2019 |
Ishak, N I; Yusof, H M; Ramlee, M R H; Sidek, S N; Rusli, N Modules of Interaction for ASD Children Using Rero Robot (Humanoid) Conference Institute of Electrical and Electronics Engineers Inc., 2019, ISBN: 9781728129716, (cited By 0). Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Commercial Robots, Developmental Disorders, Early Intervention, Human Interactions, Human Robot Interaction, Interaction Mediums, Interaction Modules, Patient Rehabilitation, Robotics, Robots @conference{Ishak2019, title = {Modules of Interaction for ASD Children Using Rero Robot (Humanoid)}, author = {N I Ishak and H M Yusof and M R H Ramlee and S N Sidek and N Rusli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078867258&doi=10.1109%2fICOM47790.2019.8952038&partnerID=40&md5=8eadb9e644d78f52f44a76a6f57c8de4}, doi = {10.1109/ICOM47790.2019.8952038}, isbn = {9781728129716}, year = {2019}, date = {2019-01-01}, journal = {2019 7th International Conference on Mechatronics Engineering, ICOM 2019}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {Autism Spectrum Disorder (ASD) is a neurological and developmental disorder that affects one's ability to understand social cues and to communicate. As it begins early in childhood and can last throughout a person's life, it is important to have an early intervention and rehabilitation. Previous research has shown that robotic platforms helped and encouraged positive outcome in ASD children rehabilitation. Early interventions through human-robot interaction (HRI) have the potential when used to improve communication and social skills of the children. In this research, a new framework has been developed featuring a robot and human interaction modules. A commercial robot, Rero has been adopted and used as the interaction medium. This robot has been selected based on its reconfigurable capability and ability to be developed into many forms. It is also mobile, speech enabled, controllable, programmable, and attractive. Five modules of interaction have been developed and approval from special education teachers and therapists has been sought. The modules are created to help the children to be able to imitate actions, follow instructions, name objects, as well as to focus and match colours. Observations from the experiment shows that the children enjoyed the interaction modules with a median of more than 70% of scores and were well engaged with the robots with certain type of modules. © 2019 IEEE.}, note = {cited By 0}, keywords = {Autism Spectrum Disorders, Commercial Robots, Developmental Disorders, Early Intervention, Human Interactions, Human Robot Interaction, Interaction Mediums, Interaction Modules, Patient Rehabilitation, Robotics, Robots}, pubstate = {published}, tppubtype = {conference} } Autism Spectrum Disorder (ASD) is a neurological and developmental disorder that affects one's ability to understand social cues and to communicate. As it begins early in childhood and can last throughout a person's life, it is important to have an early intervention and rehabilitation. Previous research has shown that robotic platforms helped and encouraged positive outcome in ASD children rehabilitation. Early interventions through human-robot interaction (HRI) have the potential when used to improve communication and social skills of the children. In this research, a new framework has been developed featuring a robot and human interaction modules. A commercial robot, Rero has been adopted and used as the interaction medium. This robot has been selected based on its reconfigurable capability and ability to be developed into many forms. It is also mobile, speech enabled, controllable, programmable, and attractive. Five modules of interaction have been developed and approval from special education teachers and therapists has been sought. The modules are created to help the children to be able to imitate actions, follow instructions, name objects, as well as to focus and match colours. Observations from the experiment shows that the children enjoyed the interaction modules with a median of more than 70% of scores and were well engaged with the robots with certain type of modules. © 2019 IEEE. |
Pichitpunpong, C; Thongkorn, S; Kanlayaprasit, S; Yuwattana, W; Plaingam, W; Sangsuthum, S; Aizat, W M; Baharum, S N; Tencomnao, T; Hu, V W; Sarachana, T PLoS ONE, 14 (3), 2019, ISSN: 19326203, (cited By 4). Abstract | Links | BibTeX | Tags: Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting @article{Pichitpunpong2019, title = {Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment}, author = {C Pichitpunpong and S Thongkorn and S Kanlayaprasit and W Yuwattana and W Plaingam and S Sangsuthum and W M Aizat and S N Baharum and T Tencomnao and V W Hu and T Sarachana}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063617126&doi=10.1371%2fjournal.pone.0214198&partnerID=40&md5=0a4c25481edee56984a59de94fedc414}, doi = {10.1371/journal.pone.0214198}, issn = {19326203}, year = {2019}, date = {2019-01-01}, journal = {PLoS ONE}, volume = {14}, number = {3}, publisher = {Public Library of Science}, abstract = {Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.}, note = {cited By 4}, keywords = {Article, Autism, Autism Spectrum Disorders, Binding Protein, Biological Marker, Biomarkers, Cell Line, Controlled Study, Developmental Disorders, Developmental Language Disorder, Diazepam Binding Inhibitor, Diazepam Binding Inhibitor Protein, Disease Severity, Female, Genetic Analysis, Human, Human Cell, Inflammation, Language Development Disorders, Language Disability, Liquid Chromatography-Mass Spectrometry, Lymphoblastoid Cell, Major Clinical Study, Male, Metabolism, Phenotype, Protein Analysis, Protein Expression, Protein Function, Proteome, Proteomics, Transcription Regulation, Transcriptome, Unclassified Drug, Western Blotting}, pubstate = {published}, tppubtype = {article} } Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes is useful for identifying candidate genes that are dysregulated in ASD subgroups. However, this strategy has not been employed in proteome profiling analyses to identify ASD biomarker proteins for specific subgroups. Methods We therefore conducted a cluster analysis of the Autism Diagnostic Interview-Revised (ADI-R) scores from 85 individuals with ASD to predict subgroups and subsequently identified dysregulated genes by reanalyzing the transcriptome profiles of individuals with ASD and unaffected individuals. Proteome profiling of lymphoblastoid cell lines from these individuals was performed via 2D-gel electrophoresis, and then mass spectrometry. Disrupted proteins were identified and compared to the dysregulated transcripts and reported dysregulated proteins from previous proteome studies. Biological functions were predicted using the Ingenuity Pathway Analysis (IPA) program. Selected proteins were also analyzed by Western blotting. Results The cluster analysis of ADI-R data revealed four ASD subgroups, including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed by Western blot analysis to be expressed at significantly decreased levels in the ASD subgroup with severe language impairment, and the DBI expression levels were correlated with the scores of several ADI-R items. Conclusions By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study. © 2019 Pichitpunpong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
2018 |
Toh, T -H; Tan, V W -Y; Lau, P S -T; Kiyu, A Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9). Abstract | Links | BibTeX | Tags: Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler @article{Toh201828, title = {Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics}, author = {T -H Toh and V W -Y Tan and P S -T Lau and A Kiyu}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028764085&doi=10.1007%2fs10803-017-3287-x&partnerID=40&md5=21bce2407197b8b1e43b4420d274861b}, doi = {10.1007/s10803-017-3287-x}, issn = {01623257}, year = {2018}, date = {2018-01-01}, journal = {Journal of Autism and Developmental Disorders}, volume = {48}, number = {1}, pages = {28-35}, publisher = {Springer New York LLC}, abstract = {This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC.}, note = {cited By 9}, keywords = {Article, Autism, Autism Assessment, Autism Spectrum Disorders, Checklist, Children, Cohort Analysis, Cohort Studies, Community Health Centers, Developmental Disorders, Diagnostic Accuracy, Female, Health Center, Human, Infant, Major Clinical Study, Malaysia, Male, Mass Screening, Modified Checklist for Autism in Toddlers, Pediatric Hospital, Predictive Value, Preschool, Preschool Child, Priority Journal, Procedures, Psychology, Retrospective Studies, Retrospective Study, Sensitivity and Specificity, Standards, Toddler}, pubstate = {published}, tppubtype = {article} } This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15–36 months) who had M-CHAT performed in 2006–2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27–36-month age cohorts (54.5–64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD. © 2017, Springer Science+Business Media, LLC. |
Tsuchida, N; Hamada, K; Shiina, M; Kato, M; Kobayashi, Y; Tohyama, J; Kimura, K; Hoshino, K; Ganesan, V; Teik, K W; Nakashima, M; Mitsuhashi, S; Mizuguchi, T; Takata, A; Miyake, N; Saitsu, H; Ogata, K; Miyatake, S; Matsumoto, N GRIN2D variants in three cases of developmental and epileptic encephalopathy Journal Article Clinical Genetics, 94 (6), pp. 538-547, 2018, ISSN: 00099163, (cited By 4). Abstract | Links | BibTeX | Tags: Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing @article{Tsuchida2018538, title = {GRIN2D variants in three cases of developmental and epileptic encephalopathy}, author = {N Tsuchida and K Hamada and M Shiina and M Kato and Y Kobayashi and J Tohyama and K Kimura and K Hoshino and V Ganesan and K W Teik and M Nakashima and S Mitsuhashi and T Mizuguchi and A Takata and N Miyake and H Saitsu and K Ogata and S Miyatake and N Matsumoto}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056487337&doi=10.1111%2fcge.13454&partnerID=40&md5=f0d32670db57261820bc244943cffd62}, doi = {10.1111/cge.13454}, issn = {00099163}, year = {2018}, date = {2018-01-01}, journal = {Clinical Genetics}, volume = {94}, number = {6}, pages = {538-547}, publisher = {Blackwell Publishing Ltd}, abstract = {N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd}, note = {cited By 4}, keywords = {Adolescent, Allele, Amino Acid Sequence, Amino Acid Substitution, Amino Terminal Sequence, Anemia, Antibiotic Agent, Antibiotic Therapy, Article, Atonic Seizure, Attention Deficit Disorder, Autism, Binding Affinity, Brain, Brain Atrophy, Carbamazepine, Case Report, Channel Gating, Chemistry, Children, Clinical Article, Clinical Feature, Clobazam, Clonazepam, Conformational Transition, Continuous Infusion, Contracture, Crystal Structure, Cysteine Ethyl Ester Tc 99m, Developmental Delay, Developmental Disorders, Electroencephalogram, Electroencephalography, Epilepsy, Epileptic Discharge, Ethosuximide, Eye Tracking, Febrile Convulsion, Female, Frontal Lobe Epilepsy, Gene, Gene Frequency, Genetic Variation, Genetics, Genotype, GRIN2D Protein, Heterozygosity, Home Oxygen Therapy, Human, Human Cell, Hydrogen Bond, Intellectual Impairment, Intelligence Quotient, Intractable Epilepsy, Ketamine, Lacosamide, Lamotrigine, Lennox Gastaut Syndrome, Levetiracetam, Magnetoencephalography, Male, Maternal Hypertension, Melatonin, Migraine, Missense Mutation, Molecular Dynamics, Molecular Dynamics Simulation, Mutation, Myoclonus Seizure, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor 2D, N-Methyl-D-Aspartate, Neonatal Pneumonia, Neonatal Respiratory Distress Syndrome, Neuroimaging, Nuclear Magnetic Resonance Imaging, Phenobarbital, Premature Labor, Preschool, Preschool Child, Priority Journal, Protein Conformation, Proximal Interphalangeal Joint, Pyridoxine, Receptors, Respiratory Arrest, Sanger Sequencing, School Child, Single Photon Emission Computed Tomography, Sleep Disordered Breathing, Static Electricity, Stridor, Structure-Activity Relationship, Subglottic Stenosis, Superior Temporal Gyrus, Supramarginal Gyrus, Thiopental, Tonic Seizure, Valproic Acid, Wakefulness, Wechsler Intelligence Scale for Children, Whole Exome Sequencing}, pubstate = {published}, tppubtype = {article} } N-methyl-d-aspartate (NMDA) receptors are glutamate-activated ion channels that are widely distributed in the central nervous system and essential for brain development and function. Dysfunction of NMDA receptors has been associated with various neurodevelopmental disorders. Recently, a de novo recurrent GRIN2D missense variant was found in two unrelated patients with developmental and epileptic encephalopathy. In this study, we identified by whole exome sequencing novel heterozygous GRIN2D missense variants in three unrelated patients with severe developmental delay and intractable epilepsy. All altered residues were highly conserved across vertebrates and among the four GluN2 subunits. Structural consideration indicated that all three variants are probably to impair GluN2D function, either by affecting intersubunit interaction or altering channel gating activity. We assessed the clinical features of our three cases and compared them to those of the two previously reported GRIN2D variant cases, and found that they all show similar clinical features. This study provides further evidence of GRIN2D variants being causal for epilepsy. Genetic diagnosis for GluN2-related disorders may be clinically useful when considering drug therapy targeting NMDA receptors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
Aziz, A A; Moganan, F F M; Mokhsin, M; Sakamat, N; Ismail, A Humanoid robot intervention with autism: The conceptual model in demonstrating the emotional responses of children with autism Journal Article Advances in Intelligent Systems and Computing, 739 , pp. 574-579, 2018, ISSN: 21945357, (cited By 0). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism Spectrum Disorders, Autistic Children, Children with Autism, Conceptual Model, Developmental Disorders, Diseases, Emotion, Emotional Response, Humanoid Robot, Robotics, Robots @article{Aziz2018574, title = {Humanoid robot intervention with autism: The conceptual model in demonstrating the emotional responses of children with autism}, author = {A A Aziz and F F M Moganan and M Mokhsin and N Sakamat and A Ismail}, editor = {Levy Mohd Lokman Chen P A K Koyama S. Yamanaka T.}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044186403&doi=10.1007%2f978-981-10-8612-0_60&partnerID=40&md5=76beda967357c1b4445593f4f3bb00fe}, doi = {10.1007/978-981-10-8612-0_60}, issn = {21945357}, year = {2018}, date = {2018-01-01}, journal = {Advances in Intelligent Systems and Computing}, volume = {739}, pages = {574-579}, publisher = {Springer Verlag}, abstract = {Autism is a lifelong developmental disorder often associated with the inability to interact and communicate with others in meaningful ways. Few studies have actually proven that individuals with autism are facing difficulties in extracting and interpreting the emotion of others. This has led to the misbelief that individuals with autism are emotionless. This paper aims to demonstrate that given the right triggers, individuals with autism will show certain level of emotional responses. With its main objectives being (i) To study the previous research on the impact of Humanoid Robot Intervention on autistic children’s emotional responses and (ii) To illustrate the conceptual model that can further elevate the emotional responses of an autistic child, it is with the best hope that the model can further aid researchers in understanding the autistic children’s emotional responses while engaging with the humanoid robot, thus may help in creating a more meaningful and successful interaction session. © Springer Nature Singapore Pte Ltd. 2018.}, note = {cited By 0}, keywords = {Anthropomorphic Robots, Autism Spectrum Disorders, Autistic Children, Children with Autism, Conceptual Model, Developmental Disorders, Diseases, Emotion, Emotional Response, Humanoid Robot, Robotics, Robots}, pubstate = {published}, tppubtype = {article} } Autism is a lifelong developmental disorder often associated with the inability to interact and communicate with others in meaningful ways. Few studies have actually proven that individuals with autism are facing difficulties in extracting and interpreting the emotion of others. This has led to the misbelief that individuals with autism are emotionless. This paper aims to demonstrate that given the right triggers, individuals with autism will show certain level of emotional responses. With its main objectives being (i) To study the previous research on the impact of Humanoid Robot Intervention on autistic children’s emotional responses and (ii) To illustrate the conceptual model that can further elevate the emotional responses of an autistic child, it is with the best hope that the model can further aid researchers in understanding the autistic children’s emotional responses while engaging with the humanoid robot, thus may help in creating a more meaningful and successful interaction session. © Springer Nature Singapore Pte Ltd. 2018. |
2017 |
Singh, Joginder S; Hussein, N H; Kamal, Mustaffa R; Hassan, F H Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Journal Article AAC: Augmentative and Alternative Communication, 33 (2), pp. 110-120, 2017, ISSN: 07434618, (cited By 10). Abstract | Links | BibTeX | Tags: Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research @article{JoginderSingh2017110, title = {Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC}, author = {S Joginder Singh and N H Hussein and R Mustaffa Kamal and F H Hassan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131769&doi=10.1080%2f07434618.2017.1309457&partnerID=40&md5=067c39e0c318e76caff96b29bb4dbb21}, doi = {10.1080/07434618.2017.1309457}, issn = {07434618}, year = {2017}, date = {2017-01-01}, journal = {AAC: Augmentative and Alternative Communication}, volume = {33}, number = {2}, pages = {110-120}, publisher = {Taylor and Francis Ltd}, abstract = {Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. To date, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. For this study, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, and (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication.}, note = {cited By 10}, keywords = {Adult, Attitude to Health, Augmentative and Alternative Communication, Children, Communication Aid, Communication Aids for Disabled, Communication Disorder, Communication Disorders, Developmental Disabilities, Developmental Disorders, Disabilities, Diseases, Family, Female, Human, Human Rehabilitation Engineering, Malaysia, Male, Middle Aged, Parents, Preschool, Preschool Child, Qualitative Research}, pubstate = {published}, tppubtype = {article} } Parents play an important role in the successful implementation of AAC. Previous research has indicated that parents in different countries have varying perceptions about the use of AAC and face different challenges in its implementation. To date, there is limited information about the use of AAC by children in Malaysia or parents’ views about its use. The aim of this study was to explore Malaysian parents’ perception of AAC and their experience when supporting their children who use AAC. For this study, 12 parents of children with autism spectrum disorder and cerebral palsy were involved in semi-structured individual interviews. Qualitative content analysis was used to analyze interview data. Following analysis, three themes were identified: (a) impact of the use of AAC, (b) challenges faced, and (c) hopes and expectations. Participants reported that the use of AAC had a positive impact on their children, but that they faced challenges related to the child, the settings, and the system itself, as well as a lack of time and support. Findings from this study provide an insight for Malaysian speech therapists about the challenges faced by parents when supporting their children who use AAC, and how important it is to overcome these challenges to ensure successful implementation of AAC. © 2017 International Society for Augmentative and Alternative Communication. |
Azahari, I N N A; Ahmad, Wan W F; Hashim, A S; Jamaludin, Z User experience of autism social-aid among autistic children: AUTISM social aid application Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 10645 LNCS , pp. 391-397, 2017, ISSN: 03029743, (cited By 0). Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Education, Mobile Applications, Mobile Computing, Mobile Telecommunication Systems, Social Communications, Social Interactions, Teaching, User Experience @article{Azahari2017391, title = {User experience of autism social-aid among autistic children: AUTISM social aid application}, author = {I N N A Azahari and W F Wan Ahmad and A S Hashim and Z Jamaludin}, editor = {Robinson Smeaton Terutoshi Badioze Zaman Jaafar Mohamad Ali P A F T H A N Shih T.K. Velastin S.}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035144320&doi=10.1007%2f978-3-319-70010-6_36&partnerID=40&md5=be011b83ad6f806d1c23182f1e9250a2}, doi = {10.1007/978-3-319-70010-6_36}, issn = {03029743}, year = {2017}, date = {2017-01-01}, journal = {Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)}, volume = {10645 LNCS}, pages = {391-397}, publisher = {Springer Verlag}, abstract = {Autism is a developmental disability that influences a significant number of daily skills, which includes social, communication and behavioural challenges. Technology has proven as one of the prompt intermediation and efficient educational method that leads to infinite improvement especially for children. Autistic children seem to have difficulties in communication and social skills and as a result of this need their teachers and parents’ support with their social interaction. Numerous educational practices and approaches have been carried out in order to assist as well as develop these children. This paper presents the results of user experience testing of Autism Social-Aid mobile application to children with autism. The session was conducted to children with medium functioning Autism Spectrum Disorder, from two different age groups that include 5–14 years old and 14–18 years old. The children’s reactions were observed and scored by a moderator. Results have shown that majority of the children with autism are more confident and satisfied when using the application. The application does need to be improved in ways that could capture the child’s attention towards the mobile activities. © Springer International Publishing AG 2017.}, note = {cited By 0}, keywords = {Autism Spectrum Disorders, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Education, Mobile Applications, Mobile Computing, Mobile Telecommunication Systems, Social Communications, Social Interactions, Teaching, User Experience}, pubstate = {published}, tppubtype = {article} } Autism is a developmental disability that influences a significant number of daily skills, which includes social, communication and behavioural challenges. Technology has proven as one of the prompt intermediation and efficient educational method that leads to infinite improvement especially for children. Autistic children seem to have difficulties in communication and social skills and as a result of this need their teachers and parents’ support with their social interaction. Numerous educational practices and approaches have been carried out in order to assist as well as develop these children. This paper presents the results of user experience testing of Autism Social-Aid mobile application to children with autism. The session was conducted to children with medium functioning Autism Spectrum Disorder, from two different age groups that include 5–14 years old and 14–18 years old. The children’s reactions were observed and scored by a moderator. Results have shown that majority of the children with autism are more confident and satisfied when using the application. The application does need to be improved in ways that could capture the child’s attention towards the mobile activities. © Springer International Publishing AG 2017. |
2016 |
Shminan, A S; Fauzan, N; Aren, M The intensity of the research activities on e learning for care givers of autistic children Conference Institute of Electrical and Electronics Engineers Inc., 2016, ISBN: 9781467366649, (cited By 1). Abstract | Links | BibTeX | Tags: Autism Intervention, Developmental Disorders, Direct Communications, Diseases, E-learning, E-learning Technology, Medical Computing, Nonverbal Communication, Personnel Training, Research, Telehealth, Web-Based @conference{Shminan2016, title = {The intensity of the research activities on e learning for care givers of autistic children}, author = {A S Shminan and N Fauzan and M Aren}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84967018440&doi=10.1109%2fICITSI.2015.7437682&partnerID=40&md5=8237166f73f04eecc5d141a283d6b5b9}, doi = {10.1109/ICITSI.2015.7437682}, isbn = {9781467366649}, year = {2016}, date = {2016-01-01}, journal = {2015 International Conference on Information Technology Systems and Innovation, ICITSI 2015 - Proceedings}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {Autism, known as a spectrum disorder (ASD) is seen in early childhood or by three years of age. ASD is a neuro-developmental disorder characterized by deficits in social responsiveness, impairments in verbal and nonverbal communication. The purpose of this paper is to demonstrate the relevance of e-learning technology to the area of training the caregivers of autistic children. Our search focused on a number of data banks that contain numerous references to autism and home based treatment. Our results found only ten papers published since 2010 that met our criteria for inclusion. Six were demonstrations of e learning to teach caregivers and professionals the basics of applied behavior analysis and some techniques for skill training. The remainder of the studies fell into the telehealth category which involved direct communication between a professional and caregiver in the home. The studies suggest that home based service delivery is effective and offers both the social service system and parents considerable financial savings. The use of Web based platform (e learning and telehealth) is depicted as an aid to caregivers of autistic children. The need for more studies of the variables related to home based service delivery is noted. © 2015 IEEE.}, note = {cited By 1}, keywords = {Autism Intervention, Developmental Disorders, Direct Communications, Diseases, E-learning, E-learning Technology, Medical Computing, Nonverbal Communication, Personnel Training, Research, Telehealth, Web-Based}, pubstate = {published}, tppubtype = {conference} } Autism, known as a spectrum disorder (ASD) is seen in early childhood or by three years of age. ASD is a neuro-developmental disorder characterized by deficits in social responsiveness, impairments in verbal and nonverbal communication. The purpose of this paper is to demonstrate the relevance of e-learning technology to the area of training the caregivers of autistic children. Our search focused on a number of data banks that contain numerous references to autism and home based treatment. Our results found only ten papers published since 2010 that met our criteria for inclusion. Six were demonstrations of e learning to teach caregivers and professionals the basics of applied behavior analysis and some techniques for skill training. The remainder of the studies fell into the telehealth category which involved direct communication between a professional and caregiver in the home. The studies suggest that home based service delivery is effective and offers both the social service system and parents considerable financial savings. The use of Web based platform (e learning and telehealth) is depicted as an aid to caregivers of autistic children. The need for more studies of the variables related to home based service delivery is noted. © 2015 IEEE. |
2015 |
Isa, N R M; Yusoff, M; Khalid, N E; Tahir, N; Nikmat, Binti A W Autism severity level detection using fuzzy expert system Conference Institute of Electrical and Electronics Engineers Inc., 2015, ISBN: 9781479957651, (cited By 2). Abstract | Links | BibTeX | Tags: Autism, Autism Severity Level, Autistic Children, Children with Autism, Data Acquisition, Developmental Disorders, Diseases, Education, Expert Systems, Fuzzy Expert Systems, Level Detections, Manufacture, Robotics, Social Communications, Surveys, System Architectures, Teaching @conference{Isa2015218, title = {Autism severity level detection using fuzzy expert system}, author = {N R M Isa and M Yusoff and N E Khalid and N Tahir and A W Binti Nikmat}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959503922&doi=10.1109%2fROMA.2014.7295891&partnerID=40&md5=63e742d59b785d14f87d98dac7dd71ee}, doi = {10.1109/ROMA.2014.7295891}, isbn = {9781479957651}, year = {2015}, date = {2015-01-01}, journal = {2014 IEEE International Symposium on Robotics and Manufacturing Automation, IEEE-ROMA2014}, pages = {218-223}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {Autism is a neuro developmental disorder that is recently well known among Malaysian. Many researches on autism detection have been conducted worldwide. However, there is lack of research conducted in detecting autism severity level. Therefore, this paper focuses on autism severity level detection using fuzzy expert system. Two main autistic behavioral criteria are selected which are social communication impairment and restricted repetitive behavior. Data acquisition was based on interview sessions with clinical psychologist and distribution of 36 questionnaires to teachers and parents that have autistic children. It was then analyzed and the cut off points for each severity level; level 1 (mild), level 2 (moderate), and level 3 (severe) is determined. The fuzzy expert system processes are employed to detect the severity levels. The processes involve Fuzzy system architecture, fuzzification, rules evaluation, rules evaluation and defuzzification. The finding demonstrates that the system is able to detect autism severity level with a good accuracy. This system also accommodates with suitable recommendation based on the generated result whether the suggestion is to go for speech therapy or behavior therapy. © 2014 IEEE.}, note = {cited By 2}, keywords = {Autism, Autism Severity Level, Autistic Children, Children with Autism, Data Acquisition, Developmental Disorders, Diseases, Education, Expert Systems, Fuzzy Expert Systems, Level Detections, Manufacture, Robotics, Social Communications, Surveys, System Architectures, Teaching}, pubstate = {published}, tppubtype = {conference} } Autism is a neuro developmental disorder that is recently well known among Malaysian. Many researches on autism detection have been conducted worldwide. However, there is lack of research conducted in detecting autism severity level. Therefore, this paper focuses on autism severity level detection using fuzzy expert system. Two main autistic behavioral criteria are selected which are social communication impairment and restricted repetitive behavior. Data acquisition was based on interview sessions with clinical psychologist and distribution of 36 questionnaires to teachers and parents that have autistic children. It was then analyzed and the cut off points for each severity level; level 1 (mild), level 2 (moderate), and level 3 (severe) is determined. The fuzzy expert system processes are employed to detect the severity levels. The processes involve Fuzzy system architecture, fuzzification, rules evaluation, rules evaluation and defuzzification. The finding demonstrates that the system is able to detect autism severity level with a good accuracy. This system also accommodates with suitable recommendation based on the generated result whether the suggestion is to go for speech therapy or behavior therapy. © 2014 IEEE. |
Mandasari, V; Theng, L B Enhancing the acquisition of social skills through the interactivity of multimedia Book IGI Global, 2015, ISBN: 9781466686151; 1466686146; 9781466686144, (cited By 0). Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Brain Abnormalities, Developmental Disorders, Education, Effective Tool, Interactivity, Pedagogical Tools, Social Behaviour, Social Skills, Teaching @book{Mandasari20151430, title = {Enhancing the acquisition of social skills through the interactivity of multimedia}, author = {V Mandasari and L B Theng}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958609292&doi=10.4018%2f978-1-4666-8614-4.ch065&partnerID=40&md5=85be5b68f81521c510657862d202e50c}, doi = {10.4018/978-1-4666-8614-4.ch065}, isbn = {9781466686151; 1466686146; 9781466686144}, year = {2015}, date = {2015-01-01}, journal = {Social Media and Networking: Concepts, Methodologies, Tools, and Applications}, volume = {3-4}, pages = {1430-1462}, publisher = {IGI Global}, abstract = {Autism Spectrum Disorders (ASD) are a group of neuro-developmental disorders caused by brain abnormalities which result in impaired social story. Research on treatment in helping children with ASD to improve social story is growing as the cases of children diagnosed with ASD are on the rise. Social story is one of the proven methods of treatment in helping children with ASD to acquire social story through scenarios written in the form of stories. However, the current approaches to present the social story lack interactivity, consuming more intensive efforts to acquire the social story. Learning is most effectual when motivated; thus, the purpose of this study is to discover a learning tool that children with ASD will be motivated to learn independently, and it is achievable by combining elements that they are interested in. This research utilizes the interactivity of multimedia as a medium to present an interactive pedagogical tool for children with ASD to acquire social story. This combination is anticipated to be an effective tool in teaching social story to children with ASD, as they are naturally drawn to computers and visual cues, combined with the fact that Social Story™ has been effective in changing the social behavior of children with ASD. Thus, this study has contributed to the emergent research of treatment for children with ASD in social story acquisition. The result of this study is important as it presents a novel assistance that can be used effectively in assisting children with ASD to improve their main deficit, social story. © 2016, IGI Global. All rights reserved.}, note = {cited By 0}, keywords = {Autism Spectrum Disorders, Brain Abnormalities, Developmental Disorders, Education, Effective Tool, Interactivity, Pedagogical Tools, Social Behaviour, Social Skills, Teaching}, pubstate = {published}, tppubtype = {book} } Autism Spectrum Disorders (ASD) are a group of neuro-developmental disorders caused by brain abnormalities which result in impaired social story. Research on treatment in helping children with ASD to improve social story is growing as the cases of children diagnosed with ASD are on the rise. Social story is one of the proven methods of treatment in helping children with ASD to acquire social story through scenarios written in the form of stories. However, the current approaches to present the social story lack interactivity, consuming more intensive efforts to acquire the social story. Learning is most effectual when motivated; thus, the purpose of this study is to discover a learning tool that children with ASD will be motivated to learn independently, and it is achievable by combining elements that they are interested in. This research utilizes the interactivity of multimedia as a medium to present an interactive pedagogical tool for children with ASD to acquire social story. This combination is anticipated to be an effective tool in teaching social story to children with ASD, as they are naturally drawn to computers and visual cues, combined with the fact that Social Story™ has been effective in changing the social behavior of children with ASD. Thus, this study has contributed to the emergent research of treatment for children with ASD in social story acquisition. The result of this study is important as it presents a novel assistance that can be used effectively in assisting children with ASD to improve their main deficit, social story. © 2016, IGI Global. All rights reserved. |
Bakar, M A A; Ismail, Z; Fikry, A; Musa, R; Hassan, H; Ahmad, S S; Samat, N; Hashim, R Review on training policy for teachers and parents in using humanoid for children with autism Conference Institute of Electrical and Electronics Engineers Inc., 2015, ISBN: 9781479957651, (cited By 1). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism, Autism Spectrum Disorders, Central Nervous System Stimulants, Children with Autism, Developmental Disorders, Diseases, Education, Humanoid Robot, Manufacture, Parents, Personnel Training, Prevalence Rates, Robotics, Teacher, Teaching @conference{Bakar2015180, title = {Review on training policy for teachers and parents in using humanoid for children with autism}, author = {M A A Bakar and Z Ismail and A Fikry and R Musa and H Hassan and S S Ahmad and N Samat and R Hashim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959501336&doi=10.1109%2fROMA.2014.7295884&partnerID=40&md5=8bce6d13363f0e49a90109feee8598fb}, doi = {10.1109/ROMA.2014.7295884}, isbn = {9781479957651}, year = {2015}, date = {2015-01-01}, journal = {2014 IEEE International Symposium on Robotics and Manufacturing Automation, IEEE-ROMA2014}, pages = {180-184}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {Autism spectrum disorder is a life-long development disorder distinguish by impairment related to central nervous system maturation with features include delay in social life development, problem in language, social skills and repetitive behavior. Autism is a global crisis due to prevalence rates higher in several countries and the need for treatment view to be important. This paper reviews on the training policy for teachers and parents in using humanoid for children with autism. In Malaysia, there is no proper and specific training policy for children with autism through implementation of humanoid. © 2014 IEEE.}, note = {cited By 1}, keywords = {Anthropomorphic Robots, Autism, Autism Spectrum Disorders, Central Nervous System Stimulants, Children with Autism, Developmental Disorders, Diseases, Education, Humanoid Robot, Manufacture, Parents, Personnel Training, Prevalence Rates, Robotics, Teacher, Teaching}, pubstate = {published}, tppubtype = {conference} } Autism spectrum disorder is a life-long development disorder distinguish by impairment related to central nervous system maturation with features include delay in social life development, problem in language, social skills and repetitive behavior. Autism is a global crisis due to prevalence rates higher in several countries and the need for treatment view to be important. This paper reviews on the training policy for teachers and parents in using humanoid for children with autism. In Malaysia, there is no proper and specific training policy for children with autism through implementation of humanoid. © 2014 IEEE. |
2014 |
Bhat, S; Acharya, U R; Adeli, H; Bairy, G M; Adeli, A Autism: Cause factors, early diagnosis and therapies Journal Article Reviews in the Neurosciences, 25 (6), pp. 841-850, 2014, ISSN: 03341763, (cited By 52). Abstract | Links | BibTeX | Tags: 4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide @article{Bhat2014841, title = {Autism: Cause factors, early diagnosis and therapies}, author = {S Bhat and U R Acharya and H Adeli and G M Bairy and A Adeli}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925284617&doi=10.1515%2frevneuro-2014-0056&partnerID=40&md5=caaa32e66af70e70ec325241d01564c9}, doi = {10.1515/revneuro-2014-0056}, issn = {03341763}, year = {2014}, date = {2014-01-01}, journal = {Reviews in the Neurosciences}, volume = {25}, number = {6}, pages = {841-850}, publisher = {Walter de Gruyter GmbH}, abstract = {Autism spectrum disorder (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 in 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH.}, note = {cited By 52}, keywords = {4 Aminobutyric Acid, Adolescent, Agenesis of Corpus Callosum, Animal Assisted Therapy, Anticonvulsive Agent, Article, Assistive Technology, Attention, Autism, Autism Spectrum Disorders, Behaviour Therapy, Biological Marker, Brain, Child Development Disorders, Children, Cognition, Cystine, Developmental Disorders, Diseases, Dolphin, Dolphin Assisted Therapy, DSM-5, Early Diagnosis, Emotion, Facial Expression, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Gaze, Glutathione, Glutathione Disulfide, Human, Infant, Interpersonal Communication, Methionine, Nervous System Inflammation, Neurobiology, Neurofeedback, Oxidative Stress, Pervasive, Physiology, Preschool Child, Priority Journal, Psychoeducation, School Child, Social Interactions, Speech Therapy, Virtual Reality, Zonisamide}, pubstate = {published}, tppubtype = {article} } Autism spectrum disorder (ASD) is a complex neurobiological disorder characterized by neuropsychological and behavioral deficits. Cognitive impairment, lack of social skills, and stereotyped behavior are the major autistic symptoms, visible after a certain age. It is one of the fastest growing disabilities. Its current prevalence rate in the U.S. estimated by the Centers for Disease Control and Prevention is 1 in 68 births. The genetic and physiological structure of the brain is studied to determine the pathology of autism, but diagnosis of autism at an early age is challenging due to the existing phenotypic and etiological heterogeneity among ASD individuals. Volumetric and neuroimaging techniques are explored to elucidate the neuroanatomy of the ASD brain. Nuroanatomical, neurochemical, and neuroimaging biomarkers can help in the early diagnosis and treatment of ASD. This paper presents a review of the types of autism, etiologies, early detection, and treatment of ASD. © 2014 Walter de Gruyter GmbH. |
Shobana, M; Saravanan, C Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Journal Article East Asian Archives of Psychiatry, 24 (1), pp. 16-22, 2014, ISSN: 20789947, (cited By 6). Abstract | Links | BibTeX | Tags: Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability @article{Shobana201416, title = {Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability}, author = {M Shobana and C Saravanan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898619897&partnerID=40&md5=e877e03b868d1a11ed8f859a33057d5d}, issn = {20789947}, year = {2014}, date = {2014-01-01}, journal = {East Asian Archives of Psychiatry}, volume = {24}, number = {1}, pages = {16-22}, publisher = {Hong Kong Academy of Medicine Press}, abstract = {Objective: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Methods: In this study, 112 mothers of children having mild and moderate levels of autism disorder, Down syndrome, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Results: Overall, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, anxiety, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Conclusion: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists.}, note = {cited By 6}, keywords = {Adult, Anxiety, Article, Attitude, Autism, Autism Spectrum Disorders, Children, Comparative Study, Depression, Developmental Disabilities, Developmental Disorders, Down Syndrome, Education, Female, General Health Questionnaire 28, Home Care, Hostility, Human, Intellectual Disability, Intellectual Impairment, Major Clinical Study, Malaysia, Male, Mental Disorders, Mother Child Relation, Mothers, Named Inventories, Parental Attitude, Parental Attitude Scale, Prevalence, Psychological Well Being, Questionnaires, Rating Scale, School Child, Social Disability}, pubstate = {published}, tppubtype = {article} } Objective: Parents' positive attitudes and psychological wellbeing play an important role in the development of the children with developmental disability. This study aimed to measure the prevalence of psychological problems among mothers of children with autism disorder, intellectual disability, and Down syndrome. The second aim was to assess the differences in mothers' attitudes and psychological problems among their children with intellectual disability, autism disorder, and Down syndrome. The third aim was to identify whether negative attitude was a predictor of psychological problems in these mothers. Methods: In this study, 112 mothers of children having mild and moderate levels of autism disorder, Down syndrome, and intellectual disability were assessed using the Parental Attitude Scale and General Health Questionnaire-28. Results: Overall, mothers of children with intellectual disability were found to have the most negative attitude towards their child. Mothers of children with autism disorder exhibited higher scores on somatic symptoms, anxiety, and social dysfunction when compared with their counterparts with Down syndrome and intellectual disability. Negative attitude was a significant predictor of psychological problems. Conclusion: Parental attitudes and psychological problems would vary among mothers of children with different types of developmental disability. © 2014 Hong Kong College of Psychiatrists. |
Samat, M R A; Shamsuddin, S; Miskam, M A; Yussof, H Institute of Electrical and Electronics Engineers Inc., 2014, ISBN: 9781479966790, (cited By 1). Abstract | Links | BibTeX | Tags: Algorithms, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Essential Elements, Face Recognition, Face Recognition Algorithms, Robotics, Social Communications, Training Modules @conference{Samat2014, title = {Development of face recognition algorithm for enhancement of social communication of robotic assistive autism therapy}, author = {M R A Samat and S Shamsuddin and M A Miskam and H Yussof}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922181743&doi=10.1109%2fMHS.2014.7006062&partnerID=40&md5=a995285772a99b9a81c11f49e0a94341}, doi = {10.1109/MHS.2014.7006062}, isbn = {9781479966790}, year = {2014}, date = {2014-01-01}, journal = {2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {In this paper, we propose a face recognition method for tracking, detecting and recognizing the faces of children with Autism Spectrum Disorder (ASD) for robotic assistive therapy application. ASD is a brain developmental disorder that manifests itself through a person's behavior and social-communication skill [1]. Face recognition stage is an essential element in robotic assistive therapy since it is the first interaction step that occurs between autistic children and robot. The algorithm aims to encourage autistic children to interact and to capture their attention using a robot that recognizes their faces. This is to establish a beneficial training environment for autistic children before engaging further in the training module. © 2014 IEEE.}, note = {cited By 1}, keywords = {Algorithms, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Essential Elements, Face Recognition, Face Recognition Algorithms, Robotics, Social Communications, Training Modules}, pubstate = {published}, tppubtype = {conference} } In this paper, we propose a face recognition method for tracking, detecting and recognizing the faces of children with Autism Spectrum Disorder (ASD) for robotic assistive therapy application. ASD is a brain developmental disorder that manifests itself through a person's behavior and social-communication skill [1]. Face recognition stage is an essential element in robotic assistive therapy since it is the first interaction step that occurs between autistic children and robot. The algorithm aims to encourage autistic children to interact and to capture their attention using a robot that recognizes their faces. This is to establish a beneficial training environment for autistic children before engaging further in the training module. © 2014 IEEE. |
Shamsuddin, S; Malik, N A; Yussof, H; Mohamed, S; Hanapiah, F A; Yunus, F W Telerehabilitation in robotic assistive therapy for children with developmental disabilities Conference Institute of Electrical and Electronics Engineers Inc., 2014, ISBN: 9781479920280, (cited By 6). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Children with Autism, Developmental Disabilities, Developmental Disorders, Diseases, Humanoid Robot, Initial Development, Medical Computing, Patient Rehabilitation, Robotics, Telecommunication, Telecommunication Technologies, Telehealth, Telerehabilitation @conference{Shamsuddin2014370, title = {Telerehabilitation in robotic assistive therapy for children with developmental disabilities}, author = {S Shamsuddin and N A Malik and H Yussof and S Mohamed and F A Hanapiah and F W Yunus}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84911960252&partnerID=40&md5=bcbf0061bc768b3c535259bd8b924579}, isbn = {9781479920280}, year = {2014}, date = {2014-01-01}, journal = {IEEE TENSYMP 2014 - 2014 IEEE Region 10 Symposium}, pages = {370-375}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {This paper embarks on the initial development of a telerehabilitation system in assistive therapy for children with disabilities. The goal is specifically for children with autism and cerebral palsy at various locations to gain access to robotic intervention. Ten learning modules targeting at specific therapy outcomes have been developed for this system. Here, this research proposes to link various stakeholders including engineers, parents, clinicians and therapists in a network that promotes robotic and telecommunication technology as a rehabilitation platform for children with disabilities. Field trials involving real users will be executed in the next phase of study. © 2014 IEEE.}, note = {cited By 6}, keywords = {Anthropomorphic Robots, Children with Autism, Developmental Disabilities, Developmental Disorders, Diseases, Humanoid Robot, Initial Development, Medical Computing, Patient Rehabilitation, Robotics, Telecommunication, Telecommunication Technologies, Telehealth, Telerehabilitation}, pubstate = {published}, tppubtype = {conference} } This paper embarks on the initial development of a telerehabilitation system in assistive therapy for children with disabilities. The goal is specifically for children with autism and cerebral palsy at various locations to gain access to robotic intervention. Ten learning modules targeting at specific therapy outcomes have been developed for this system. Here, this research proposes to link various stakeholders including engineers, parents, clinicians and therapists in a network that promotes robotic and telecommunication technology as a rehabilitation platform for children with disabilities. Field trials involving real users will be executed in the next phase of study. © 2014 IEEE. |
2013 |
Mandasari, V; Theng, L B Enhancing the acquisitionof social skills through the interactivity of multimedia Book IGI Global, 2013, ISBN: 9781466646247; 1466646233; 9781466646230, (cited By 1). Abstract | Links | BibTeX | Tags: Autism Spectrum Disorders, Brain Abnormalities, Developmental Disorders, Education, Effective Tool, Interactivity, Pedagogical Tools, Social Behaviour, Social Skills, Teaching @book{Mandasari201395, title = {Enhancing the acquisitionof social skills through the interactivity of multimedia}, author = {V Mandasari and L B Theng}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944882717&doi=10.4018%2f978-1-4666-4623-0.ch005&partnerID=40&md5=c37aba1d085474c73c684dda79ba7da3}, doi = {10.4018/978-1-4666-4623-0.ch005}, isbn = {9781466646247; 1466646233; 9781466646230}, year = {2013}, date = {2013-01-01}, journal = {Emerging Research and Trends in Interactivity and the Human-Computer Interface}, pages = {95-126}, publisher = {IGI Global}, abstract = {Autism Spectrum Disorders (ASD) are a group of neuro-developmental disorders caused by brain abnormalities which result in impaired social story. Research on treatment in helping children with ASD to improve social story is growing as the cases of children diagnosed with ASD are on the rise. Social story is one of the proven methods of treatment in helping children with ASD to acquire social story through scenarios written in the form of stories. However, the current approaches to present the social story lack interactivity, consuming more intensive efforts to acquire the social story. Learning is most effectual when motivated; thus, the purpose of this study is to discover a learning tool that children with ASD will be motivated to learn independently, and it is achievable by combining elements that they are interested in. This research utilizes the interactivity of multimedia as a medium to present an interactive pedagogical tool for children with ASD to acquire social story. This combination is anticipated to be an effective tool in teaching social story to children with ASD, as they are naturally drawn to computers and visual cues, combined with the fact that Social Story™ has been effective in changing the social behavior of children with ASD. Thus, this study has contributed to the emergent research of treatment for children with ASD in social story acquisition. The result of this study is important as it presents a novel assistance that can be used effectively in assisting children with ASD to improve their main deficit, social story. © 2014 by IGI Global. All rights reserved.}, note = {cited By 1}, keywords = {Autism Spectrum Disorders, Brain Abnormalities, Developmental Disorders, Education, Effective Tool, Interactivity, Pedagogical Tools, Social Behaviour, Social Skills, Teaching}, pubstate = {published}, tppubtype = {book} } Autism Spectrum Disorders (ASD) are a group of neuro-developmental disorders caused by brain abnormalities which result in impaired social story. Research on treatment in helping children with ASD to improve social story is growing as the cases of children diagnosed with ASD are on the rise. Social story is one of the proven methods of treatment in helping children with ASD to acquire social story through scenarios written in the form of stories. However, the current approaches to present the social story lack interactivity, consuming more intensive efforts to acquire the social story. Learning is most effectual when motivated; thus, the purpose of this study is to discover a learning tool that children with ASD will be motivated to learn independently, and it is achievable by combining elements that they are interested in. This research utilizes the interactivity of multimedia as a medium to present an interactive pedagogical tool for children with ASD to acquire social story. This combination is anticipated to be an effective tool in teaching social story to children with ASD, as they are naturally drawn to computers and visual cues, combined with the fact that Social Story™ has been effective in changing the social behavior of children with ASD. Thus, this study has contributed to the emergent research of treatment for children with ASD in social story acquisition. The result of this study is important as it presents a novel assistance that can be used effectively in assisting children with ASD to improve their main deficit, social story. © 2014 by IGI Global. All rights reserved. |
Mitchell, Peter Mentalizing in autism: Interpreting facial expressions, following gaze, reading body language and inferring traits Journal Article JOURNAL OF EDUCATIONAL SCIENCES & PSYCHOLOGY, 3 (1), pp. 111-120, 2013, ISSN: 2247-6377. Abstract | BibTeX | Tags: Autism, Developmental Disorders, Mentalizing, Social Functioning @article{ISI:000217241600014, title = {Mentalizing in autism: Interpreting facial expressions, following gaze, reading body language and inferring traits}, author = {Peter Mitchell}, issn = {2247-6377}, year = {2013}, date = {2013-01-01}, journal = {JOURNAL OF EDUCATIONAL SCIENCES & PSYCHOLOGY}, volume = {3}, number = {1}, pages = {111-120}, publisher = {PETROLEUM-GAS UNIV PLOIESTI}, address = {BD BUCURESTI 39, PLOIESTI, 100680, ROMANIA}, abstract = {Autism is a pervasive developmental disorder occurring at about the rate of one per hundred of the population. Past research has been interpreted to suggest that people with autism have profound deficits in understanding people's minds. The research summarized in this article suggests, however, that high functioning adults with autism differ in but a subtle way from comparison participants in the cognitive underpinnings of their social functioning. In particular, it seems participants with autism are fairly effective in interpreting psychological information from another person's eyes, are effective in following gaze and to some degree they are successful in guessing what happened to a person from their body language. In all of these skills, people with autism are not quite as skillful as people without autism. Speculations are offered on how developmental factors might contribute to lack of opportunity to refine cognitive skills associated with interpersonal activities in people with autism.}, keywords = {Autism, Developmental Disorders, Mentalizing, Social Functioning}, pubstate = {published}, tppubtype = {article} } Autism is a pervasive developmental disorder occurring at about the rate of one per hundred of the population. Past research has been interpreted to suggest that people with autism have profound deficits in understanding people's minds. The research summarized in this article suggests, however, that high functioning adults with autism differ in but a subtle way from comparison participants in the cognitive underpinnings of their social functioning. In particular, it seems participants with autism are fairly effective in interpreting psychological information from another person's eyes, are effective in following gaze and to some degree they are successful in guessing what happened to a person from their body language. In all of these skills, people with autism are not quite as skillful as people without autism. Speculations are offered on how developmental factors might contribute to lack of opportunity to refine cognitive skills associated with interpersonal activities in people with autism. |
Miskam, M A; Hamid, M A C; Yussof, H; Shamsuddin, S; Malik, N A; Basir, S N Study on social interaction between children with autism and humanoid robot NAO Journal Article Applied Mechanics and Materials, 393 , pp. 573-578, 2013, ISSN: 16609336, (cited By 10). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism, Children with Autism, Communication, Developmental Disorders, Diseases, Education, Educational Intervention, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Mechanical Engineering, Patient Rehabilitation, Social Interactions, Social Sciences, Two-Way Communications @article{Miskam2013573, title = {Study on social interaction between children with autism and humanoid robot NAO}, author = {M A Miskam and M A C Hamid and H Yussof and S Shamsuddin and N A Malik and S N Basir}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886245367&doi=10.4028%2fwww.scientific.net%2fAMM.393.573&partnerID=40&md5=95d6cec2dc5888c99213397d5b94b003}, doi = {10.4028/www.scientific.net/AMM.393.573}, issn = {16609336}, year = {2013}, date = {2013-01-01}, journal = {Applied Mechanics and Materials}, volume = {393}, pages = {573-578}, abstract = {Autism cannot run away from their triangle deficits: social, communication and stereotyped behaviour. There is no cure for autism or any definitive treatment to treat the core symptoms of this developmental disorder. However, the deficits can be minimized by maximize their learning through behavioural therapy and educational intervention. Nowadays, the methods in the rehabilitation of autism have been upgraded by the innovation of humanoid robots, in particular the humanoid robot NAO. In this study, NAO has being programmed using Choregraphe as programming tool to develop lesson modules for children with autism to practice their social interaction skill. This paper focuses specifically on social interaction subscale to observe the behaviour of the autistic children during interaction with the humanoid robot NAO. The observation is based on six items referenced from the Gilliam Autism Rating Scale-second edition (GARS-2). The use of humanoid robot NAO in the rehabilitation of autistic children is expected to help them to interact and practice their social traits just like normal children. The results evidently showed that children with autism are positively affected by NAO by giving encouraging responses in social interaction when interacting with the robot. Two-way communication between the child and robot in real time significantly give positive impact in the responses towards the robot. © (2013) Trans Tech Publications, Switzerland.}, note = {cited By 10}, keywords = {Anthropomorphic Robots, Autism, Children with Autism, Communication, Developmental Disorders, Diseases, Education, Educational Intervention, Human Robot Interaction, Humanoid Robot, Humanoid Robot NAO, Mechanical Engineering, Patient Rehabilitation, Social Interactions, Social Sciences, Two-Way Communications}, pubstate = {published}, tppubtype = {article} } Autism cannot run away from their triangle deficits: social, communication and stereotyped behaviour. There is no cure for autism or any definitive treatment to treat the core symptoms of this developmental disorder. However, the deficits can be minimized by maximize their learning through behavioural therapy and educational intervention. Nowadays, the methods in the rehabilitation of autism have been upgraded by the innovation of humanoid robots, in particular the humanoid robot NAO. In this study, NAO has being programmed using Choregraphe as programming tool to develop lesson modules for children with autism to practice their social interaction skill. This paper focuses specifically on social interaction subscale to observe the behaviour of the autistic children during interaction with the humanoid robot NAO. The observation is based on six items referenced from the Gilliam Autism Rating Scale-second edition (GARS-2). The use of humanoid robot NAO in the rehabilitation of autistic children is expected to help them to interact and practice their social traits just like normal children. The results evidently showed that children with autism are positively affected by NAO by giving encouraging responses in social interaction when interacting with the robot. Two-way communication between the child and robot in real time significantly give positive impact in the responses towards the robot. © (2013) Trans Tech Publications, Switzerland. |
2012 |
Clark, M; Brown, R; Karrapaya, R An initial look at the quality of life of Malaysian families that include children with disabilities Journal Article Journal of Intellectual Disability Research, 56 (1), pp. 45-60, 2012, ISSN: 09642633, (cited By 16). Abstract | Links | BibTeX | Tags: Adolescent, Adult, Article, Autism, Caregiver, Cerebral Palsy, Children, Cost of Illness, Cross-Cultural Comparison, Developmental Disabilities, Developmental Disorders, Disabled Children, Down Syndrome, Family, Family Health, Female, Health Care, Health Care Delivery, Health Survey, Human, Intellectual Disability, Intellectual Impairment, Life Satisfaction, Malaysia, Male, Parents, Policy, Preschool, Preschool Child, Psychometrics, Quality of Life, Questionnaires, School Child, Social Support, Socioeconomic Factors @article{Clark201245, title = {An initial look at the quality of life of Malaysian families that include children with disabilities}, author = {M Clark and R Brown and R Karrapaya}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-83855165819&doi=10.1111%2fj.1365-2788.2011.01408.x&partnerID=40&md5=4822406179501d1b0b93c5374e383637}, doi = {10.1111/j.1365-2788.2011.01408.x}, issn = {09642633}, year = {2012}, date = {2012-01-01}, journal = {Journal of Intellectual Disability Research}, volume = {56}, number = {1}, pages = {45-60}, abstract = {Background While there is a growing body of literature in the quality of life of families that include children with disabilities, the majority of research has been conducted in western countries. The present study provides an initial exploration of the quality of life of Malaysian families that include children with developmental/intellectual disabilities. Dynamics characterising Malaysian society are described as developments in social policy and service delivery that support persons with disabilities and their families. Method Questionnaire data were collected using the Family Quality of Life Survey - Short Version. Members of 52 families that included one or two children with disabilities were interviewed. Their responses provided their perceptions within six dimensions of family quality of life across the nine life domains assessed. Results Findings showed a consistent pattern of relatively strong perceived ímportance' ratings in each of life domains as compared to mean ratings for other family quality of life dimensions. Some dimensions of family quality of life, in particular ópportunities', ínitiative' and áttainment', demonstrated particularly strong associations with each other. Overall means of satisfaction with and attainment of family quality of life as well as global evaluations of quality of life and satisfaction all demonstrated significant associations, although each of these correlations accounted for less than 50% of the common variance. Conclusions The importance rating can be viewed as a determining factor in terms of quality of life, and it played a critical role in supporting attainment of, and satisfaction with, family quality of life, assuming opportunities, initiative and stability are adequate. The need for a broader sample including families that were not receiving services was noted. Future research questions based on the results of the current study and some of the dynamics impacting Malaysian society are also suggested. © 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd.}, note = {cited By 16}, keywords = {Adolescent, Adult, Article, Autism, Caregiver, Cerebral Palsy, Children, Cost of Illness, Cross-Cultural Comparison, Developmental Disabilities, Developmental Disorders, Disabled Children, Down Syndrome, Family, Family Health, Female, Health Care, Health Care Delivery, Health Survey, Human, Intellectual Disability, Intellectual Impairment, Life Satisfaction, Malaysia, Male, Parents, Policy, Preschool, Preschool Child, Psychometrics, Quality of Life, Questionnaires, School Child, Social Support, Socioeconomic Factors}, pubstate = {published}, tppubtype = {article} } Background While there is a growing body of literature in the quality of life of families that include children with disabilities, the majority of research has been conducted in western countries. The present study provides an initial exploration of the quality of life of Malaysian families that include children with developmental/intellectual disabilities. Dynamics characterising Malaysian society are described as developments in social policy and service delivery that support persons with disabilities and their families. Method Questionnaire data were collected using the Family Quality of Life Survey - Short Version. Members of 52 families that included one or two children with disabilities were interviewed. Their responses provided their perceptions within six dimensions of family quality of life across the nine life domains assessed. Results Findings showed a consistent pattern of relatively strong perceived ímportance' ratings in each of life domains as compared to mean ratings for other family quality of life dimensions. Some dimensions of family quality of life, in particular ópportunities', ínitiative' and áttainment', demonstrated particularly strong associations with each other. Overall means of satisfaction with and attainment of family quality of life as well as global evaluations of quality of life and satisfaction all demonstrated significant associations, although each of these correlations accounted for less than 50% of the common variance. Conclusions The importance rating can be viewed as a determining factor in terms of quality of life, and it played a critical role in supporting attainment of, and satisfaction with, family quality of life, assuming opportunities, initiative and stability are adequate. The need for a broader sample including families that were not receiving services was noted. Future research questions based on the results of the current study and some of the dynamics impacting Malaysian society are also suggested. © 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd. |
Salih, M R M; Bahari, M B; Hassali, M A A; Shafie, A A; Al-Lela, O Q B; Abd, A Y; Ganesan, V M Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Journal Article Journal of Neurosciences in Rural Practice, 3 (3), pp. 244-250, 2012, ISSN: 09763147, (cited By 1). Abstract | Links | BibTeX | Tags: Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease @article{Salih2012244, title = {Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy}, author = {M R M Salih and M B Bahari and M A A Hassali and A A Shafie and O Q B Al-Lela and A Y Abd and V M Ganesan}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870233746&doi=10.4103%2f0976-3147.102596&partnerID=40&md5=039bd22d6c38366ebfdd00a4254c20f0}, doi = {10.4103/0976-3147.102596}, issn = {09763147}, year = {2012}, date = {2012-01-01}, journal = {Journal of Neurosciences in Rural Practice}, volume = {3}, number = {3}, pages = {244-250}, abstract = {Introduction: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form. Results: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.}, note = {cited By 1}, keywords = {Adolescent, Anticonvulsive Agent, Article, Autism, Benign Childhood Epilepsy, Brain Disease, Carbamazepine, Cerebral Palsy, Children, Chinese, Clonazepam, Cohort Analysis, Congenital Toxoplasmosis, Controlled Study, Corpus Callosum Agenesis, Dandy Walker Syndrome, Degenerative Disease, Developmental Disorders, Disorders of Mitochondrial Functions, Down Syndrome, Epilepsy, Ethnicity, Etiracetam, Female, Focal Epilepsy, Happy Puppet Syndrome, Human, Hydrocephalus, Indian, Intellectual Impairment, Lamotrigine, Major Clinical Study, Malay, Male, Medical Record, Microcephaly, Monotherapy, Preschool Child, Priority Journal, Retrospective Study, School Child, Seizure, Structural Metabolic Epilepsy, Tuberous Sclerosis, Valproic Acid, Wilson Disease}, pubstate = {published}, tppubtype = {article} } Introduction: Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. Materials and Methods: A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form. Results: Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001). Conclusion: Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients. |
Shamsuddin, S; Yussof, H; Ismail, L; Hanapiah, F A; Mohamed, S; Piah, H A; Zahari, N I Initial response of autistic children in human-robot interaction therapy with humanoid robot NAO Conference 2012, ISBN: 9781467309615, (cited By 103). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Autism Spectrum Disorders, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Human Computer Interaction, Human Robot Interaction, Humanoid Robot, Man Machine Systems, Pilot Experiment, Rehabilitation Robotics, Research, Robotics, Signal Processing, Visual Systems @conference{Shamsuddin2012188, title = {Initial response of autistic children in human-robot interaction therapy with humanoid robot NAO}, author = {S Shamsuddin and H Yussof and L Ismail and F A Hanapiah and S Mohamed and H A Piah and N I Zahari}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861537641&doi=10.1109%2fCSPA.2012.6194716&partnerID=40&md5=32572eb3ebc7d201c02a90908128ae28}, doi = {10.1109/CSPA.2012.6194716}, isbn = {9781467309615}, year = {2012}, date = {2012-01-01}, journal = {Proceedings - 2012 IEEE 8th International Colloquium on Signal Processing and Its Applications, CSPA 2012}, pages = {188-193}, abstract = {The overall context proposed in this paper is part of our long-standing goal to contribute to a group of community that suffers from Autism Spectrum Disorder (ASD); a lifelong developmental disability. The objective of this paper is to present the development of our pilot experiment protocol where children with ASD will be exposed to the humanoid robot NAO. This fully programmable humanoid offers an ideal research platform for human-robot interaction (HRI). This study serves as the platform for fundamental investigation to observe the initial response and behavior of the children in the said environment. The system utilizes external cameras, besides the robot's own visual system. Anticipated results are the real initial response and reaction of ASD children during the HRI with the humanoid robot. This shall leads to adaptation of new procedures in ASD therapy based on HRI, especially for a non-technical-expert person to be involved in the robotics intervention during the therapy session. © 2012 IEEE.}, note = {cited By 103}, keywords = {Anthropomorphic Robots, Autism Spectrum Disorders, Autistic Children, Children with Autism, Developmental Disorders, Diseases, Human Computer Interaction, Human Robot Interaction, Humanoid Robot, Man Machine Systems, Pilot Experiment, Rehabilitation Robotics, Research, Robotics, Signal Processing, Visual Systems}, pubstate = {published}, tppubtype = {conference} } The overall context proposed in this paper is part of our long-standing goal to contribute to a group of community that suffers from Autism Spectrum Disorder (ASD); a lifelong developmental disability. The objective of this paper is to present the development of our pilot experiment protocol where children with ASD will be exposed to the humanoid robot NAO. This fully programmable humanoid offers an ideal research platform for human-robot interaction (HRI). This study serves as the platform for fundamental investigation to observe the initial response and behavior of the children in the said environment. The system utilizes external cameras, besides the robot's own visual system. Anticipated results are the real initial response and reaction of ASD children during the HRI with the humanoid robot. This shall leads to adaptation of new procedures in ASD therapy based on HRI, especially for a non-technical-expert person to be involved in the robotics intervention during the therapy session. © 2012 IEEE. |
2011 |
Ismail, L; Shamsuddin, S; Yussof, H; Hashim, H; Bahari, S; Jaafar, A; Zahari, I Face detection technique of Humanoid Robot NAO for application in robotic assistive therapy Conference 2011, ISBN: 9781457716423, (cited By 14). Abstract | Links | BibTeX | Tags: Anthropomorphic Robots, Assistive, Autism Spectrum Disorders, Autistic Children, Cameras, Children with Autism, Communication, Concentration Levels, Control Systems, Cutting Edges, Detection Tools, Developmental Disorders, Diseases, Face Detection, Face Recognition, Graphical User Interfaces, Humanoid Robot, Robotics, Social Interactions @conference{Ismail2011517, title = {Face detection technique of Humanoid Robot NAO for application in robotic assistive therapy}, author = {L Ismail and S Shamsuddin and H Yussof and H Hashim and S Bahari and A Jaafar and I Zahari}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862067305&doi=10.1109%2fICCSCE.2011.6190580&partnerID=40&md5=954caf63c5c5f7f05062436598a32a91}, doi = {10.1109/ICCSCE.2011.6190580}, isbn = {9781457716423}, year = {2011}, date = {2011-01-01}, journal = {Proceedings - 2011 IEEE International Conference on Control System, Computing and Engineering, ICCSCE 2011}, pages = {517-521}, abstract = {This paper proposed a face detection method for tracking the faces of children with Autism Spectrum Disorder in a robotic assistive therapy. The face detection is a novel approach in robotic assistive therapy involving autistic children since it is believe that those children will positively react with high-end devices, gadget and cutting edge devices. The intention of tracking the autistic children's faces is to measure the concentration level of the children in social interaction and communication since everyone knows that those children are suffering from communication disabilities and deficits due to brain developmental disorder. Humanoid Robot Nao with 573.2mm height equipped with 2 internal cameras is utilized for this research. The face detection tools in choregraphe and telepathe based on Graphical User Interface (GUI) module is used in this study. The non-verbal interaction between humanoid robot and autistic children is recorded by using 2 internal cameras from the robot's head. The interaction is going to take about 30 minutes and supervised by occupational therapist and certified psychologist. The autistic children will be introduced to the Humanoid Robot Nao and their reaction will be recorded simultaneously while the robot is trying to track their faces. © 2011 IEEE.}, note = {cited By 14}, keywords = {Anthropomorphic Robots, Assistive, Autism Spectrum Disorders, Autistic Children, Cameras, Children with Autism, Communication, Concentration Levels, Control Systems, Cutting Edges, Detection Tools, Developmental Disorders, Diseases, Face Detection, Face Recognition, Graphical User Interfaces, Humanoid Robot, Robotics, Social Interactions}, pubstate = {published}, tppubtype = {conference} } This paper proposed a face detection method for tracking the faces of children with Autism Spectrum Disorder in a robotic assistive therapy. The face detection is a novel approach in robotic assistive therapy involving autistic children since it is believe that those children will positively react with high-end devices, gadget and cutting edge devices. The intention of tracking the autistic children's faces is to measure the concentration level of the children in social interaction and communication since everyone knows that those children are suffering from communication disabilities and deficits due to brain developmental disorder. Humanoid Robot Nao with 573.2mm height equipped with 2 internal cameras is utilized for this research. The face detection tools in choregraphe and telepathe based on Graphical User Interface (GUI) module is used in this study. The non-verbal interaction between humanoid robot and autistic children is recorded by using 2 internal cameras from the robot's head. The interaction is going to take about 30 minutes and supervised by occupational therapist and certified psychologist. The autistic children will be introduced to the Humanoid Robot Nao and their reaction will be recorded simultaneously while the robot is trying to track their faces. © 2011 IEEE. |
2008 |
Amar, H S S Meeting the needs of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 1-3, 2008, ISSN: 03005283, (cited By 20). Links | BibTeX | Tags: Autism, Behaviour Modification, Child Development, Child Health Care, Children, Clinical Assessment, Clinical Decision Making, Developmental Disorders, Developmental Screening, Disabled Children, Editorial, Health Care, Health Care Delivery, Health Practitioner, Health Program, Health Survey, Human, Intellectual Impairment, Learning Disorder, Malaysia, Pediatric Physiotherapy, Pediatric Rehabilitation, Physical Disability, Preschool, Public Health Service, Register, Sensitivity and Specificity, Sensory Dysfunction, Social Adaptation, Social Welfare, Speech Therapy, Support Group, United Kingdom, United States @article{Amar20081, title = {Meeting the needs of children with disability in Malaysia}, author = {H S S Amar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49749107033&partnerID=40&md5=968c527b940374a37322a599d3ccc812}, issn = {03005283}, year = {2008}, date = {2008-01-01}, journal = {Medical Journal of Malaysia}, volume = {63}, number = {1}, pages = {1-3}, note = {cited By 20}, keywords = {Autism, Behaviour Modification, Child Development, Child Health Care, Children, Clinical Assessment, Clinical Decision Making, Developmental Disorders, Developmental Screening, Disabled Children, Editorial, Health Care, Health Care Delivery, Health Practitioner, Health Program, Health Survey, Human, Intellectual Impairment, Learning Disorder, Malaysia, Pediatric Physiotherapy, Pediatric Rehabilitation, Physical Disability, Preschool, Public Health Service, Register, Sensitivity and Specificity, Sensory Dysfunction, Social Adaptation, Social Welfare, Speech Therapy, Support Group, United Kingdom, United States}, pubstate = {published}, tppubtype = {article} } |
Tan, K L; Yadav, H Reassessment on the development of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 17-20, 2008, ISSN: 03005283, (cited By 5). Abstract | Links | BibTeX | Tags: Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance @article{Tan200817, title = {Reassessment on the development of children with disability in Malaysia}, author = {K L Tan and H Yadav}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-49649115291&partnerID=40&md5=8838ddaa3d9906d8b696be13e88f1baa}, issn = {03005283}, year = {2008}, date = {2008-01-01}, journal = {Medical Journal of Malaysia}, volume = {63}, number = {1}, pages = {17-20}, abstract = {This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. A total of 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autism, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment.}, note = {cited By 5}, keywords = {Article, Autism, Child Development, Children, Clinical Assessment Tool, Cohort Analysis, Controlled Study, Developmental Disorders, Developmental Screening, Disabled Children, Down Syndrome, Family, Female, Follow Up, Human, Infant, Learning Disorder, Major Clinical Study, Malaysia, Male, Mental Deficiency, Patient Selection, Pediatric Rehabilitation, Preschool, Primary Health Care, Register, Speech Disorder, Statistical Significance}, pubstate = {published}, tppubtype = {article} } This is a cohort study investigating the profile of children with disability registered with the primary health care clinics in Malaysia. The purpose of the study was to determine whether reassessment on the development of children with disability under rehabilitation should be done at three months interval or six months interval. Secondary data from the pilot project conducted by the Family Health Development Division, Ministry of Health Malaysia was used in this study. The study was carried out for seven months from 1st August 2004 until 28th February 2005. A total of 168 disabled children followed up for six months were selected in this study. Schedule of Growing Scale (SGS) II was the tool used for analysis. Results showed a statistically significant difference in the mean total SGS score at six months interval but not at three months interval. The result suggests that reassessment on children with Down Syndrome, Autism, Cerebral Palsy, mental retardation and delayed speech under rehabilitation should be carried out every six months while children with gross developmental delay and slow learner might need a longer interval for reassessment. |
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2019 |
Modules of Interaction for ASD Children Using Rero Robot (Humanoid) Conference Institute of Electrical and Electronics Engineers Inc., 2019, ISBN: 9781728129716, (cited By 0). |
PLoS ONE, 14 (3), 2019, ISSN: 19326203, (cited By 4). |
2018 |
Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics Journal Article Journal of Autism and Developmental Disorders, 48 (1), pp. 28-35, 2018, ISSN: 01623257, (cited By 9). |
GRIN2D variants in three cases of developmental and epileptic encephalopathy Journal Article Clinical Genetics, 94 (6), pp. 538-547, 2018, ISSN: 00099163, (cited By 4). |
Humanoid robot intervention with autism: The conceptual model in demonstrating the emotional responses of children with autism Journal Article Advances in Intelligent Systems and Computing, 739 , pp. 574-579, 2018, ISSN: 21945357, (cited By 0). |
2017 |
Reflections of Malaysian parents of children with developmental disabilities on their experiences with AAC Journal Article AAC: Augmentative and Alternative Communication, 33 (2), pp. 110-120, 2017, ISSN: 07434618, (cited By 10). |
User experience of autism social-aid among autistic children: AUTISM social aid application Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 10645 LNCS , pp. 391-397, 2017, ISSN: 03029743, (cited By 0). |
2016 |
The intensity of the research activities on e learning for care givers of autistic children Conference Institute of Electrical and Electronics Engineers Inc., 2016, ISBN: 9781467366649, (cited By 1). |
2015 |
Autism severity level detection using fuzzy expert system Conference Institute of Electrical and Electronics Engineers Inc., 2015, ISBN: 9781479957651, (cited By 2). |
Enhancing the acquisition of social skills through the interactivity of multimedia Book IGI Global, 2015, ISBN: 9781466686151; 1466686146; 9781466686144, (cited By 0). |
Review on training policy for teachers and parents in using humanoid for children with autism Conference Institute of Electrical and Electronics Engineers Inc., 2015, ISBN: 9781479957651, (cited By 1). |
2014 |
Autism: Cause factors, early diagnosis and therapies Journal Article Reviews in the Neurosciences, 25 (6), pp. 841-850, 2014, ISSN: 03341763, (cited By 52). |
Comparative study on attitudes and psychological problems of mothers towards their children with developmental disability Journal Article East Asian Archives of Psychiatry, 24 (1), pp. 16-22, 2014, ISSN: 20789947, (cited By 6). |
Institute of Electrical and Electronics Engineers Inc., 2014, ISBN: 9781479966790, (cited By 1). |
Telerehabilitation in robotic assistive therapy for children with developmental disabilities Conference Institute of Electrical and Electronics Engineers Inc., 2014, ISBN: 9781479920280, (cited By 6). |
2013 |
Enhancing the acquisitionof social skills through the interactivity of multimedia Book IGI Global, 2013, ISBN: 9781466646247; 1466646233; 9781466646230, (cited By 1). |
Mentalizing in autism: Interpreting facial expressions, following gaze, reading body language and inferring traits Journal Article JOURNAL OF EDUCATIONAL SCIENCES & PSYCHOLOGY, 3 (1), pp. 111-120, 2013, ISSN: 2247-6377. |
Study on social interaction between children with autism and humanoid robot NAO Journal Article Applied Mechanics and Materials, 393 , pp. 573-578, 2013, ISSN: 16609336, (cited By 10). |
2012 |
An initial look at the quality of life of Malaysian families that include children with disabilities Journal Article Journal of Intellectual Disability Research, 56 (1), pp. 45-60, 2012, ISSN: 09642633, (cited By 16). |
Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy Journal Article Journal of Neurosciences in Rural Practice, 3 (3), pp. 244-250, 2012, ISSN: 09763147, (cited By 1). |
Initial response of autistic children in human-robot interaction therapy with humanoid robot NAO Conference 2012, ISBN: 9781467309615, (cited By 103). |
2011 |
Face detection technique of Humanoid Robot NAO for application in robotic assistive therapy Conference 2011, ISBN: 9781457716423, (cited By 14). |
2008 |
Meeting the needs of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 1-3, 2008, ISSN: 03005283, (cited By 20). |
Reassessment on the development of children with disability in Malaysia Journal Article Medical Journal of Malaysia, 63 (1), pp. 17-20, 2008, ISSN: 03005283, (cited By 5). |