in autism spectrum disorders},
author = {M Assaf and C J Hyatt and C G Wong and M R Johnson and R T Schultz and T Hendler and G D Pearlson},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885394367&doi=10.1016%2fj.nicl.2013.09.005&partnerID=40&md5=b63630c997b658167792266e40e855b6},
doi = {10.1016/j.nicl.2013.09.005},
issn = {22131582},
year = {2013},
date = {2013-01-01},
journal = {NeuroImage: Clinical},
volume = {3},
pages = {321-331},
abstract = {Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors.},
note = {cited By 28},
keywords = {Adolescent, Adult, Article, Autism, Brain Function, Children, Computer, Controlled Study, Female, Functional Magnetic Resonance Imaging, Games, Groups by Age, Human, Major Clinical Study, Male, Mental Capacity, Middle Temporal Gyrus, Motivation, Motor Performance, Nerve Cell, Nerve Function, Nucleus Accumbens, Priority Journal, Punishment, Reward, School Child, Social Cognition, Social Environment, Social Interactions, Task Performance, Theory of Mind, Vision},
pubstate = {published},
tppubtype = {article}
}

Close

Autism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12-24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster < 0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols. © 2013 The Authors.

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Salih, M R M; Bahari, M B; Hassali, M A A; Shafie, A A; Al-Lela, O Q B; Abd, A Y; Ganesan, V M

Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Journal Article

Journal of Neurosciences in Rural Practice, 3 (3), pp. 244-250, 2012, ISSN: 09763147, (cited By 1).

Abstract | Links | BibTeX | Tags: Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease

@article{Salih2012244,
title = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy},
author = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&partnerID=40&md5=039bd22d6c38366ebfdd00a4254c20f0},
doi = {10.4103/0976-3147.102596},
issn = {09763147},
year = {2012},
date = {2012-01-01},
journal = {Journal of Neurosciences in Rural Practice},
volume = {3},
number = {3},
pages = {244-250},
abstract = {Introduction: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form. Results: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.},
note = {cited By 1},
keywords = {Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease},
pubstate = {published},
tppubtype = {article}
}

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Tan, K L; Yadav, H

Reassessment on the development of children with disability in Malaysia Journal Article

Medical Journal of Malaysia, 63 (1), pp. 17-20, 2008, ISSN: 03005283, (cited By 5).

Abstract | Links | BibTeX | Tags: Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance

@article{Tan200817,
title = {Reassessment on the development of children with disability in Malaysia},
author = {K L Tan and H Yadav},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649115291&partnerID=40&md5=8838ddaa3d9906d8b696be13e88f1baa},
issn = {03005283},
year = {2008},
date = {2008-01-01},
journal = {Medical Journal of Malaysia},
volume = {63},
number = {1},
pages = {17-20},
abstract = {This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. A total of 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autism, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment.},
note = {cited By 5},
keywords = {Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance},
pubstate = {published},
tppubtype = {article}
}

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